GB-GOV-10-NIHR_GHRUG1 UK - Department of Health and Social Care (DHSC) The NIHR's first Global Health Research call for Units and Groups. UK universities and research institutes were invited to submit applications, working in equitable partnerships with researchers in low- and middle-income countries (LMICs), to either expand (Units) or develop (Groups) their ambitions to deliver world-class applied global health research to address under-funded or under-researched global health areas specific to those countries. 1) Deliver the UK's ambition to be internationally outstanding in global health research, improving the lives of people in LMICs. 2) Create an environment where world-class global health research, focused on the needs of LMICs can thrive. 3) Translate advances in applied global health research into benefits for patients and the public in LMICs. 4) Focus on priority areas which will have the greatest impact on health in LMICs in the short, medium and long term. 5) Provide high quality research evidence to inform decision-making by public health officials, practitioners and policy makers. 6) Increase the volume and quality of multi-disciplinary global health research from the UK. 7) Develop knowledge and capacity within existing UK institutions which can be translated into global health research practice. 8) Retain a level of responsive research capacity to address emerging global health research requirements (Units only). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Queen Margaret University University of Dundee The University of Edinburgh University of Oxford University of Sussex The University of Edinburgh Liverpool School of Tropical Medicine University College London King's College London Imperial College London Queen Mary University of London University of Birmingham University of Warwick University of Liverpool University of Cambridge University of Warwick London School of Hygience and Tropical Medicine Swansea University Liverpool School of Tropical Medicine University of Southampton University of Central Lancashire University of Cambridge University of Leeds Imperial College London The University of the West of England, Bristol Liverpool School of Tropical Medicine Newcastle University The Queen's University of Belfast Liverpool School of Tropical Medicine University of York University of Birmingham Bart's and The London School of Medicine & Dentistry University of Glasgow UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_136_29 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to improve diagnosis, prevention, response and treatment of podoconiosis, mycetoma and scabies. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) To improve the ability to diagnose, prevent and treat podoconiosis. 2) To develop tools to prevent mycetoma - there is no effective treatment. 3) To strengthen the ability of low-income countries to respond to scabies outbreaks. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Sussex UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 1237352 1618236 1508777 1381224 5745589 GB-GOV-10-16_136_29 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Sussex 257782 GB-GOV-10-16_136_29 2017/18 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Sussex 257782 GB-GOV-10-16_136_29 2017/18 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Sussex 173199 GB-GOV-10-16_136_29 2017/18 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 548589 GB-GOV-10-16_136_29 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 503572 GB-GOV-10-16_136_29 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 557332 GB-GOV-10-16_136_29 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 389208 GB-GOV-10-16_136_29 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 378673 GB-GOV-10-16_136_29 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 606296 GB-GOV-10-16_136_29 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 104060 GB-GOV-10-16_136_29 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 278972 GB-GOV-10-16_136_29 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 845062 GB-GOV-10-16_136_29 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 359431 GB-GOV-10-16_136_29 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 121068 GB-GOV-10-16_136_29 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 77285 GB-GOV-10-16_136_29 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 195716.83 GB-GOV-10-16_136_29 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 53843.62 GB-GOV-10-16_136_29 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex GB-GOV-10-16_136_33 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to reduce the burden of infectious diseases by strengthening health systems in Africa. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Improve the diagnosis and surveillance of infectious diseases in resource-poor settings. 2) Improve the deployment of existing drug treatments and enhance local capacity to develop new ones. 3) Improve the management of both endemic and emerging infections by strengthening health systems, with special attention to ethics and governance; improving policy development and implementation (e.g. drug procurement, local licensing, regulatory harmonization); and enhancing capacity to respond to infectious diseases emergencies, while protecting capacity to manage endemic diseases concurrently. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Edinburgh UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 633543 2959838.38 2751308.42 542162 6886851.8 GB-GOV-10-16_136_33 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 295887 GB-GOV-10-16_136_33 2017/18 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The University of Edinburgh 295887 GB-GOV-10-16_136_33 2017/18 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The University of Edinburgh 41769 GB-GOV-10-16_136_33 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 455200 GB-GOV-10-16_136_33 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 461853 GB-GOV-10-16_136_33 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 935942 GB-GOV-10-16_136_33 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 360094 GB-GOV-10-16_136_33 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 475740 GB-GOV-10-16_136_33 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 765740 GB-GOV-10-16_136_33 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 1360859 GB-GOV-10-16_136_33 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 539475 GB-GOV-10-16_136_33 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 449203 GB-GOV-10-16_136_33 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 104860 GB-GOV-10-16_136_33 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh -371057.65 GB-GOV-10-16_136_33 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh GB-GOV-10-16_136_35 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to improve the health of children and adults through multi-disciplinary applied health research on lung health and tuberculosis, including non-communicable lung diseases and acute presentations of lung disease. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) To focus their research efforts on improving lung health and fighting TB in Africa. 2) To support scientists and work to strengthen the research infrastructure of their institutions. 3) To conduct collaborative research to fill gaps in the current evidence base. For example, to explore ways to bring basic effective and affordable care to people living in both remote rural areas and expanding cities and slums. 4) To develop a 10 to 20 year strategy for Unit-led applied global health research in lung health and TB to look well beyond the initial funding with their sights set on delivering improvements in health for Africa's poorest populations. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 1348795 1746081.3 1923961.93 1979822.75 6998660.98 GB-GOV-10-16_136_35 COMMITMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 676658 GB-GOV-10-16_136_35 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 16808 GB-GOV-10-16_136_35 2017/18 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 655329 GB-GOV-10-16_136_35 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 389230 GB-GOV-10-16_136_35 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 646893 GB-GOV-10-16_136_35 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 16525 GB-GOV-10-16_136_35 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 390912 GB-GOV-10-16_136_35 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 394423 GB-GOV-10-16_136_35 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 521193 GB-GOV-10-16_136_35 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 572069 GB-GOV-10-16_136_35 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 289050 GB-GOV-10-16_136_35 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 469236 GB-GOV-10-16_136_35 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 980168 GB-GOV-10-16_136_35 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 189392 GB-GOV-10-16_136_35 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 440842 GB-GOV-10-16_136_35 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 23255.24 GB-GOV-10-16_136_35 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-16_136_46 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to optimise control of mucosal pathogens causing pneumonia, meningitis and sepsis in young children. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Improved Diseases Intelligence: targeted surveillance of mucosal pathogens incorporating new molecular epidemiology, mathematical modelling and diagnostic tools to support vaccine evaluation, uptake and safety monitoring. 2) New Measures of Immunity: novel approaches to measuring protective immunity to determine how best to use new and existing vaccines; and determine how other non-vaccine interventions, such as harmless “commensal bacteria” will impact on disease. 3) Testing Interventions: as a prelude to large-scale trials, develop novel trial designs and feasibility studies of vaccine and other interventions. 4) Public Engagement: encourage a two-way dialogue with public and policymaker input into their thinking, ensuring that MPRU research is grounded in experience and needs of the public/policymakers. In collaboration with the NIHR Health Protection Research Unit (HPRU) in Immunisation, MPRU will support national/international policymaking through model development and research briefs. Public engagement will use websites, newsletters and social media; events involving policymakers, interest groups, schools and industry. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 1417263 1978896.71 1971831.78 1437341.02 6805332.51 GB-GOV-10-16_136_46 COMMITMENT UK - Department of Health and Social Care (DHSC) University College London 306798 GB-GOV-10-16_136_46 2017/18 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University College London 306798 GB-GOV-10-16_136_46 2017/18 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University College London 141265 GB-GOV-10-16_136_46 2017/18 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 662402 GB-GOV-10-16_136_46 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 241029 GB-GOV-10-16_136_46 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 54557 GB-GOV-10-16_136_46 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 484175 GB-GOV-10-16_136_46 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 573858 GB-GOV-10-16_136_46 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 568858 GB-GOV-10-16_136_46 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 580000 GB-GOV-10-16_136_46 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 1442796 GB-GOV-10-16_136_46 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 1102529.44 GB-GOV-10-16_136_46 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 123293.03 GB-GOV-10-16_136_46 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London GB-GOV-10-16_136_54 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to work across primary care, maternal and surgical care platforms, to develop, adapt and evaluate health system strengthening interventions to enhance the processes and outcomes of evidence-based care. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Identify and evaluate system approaches to enhance guideline operationalisation; more explicit care pathways, manualised interventions, and technologies to improve detection/diagnosis (guideline optimisation). 2) Identify health system-strengthening needs for more effective delivery of GBC (health system assessment/diagnostic phase). 3) Develop and refine content and delivery of tailored health-system strengthening interventions (HSSI) with rigorous piloting and evaluation (development and piloting phase). 4) Evaluate the effects of scaling-up the resulting health system strengthening interventions (HSSI) package, on guideline-based care (GBC) processes and outcomes. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) King's College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 1729102.5 1410370.78 2251882.79 1606373.95 6997730.02 GB-GOV-10-16_136_54 COMMITMENT UK - Department of Health and Social Care (DHSC) King's College London 397966 GB-GOV-10-16_136_54 2017/18 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) King's College London 397966 GB-GOV-10-16_136_54 2017/18 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) King's College London 933170.5 GB-GOV-10-16_136_54 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 558991 GB-GOV-10-16_136_54 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 780669 GB-GOV-10-16_136_54 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 254103 GB-GOV-10-16_136_54 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 569613 GB-GOV-10-16_136_54 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 848776 GB-GOV-10-16_136_54 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 465422 GB-GOV-10-16_136_54 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 895527 GB-GOV-10-16_136_54 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 278329.5 GB-GOV-10-16_136_54 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 3114 GB-GOV-10-16_136_54 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 264196.01 GB-GOV-10-16_136_54 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 183558 GB-GOV-10-16_136_54 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London -12719.33 GB-GOV-10-16_136_54 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London GB-GOV-10-16_136_68 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to translate scientific discoveries and technological innovations into sustainable improvements in healthcare, to deliver improved prevention and better treatment of both diabetes and heart disease, amongst people from South Asia. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Strengthen disease surveillance for type-2 diabetes and cardiovascular disease to assess needs, priorities and performance. 2) Prioritise interventions for prevention, early detection and management of type-2 diabetes and cardiovascular disease, taking account of efficacy, scalability, sustainability and equity. 3) Develop capacity at Centres of Excellence, in regional Translational Research Networks, and through high-quality training. 4) Support frameworks for dissemination and implementation (policy, guidelines, pathways, standards) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 1406820 2438843 2128077.44 1023869.32 6997609.76 GB-GOV-10-16_136_68 COMMITMENT UK - Department of Health and Social Care (DHSC) Imperial College London 351705 GB-GOV-10-16_136_68 2017/18 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Imperial College London 351705 GB-GOV-10-16_136_68 2017/18 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Imperial College London 185612 GB-GOV-10-16_136_68 2017/18 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 517798 GB-GOV-10-16_136_68 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 725022 GB-GOV-10-16_136_68 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 340099 GB-GOV-10-16_136_68 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 171896 GB-GOV-10-16_136_68 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 63915 GB-GOV-10-16_136_68 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 1820715 GB-GOV-10-16_136_68 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 1120989 GB-GOV-10-16_136_68 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 614971 GB-GOV-10-16_136_68 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 383302.03 GB-GOV-10-16_136_68 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 120720.4 GB-GOV-10-16_136_68 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London GB-GOV-10-16_136_77 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to reduce salt intake amongst the poorest and most vulnerable populations through research and public health programmes. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. To develop and implement a comprehensive, effective and sustainable national salt reduction programme in China, through a series of programme, with special focus in rural areas to achieve a 30% reduction by 2025 as set by WHO. The programmes will include: 1) A health education programme to increase salt awareness; 2) a community/school-based education programme to encourage individuals to reduce salt during cooking; 3) a programme to work with restaurants to reduce salt in restaurant food; and 4) a programme to reduce salt in pre-packaged food by setting targets, improving labelling and providing tools to help consumers choose lower-salt food. Community and family-based strategies will be adopted in all activities with the support of traditional and innovative education and promotion technologies. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Queen Mary University of London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 1721464 1433683.73 1368024.26 2084301.03 6607473.02 GB-GOV-10-16_136_77 COMMITMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 430366 GB-GOV-10-16_136_77 2017/18 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Queen Mary University of London 430366 GB-GOV-10-16_136_77 2017/18 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Queen Mary University of London 860732 GB-GOV-10-16_136_77 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 249270 GB-GOV-10-16_136_77 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 397752 GB-GOV-10-16_136_77 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 364799 GB-GOV-10-16_136_77 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 471994 GB-GOV-10-16_136_77 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 530193 GB-GOV-10-16_136_77 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 661053 GB-GOV-10-16_136_77 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 188843 GB-GOV-10-16_136_77 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 418975 GB-GOV-10-16_136_77 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 801565 GB-GOV-10-16_136_77 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 97475 GB-GOV-10-16_136_77 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 373716.68 GB-GOV-10-16_136_77 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 336611.59 GB-GOV-10-16_136_77 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 81883.31 GB-GOV-10-16_136_77 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London GB-GOV-10-16_136_79 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to develop context-appropriate global surgical research by establishing sustainable international research hubs and delivering practice-changing research for better patient outcomes. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. To create a sustainable platform where patients and surgeons from LMIC can identify priority areas, perform studies to find solutions, and find ways to bring these solutions to their patients. This will initially focus on surgery of the abdomen, but will cross over into other neglected areas of surgery, including women’s health and cancer treatment. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Birmingham UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 1221070 1384780.61 2170386.01 2184124.54 6960361.16 GB-GOV-10-16_136_79 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 323464 GB-GOV-10-16_136_79 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 191065 GB-GOV-10-16_136_79 2017/18 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 706541 GB-GOV-10-16_136_79 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 279431 GB-GOV-10-16_136_79 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 722502 GB-GOV-10-16_136_79 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 514529 GB-GOV-10-16_136_79 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 691061 GB-GOV-10-16_136_79 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 1181075 GB-GOV-10-16_136_79 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 415069 GB-GOV-10-16_136_79 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 967812 GB-GOV-10-16_136_79 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 127696 GB-GOV-10-16_136_79 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 209525 GB-GOV-10-16_136_79 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 282572.58 GB-GOV-10-16_136_79 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham -225535.58 GB-GOV-10-16_136_79 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 525677.07 GB-GOV-10-16_136_79 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham GB-GOV-10-16_136_87 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to improve the health and welfare of people who live in slums. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) To develop a partnership between the Liverpool School of Tropical Medicine (LSTM), African researchers in Uganda and Tanzania, health policy makers and programme managers, patient groups and community representatives and engage with other stakeholders to conduct research that has maximum immediate benefit on patient outcomes in Africa. 2) To develop and strengthen capacity in NCDs and in research methods, particularly in epidemiology, statistics, health economics and social science, both at LSTM and at our partner institutions in Africa. 3) To conduct early phase (pilot) studies and assess how diagnostic and treatment services for HIV infection, diabetes and hypertension should be integrated at health facilities, how these integrated services should be decentralised, how task-shifting should be organised and how patients should be supported and monitored. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Warwick UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 906970 1774981 1607254 1397562 5686767 GB-GOV-10-16_136_87 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Warwick 291654 GB-GOV-10-16_136_87 2017/18 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Warwick 291654 GB-GOV-10-16_136_87 2017/18 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Warwick 323662 GB-GOV-10-16_136_87 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 281330 GB-GOV-10-16_136_87 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 412821 GB-GOV-10-16_136_87 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 452332 GB-GOV-10-16_136_87 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 431305 GB-GOV-10-16_136_87 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 373690 GB-GOV-10-16_136_87 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 322808 GB-GOV-10-16_136_87 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 409718 GB-GOV-10-16_136_87 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 397883 GB-GOV-10-16_136_87 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 365392 GB-GOV-10-16_136_87 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 372041 GB-GOV-10-16_136_87 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 480238 GB-GOV-10-16_136_87 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 195901.72 GB-GOV-10-16_136_87 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 278918.46 GB-GOV-10-16_136_87 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick GB-GOV-10-16_136_100 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to analyse the challenges of delivering health services and promoting health in fragile situations, with the aim of identifying sources of resilience within formal health systems and local community mechanisms to facilitate effective provision for health priorities - particularly mental health and non-communicable disease - in situations of fragility. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) to develop a systematic program of research identifying effective strategies to enhance the quality, accountability, coverage, and accessibility of priority health interventions through an integrated ‘systems for health’ approach to the growing burden of noncommunicable diseases (NCDs) and mental health. 2) to deploy cutting-edge methodologies for participatory health systems analysis and appraisal of community dynamics and resources to ensure that strategies to support intervention effectiveness are identified through rigorous analytical assessment. 3) to support development of a generalisable framework for fragility assessment as well as focused evidence regarding strategies to mitigate fragility for specific health interventions in localised settings. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Queen Margaret University UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 729682 652483.63 1089141.47 983251.0500000002 3454558.15 GB-GOV-10-16_136_100 COMMITMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 164460 GB-GOV-10-16_136_100 2017/18 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Queen Margaret University 164460 GB-GOV-10-16_136_100 2017/18 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Queen Margaret University 65764 GB-GOV-10-16_136_100 2017/18 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 334998 GB-GOV-10-16_136_100 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 142512 GB-GOV-10-16_136_100 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 256978 GB-GOV-10-16_136_100 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 256978 GB-GOV-10-16_136_100 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 62256 GB-GOV-10-16_136_100 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 128010 GB-GOV-10-16_136_100 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 388436 GB-GOV-10-16_136_100 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 403521 GB-GOV-10-16_136_100 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 307469 GB-GOV-10-16_136_100 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 389358 GB-GOV-10-16_136_100 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 102475 GB-GOV-10-16_136_100 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 114155.15 GB-GOV-10-16_136_100 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 53351.38 GB-GOV-10-16_136_100 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 84569.78 GB-GOV-10-16_136_100 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University GB-GOV-10-16_136_102 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to use innovative big data and mobile technologies to provide low-cost personalised medicine to combat ill health associated with diabetes. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) To develop a large scale Scotland-India Clinical Partnership to combat diabetes. 2) To understand the heterogeneity of diabetes in India. 3) To develop innovative new tools and big data science to facilitate low-cost diabetes screening in India 4) To implement next generation precision telemedicine in India. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Dundee UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 2127218.25 1445085.34 1880795.65 1517323.66 6970422.9 GB-GOV-10-16_136_102 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Dundee 413855 GB-GOV-10-16_136_102 2017/18 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Dundee 413855 GB-GOV-10-16_136_102 2017/18 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Dundee 413855 GB-GOV-10-16_136_102 2017/18 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 885653.25 GB-GOV-10-16_136_102 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 221463.75 GB-GOV-10-16_136_102 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 232108 GB-GOV-10-16_136_102 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 720603 GB-GOV-10-16_136_102 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 500056 GB-GOV-10-16_136_102 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 849258 GB-GOV-10-16_136_102 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 448654 GB-GOV-10-16_136_102 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 344695 GB-GOV-10-16_136_102 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 251605 GB-GOV-10-16_136_102 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 637381 GB-GOV-10-16_136_102 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 260072 GB-GOV-10-16_136_102 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 28788 GB-GOV-10-16_136_102 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 254806 GB-GOV-10-16_136_102 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Dundee 8209.77 GB-GOV-10-16_136_102 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee GB-GOV-10-16_136_109 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to improve respiratory outcomes from common respiratory communicable and non-communicable disorders. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) To build on their track-record of epidemiological research and capacity development in LMIC. 2) To invest in and strengthen our existing collaborations with leading research groups in South Asia. 3) To leverage their critical mass in respiratory, informatics and health services research, to expand efforts into the neglected field of applied respiratory research. 4) Build a network of laboratories and experts across strategically important countries from which to expand to similar local contexts elsewhere. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Edinburgh UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 849081 1962560 1970268 2216578 6998487 GB-GOV-10-16_136_109 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 283027 GB-GOV-10-16_136_109 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 727233.25 GB-GOV-10-16_136_109 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 519310.75 GB-GOV-10-16_136_109 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 121020 GB-GOV-10-16_136_109 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 492850 GB-GOV-10-16_136_109 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 522184 GB-GOV-10-16_136_109 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 571945 GB-GOV-10-16_136_109 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 894560 GB-GOV-10-16_136_109 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 561478 GB-GOV-10-16_136_109 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 1152440 GB-GOV-10-16_136_109 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 269221 GB-GOV-10-16_136_109 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 533294 GB-GOV-10-16_136_109 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 222326 GB-GOV-10-16_136_109 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 82472.63 GB-GOV-10-16_136_109 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh GB-GOV-10-16_136_111 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to establish expertise and local research capacity in the use of whole genome sequencing in LMICs in order to provide intelligent global surveillance of microbial pathogens and antimicrobial resistance. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Develop capacity for locally-led research projects in LMICs and sampling frameworks to address national public health and research needs. 2) Provide actionable data at national and international levels to identify high-risk lineages of bacterial pathogens and determinants of antibiotic resistance, and open-access tools to understand their distribution and spread. 3) Provide resourcing and training for local capacity and expertise to ensure ownership of outputs and utility for action. 4) Build a network of laboratories and experts across strategically important countries from which to expand to similar local contexts elsewhere. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Oxford UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 2319527.98 1495120.64 1535158.44 1513564.2 6863371.260000001 GB-GOV-10-16_136_111 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Oxford 42020 GB-GOV-10-16_136_111 2017/18 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 916884 GB-GOV-10-16_136_111 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 1058352 GB-GOV-10-16_136_111 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 624843 GB-GOV-10-16_136_111 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 95046 GB-GOV-10-16_136_111 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 253441 GB-GOV-10-16_136_111 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 925823 GB-GOV-10-16_136_111 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 322668 GB-GOV-10-16_136_111 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 429389 GB-GOV-10-16_136_111 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 1097453 GB-GOV-10-16_136_111 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 12892 GB-GOV-10-16_136_111 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 612452 GB-GOV-10-16_136_111 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 156181 GB-GOV-10-16_136_111 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Oxford 64729 GB-GOV-10-16_136_111 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford GB-GOV-10-16_137_16 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to improve stroke care in acute settings. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. NIHR Global Health Research Group on Improving Stroke Care objectives: 1) Create a partnership of clinicians, academics, patients and the public in India to develop research capacity to support innovation in healthcare in order to improve the management of stroke. 2) Develop effective ways of working together to prioritise, develop, deliver and implement research. 3) Engage with key stakeholders in healthcare in India to ensure that our research is relevant, important, accessible and practically focused. 4) Build sustainability for health research by supporting people and organisations to develop research, by building systems to facilitate research, and by capturing funding to support work to continue beyond the end of the project. 5) Identify key transferable knowledge for potential implementation in other settings and relevant health conditions. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Central Lancashire UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 352482 757805 310465 826882.59 164418.91 1918796.8 GB-GOV-10-16_137_16 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Central Lancashire 50000 GB-GOV-10-16_137_16 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire 151241 GB-GOV-10-16_137_16 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Central Lancashire 151241 GB-GOV-10-16_137_16 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Central Lancashire 188213 GB-GOV-10-16_137_16 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire 164389 GB-GOV-10-16_137_16 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire 170202 GB-GOV-10-16_137_16 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire 235001 GB-GOV-10-16_137_16 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire 105585 GB-GOV-10-16_137_16 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire 38540 GB-GOV-10-16_137_16 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire 493256.7 GB-GOV-10-16_137_16 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Central Lancashire 166340 GB-GOV-10-16_137_16 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire 133913 GB-GOV-10-16_137_16 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire 250014 GB-GOV-10-16_137_16 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire 223999 GB-GOV-10-16_137_16 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire 114822 GB-GOV-10-16_137_16 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire 67195 GB-GOV-10-16_137_16 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire 80755.5 GB-GOV-10-16_137_16 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire 111804.89 GB-GOV-10-16_137_16 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire -17610.14 GB-GOV-10-16_137_16 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Central Lancashire NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_34 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to understand the determinants of population levels of diet and activity behaviour in LMICs and evaluate population-level interventions aimed at changing these behaviours in order to reduce the risk of non-communicable disease. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Generate evidence on the factors that lead to poor diet and physical inactivity in LMICs. 2) Design and evaluate interventions to change these factors (also known as determinants). 3) Use mathematical modelling to investigate the long-term health and economic effects of such interventions. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Cambridge UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 121120.99 720787 765224 809172.24 83298.03 1999814 GB-GOV-10-16_137_34 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Cambridge 50000 GB-GOV-10-16_137_34 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 37319.18 GB-GOV-10-16_137_34 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Cambridge 33801.81 GB-GOV-10-16_137_34 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Cambridge 198027 GB-GOV-10-16_137_34 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 221408 GB-GOV-10-16_137_34 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 301352 GB-GOV-10-16_137_34 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 71793 GB-GOV-10-16_137_34 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 134427 GB-GOV-10-16_137_34 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 195435 GB-GOV-10-16_137_34 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 499788.26 GB-GOV-10-16_137_34 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Cambridge 363569 GB-GOV-10-16_137_34 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 16811 GB-GOV-10-16_137_34 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 177118 GB-GOV-10-16_137_34 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 295093 GB-GOV-10-16_137_34 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 204085 GB-GOV-10-16_137_34 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 74383.27 GB-GOV-10-16_137_34 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 65823.19 GB-GOV-10-16_137_34 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_44 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to identify areas of surgical need and develop and evaluate new context-appropriate technological solutions. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Building on established academic and surgical networks and working with local ministries of health, NGOs, and private healthcare providers to conduct collaborative research. 2) Undertaking social science research to better understand local healthcare systems, including cultural and social attitudes to surgery, defining the unmet surgical needs, and assessing existing research strengths and capacity. 3) Using NIHR medical technology capability (Leeds NIHR Healthcare Technology Co-operative and Leeds Diagnostic Evaluation Centre) to develop disruptive, yet affordable, solutions to unmet surgical needs relevant to local healthcare settings. 4) Undertaking clinical evaluations, including cost-effectiveness assessment, in partnership with local researchers to inform wider adoption. 5) Establishing an advocacy programme, linked to other global health organisations, to influence awareness of health inequalities and promote the impact of our research. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Leeds UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 390605.93 680022.05 738226.45 184938.57 1993793 GB-GOV-10-16_137_44 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Leeds 50000 GB-GOV-10-16_137_44 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds 74082.38 GB-GOV-10-16_137_44 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Leeds 266523.55 GB-GOV-10-16_137_44 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Leeds 53224 GB-GOV-10-16_137_44 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds 224979 GB-GOV-10-16_137_44 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds 224979 GB-GOV-10-16_137_44 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds 224979 GB-GOV-10-16_137_44 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds 66321 GB-GOV-10-16_137_44 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds 202977 GB-GOV-10-16_137_44 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds 181368 GB-GOV-10-16_137_44 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds 215832 GB-GOV-10-16_137_44 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds 108528.23 GB-GOV-10-16_137_44 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds 61170.3 GB-GOV-10-16_137_44 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_45 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to improve the health and wellbeing of civilians afflicted by blast injuries, reduce the socio-economic burden of explosive remnants of war in the developing world, develop a research and innovation hub for orthopaedic, trauma and biomaterials researchers, engineers and clinicians and advance understanding of biomaterials and orthopaedic technology. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Identify patient characteristics that have led to early avoidable amputation. 2) Provide immediate surgeon education for limb salvage/amputation using state of the art techniques. 3) Co-develop with our partners a biomaterial for bone that can be made locally, based on x-rays, and that will resorb over time. CAPACITY BUILDING: 1) Build a single research and translation team with surgeons, engineers and materials scientists co-located in both Sri Lanka and the UK, leveraging the expertise and caseload in Lebanon. 2) Strengthen the Biomedical Engineering programme at the University of Moratuwa (UoM) in Sri Lanka to include a Trauma stream with leadership from Dr Karunaratne. 3) Share unique and rare data and experiences to allow an improved understanding of civilian blast injury where global terror remains a threat to civilian populations. 4) Understand the healthcare burden post conflict to influence and enable overseas intervention. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 264628.66 403327 430435 1106276.07 161271.46 1882125 GB-GOV-10-16_137_45 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Imperial College London 50000 GB-GOV-10-16_137_45 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 65780.53 GB-GOV-10-16_137_45 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Imperial College London 148848.13 GB-GOV-10-16_137_45 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Imperial College London 130580 GB-GOV-10-16_137_45 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 53513 GB-GOV-10-16_137_45 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 138564 GB-GOV-10-16_137_45 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 80670 GB-GOV-10-16_137_45 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 173802 GB-GOV-10-16_137_45 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 40144 GB-GOV-10-16_137_45 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 91068 GB-GOV-10-16_137_45 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 125421 GB-GOV-10-16_137_45 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 187737 GB-GOV-10-16_137_45 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 483813.19 GB-GOV-10-16_137_45 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Imperial College London 176340 GB-GOV-10-16_137_45 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 301156 GB-GOV-10-16_137_45 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 230878 GB-GOV-10-16_137_45 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 228666 GB-GOV-10-16_137_45 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 24473.13 GB-GOV-10-16_137_45 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 5212.05 GB-GOV-10-16_137_45 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_49 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to prevent injuries, make communities safer and improve injury outcomes in Nepal through collaborative research, surveillance, innovation, training, capacity building and policy development. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Engaging with stakeholders to understand their perspectives, awareness of the problem and priorities for change, and enable effective uptake of research. 2) Evidence through data will develop and pilot a hospital based injury surveillance system and explore the feasibility of collecting information on injuries from rural health posts. The Group will understand how injuries happened through interview, focus group, survey and verbal autopsy methods. 3) Effective and cost effective interventions will be developed and tested, adapting proven interventions from other LMICs where possible, and creating new interventions where necessary. Existing knowledge suggests that priority areas are likely to be road injuries, home injuries and the first response to trauma. 4) Enhancing capacity and enabling sustainability. Nepal has a limited and fragmented injury research capacity. The Group will establish partnerships to reduce isolation of researchers, and identify and meet their training needs to enable them to generate internationally excellent research. The Group will work with the Government of Nepal, academic institutions, NGOs and the WHO to plan the sustainability of the research centre in the long term. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Nepal Medical research Research and Innovation 134268 834972 488839 753375.19 70513.74 1999913.0000000002 GB-GOV-10-16_137_49 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 50000 GB-GOV-10-16_137_49 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 84268 GB-GOV-10-16_137_49 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 216567 GB-GOV-10-16_137_49 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 145155 GB-GOV-10-16_137_49 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 236625 GB-GOV-10-16_137_49 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 236625 GB-GOV-10-16_137_49 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 64530 GB-GOV-10-16_137_49 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 191389 GB-GOV-10-16_137_49 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 74813 GB-GOV-10-16_137_49 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 282054.93 GB-GOV-10-16_137_49 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 158107 GB-GOV-10-16_137_49 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 162671 GB-GOV-10-16_137_49 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 105857 GB-GOV-10-16_137_49 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 124987 GB-GOV-10-16_137_49 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 127836 GB-GOV-10-16_137_49 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 188439.93 GB-GOV-10-16_137_49 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol -101430.09 GB-GOV-10-16_137_49 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_53 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to improve the prevention and management of stillbirth. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Prevention of stillbirth through improved identification of women with high risk pregnancies. We will explore how mother’s reporting of reduced baby movements during late pregnancy (a low cost method used widely in high income countries to alert clinicians to poor growth) could be adapted for use in LMIC settings. 2) Better childbirth care by examining factors which influence how women seek and access care, the quality of the care received and specific causes of stillbirth in local healthcare facilities, using new effective tools. 3) Ensuring humane and respectful care for bereaved parents through understanding the experiences of women, partners and health workers after stillbirth. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 343164.6 705590 711176.97 601916.93 128119.50000000023 1990018 GB-GOV-10-16_137_53 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 50000 GB-GOV-10-16_137_53 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 68550.43 GB-GOV-10-16_137_53 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 224614.17 GB-GOV-10-16_137_53 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 207953.82 GB-GOV-10-16_137_53 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 146341 GB-GOV-10-16_137_53 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 165879 GB-GOV-10-16_137_53 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 165879 GB-GOV-10-16_137_53 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 156270 GB-GOV-10-16_137_53 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 170726 GB-GOV-10-16_137_53 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 188868 GB-GOV-10-16_137_53 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 499950 GB-GOV-10-16_137_53 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 212701 GB-GOV-10-16_137_53 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 127658 GB-GOV-10-16_137_53 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 96356 GB-GOV-10-16_137_53 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 333958 GB-GOV-10-16_137_53 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 62309.57 GB-GOV-10-16_137_53 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine -12593.99 GB-GOV-10-16_137_53 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 60045.39 GB-GOV-10-16_137_53 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 3086.6 GB-GOV-10-16_137_53 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_62 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to bring together expertise in public health and primary care with global epidemiological research to look at enhancing dementia prevention and care. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Create a new Global Research Group on dementia risk reduction and improved post-diagnostic care to map existing dementia research and care in partner LMIC. 2) Develop simple tools to identify people at high risk of developing dementia and those with undetected dementia. 3) Establish dementia risk reduction research in LMIC by setting up and piloting an intervention to reduce dementia risk. 4) Determine efficient and feasible dementia care models for LMICs and transferable educational initiatives for a skilled workforce. 5) Develop an impact strategy for each partner LMIC, including research priorities, service organisation and workforce development. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Newcastle University UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 399053.4 702383.43 601299.24 225732 1928468.07 GB-GOV-10-16_137_62 COMMITMENT UK - Department of Health and Social Care (DHSC) Newcastle University 50000 GB-GOV-10-16_137_62 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 91072.44 GB-GOV-10-16_137_62 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Newcastle University 257980.96 GB-GOV-10-16_137_62 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Newcastle University 1626 GB-GOV-10-16_137_62 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 139389 GB-GOV-10-16_137_62 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 209020 GB-GOV-10-16_137_62 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 180093 GB-GOV-10-16_137_62 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 1604 GB-GOV-10-16_137_62 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 225198 GB-GOV-10-16_137_62 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 264854 GB-GOV-10-16_137_62 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 10501 GB-GOV-10-16_137_62 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 106018 GB-GOV-10-16_137_62 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 141115 GB-GOV-10-16_137_62 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 117505 GB-GOV-10-16_137_62 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 32492.3 GB-GOV-10-16_137_62 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University -93554.76 GB-GOV-10-16_137_62 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_85 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to support the implementation and evaluation of early childhood development programmes and the potential to promote sustainable development and peacebuilding in LMICs affected by conflict. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) To create a sustainable network of early childhood development (ECD) researchers and practitioners from six countries affected by conflict. 2) To share knowledge and expertise across participants of the network and build research capacity in country to support the development and robust evaluation of ECD programmes. 3) To build specialist research capacity at Centre for Evidence and Social Innovation (CESI) to undertake global health research in relation to ECD,through the support of Yale and NYU. 4) To support the evaluation of ECD pilot programmes in six LMIC partner count ries that are to be delivered through support from UNICEF. 5) Work with UNICEF and the wider global Early Childhood Peace Consortium (ECPC) to develop and implement effective advocacy strategies for ECD programmes within partner countries and internationally. 6) Develop and implement a strategy to generate external funding to sustain and grow the network beyond the current three-year funding window in alignment with ECPC. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 336665.04 546285 552917 183311 238749.96 1857928 GB-GOV-10-16_137_85 COMMITMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 50000 GB-GOV-10-16_137_85 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 79836 GB-GOV-10-16_137_85 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 206829.04 GB-GOV-10-16_137_85 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 56562 GB-GOV-10-16_137_85 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 163241 GB-GOV-10-16_137_85 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 163241 GB-GOV-10-16_137_85 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 163241 GB-GOV-10-16_137_85 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 68248 GB-GOV-10-16_137_85 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 243088 GB-GOV-10-16_137_85 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 241581 GB-GOV-10-16_137_85 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 183311 GB-GOV-10-16_137_85 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 138749.96 GB-GOV-10-16_137_85 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast -37018.25 GB-GOV-10-16_137_85 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_87 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to evaluate integrated prevention and management of chronic conditions in Africa, focusing on the double burden of HIV-infection with diabetes and hypertension, and on research that is relevant for policy and practice. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) To develop a partnership between the Liverpool School of Tropical Medicine (LSTM), African researchers in Uganda and Tanzania, health policy makers and programme managers, patient groups and community representatives and engage with other stakeholders to conduct research that has maximum immediate benefit on patient outcomes in Africa. 2) To develop and strengthen capacity in NCDs and in research methods, particularly in epidemiology, statistics, health economics and social science, both at LSTM and at our partner institutions in Africa. These skills are severely lacking and inhibiting research in chronic diseases. 3) To conduct early phase (pilot) studies and assess how diagnostic and treatment services for HIVinfection, diabetes and hypertension should be integrated at health facilities, how these integrated services should be decentralised, how task-shifting should be organised and how patients should be supported and monitored. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 97032.63 662827 1008361 645952.37 83332.44 1997510.87 GB-GOV-10-16_137_87 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 50000 GB-GOV-10-16_137_87 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 47032.63 GB-GOV-10-16_137_87 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 241612 GB-GOV-10-16_137_87 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 116012 GB-GOV-10-16_137_87 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 305203 GB-GOV-10-16_137_87 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 178192 GB-GOV-10-16_137_87 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 209802 GB-GOV-10-16_137_87 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 315717 GB-GOV-10-16_137_87 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 499994.57 GB-GOV-10-16_137_87 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 304650 GB-GOV-10-16_137_87 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 241852 GB-GOV-10-16_137_87 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 179463 GB-GOV-10-16_137_87 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 67037 GB-GOV-10-16_137_87 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 116057.81 GB-GOV-10-16_137_87 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 145755 GB-GOV-10-16_137_87 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 18809 GB-GOV-10-16_137_87 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_90 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to address the evidence gap in population- and health system-level interventions by applying and developing methods to (1) estimate their average and distributional impact and (2) assess their value-for-money. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) To employ state-of-the-art empirical methods applied to existing but under-exploited data sources to assess average population health impact and distributional effects, thereby establishing both whether interventions work overall and whether health outcomes of the poorest and most vulnerable improve more than those of the rich. 2) To complement the evaluation of the effectiveness of interventions with an assessment of the value-for-money they offer (economic evaluation), which constitutes a critical, and currently underdeveloped, link between evidence and decision-making in the context of budget constrained choices. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of York UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 322434.89 670989.15 630789.04 356795.92 1981009 GB-GOV-10-16_137_90 COMMITMENT UK - Department of Health and Social Care (DHSC) University of York 50000 GB-GOV-10-16_137_90 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 121659.71 GB-GOV-10-16_137_90 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of York 150775.32 GB-GOV-10-16_137_90 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of York 129678 GB-GOV-10-16_137_90 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 138650 GB-GOV-10-16_137_90 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 151135 GB-GOV-10-16_137_90 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 184733 GB-GOV-10-16_137_90 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 103674 GB-GOV-10-16_137_90 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 174928 GB-GOV-10-16_137_90 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 127830 GB-GOV-10-16_137_90 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 161543 GB-GOV-10-16_137_90 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 76035 GB-GOV-10-16_137_90 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 86796 GB-GOV-10-16_137_90 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 79463 GB-GOV-10-16_137_90 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 144108.61 GB-GOV-10-16_137_90 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York -5964.48 GB-GOV-10-16_137_90 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of York -88199.28 GB-GOV-10-16_137_90 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 422.03 GB-GOV-10-16_137_90 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_95 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to foster research in primary care and communities to improve the diagnosis, management and prognosis of Chronic Obstructive Pulmonary Disease (COPD) patients in LMICs. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) To strengthen local research capacity in the partner countries in community-based COPD research and generic population research methods. 2) To develop and test community-based and culturally-appropriate approaches for identifying undiagnosed COPD in low resource countries. 3) To adapt evidence-based behavioural approaches for management of COPD according to cultural needs and the local healthcare infrastructure, and assess the feasibility of their implementation. 4) To build a robust platform for future collaborative research within the partner countries and other similar settings. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Birmingham UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 354651.84 818332.9 658067.95 87165.31 1918218 GB-GOV-10-16_137_95 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 50000 GB-GOV-10-16_137_95 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 10912.06 GB-GOV-10-16_137_95 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Birmingham 293739.78 GB-GOV-10-16_137_95 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Birmingham 175079 GB-GOV-10-16_137_95 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 145341 GB-GOV-10-16_137_95 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 245947 GB-GOV-10-16_137_95 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 245946 GB-GOV-10-16_137_95 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 138248 GB-GOV-10-16_137_95 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 197016 GB-GOV-10-16_137_95 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 233670 GB-GOV-10-16_137_95 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 48903 GB-GOV-10-16_137_95 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 33415.83 GB-GOV-10-16_137_95 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 62083.86 GB-GOV-10-16_137_95 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 36954.66 GB-GOV-10-16_137_95 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_97 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to Develop psycho-social interventions for people with severe mental illnesses, utilising existing resources in communities. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) To explore alternative forms of care that utilise existing personal and social resources, which can be provided through trained lay people, volunteers, peers, and families. 2) To build up the capacity and local expertise to conduct such research in three LMICs: Bosnia-Herzegovina, Colombia and Uganda. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 183868.63 789842 398945 899031.95 140754.71 1990178.17 GB-GOV-10-16_137_97 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 50000 GB-GOV-10-16_137_97 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 7600.54 GB-GOV-10-16_137_97 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 126268.09 GB-GOV-10-16_137_97 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 203765 GB-GOV-10-16_137_97 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 58953 GB-GOV-10-16_137_97 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 263562 GB-GOV-10-16_137_97 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 263562 GB-GOV-10-16_137_97 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 117302 GB-GOV-10-16-137_97 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 108314 GB-GOV-10-16_137_97 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 173329 GB-GOV-10-16_137_97 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 101355 GB-GOV-10-16_137_97 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 422264.12 GB-GOV-10-16_137_97 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 145911 GB-GOV-10-16_137_97 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 271069 GB-GOV-10-16_137_97 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 195688 GB-GOV-10-16_137_97 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 52135 GB-GOV-10-16_137_97 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 106833 GB-GOV-10-16_137_97 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 46173.66 GB-GOV-10-16_137_97 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 35376 GB-GOV-10-16_137_97 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry 23731.73 GB-GOV-10-16_137_97 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bart's and The London School of Medicine & Dentistry NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_99 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to improve population health by studying the social determinants of health and to further understanding of how social policy may reduce health inequalities globally. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Expand the research potential of the 100M cohort by adding further data: geographical information including an indicator of the deprivation of each person’s area of residence (created as part of this project) and data on non-communicable diseases from hospitals and other sources. 2) Evaluate the impact of specific policies (a welfare programme and a subsidised housing programme) on health and health inequalities. 3) Measure Brazil’s progress against the Sustainable Development Goals on non-communicable diseases for different social groups. 4) Build research capacity in the evaluation of public health programmes internationally through the development and delivery of a course. 5) Develop and maintain a strong relationship with stakeholders, including policy makers and practitioners, so that analyses and results are focused, useful, timely and accessible. This will maximise the opportunity for action to be taken as a result of this research and will lead to the joint production of future research. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Glasgow UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 517205 332783 451256 1106428 81583.61 1999754 GB-GOV-10-16_137_99 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Glasgow 50000 GB-GOV-10-16_137_99 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 56732.31 GB-GOV-10-16_137_99 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Glasgow 410472.69 GB-GOV-10-16_137_99 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Glasgow 125747 GB-GOV-10-16_137_99 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 207036 GB-GOV-10-16_137_99 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 112304 GB-GOV-10-16_137_99 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 52307 GB-GOV-10-16_137_99 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 489501.61 GB-GOV-10-16_137_99 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Glasgow 286645 GB-GOV-10-16_137_99 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 113957 GB-GOV-10-16_137_99 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 267000 GB-GOV-10-16_137_99 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 220969 GB-GOV-10-16_137_99 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 61911 GB-GOV-10-16_137_99 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 166229.61 GB-GOV-10-16_137_99 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 233482 GB-GOV-10-16_137_99 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow -248320.94 GB-GOV-10-16_137_99 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 31189.34 GB-GOV-10-16_137_99 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 10399.9 GB-GOV-10-16_137_99 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_101 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to improve anticoagulation with warfarin - an important area of unmet medical need in LMICs - by developing context-appropriate dosing algorithms, and further improve anticoagulation quality by using novel technological advances. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1. Evaluate the quality of anticoagulant services in Cape Town and rural and urban Uganda. 2. Recruit patients currently on warfarin to identify clinical and other non-genetic factors associated with poor anticoagulation control. 3. Develop a warfarin clinical dosing algorithm. 4. Evaluate genes specific to the local African populations in Uganda and South Africa that can impact on anticoagulation control, and the development of a novel genetic dosing algorithm. 5. Initiate a study to implement the clinical dosing algorithm in the two sites. Objectives for new work packages are: 1. Develop protocols and guidance documents for the bundle, according to SQUIRE guidelines (squirestatement.org) and attain necessary governance approvals; 2. Develop locally-appropriate training packages to ensure hospital staff are aware of the bundle aims to support adherence and educate patients; 3. Work with local patient groups to co-create tools to support adherence and educate patients; 4. Implement the bundle in hospitals (in Kampala & Cape Town) and their down-referral anticoagulation clinics; 5. Assess the clinical effectiveness and cost effectiveness of the bundle; 6. Assess staff and patient views on the bundle. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 201176.17 687109 715372 751288.17 118315.1 1954155.93 GB-GOV-10-16_137_101 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Liverpool 50000 GB-GOV-10-16_137_101 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 54849.87 GB-GOV-10-16_137_101 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Liverpool 96326.3 GB-GOV-10-16_137_101 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Liverpool 143397 GB-GOV-10-16_137_101 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 117672 GB-GOV-10-16_137_101 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 207960 GB-GOV-10-16_137_101 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 218080 GB-GOV-10-16_137_101 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 83904 GB-GOV-10-16_137_101 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 76295 GB-GOV-10-16_137_101 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 222286 GB-GOV-10-16_137_101 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 332887 GB-GOV-10-16_137_101 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 45844.07 GB-GOV-10-16_137_101 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Liverpool 473260.44 GB-GOV-10-16_137_101 COMMITMENT (3) UK - Department of Health and Social Care (DHSC) University of Liverpool 82321 GB-GOV-10-16_137_101 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 218897 GB-GOV-10-16_137_101 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 181306 GB-GOV-10-16_137_101 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 8959 GB-GOV-10-16_137_101 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 163124 GB-GOV-10-16_137_101 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 91333.27 GB-GOV-10-16_137_101 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 106124 GB-GOV-10-16_137_101 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 339.81 GB-GOV-10-16_137_101 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_105 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to advance global neurotrauma care and research in order to save lives, reduce disability and improve the quality of life for patients with traumatic brain injury. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Map the current landscape, understand the current systems and challenges in traumatic brain injury (TBI) clinical care and research in a range of LMIC (Colombia, Ethiopia, India, Indonesia, Malaysia, Myanmar, South Africa,Tanzania). 2) develop organisational and cost-effective solutions to the challenges faced in these areas. 3) establish clinical networks, research capacity, and pathways for the testing and implementation of the proposed solutions in the partner LMIC. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Cambridge UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 312363.84 636738 582936 585812.49 166666.67 1784517 GB-GOV-10-16_137_105 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Cambridge 50000 GB-GOV-10-16_137_105 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 14903.85 GB-GOV-10-16_137_105 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Cambridge 247459.99 GB-GOV-10-16_137_105 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Cambridge 30460 GB-GOV-10-16_137_105 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 162605 GB-GOV-10-16_137_105 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 221952 GB-GOV-10-16_137_105 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 221721 GB-GOV-10-16_137_105 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 39311 GB-GOV-10-16_137_105 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 277549 GB-GOV-10-16_137_105 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 500000 GB-GOV-10-16_137_105 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Cambridge 266076 GB-GOV-10-16_137_105 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 81943 GB-GOV-10-16_137_105 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 235361 GB-GOV-10-16_137_105 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 180135 GB-GOV-10-16_137_105 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 2138 GB-GOV-10-16_137_105 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 138676.16 GB-GOV-10-16_137_105 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 62402.68 GB-GOV-10-16_137_105 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_107 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to improve outcomes of psychotic disorders, harnessing the potential of digital and mobile technologies. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Develop and evaluate evidence-informed psychosis interventions to make sustained health improvements for poorly-served vulnerable individuals. 2) Understand pathways of care to develop early detection strategies in India. 3) Create a dataset of well-characterised inception cohorts of FEP with ‘research readiness’ systems and processes. 4) Investigate clinical and cost-effectiveness of innovative community care models including digital and mobile applications. 5) Build capacity by providing a strong multidisciplinary research and training programme. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Warwick UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 268006.74 485145 491055 585396.63 110506.56 1498083.66 GB-GOV-10-16_137_107 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Warwick 50000 GB-GOV-10-16_137_107 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 84253.85 GB-GOV-10-16_137_107 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Warwick 133752.89 GB-GOV-10-16_137_107 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Warwick 86878 GB-GOV-10-16_137_107 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 119307 GB-GOV-10-16_137_107 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 147625 GB-GOV-10-16_137_107 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 131335 GB-GOV-10-16_137_107 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 32720 GB-GOV-10-16_137_107 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 169212 GB-GOV-10-16_137_107 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 84794 GB-GOV-10-16_137_107 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 204329 GB-GOV-10-16_137_107 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 198290 GB-GOV-10-16_137_107 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 442026.27 GB-GOV-10-16_137_107 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Warwick 68930 GB-GOV-10-16_137_107 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 11662 GB-GOV-10-16_137_107 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 130319 GB-GOV-10-16_137_107 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 66692.19 GB-GOV-10-16_137_107 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 120010 GB-GOV-10-16_137_107 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick -86837.64 GB-GOV-10-16_137_107 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 100177.2 GB-GOV-10-16_137_107 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_109 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to conduct applied vaccine research to help decision makers build a vaccination programme that ensures reliable, affordable, equitable and uninterrupted supply of vaccines to the poorest and most at-risk members of the population. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. NIHR Global Health Research Group on Evidence to Policy Pathway to Immunisation in China (NIHR EPIC) objectives: 1) Conduct research to inform vaccination policy in China, focused around three themes: (i) understanding the epidemiology and burden of vaccine-preventable diseases, (ii) understanding manufacturing capacity, public demand and confidence around vaccines, and (iii) modelling the health, economic and equity impact of vaccine strategies, particularly on vulnerable populations. 2) Use results in collaboration with key stakeholders to strengthen the evidence-to-policy pathway for immunisation in China (and eventually other countries). 3) Set up a cross-national and cross-sectoral collaboration between four British and Chinese public health and academic organisations: the London School of Hygiene and Tropical Medicine (LSHTM), Public Health England (PHE), Chinese Centre for Disease Control and Prevention (China CDC) and Fudan University (Fudan). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 315282 525900 565164 190517.2 1596863.2 GB-GOV-10-16_137_109 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 50000 GB-GOV-10-16_137_109 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 443429.16 GB-GOV-10-16_137_109 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 103868 GB-GOV-10-16_137_109 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 248939 GB-GOV-10-16_137_109 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 14958 GB-GOV-10-16_137_109 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 235067 GB-GOV-10-16_137_109 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 163721 GB-GOV-10-16_137_109 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 170946 GB-GOV-10-16_137_109 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 65935.04 GB-GOV-10-16_137_109 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 45622 GB-GOV-10-16_137_109 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 23340.94 GB-GOV-10-16_137_109 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_110 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to transform the standard of burn care and prevention in some of the poorest regions of the world using a systems-based approach backed by implementation science. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Building robust partnerships with national and international academic departments, global institutions and clinical burns services. 2) Developing a portfolio of high quality evidence-based research to identify and address the key priorities in global burn injury, with particular focus on resource-poor settings. 3) Advocating for effective, evidence-based regional and national policies for burn prevention and treatment. 4) Working in partnership with key policy-makers, funders and philanthropists to increase resource allocation to tackle the ’forgotten global public crisis’ of burn injuries. 5) Utilising implementation science and knowledge to action theory to support the scaling up of proven interventions and promote their integration into national health strategies. 6) Creating a global hub for aspiring clinicians and researchers dedicated to global burn care to exchange ideas, share innovations and work in an inspiring and interdisciplinary environment. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Swansea University UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 260827.48 809090.32 759271.25 470941.1700000003 152515.78 1997557.25 GB-GOV-10-16_137_110 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Swansea University 50000 GB-GOV-10-16_137_110 2017/18 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Swansea University 32976.98 GB-GOV-10-16_137_110 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Swansea University 177850.5 GB-GOV-10-16_137_110 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Swansea University 155978 GB-GOV-10-16_137_110 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Swansea University 209417 GB-GOV-10-16_137_110 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Swansea University 264800 GB-GOV-10-16_137_110 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Swansea University 177861 GB-GOV-10-16_137_110 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Swansea University 47189 GB-GOV-10-16_137_110 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Swansea University 148134 GB-GOV-10-16_137_110 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Swansea University 203269 GB-GOV-10-16_137_110 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Swansea University 312468 GB-GOV-10-16_137_110 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Swansea University 455088.75 GB-GOV-10-16_137_110 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Swansea University 88143 GB-GOV-10-16_137_110 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Swansea University 264351 GB-GOV-10-16_137_110 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Swansea University 113012 GB-GOV-10-16_137_110 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Swansea University 72444 GB-GOV-10-16_137_110 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Swansea University 12120.27 GB-GOV-10-16_137_110 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Swansea University -94677.89 GB-GOV-10-16_137_110 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Swansea University -14916.12 GB-GOV-10-16_137_110 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Swansea University NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_114 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to establish self-sustaining regional hubs of snakebite expertise to support national and regional authorities design and implement systems to reduce snakebite deaths and disability. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Snakebite Rapid Diagnostic Test: with our Kenya partners and the Liverpool School of Tropical Medicine (LSTM)’s Research Centre for Drugs and Diagnosis, we will develop Africa’s first near-patient snakebite diagnostic kit. 2) Generation of Important New Research Data by: a) Conducting clinical pharmacological studies of systemic venom/anti-venom interactions. b) Conducting hospital and community surveys in each country to develop accurate estimates of snakebite burden and socio-economic impact. c) Utilising LSTM’s preclinical antivenom testing expertise to develop systems for rapid and costeffective antivenom efficacy testing, initially in Kenya. 3) Capacity-Strengthening Benefits: a) We will pilot and establish region-specific first aid, hospital and rehabilitation guidelines and clinical training. b) We will test, first in Kenya and then in Nigeria and Cameroon, the first Snakebite Emergency Response System - a smartphone app-activation of motorcycle ambulances to speed rural snakebite victims to hospital. This will inexpensively improve local health capacity and snakebite outcomes. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 510428.41 566343 676858 629561 115384.62 1998575.03 GB-GOV-10-16_137_114 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 50000 GB-GOV-10-16_137_114 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 90558.05 GB-GOV-10-16_137_114 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 369870.36 GB-GOV-10-16_137_114 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 171157 GB-GOV-10-16_137_114 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 17378 GB-GOV-10-16_137_114 2018/19 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 198011 GB-GOV-10-16_137_114 2018/19 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 179797 GB-GOV-10-16_137_114 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 157991 GB-GOV-10-16_137_114 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 191286 GB-GOV-10-16_137_114 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 166014 GB-GOV-10-16_137_114 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 161567 GB-GOV-10-16_137_114 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 96969.98 GB-GOV-10-16_137_114 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 500000 GB-GOV-10-16_137_114 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 234075 GB-GOV-10-16_137_114 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 176351 GB-GOV-10-16_137_114 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 112620.64 GB-GOV-10-16_137_114 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 208839.65 GB-GOV-10-16_137_114 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 3751.8 GB-GOV-10-16_137_114 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-16_137_122 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to reduce the number and severity of road accidents in LMICs through the underpinning philosophy of local solutions for local problems. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Capture the current situation in each LMIC through local data collection of the road transport system. 2) Develop solutions and countermeasures from a socio-technical systems-based perspective based on the local data. 3) Evaluate these solutions in simulated environments (a significant output of the project is establishing simulator facilities at each LMIC institution). 4) Disseminate findings at local and national levels in order to shape the interventions, policy and regulations to reduce road crashes and associated public health trauma. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Southampton UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 496938.2 625258.2 628095.57 736095.0300000005 1986387 GB-GOV-10-16_137_122 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Southampton 50000 GB-GOV-10-16_137_122 2017/18 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 56976.76 GB-GOV-10-16_137_122 2017/18 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Southampton 389962.44 GB-GOV-10-16_137_122 2017/18 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Southampton 255538 GB-GOV-10-16_137_122 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 166737 GB-GOV-10-16_137_122 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 166737 GB-GOV-10-16_137_122 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 73410 GB-GOV-10-16_137_122 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 168493 GB-GOV-10-16_137_122 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 150819 GB-GOV-10-16_137_122 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 210321 GB-GOV-10-16_137_122 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 161287 GB-GOV-10-16_137_122 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 500000 GB-GOV-10-16_137_122 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Southampton 89391 GB-GOV-10-16_137_122 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 167929 GB-GOV-10-16_137_122 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 254467.29 GB-GOV-10-16_137_122 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton -62402.99 GB-GOV-10-16_137_122 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 16352.79 GB-GOV-10-16_137_122 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-NIHR_GHRG2 UK - Department of Health and Social Care (DHSC) The NIHR's second Global Health Research call for Groups. UK universities and research institutes were invited to submit applications, working in equitable partnerships with researchers in low- and middle-income countries (LMIC), to develop their ambitions to deliver world-class applied global health research to address under-funded or under-researched global health areas specific to those countries. 1) Deliver the UK's ambition to be internationally outstanding in global health research, improving the lives of people in LMIC. 2) Create an environment where world-class global health research, focused on the needs of LMIC can thrive. 3) Translate advances in applied global health research into benefits for patients and the public in LMIC. 4) Focus on priority areas which will have the greatest impact on health in LMIC in the short, medium and long term. 5) Provide high quality research evidence to inform decision-making by public health officials, practitioners and policy makers. 6) Increase the volume and quality of multi-disciplinary global health research from the UK. 7) Develop knowledge and capacity within existing UK institutions which can be translated into global health research practice. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool University of Liverpool University of Birmingham University of Bristol University of York University of Exeter International Institute for Environment and Development University of Southampton University of Liverpool University of Leicester The University of Sheffield University of Glasgow Queen Mary University of London Liverpool School of Tropical Medicine University College London St George's, University of London King's College London University of York University of Warwick Genome Research Limited UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_08 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to reduce preterm birth and stillbirth and to optimise outcomes for babies born preterm. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Enhance clinical care strategies for the prevention of stillbirth and preterm birth in Malawi and Zambia, reducing rates of preterm birth, stillbirth and under-5 deaths. 2) Generate new knowledge on the effectiveness of interventions and on how best to implement them. 3) Develop a clinical trials platform to test novel interventions, initially for stillbirth and preterm birth, but longterm in an NIHR unit on maternal newborn global health. 4) Enhance the collection of perinatal outcomes in vital statistics and hospital datasets. 5) Increase the accuracy of prematurity estimates by using first trimester ultrasound scanning to optimise assessment of gestational age. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 384394 457452 920233 718694.12 1941094.24 GB-GOV-10-17_63_08 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Liverpool 50000 GB-GOV-10-17_63_08 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 202996 GB-GOV-10-17_63_08 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 131398 GB-GOV-10-17_63_08 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 42859 GB-GOV-10-17_63_08 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 107755 GB-GOV-10-17_63_08 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 67057 GB-GOV-10-17_63_08 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 239811 GB-GOV-10-17_63_08 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 154544 GB-GOV-10-17_63_08 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 384517 GB-GOV-10-17_63_08 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 539678.88 GB-GOV-10-17_63_08 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Liverpool 336189 GB-GOV-10-17_63_08 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 519957.98 GB-GOV-10-17_63_08 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 413026.52 GB-GOV-10-17_63_08 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool -293346.38 GB-GOV-10-17_63_08 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 111577.64 GB-GOV-10-17_63_08 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 9309.3 GB-GOV-10-17_63_08 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_20 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to deliver an intervention to reduce disability through pulmonary rehabilitation in Kyrgyzstan, Uganda, India and Sri Lanka. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Understand the challenges of providing a pulmonary rehabilitation (PR) in LMIC countries. 2) Establish culturally appropriate and innovative methods of delivering PR in LMIC partner sites and evaluate the new PR programmes. 3) Understand the workforce and training issues in the LMIC partners to support the delivery of clinically effective PR programmes. 4) Set priorities and outcome measures for the delivery and evaluation of a co-produced PR programme. 5) Develop an international standardised database (with anonymised individual patient data) to allow international benchmarking of PR programmes and to strengthen infrastructure for future research in this area. 6) Develop multi-disciplinary research capacity, strong governance and data management. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Leicester UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 504220 307135 456753 1085576.47 1854645.56 GB-GOV-10-17_63_20 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Leicester 50000 GB-GOV-10-17_63_20 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 255277 GB-GOV-10-17_63_20 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 198943 GB-GOV-10-17_63_20 2018/19 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Leicester 71245 GB-GOV-10-17_63_20 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 17209 GB-GOV-10-17_63_20 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 218681 GB-GOV-10-17_63_20 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 105381 GB-GOV-10-17_63_20 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 499038.91 GB-GOV-10-17_63_20 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Leicester 168310 GB-GOV-10-17_63_20 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 135861 GB-GOV-10-17_63_20 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 83313 GB-GOV-10-17_63_20 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 314588 GB-GOV-10-17_63_20 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 308600.74 GB-GOV-10-17_63_20 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Leicester 308601.47 GB-GOV-10-17_63_20 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Leicester 51003 GB-GOV-10-17_63_20 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 58192.13 GB-GOV-10-17_63_20 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester -151163.43 GB-GOV-10-17_63_20 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_26 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to address the challenges of preterm birth in LMICs, where its prevalence is highest. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Synthesise current knowledge and define the evidence gap in low and middle income countries (LMICs) regarding the prevalence, pattern, and perinatal management of pre-term birth (PTB) 2) Carry out a series of network research events to focus on understanding differential access, experiences and outcomes in advantaged and deprived populations. 3) Determine a research agenda (immediate, medium-, and long-term) relevant to each LMIC, to be developed/implemented during the term of the project and beyond. 4) Develop prenatal and postnatal evidence- based multi-professional guidelines for perinatal care for PTB. 5) Carry out pilot studies on term and preterm placentas to improve understanding of the contribution of these specific, often endemic, infections in LMICs to PTB in order to inform new research priorities around prevention of, and screening for identified infections. 6) Carry out vaginal swab studies in partner LMICs and explore at stakeholder-led research prioritisation exercises whether future studies of cervical electrical impedance spectroscopy (EIS) devices would be feasible, practical and acceptable in LMICs contexts. 7) Work directly with the Project Management Group to provide patient and public involvement (PPI) input into all project matter. Following a costed extension, additional objectives will include: Work Package 1: Work with families, health care workers and policy planners. 1. Design and carry out pilot/ feasibility studies of interventions to improve adolescent sexual reproductive health (SRH), prevent unintended pregnancy, and reduce miscarriage, preterm birth (PTB), and “small for dates” in three locations. 2. Develop need-based and culturally sensitive intervention packages to improve adolescent SRH, antenatal care (ANC) and nutrition. 3. Test the feasibility of implementation, health systems integration, geographical scale-up and sustainability of these interventions. Work Package 2: Employ metagenomics/ transcriptomics to identify viral pathogens in preterm vs. term placental tissues already collected from UK and Bangladesh women by 03/2021. Work Package 3: Bridge the gap between research findings, policy and practice. 1. Implement PRIME (PReterm bIrth prevention and manageMEnt) research outputs (PTB guidelines, education and training resources by engagement/ advocacy workshops with families, healthcare workers, policy planners, and non-government organisations. 2. Systematically capture the impact of PRIME research outputs. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Sheffield UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 362589 734606 819691.73 563226.27 1980113 GB-GOV-10-17_63_26 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) The University of Sheffield 50000 GB-GOV-10-17_63_26 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 234051 GB-GOV-10-17_63_26 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 78538 GB-GOV-10-17_63_26 2018/19 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The University of Sheffield 189611 GB-GOV-10-17_63_26 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 190785 GB-GOV-10-17_63_26 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 132695 GB-GOV-10-17_63_26 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 221515 GB-GOV-10-17_63_26 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 124561 GB-GOV-10-17_63_26 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 500000 GB-GOV-10-17_63_26 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) The University of Sheffield 151607 GB-GOV-10-17_63_26 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 224033 GB-GOV-10-17_63_26 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 181039.73 GB-GOV-10-17_63_26 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 86227 GB-GOV-10-17_63_26 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 135189 GB-GOV-10-17_63_26 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 192916 GB-GOV-10-17_63_26 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 163338.99 GB-GOV-10-17_63_26 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 62672 GB-GOV-10-17_63_26 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 16442.17 GB-GOV-10-17_63_26 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_35 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to establish a centre of excellence in Tanzania in social science research to understand the distribution and impact of arthritis in Tanzania and inform prevention and intervention plans. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Establish new research collaborations between Universities of Glasgow/Newcastle and Kilimanjaro Clincial Research Institute. 2) Understand and describe the lived experience of joint pain and arthritis in Tanzania. 3) Describe how the ‘arthritis and joint pain’ problem is managed in clinical settings. 4) Estimate the prevalence of the main forms of arthritis in community settings in Tanzania. 5) Identify existing evidence on arthritis quality of life, health seeking behaviour and resource utilisation and pilot instruments. 6) Increase training and capacity building in social science in Tanzania. Following a costed extension, additional objectives will include: Study 1: Evaluate a new rheumatology clinic through documenting and evaluating the process by which the clinic is established, who is referred, how patients are identified and managed, and short-term outcomes. 1. Describe the socio-demographics, clinical characteristics and short-term outcomes of patients. 2. Evaluate the processes through which the clinic is established and identify future directions. Study 2: Identify culturally relevant attributes of capacity wellbeing by building directly on initial qualitative findings. 1. Conduct formative qualitative research to inform the development of a future instrument for intervention evaluation research into non-communicable diseases. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Glasgow UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Tanzania, the United Republic of Research for prevention and control of NCDs Research and Innovation 450850 650491 535464.02 856468.15 1993935.17 GB-GOV-10-17_63_35 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Glasgow 50000 GB-GOV-10-17_63_35 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 336579 GB-GOV-10-17_63_35 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 64271 GB-GOV-10-17_63_35 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 13589 GB-GOV-10-17_63_35 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 215218 GB-GOV-10-17_63_35 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 197406 GB-GOV-10-17_63_35 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 224278 GB-GOV-10-17_63_35 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 112230 GB-GOV-10-17_63_35 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 499338 GB-GOV-10-17_63_35 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Glasgow 114660 GB-GOV-10-17_63_35 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 170923 GB-GOV-10-17_63_35 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 222962 GB-GOV-10-17_63_35 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 48022.9 GB-GOV-10-17_63_35 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 234971 GB-GOV-10-17_63_35 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 148890 GB-GOV-10-17_63_35 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 214609.02 GB-GOV-10-17_63_35 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 64980.7 GB-GOV-10-17_63_35 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 36618.94 GB-GOV-10-17_63_35 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 2163 GB-GOV-10-17_63_35 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_38 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to assess asthma control, current treatment, knowledge of and attitudes to asthma in African schools, and the barriers to achieving good control in 3000 asthmatic children aged 12 to 14 years in schools in six African countries, utilising data to design a school-based intervention. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Adaption of a UK online asthma survey for schools so that it is applicable to secondary schoolchildren in urban Africa via focus groups of asthmatic children at each centre. 2) Provide the survey online to children aged 12 to 14 years presenting to secondary care with an acute asthma attack in order to generate data from asthmatic children who may not be attending school. 3) Since there are many phenotypes of asthma, the group will phenotype children with asthma by; i) pre-and postbronchodilator spirometry, ii) exhaled nitric oxide (FeNO), a marker of airway eosinophilia, and iii) by the reported pattern of wheeze (e.g. predominately viral-triggered attacks, persistent wheeze with with atopic symptoms). To obtain objective data on medication adherence, and daily changes in lung function, a subgroup of children will be provided with a mobile smart phone, a personal peak flow device, and inhaler adherence assessment technology. Real-time data on adherence and lung function will be delivered via mobile technology to the data platform. Following a costed extension, additional objectives will include: 1. Describe the burden of microenvironmental air pollution exposure in urban children with asthma symptoms in sub-Saharan Africa. 2. Explore connections of air pollution exposure to lung health and function in these children. 3. Collect personal air pollution exposure data, lung function and exhaled nitric oxide, and activity profiled from 420 children with asthma symptoms aged between 12 and 16 in 7 African cities. 4. Analyse personal air pollution data for exposure patterns and peak exposures, and to compare air pollution and activity profiles of children in relation to their socioeconomic and geographical backgrounds. 5. Explore potentially detrimental effects of air pollution and feasibility of potential mitigation strategies in children with asthma symptoms identified by ACACIA (Achieving Control of Asthma in Children in Africa). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Queen Mary University of London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 453914 557151 548097.91 939344.93 1998507.84 GB-GOV-10-17_63_38 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Queen Mary University of London 50000 GB-GOV-10-17_63_38 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 295057 GB-GOV-10-17_63_38 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 108857 GB-GOV-10-17_63_38 2018/19 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Queen Mary University of London 124253 GB-GOV-10-17_63_38 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 160475 GB-GOV-10-17_63_38 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 103041 GB-GOV-10-17_63_38 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 169382 GB-GOV-10-17_63_38 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 65442 GB-GOV-10-17_63_38 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 500000 GB-GOV-10-17_63_38 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Queen Mary University of London 123515 GB-GOV-10-17_63_38 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 162255.91 GB-GOV-10-17_63_38 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 121617 GB-GOV-10-17_63_38 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 199133 GB-GOV-10-17_63_38 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 261207 GB-GOV-10-17_63_38 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 146654 GB-GOV-10-17_63_38 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 282693.94 GB-GOV-10-17_63_38 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 79787.37 GB-GOV-10-17_63_38 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_42 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to advance a multidisciplinary approach to address the problem of sepsis in sub-Saharan Africa. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Sustainably improve sepsis research training. 2) Reach consensus on research priorities and sepsis care quality indicators for Africa. 3) Pilot test innovative sepsis care interventions. 4) Test novel clinical trial platforms to answer key sepsis questions for Africa. Following a costed extension, additional objectives will include: Work Package 1 : Extend cohort enrolment by 6-12 months dependent on site. 1. Improve estimate precision of hospital admission over a longer time period. 2. Provide sufficient numbers for investigating post-discharge mortality, morbidity, and re-hospitalisation risk factors. Work Package 2: Host response to sepsis. Inclusion of transcriptomic or immunological profiles to facilitate patient stratification into subgroups (endotypes). 1. Compare sepsis endotypes between High Income Countries and Low and Middle Income Countries. 2. Develop an accurate temporal association of endotypes and clinical outcomes for patients in Malawi and Uganda. 3. Identify transcriptomic biomarkers for validation of a pan-sepsis prognostic panel. Work Package 3: Expand the capabilities of the BASIS research network (addition of three countries to the current core sites). 1. Describe important differences in the presenting features of patients with sepsis in African hospitals. Work Package 4: Refinement of the eSIMS (electronic Severe Illness Management Support) platform. 1. Add functionality informed by the current work. 2. Evaluate whether eSIMS impacts the processes of sepsis care in platform-naïve health facilities UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 403047 716703 876534.88 499912.56 1996284.88 GB-GOV-10-17_63_42 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 50000 GB-GOV-10-17_63_42 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 273621 GB-GOV-10-17_63_42 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 79426 GB-GOV-10-17_63_42 2018/19 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 81635 GB-GOV-10-17_63_42 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 208110 GB-GOV-10-17_63_42 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 132069 GB-GOV-10-17_63_42 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 294889 GB-GOV-10-17_63_42 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 67039 GB-GOV-10-17_63_42 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 499912.56 GB-GOV-10-17_63_42 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 218698 GB-GOV-10-17_63_42 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 213027 GB-GOV-10-17_63_42 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 213613 GB-GOV-10-17_63_42 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 143335 GB-GOV-10-17_63_42 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 71878 GB-GOV-10-17_63_42 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 145581 GB-GOV-10-17_63_42 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 178466.44 GB-GOV-10-17_63_42 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 137695 GB-GOV-10-17_63_42 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 24064.51 GB-GOV-10-17_63_42 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_47 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to develop a comprehensive, adaptable package of care to improve the mental health of survivors of violence against women (VAW), modern slavery, and civil conflict in resource-constrained settings in South Asia. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Identify candidate interventions through systematic review and expert networks. Through household and institutional surveys, augment existing partner data with quantitative and qualitative information on mental health burden, needs, stigma, and care-seeking. Through interviews and workshops, work with survivors and providers to understand local perspectives, mental health and social support services, intervention opportunities, and potential resources. 2) Collaborate with survivors and providers to pinpoint promising interventions and opportunities, barriers to uptake, and potential unintended outcomes. Through workshops and consultation, co-develop theories of change and delineate a provisional intervention package. 3) Pilot interventions to understand feasibility (cultural appropriateness, delivery, uptake, barriers and enablers), acceptability (motivations and expectations, safety and unintended outcomes), and potential effectiveness. Following a costed extension, additional objectives will include: Work Package 1: Further research 1. Improve the mental health of survivors of violence by extending the current package of care to adolescent girls and boys aged 15-19 years. 2. Additional nested studies led by Early Career Researchers (ECRs). Work Package 2: Enhance dissemination and impact. 1. Present package of care to government and civil society stakeholders at a regional event in India. Work Package 3: Career development for ECRs. 1. Organise and lead an international symposium immediately following the dissemination event. 2. Have ECRs design and lead their own nested studies on dating violence and with mothers-in-law of young women. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 260604 887388 444834.86 835331.75 1991234.61 GB-GOV-10-17_63_47 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University College London 50000 GB-GOV-10-17_63_47 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 210604 GB-GOV-10-17_63_47 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 151654 GB-GOV-10-17_63_47 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 118362 GB-GOV-10-17_63_47 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 239558 GB-GOV-10-17_63_47 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 377814 GB-GOV-10-17_63_47 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 436924 GB-GOV-10-17_63_47 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University College London 2318 GB-GOV-10-17_63_47 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 210854 GB-GOV-10-17_63_47 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 142506 GB-GOV-10-17_63_47 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 124086 GB-GOV-10-17_63_47 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 151054 GB-GOV-10-17_63_47 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 229661 GB-GOV-10-17_63_47 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 298279.61 GB-GOV-10-17_63_47 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 68129.86 GB-GOV-10-17_63_47 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 44069.88 GB-GOV-10-17_63_47 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_62 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to study causes of and test a strategy to prevent asthma attacks in Latin America, focussing on underserved urban settings in Brazil and Ecuador, with high levels of inequality. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Set up a Global Health Research Group at St George’s in collaboration with key partners in Brazil, Ecuador, and the UK. 2) Deliver a programme of implementation and epidemiological research through prevention of severe asthma attacks among adults in Brazil and asthma attacks in children and adolescents in Ecuador, and identification of risk factors associated with asthma attacks and recurrence of asthma attacks. 3) Establish collaborative links with LMIC partners by strengthening existing links with Brazilian and Ecuadorian partners, establishing new links with academic institutions in Ecuador involved in asthma research and control and establishing new/ strengthening existing links with key stakeholders including Ministries of Public Health, municipal departments of health, national respiratory societies, other NGOs and patient groups in Ecuador and Brazil. 4) Develop research capacity through short to extended periods of research training and exchanges between Brazil and Ecuador. Short exchanges will be funded through this programme while extended periods will be funded through alternative sources within Brazil and Ecuador. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) St George's, University of London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 553587.58 714523.64 731507.32 1999618.54 GB-GOV-10-17_63_62 COMMITMENT UK - Department of Health and Social Care (DHSC) St George's, University of London 50000 GB-GOV-10-17_63_62 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) St George's, University of London 251794 GB-GOV-10-17_63_62 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) St George's, University of London 251794 GB-GOV-10-17_63_62 2018/19 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) St George's, University of London 344950 GB-GOV-10-17_63_62 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) St George's, University of London 25580 GB-GOV-10-17_63_62 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) St George's, University of London 343994 GB-GOV-10-17_63_62 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) St George's, University of London 85075 GB-GOV-10-17_63_62 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) St George's, University of London 186583 GB-GOV-10-17_63_62 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) St George's, University of London 100554 GB-GOV-10-17_63_62 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) St George's, University of London 220214 GB-GOV-10-17_63_62 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) St George's, University of London 39080.54 GB-GOV-10-17_63_62 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) St George's, University of London 93880 GB-GOV-10-17_63_62 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) St George's, University of London 6120 GB-GOV-10-17_63_62 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) St George's, University of London NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_66 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to integrate existing stroke research excellence with healthcare and training infrastructures to improve stroke outcomes for people in Sierra Leone within five years. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Facilitate links with the UK, Ghana and Sierra Leone to set up the Stroke Unit at Connaught Hospital (Sierra Leone). 2) Deliver stroke specialist training to nurses to improve quality of care. 3) Facilitate a stroke team at 34 Military Hospital (Sierra Leone). 4) Train research and clinical staff in GCP, consent, and data collection and management. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) King's College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Sierra Leone Research for prevention and control of NCDs Research and Innovation 493098.9199999999 835049.29 664160.72 1992308.93 GB-GOV-10-17_63_66 COMMITMENT UK - Department of Health and Social Care (DHSC) King's College London 50000 GB-GOV-10-17_63_66 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 221549 GB-GOV-10-17_63_66 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 202154 GB-GOV-10-17_63_66 2018/19 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) King's College London 125078 GB-GOV-10-17_63_66 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 104065 GB-GOV-10-17_63_66 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 262233 GB-GOV-10-17_63_66 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 26937 GB-GOV-10-17_63_66 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 128934 GB-GOV-10-17_63_66 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 199161 GB-GOV-10-17_63_66 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 159162 GB-GOV-10-17_63_66 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 221877 GB-GOV-10-17_63_66 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 191158.93 GB-GOV-10-17_63_66 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London -3325.95 GB-GOV-10-17_63_66 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_76 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to use Medical Research Council (MRC) frameworks on natural experiments and complex interventions to guide the development and evaluation of interventions on smokeless tobacco (ST) and to assess policies in Bangladesh, India and Pakistan, where 85% of the world’s 300 million ST users live and use the most lethal ST forms. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Enhance the ability to monitor and evaluate the impact of existing WHO-FCTC policies on smokeless tobacco (ST) uptake, particularly among adolescents, by providing a strong evidence-base for future policy development. 2) Design/adapt behavioural and pharmacological interventions to help adult ST users quit, test their feasibility and acceptability, and assess whether definitive trials to assess their (cost-) effectiveness can be carried out. 3) Engage stakeholders in the research plans, co-creation and knowledge transfer activities and advocacy efforts, thereby enhancing the translation and impact of the findings. 4) Build research capacity in participating institutions in South Asia by offering bespoke training in tobacco prevention and control science and applied health research, sharing examples of good practice, offering mentorship and helping them to secure research fellowships/studentships. 5) Sustain and scale up research activities through a strong research team, establishing institutional links with academic, governmental and advocacy organisations, seeking additional funding and involving more countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of York UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 390408.29 790295.4 819294.53 1999998.22 GB-GOV-10-17_63_76 COMMITMENT UK - Department of Health and Social Care (DHSC) University of York 50000 GB-GOV-10-17_63_76 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 170204 GB-GOV-10-17_63_76 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 123792 GB-GOV-10-17_63_76 2018/19 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of York 131620 GB-GOV-10-17_63_76 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 143147 GB-GOV-10-17_63_76 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 179583 GB-GOV-10-17_63_76 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 255610 GB-GOV-10-17_63_76 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 118612 GB-GOV-10-17_63_76 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 81197 GB-GOV-10-17_63_76 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 188643 GB-GOV-10-17_63_76 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 167202 GB-GOV-10-17_63_76 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 55008 GB-GOV-10-17_63_76 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 101799 GB-GOV-10-17_63_76 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 27510 GB-GOV-10-17_63_76 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 106071.22 GB-GOV-10-17_63_76 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 4951.14 GB-GOV-10-17_63_76 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 94779.27 GB-GOV-10-17_63_76 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_82 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to redress the imbalance of understanding, community spread and optimal control of infection diseases in East Africa. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Create a sustainable collaborative network of institutes (UK and East Africa) that collectively support applied virus epidemiological research and provide an evidence base for decision making by public health authorities in East Africa. 2) Provide training and research support for a cohort of 20 quantitative East African scientists to develop advanced skills in viral genomics and predictive modelling. This will enable them to address locally defined problems and input into country-specific recommendations. 3) Establish and transfer genome sequencing methods (eg compact real-time Nanopore technology) with associated analysis steps (or pipelines) for virus Next Generation Sequence (NGS) data, and construct mathematical models to predict the impact of different intervention options. Outputs will be open source resources for combining sequence and epidemiological data analysis with transmission dynamic modelling. 4) Develop the Zeeman Institute at the University of Warwick as a centre of expertise for integrated mathematical and genomic epidemiology, with meaningful ties to East African Institutes. 5) Establish an East African Alliance for Virus Prevention and Control Preparedness (VPCP) with the aim of coordinating research-evidenced responses to public health needs. Following a costed extension, additional objectives will include: Work Package 1: Enhance public health virus surveillance and research through cost-effective next generation sequencing (NGS) capacity in public health laboratories across the East African Region. 1. Use of the low-cost portable Oxford Nanopore Technology NGS platform MinION in Low and Middle Income Country laboratories to allow pathogen whole genome sequencing. Work Package 2: Strengthen the role of mathematical modelling in providing evidence for public health decision making. 1. Establish greater modelling capacity at KWTRP, Nairobi by linking health systems and economics teams with university departments and relevant Ministry of Health departments. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Warwick UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Infectious disease control Research and Innovation 289578 786568 922124.11 495997.01 1998270.11 GB-GOV-10-17_63_82 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Warwick 50000 GB-GOV-10-17_63_82 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 239578 GB-GOV-10-17_63_82 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 104999 GB-GOV-10-17_63_82 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 190701 GB-GOV-10-17_63_82 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 135659 GB-GOV-10-17_63_82 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 355209 GB-GOV-10-17_63_82 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 156051 GB-GOV-10-17_63_82 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 495997.01 GB-GOV-10-17_63_82 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Warwick 127425 GB-GOV-10-17_63_82 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 263450 GB-GOV-10-17_63_82 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 282463 GB-GOV-10-17_63_82 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 4235 GB-GOV-10-17_63_82 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 170961 GB-GOV-10-17_63_82 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 86189 GB-GOV-10-17_63_82 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 202634.12 GB-GOV-10-17_63_82 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 101385 GB-GOV-10-17_63_82 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 2372.22 GB-GOV-10-17_63_82 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 20955.78 GB-GOV-10-17_63_82 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_91 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to establish local capacity in West Africa for genomic surveillance of malaria parasites and vectors, and to develop analytical outputs that will be of practical value to National Malaria Control Programmes (NMCPs) in planning effective interventions in the face of increasing drug and insecticide resistance. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Establish laboratory and computational systems for genomic surveillance of malaria at the University of Ghana in Accra and the Medical Research Council (MRC) Unit in The Gambia. 2) Work with local partners to optimise the pipeline for reliability, scalability and cost-effectiveness, and to learn how to integrate it most effectively into NMCP operations. 3) We aim to learn how to translate genomic data into actionable knowledge, e.g. by providing early warning of newly emerging resistance, and by showing how specific interventions are causing levels of resistance to rise or fall. 4) Develop sufficient proof of concept to start integrating these systems into the routine working practices of NMCPs in Ghana and The Gambia, and to provide a working example of how such systems could be deployed at other locations in Africa. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Genome Research Limited UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Malaria control Research and Innovation 616913.02 690167.36 692098.62 1999179 GB-GOV-10-17_63_91 COMMITMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 50000 GB-GOV-10-17_63_91 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 283457 GB-GOV-10-17_63_91 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 283457 GB-GOV-10-17_63_91 2018/19 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Genome Research Limited 123040 GB-GOV-10-17_63_91 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 363054 GB-GOV-10-17_63_91 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 16856 GB-GOV-10-17_63_91 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 194948 GB-GOV-10-17_63_91 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 96253 GB-GOV-10-17_63_91 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 11092 GB-GOV-10-17_63_91 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 43933 GB-GOV-10-17_63_91 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 219774 GB-GOV-10-17_63_91 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 213315 GB-GOV-10-17_63_91 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 93481 GB-GOV-10-17_63_91 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_110 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to improve the diagnosis of acute brain infections in adults and children, guide treatment and improve outcomes, while developing research capacity and establishing a broad network of hospitals interested in studying brain infections. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Understand the behaviours, knowledge, attitudes and practice of patients, families and health care workers to suspected brain infection through interviews and focus group discussions. 2) Improve early management through development of a compound intervention by working with service users and providers to develop an intervention which improves patient management, and addresses underuse of lumber puncture, and inadequate laboratory methods. 3) Strengthen diagnosis through pathogen discovery and host genomic approaches. 4) Consider the funding impacts of any changes in care in advance of their development, to help determine if they are worth exploring, and the cost at which they might be implemented. 5) Provide training, capacity building and long-term sustainability to include studentships on the Masters in Research, PhD exchange projects, short course staff training, and online research training modules, both generic and specific to brain infections, offered through partnership with the Global Health Research Network. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 636473.96 775482.27 588043.76 1999999.99 GB-GOV-10-17_63_110 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 50000 GB-GOV-10-17_63_110 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 293237 GB-GOV-10-17_63_110 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 94895 GB-GOV-10-17_63_110 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 70514 GB-GOV-10-17_63_110 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 245785 GB-GOV-10-17_63_110 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 339175 GB-GOV-10-17_63_110 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 131900 GB-GOV-10-17_63_110 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 231320 GB-GOV-10-17_63_110 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 51750 GB-GOV-10-17_63_110 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 192337 GB-GOV-10-17_63_110 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 199087 GB-GOV-10-17_63_110 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 45100.58 GB-GOV-10-17_63_110 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_121 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to build and establish long-term, sustainable collaborations in China, Brazil and Sri Lanka to increase research capacity and atrial fibrillation (AF) education/awareness amongst key stakeholders through co-developed, culturally-adapted, community-based approaches, and deliver locally-focused evidence-based research investigating developments of pragmatic patient pathways to generate further funding opportunities. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Develop and consolidate sustainable collaboration, shared vision and links with patients and policy makers to sustainably improve local services. 2) Strengthen community-based research culture, including patient and public involvement (PPI), and capacity to improve understanding of atrial fibrillation (AF) and improve health outcomes. 3) To adapt, with PPI, and assess feasibility of prioritised evidence-based sustainable pharmacological and behavioural approaches for integrated AF management within the resource confines of local health systems. 4) To develop, with PPI, and test feasibility of culturally-adapted, community-based approaches to increase education/awareness and to provide sufficient knowledge (patient, families, HCP) about AF and its complications to empower patients. 5) To provide evidence and develop local models of best care for local policy makers to improve well-being of AF patients and provide a template for extending this work to other chronic conditions. 6) To build a sustainable research platform within partner countries for future collaborations. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Birmingham UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 469628 742360 714905.08 1926893.08 GB-GOV-10-17_63_121 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 50000 GB-GOV-10-17_63_121 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 209814 GB-GOV-10-17_63_121 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 58620 GB-GOV-10-17_63_121 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 67484 GB-GOV-10-17_63_121 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 76444 GB-GOV-10-17_63_121 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 25814 GB-GOV-10-17_63_121 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 319549 GB-GOV-10-17_63_121 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 102033 GB-GOV-10-17_63_121 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 135032.39 GB-GOV-10-17_63_121 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 265832 GB-GOV-10-17_63_121 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 57846 GB-GOV-10-17_63_121 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 217208 GB-GOV-10-17_63_121 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 241216.69 GB-GOV-10-17_63_121 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham -77480.64 GB-GOV-10-17_63_121 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_125 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to support health care systems to respond effectively to women subjected to violence, and build mixed-method gender violence research capacity in Nepal, Sri Lanka, the Occupied Palestinian Territories and Brazil. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Evaluate the readiness of the Brazilian, Occupied Palestinian Territory/West Bank (OPT/WB), Nepalese and Sri Lankan sexual and reproductive health services to identify violence against women (VAW), respond to the needs of women experiencing violence, and offer referral to VAW services. 2) Conduct research studies with patients and providers to inform the development of the intervention. 3) Develop a tailored training and support intervention for health care professionals with stakeholder involvement. 4) Pilot the intervention in reproductive and sexual health settings (all collaborating countries) and primary care settings (Nepal and Sri Lanka). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Bristol UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 216112 726516 625738 707484.06 1813693 GB-GOV-10-17_63_125 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Bristol 50000 GB-GOV-10-17_63_125 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 166112 GB-GOV-10-17_63_125 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 139256 GB-GOV-10-17_63_125 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 239027 GB-GOV-10-17_63_125 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 96647 GB-GOV-10-17_63_125 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 251586 GB-GOV-10-17_63_125 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 18075 GB-GOV-10-17_63_125 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 196233 GB-GOV-10-17_63_125 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 208380 GB-GOV-10-17_63_125 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 462157.06 GB-GOV-10-17_63_125 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Bristol 184632 GB-GOV-10-17_63_125 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 312887 GB-GOV-10-17_63_125 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 134189 GB-GOV-10-17_63_125 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 165034.06 GB-GOV-10-17_63_125 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 22717.2 GB-GOV-10-17_63_125 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_130 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to improve the physical health of people with severe mental illness and the mental health of people with chronic physical conditions in LMICs. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Improve health and reduce deaths associated with diabetes, heart and lung diseases in people with severe mental illness (SMI) by addressing the most common health risk behaviours identified by a physical health survey, assembling a cohort of people who can be approached for future research and by designing interventions aimed at changing health risk behaviours (tobacco, physical activity, alcohol and diet) based on a brief talking therapy. 2) Reduce depression and anxiety in people with chronic physical health conditions by integrating the detection and treatment of depression/anxiety into an intervention package for chronic diseases delivered in primary care. 3) Build research teams and capacity to secure competitive funding and delivery world class applied health research informing policy and practice in these areas. Following a costed extension, additional objectives will include: Work stream 1: Conduct workshops with a range of stakeholders to understand facilitators and barriers to integrating services for identifying and managing depression in tuberculosis (TB) and chronic hepatitis services. 1. Train staff in TB and hepatitis services to identify depression and deliver treatment. 2. Provide specialist supervision for non-mental health specialists in those settings. 3. Release staff and other resources to help integrate depression care. 4. Scale up and sustain integrated provision. 5. Explore with patients the acceptability of routine depression case-finding and treatment within TB/ chronic hepatitis care and potential adverse outcomes of integration. Work stream 2: Run co-designed workshops with patients and healthcare staff to develop plans, pathways and materials for integrating depression care in TB and chronic hepatitis services. Work stream 3: Test feasibility of plans and materials for depression case-finding. 1. Identify and train staff in exemplar sites to case find using standard instruments. 2. Collect quantitative and qualitative data form audits, focus groups and individual interviews. 3. Revise plans, materials, future intervention and trial design based on results. 4. Develop new partnerships with National TB programmes and hepatitis services in partner countries. 5. Continued capacity-strengthening and skill development for early career researchers. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of York UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 352550 657204 652847 835512.7 1999682.72 GB-GOV-10-17_63_130 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of York 50000 GB-GOV-10-17_63_130 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 181795 GB-GOV-10-17_63_130 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 120755 GB-GOV-10-17_63_130 2018/19 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of York 128223 GB-GOV-10-17_63_130 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 149177 GB-GOV-10-17_63_130 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 123280 GB-GOV-10-17_63_130 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 256524 GB-GOV-10-17_63_130 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 57187 GB-GOV-10-17_63_130 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 101558 GB-GOV-10-17_63_130 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 498430.98 GB-GOV-10-17_63_130 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of York 179649 GB-GOV-10-17_63_130 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 225701 GB-GOV-10-17_63_130 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 208731 GB-GOV-10-17_63_130 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 149781 GB-GOV-10-17_63_130 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 212265 GB-GOV-10-17_63_130 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 228581.7 GB-GOV-10-17_63_130 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 51228.51 GB-GOV-10-17_63_130 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 71748.34 GB-GOV-10-17_63_130 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_131 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to build on existing relationships between Exeter and leading partners in Uganda and Cameroon to form a collaborative, multi-disciplinary research group to answer fundamental questions for diabetes detection and treatment needed for effective patient care, train the next generation of clinical researchers, and build crucial research capacity in sub-Saharan Africa. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Create the foundation of a long-term partnership between Exeter and researchers, healthcare professionals and patient groups in Uganda and Cameroon to identify, design and perform critical research to improve the care of people with diabetes in sub-Saharan Africa (SSA). 2) Strengthen research capacity in SSA through an extensive programme of training in Exeter for African researchers at all levels, and reciprocal placements of UK researchers in African institutions. 3) Conduct initial studies to determine the best methods for detection and monitoring of different diabetes subtypes found in SSA, aiming to find practical solutions that make the best use of limited resources. 4) Establish long term studies (cohorts) of patients with diabetes in SSA that will form the basis of future research into the best treatment of diabetes in this population. Following a costed extension, additional objectives will include: Overall aim: To understand the pathogenesis and characteristics of thin non-autoimmune diabetes to optimise their identification, diabetes classification, prevention and treatment in sub-Saharan Africa. 1. Use cohort data from the original award to identify characteristics at diagnosis that discriminate autoimmune (Type 1) from non-autoimmune (Type 2) diabetes and assess diagnostic performance to inform clinical guidelines. 2. Perform preliminary studies to determine the contribution of insulin resistance and beta cell failure in the pathogenesis of thin non-autoimmune diabetes and explore the role of ectopic fat and pancreatic disease. 3. Perform a pilot study assessing response to oral therapy in those with non-obese Type 2 diabetes previously thought to have Type 1 diabetes. 4. Use initial findings from these studies to design a future large program of work for understanding pathogenesis, prevention and treatment. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Exeter UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 195339 897615 904797 499886.66 1997751 GB-GOV-10-17_63_131 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Exeter 50000 GB-GOV-10-17_63_131 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 145339 GB-GOV-10-17_63_131 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 157237 GB-GOV-10-17_63_131 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 216108 GB-GOV-10-17_63_131 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 275549 GB-GOV-10-17_63_131 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 248721 GB-GOV-10-17_63_131 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 499886.66 GB-GOV-10-17_63_131 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Exeter 163235 GB-GOV-10-17_63_131 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 199045 GB-GOV-10-17_63_131 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 236775 GB-GOV-10-17_63_131 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 61311 GB-GOV-10-17_63_131 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 88733 GB-GOV-10-17_63_131 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 530702.66 GB-GOV-10-17_63_131 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 68678.34 GB-GOV-10-17_63_131 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 17012.15 GB-GOV-10-17_63_131 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_145 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to offer a holistic assessment of the occupational health risks to which urban informal workers are exposed in Zimbabwe and India, including consideration of climate-related risks, and identify priority interventions to address risks, strengthen assets and promote public, environmental and occupational health while also enhancing informal workers' resilience to climate change. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Assess and promote the health of informal workers, including those who work and live in informal settlements (hereafter ‘informal workers’). 2) Analyse the key health determinants and health outcomes for informal workers and those living in informal settlements, the interaction between these in relation to public health, occupational health and environmental health and how current and projected impacts of climate change affect this interaction. 3) Ascertain the approaches being used by informal workers to mitigate risks and enhance benefits. 4) Use these findings to identify the priority interventions to address risks, strengthen assets, promote public, environmental, and occupational health, enhance informal workers’ resilience to climate change and to promote workers’ well-being, and complement the rising interest in slum health, occupational health, and resilient urban development. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) International Institute for Environment and Development UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 413252.31 550766.43 564601.17 1528619.91 GB-GOV-10-17_63_145 COMMITMENT UK - Department of Health and Social Care (DHSC) International Institute for Environment and Development 50000 GB-GOV-10-17_63_145 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Institute for Environment and Development 181626 GB-GOV-10-17_63_145 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Institute for Environment and Development 201094 GB-GOV-10-17_63_145 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Institute for Environment and Development 104424 GB-GOV-10-17_63_145 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Institute for Environment and Development 112626 GB-GOV-10-17_63_145 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Institute for Environment and Development 180503 GB-GOV-10-17_63_145 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Institute for Environment and Development 50495 GB-GOV-10-17_63_145 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Institute for Environment and Development 56953 GB-GOV-10-17_63_145 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Institute for Environment and Development 137597 GB-GOV-10-17_63_145 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Institute for Environment and Development 153896 GB-GOV-10-17_63_145 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Institute for Environment and Development 145135 GB-GOV-10-17_63_145 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Institute for Environment and Development 54270.91 GB-GOV-10-17_63_145 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Institute for Environment and Development 108438.3 GB-GOV-10-17_63_145 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Institute for Environment and Development NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_154 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to develop context-appropriate interventions to optimise nutrition preconception, intra- and postpartum, which are likely to set-up better health and human capital trajectories. The network will deliver substantial societal and economic benefits, building LMIC partner capacity and improving knowledge for human health. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Establish a multidisciplinary group of researchers across SSA, with UK Southampton. 2) Undertake in-depth review of nutrition policy and engagement of health policy-makers and healthcare leaders with the issue, in three different SSA countries, to establish the barriers and the opportunities to instituting a clear 1000 DaysPlus double duty healthy nutrition policy. 3) Formulate the economic case for investment in nutrition in the 1000 DaysPlus for optimal health of people and their future offspring. 4) Leverage their on-going work in different contexts and with a range of stakeholders to identify the best 1000 DaysPlus nutrition interventions that could be embedded in ongoing reproductive health services, community health worker programmes, community antenatal care clinics, or fiscal measures (for example, sugar sweetened beverage tax). 5) Develop protocols and pilot novel approaches to improve the nutritional status in the 1000 DaysPlus period. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Southampton UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 426970 769766 630410 499999.61 1827146 GB-GOV-10-17_63_154 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Southampton 50000 GB-GOV-10-17_63_154 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 188485 GB-GOV-10-17_63_154 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 174935 GB-GOV-10-17_63_154 2018/19 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Southampton 125303 GB-GOV-10-17_63_154 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 142597 GB-GOV-10-17_63_154 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 103027 GB-GOV-10-17_63_154 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 199696 GB-GOV-10-17_63_154 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 217589 GB-GOV-10-17_63_154 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 215520 GB-GOV-10-17_63_154 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 499999.61 GB-GOV-10-17_63_154 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Southampton 213995 GB-GOV-10-17_63_154 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 39614 GB-GOV-10-17_63_154 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 70532 GB-GOV-10-17_63_154 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 171406 GB-GOV-10-17_63_154 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 190792 GB-GOV-10-17_63_154 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 107297.61 GB-GOV-10-17_63_154 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 2267.52 GB-GOV-10-17_63_154 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 56594.34 GB-GOV-10-17_63_154 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-17_63_155 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to conduct high quality translational research supporting sustained, evidenced-based equitable transition to clean household energy at scale in Cameroon, Kenya and Ghana, demonstrating the health (through reductions in non-communicable disease), health inequalities and climate impacts of this transition. This research has the direct and primary aim of improving the health, wellbeing and economic development of people in LMICs. 1) Inform strategies to support more equitable uptake of clean fuel across the population by evaluating enabling/ inhibiting factors and testing interventions to address identified barriers and facilitate equitable adoption/ use of liquified petrolium gas (LPG) (including consumer finance solutions). 2) Estimate the impacts of scaled LPG adoption, in line with governmental targets, on health and climate by using advanced statistical techniques, thereby providing evidence for national/international policymakers to advocate for widespread transition to clean fuel. 3) Develop capacity through health systems strengthening in the partner countries, equipping health practitioners to intervene early to ‘prescribe’ clean household energy solutions to their patients. 4) Facilitate engagement between the general public and policymakers as research is undertaken alongside national policy implementation. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 428746 890218 673784 499908.81 1992748 GB-GOV-10-17_63_155 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Liverpool 50000 GB-GOV-10-17_63_155 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 228759 GB-GOV-10-17_63_155 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 149987 GB-GOV-10-17_63_155 2018/19 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Liverpool 211304 GB-GOV-10-17_63_155 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 202911 GB-GOV-10-17_63_155 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 236667 GB-GOV-10-17_63_155 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 239336 GB-GOV-10-17_63_155 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 188426 GB-GOV-10-17_63_155 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 186364 GB-GOV-10-17_63_155 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 174208 GB-GOV-10-17_63_155 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 499908.81 GB-GOV-10-17_63_155 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Liverpool 150491 GB-GOV-10-17_63_155 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 124089 GB-GOV-10-17_63_155 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 90313 GB-GOV-10-17_63_155 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 132060 GB-GOV-10-17_63_155 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 3108.81 GB-GOV-10-17_63_155 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 140268 GB-GOV-10-17_63_155 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool -20178.75 GB-GOV-10-17_63_155 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool NIHR Global Health Research Groups are subject to a six month progress review, assessed by an independent panel, to determine whether Groups should advance to full funding. GB-GOV-10-NIHR_GHRG3 UK - Department of Health and Social Care (DHSC) The NIHR's third Global Health Research call for Groups. UK universities and research institutes were invited to submit applications, working in equitable partnerships with researchers in low- and middle-income countries (LMIC), to develop their ambitions to deliver world-class applied global health research to address under-funded or under-researched global health areas specific to those countries. Global Health Research Groups are defined as a partnership of specialist researchers within universities and research institutes in LMICs and the UK: 1. Either new to delivering applied health research globally, or expanding to new global partnerships to deliver applied global health research addressing unmet needs in new health areas or geographies in ODA-eligible countries; 2. Who, through a planned start-up phase, will develop or expand equitable research partnerships and networks, to undertake LMIC-led needs analysis designed to refine relevant research questions and priorities through engagement with policy makers, evidence users and local communities, as appropriate; 3. Who will establish a new programme of applied health research delivered through ambitious, structured plans for e.g. scoping studies, needs analysis, economic analysis, pilot studies and potentially trials; 4. Who are able to develop the strength of the partnership to improve practice and inform policy based on scientific evidence; 5. Who will set up and deliver a focussed programme of capacity and capability strengthening at individual and institutional level appropriate to the respective goals. The strategic aim across the Global Health Research Groups programme is to: 1. Address locally-identified challenges in LMICs through equitable research partnerships between researchers and institutions in the UK and ODA-eligible countries 2. To generate the scientific evidence that can improve health outcomes for people in low resource setting through improving practice and informing policy. 3. Strengthen research and research management capacity and capability to support future sustainability of research in partner countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Cambridge University College London University of Leicester University of Liverpool University of Strathclyde University of Birmingham Liverpool School of Tropical Medicine University of Cambridge University of Dundee Queen Mary University of London King's College London Imperial College London London School of Hygiene and Tropical Medicine The University of Manchester King's College London Newcastle University The University of Aberdeen Queen Mary University of London The University of Edinburgh London School of Hygiene and Tropical Medicine King's College London Liverpool School of Tropical Medicine London School of Hygiene and Tropical Medicine London School of Hygiene and Tropical Medicine University of Essex The University of Manchester University of Exeter Imperial College London Genome Research Limited University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-GHRG_3_132455 UK - Department of Health and Social Care (DHSC) The NIHR Global Health Research Group on Acquired Brain and Spine Injury (ABSI) aims to build on the work of our previously funded NIHR global health project which focused on neurotrauma. In addition to examining brain injury, this project has been expanded to include a number of other conditions namely traumatic spinal injury, stroke, brain infection and cerebrospinal fluid disorders and hydrocephalus. To structure the project it has been divided into four themes: mapping care, understanding care, generating and implementing knowledge and capacity building. The project will be managed by 2 lead directors, Professor Peter Hutchinson in the UK and Professor Anthony Figaji based in South Africa. In addition there are 26 coapplicants and a further 18 collaborators from a wide range of low- and middle-income countries (LMICs): Brazil, Cameroon, Colombia, Ethiopia, India, Kenya, Malaysia, Pakistan, Philippines, Tanzania, Zambia, Afghanistan, Bolivia, Indonesia, Nigeria, Sri Lanka and Zimbabwe. There is a diverse range of research studies and methodologies within each theme which will be based mainly in the LMIC collaborating sites and overseen by the central management team in the UK and South Africa. The majority of the projects will complete enrolment within 3 years with the final year reserved for preparing reports and dissemination of the data. The aim of the project is to significantly influence health policy. Furthermore the networks and partnerships created will establish a sustainable platform for global health researchers to continue for years to come. 1. Expand the previously funded NIHR Global Health Research Group on Neurotrauma (focus on traumatic brain injury) to focus on the four overarching themes (Mapping care; Understanding Care; Generating and implementing innovation; Capacity building) consisting of five conditions (traumatic brain injury, traumatic spine injury, stroke, brain infections, cerebrospinal fluid (CSF disorders/hydrocephalus) causing a substantial burden of disease in LMICs 2. Create training and educational opportunities for LMIC researchers and establish a global health fellowship exchange programme 3. Ensure nurses, allied health professionals, and patients are an integral part of the working group and lead in developing the projects – an area in need of development in LMICs. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Cambridge UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 537950 797444 786828 571800 305215 2999237 GB-GOV-10-GHRG_3_132455 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 134488 GB-GOV-10-GHRG_3_132455 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) University of Cambridge 201731 GB-GOV-10-GHRG_3_132455 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) University of Cambridge 39760 GB-GOV-10-GHRG_3_132455 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 25900 GB-GOV-10-GHRG_3_132455 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 291210 GB-GOV-10-GHRG_3_132455 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 57257 GB-GOV-10-GHRG_3_132455 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 38345.82 GB-GOV-10-GHRG_3_132455 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 150663.72 GB-GOV-10-GHRG_3_132455 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 426724.07 GB-GOV-10-GHRG_3_132455 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 63636.58 GB-GOV-10-GHRG_3_132455 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 323379 GB-GOV-10-GHRG_3_132455 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 51419 GB-GOV-10-GHRG_3_132455 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 276574.94 GB-GOV-10-GHRG_3_132455 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 153452.47 GB-GOV-10-GHRG_3_132455 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge GB-GOV-10-GHRG_3_132731 UK - Department of Health and Social Care (DHSC) Oral diseases include a range of chronic conditions affecting the mouth and teeth including dental caries (tooth decay), periodontal (gum) disease, and mouth cancers. Despite being largely preventable, these oral conditions are among the most common diseases globally affecting over 3.5 billion people worldwide with disease rates increasing in many low and middle-income countries (LMICs). Untreated oral diseases have significant adverse effects causing severe pain, infection, reduced quality of life, and death. Oral diseases disproportionally affect poorer and marginalised groups, being very closely linked to levels of education and income. Oral diseases share common risks with other chronic diseases including sugar consumption, poor hygiene, tobacco use, harmful alcohol consumption, and the broader underlying social environment (the conditions in which people are born, grow, live, work and age). Increasing attention is also now being placed on the role of multinational corporations who market, promote and sell products which are detrimental to health (commercial determinants). In many LMICs dental services are often inaccessible and unaffordable to large segments of the population but particularly the rural poor. This research programme will address the neglect of oral diseases in four middle-income countries – Kenya, Colombia, India and Brazil. In these countries oral diseases are a major public health problem and there is a pressing need for high quality public health research to promote oral health and reduce oral health inequalities. The research is being co-led by Professor Richard Watt (University College London) and Dr Carol Guarnizo-Herreno (National University of Colombia) and an academic team from the UK, Brazil, India, Kenya and Colombia. In addition collaborators from the US, Australia, Ireland, The Netherlands and Singapore will support the research. The overall aim of the programme is to explore the causes of oral health inequalities and to co-produce and pilot interventions to improve population oral health and reduce oral health inequalities in each country. The four-year programme will comprise of three interconnected work packages including: WP1 Oral Health Inequalities; WP2 Commercial determinants; WP3 Oral health system reform and innovation. In addition, the programme will develop local research capacity through an extensive range of training and short courses. Community engagement and involvement activities will fully inform and support all aspects of the planned research. The results from the programme of research will be shared and disseminated across policy, professional, and community networks in each of the participating LMIC countries but also more widely across existing international research and policy networks. 1. To establish an equitable, effective and sustainable research partnership across the UK academic institutions, participating Low and Middle Income Countries (Kenya, Colombia, India and Brazil), and the other academic collaborators to share respective expertise, experience and local knowledge of oral health. 2. To develop and undertake a programme of research on oral diseases and their causes to inform the co-production and feasibility testing of public health interventions to reduce oral health inequalities and promote oral health, and reform oral health systems in each country. 3. To build and develop dental public health research capacity amongst early career oral health researchers in each country through postgraduate training, short courses, and mentoring opportunities. 4. To establish and develop meaningful communication with local communities in each country to better understand community experiences of oral diseases and use of dental services, and the best ways ahead of promoting sustainable community engagement and involvement in oral health research. 5. To engage and advocate with key local stakeholders in each country, including policy makers, senior clinicians and leaders of health professional organisations, public health agencies and community organisations on the public health importance of oral diseases and the need for a sustainable oral health research agenda. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 641617 721898 638175 625816 352501 2980007 GB-GOV-10-GHRG_3_132731 COMMITMENT UK - Department of Health and Social Care (DHSC) University College London 160404 GB-GOV-10-GHRG_3_132731 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University College London 240606 GB-GOV-10-GHRG_3_132731 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University College London 887157.91 GB-GOV-10-GHRG_3_132731 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 154217 GB-GOV-10-GHRG_3_132731 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 224181 GB-GOV-10-GHRG_3_132731 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 438994 GB-GOV-10-GHRG_3_132731 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London GB-GOV-10-GHRG_3_132995 UK - Department of Health and Social Care (DHSC) Background African healthcare was developed to focus on infectious diseases like HIV. This means that African healthcare is not set up well to cope with non-infectious diseases becoming more common. The most common non-infectious diseases are ‘cardiometabolic diseases’. These includes heart disease, diabetes and high blood pressure. All of these can lead to early death. It makes sense to tackle cardiometabolic diseases together because they can be treated in similar ways. For example, losing weight and increasing exercise can help with all of them. Aims The aims of this work are to develop care models to improve outcomes and control of common risk factors for cardiometabolic diseases for adults in 3 low-income countries: Ghana, Kenya, and Mozambique. Workplan Researchers from University of Leicester will work together with researchers and doctors from these countries to determine what healthcare needs are most important to patients and health workers. This will support development of a care model which can be used to provide better healthcare to patients with cardiometabolic diseases. A study involving patients, healthcare professionals and community participants will be conducted prior to design and planning of a randomised controlled trial to test the care model developed. Themes within this project will focus on training and capacity building and establishing a programme of community engagement and involvement. Capacity building will be tailored to develop future leaders in research management and expertise in sub-Saharan Africa. Community engagement will be utilised to shape delivery of this research programme, maximise impact and build lasting capacity to support future research. The primary impact will be a substantial improvement in cardiometabolic health management for those living in Ghana, Kenya, and Mozambique, with improved research and community engagement in healthcare. These benefits will likely translate to substantial economic benefits for the patients, health systems and local healthcare providers. Objectives: • To identify and prioritise healthcare needs for patients with cardiometabolic diseases, in Ghana, Kenya, and Mozambique. • To develop a model for people with cardiometabolic diseases, ready to be used in Ghana, Kenya, and Mozambique. • To investigate the practical implications of delivering the model developed in this research and the parameters required to design a randomised controlled trial (RCT). • To maximise impact, uptake and implementation of the Group activities, by putting in place enablers to secure sustainability beyond the funding. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Leicester UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 524466 769268 603280 327624.29 74924 GB-GOV-10-GHRG_3_132995 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 224771 GB-GOV-10-GHRG_3_132995 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 224771 GB-GOV-10-GHRG_3_132995 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 2224638.29 GB-GOV-10-GHRG_3_132995 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Leicester 40542 GB-GOV-10-GHRG_3_132995 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Leicester 230253.38 GB-GOV-10-GHRG_3_132995 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Leicester 238689 GB-GOV-10-GHRG_3_132995 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 147134 GB-GOV-10-GHRG_3_132995 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 279076 GB-GOV-10-GHRG_3_132995 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 136742 GB-GOV-10-GHRG_3_132995 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 358281 GB-GOV-10-GHRG_3_132995 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 158223 GB-GOV-10-GHRG_3_132995 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 19359.04 GB-GOV-10-GHRG_3_132995 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester GB-GOV-10-GHRG_3_133066 UK - Department of Health and Social Care (DHSC) The NIHR Global Health Research Group in Gastrointestinal Infections will apply world leading infection and vaccine research to improve health outcomes from childhood diarrhoea in Eastern and Southern Africa. Diarrhoea kills about half a million children under 5 years of age each year, and most of these deaths occur in Africa and Asia. The highest rates of diarrhoea deaths occur in sub-Saharan Africa. In children who survive a diarrhoeal illness, malnutrition, poor growth and impaired brain development commonly follow. Vaccines represent a critical public health tool to reduce this disease burden. Informed by a longstanding research programme in Malawi undertaken by the Lead Investigator, vaccination against a virus called rotavirus has helped to reduce diarrhoeal illness and deaths in African children. But the benefit has not been equal across countries. In some populations, vaccination does not work well, or vaccination is not administered at the optimum age or not at all. Vaccines being developed against other organisms causing diarrhoea, including a bacterium called Shigella, offer hope that suffering and death can be further reduced. More research is required to enable current and future vaccines to bring improved and equitable benefit to all children. The Global Health Research Group in Gastrointestinal Infections will address inequalities in diarrhoea burden by combining expertise in epidemiology, laboratory science, social science, mathematical modelling, statistics, health economics and policy. This multidisciplinary programme, jointly led by the University of Liverpool and the Kamuzu University of Health Sciences, will extend the scientific depth and the geographical scope of our research beyond Malawi. New partnerships will be developed in Kenya (Kenya Medical Research Institute) and Ethiopia (Addis Ababa University), countries in which childhood diarrhoeal morbidity and mortality is high and where vaccination to reduce this burden is a priority. Responding to input from key stakeholders including Ministries of Health and Community Leaders, research will be undertaken in each of Malawi, Kenya and Ethiopia in order to: • develop sustained engagement with communities and key stakeholders to provide greater national and regional visibility of gastrointestinal infection research; • estimate the burden of vaccine preventable diarrhoeal diseases; • predict the clinical impact and cost-effectiveness of vaccination; • work with policy makers to inform vaccine introduction and evaluation; • build capacity in gastrointestinal infection and vaccine research through Masters training programmes run by the partner organisations. Through close links with each Ministry of Health and ongoing community engagement, the Global Health Research Group in Gastrointestinal Infections will ensure its research findings are translated into policy for public benefit. Development of a cohort of researchers and public health practitioners with expertise in gastrointestinal infections will sustain this work in the years ahead. The Group’s impact will include enhanced and more equitable use of current and future vaccines to prevent diarrhoea and its consequences, particularly among disadvantaged children in sub-Saharan Africa. 1. To facilitate sustained engagement between regional and national authorities and local communities together with other key stakeholders, to provide greater visibility of gastrointestinal infection research in Malawi, Kenya and Ethiopia. This will create increased awareness of gastrointestinal infections among clinicians, policymakers and the public. 2. To estimate the clinical and cost burden of diarrhoeal diseases presenting to health facilities. This will inform national estimates of disease burden attributed to key, vaccine-preventable diarrhoeal diseases. 3. To predict the clinical impact and cost-effectiveness of vaccines against leading causes of childhood diarrhoea. These data will be shared with Ministries of Health to inform policy. 4. To create sustainable systems to measure the burden of gastrointestinal infections and the outcome of vaccine interventions. This policy framework will inform population-wide vaccine introduction and evaluation against diarrhoeal diseases. 5. To develop a cohort of African scientists with expertise in gastrointestinal infection research. This cohort of trained staff and students will help to sustain this work in the years ahead. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 358030 848362.99 912241.59 731039.57 149982.85 2999657 GB-GOV-10-GHRG_3_133066 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 143212 GB-GOV-10-GHRG_3_133066 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 214818 GB-GOV-10-GHRG_3_133066 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 44193.99 GB-GOV-10-GHRG_3_133066 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 211281 GB-GOV-10-GHRG_3_133066 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 354351 GB-GOV-10-GHRG_3_133066 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 238537 GB-GOV-10-GHRG_3_133066 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 62026 GB-GOV-10-GHRG_3_133066 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 186498.97 GB-GOV-10-GHRG_3_133066 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 325744.53 GB-GOV-10-GHRG_3_133066 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 337972.09 GB-GOV-10-GHRG_3_133066 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 189449.93 GB-GOV-10-GHRG_3_133066 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 337479 GB-GOV-10-GHRG_3_133066 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 204110.64 GB-GOV-10-GHRG_3_133066 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool GB-GOV-10-GHRG_3_133128 UK - Department of Health and Social Care (DHSC) Our research will focus on the health and wellbeing of adolescents in Malawi from 2022 to 2026. We will work hand in hand with adolescents (10–14 years old) from rural (Mchinji) and urban (Blantyre) backgrounds to understand their lived experience, and the challenges they face in their day to day lives. We will then work with adolescents, parents and guardians and other interested parties to develop promising approaches to improve their health and wellbeing. These interventions will focus on three areas (1) gender, sexual and reproductive health rights, (2) aspirations and wellbeing including mental health, and (3) water, sanitation and hygiene. Work in these areas will be supported by research on the policy and economic environment in which adolescent health and wellbeing sits. This is a collaboration between the University of Strathclyde (UK), Kamuzu University of Health Sciences (Malawi) and the Malawi University of Business and Applied Sciences. The research will be transdisciplinary, meaning that our team of researchers from different disciplines (social care, education, sexual and reproductive health, environmental health, mental health, health economics, and health systems), and will work hand in hand with adolescents, family and community members, health workers, policy makers, and other organisations to design, implement and evaluate the research. We are focussing on adolescent health and wellbeing because the United Nations estimate that there are more young people (10-24 year olds) alive today than at any other time in human history, the majority of which live in low and middle income countries such as Malawi. Within these settings, adolescence is affected by several health and wellbeing burdens that are worsened by poverty. However, adolescents are often the most neglected group in health care service provision, particularly those in early adolescence (10–14 years), a time considered critical in shaping their future lives. In Malawi, despite efforts to prohibit child marriage, and expand youth-friendly health services, there has been limited progress towards meeting the needs of adolescents. For example, rates for completion of primary school remain low (44% male; 37% female), and pregnancy rates for adolescents remains high. These factors have worsened because of the COVID-19 pandemic which has affected both schooling and health access. We hope that our approach will bring immediate benefits to adolescents, as well as benefits throughout their future adult lives and for the next generation of children. We aim to identify new approaches that will ensure more effective peer, parental and multisectoral support to enable young people to maximise their life chances. Objectives Our vision offers a programme of transdisciplinary applied health research to be undertaken in a range of contexts in Malawi that will aim to generate new knowledge on the best preventive and nurturing strategies for adolescent health and wellbeing. Overarching Aim: To understand the psychological, sociocultural, socioeconomic, educational, political and geographical contexts which influence adolescent health and wellbeing, and to explore which interventions and policies can best support these in the future. Overarching Research Objectives: These summarise the overarching objectives of the Global Health Research Group on Adolescent Health and Wellbeing in Malawi, and are supplemented by Work Package specific objectives as outlined in the table below: a) Determine the psychological, sociocultural, socioeconomic, educational, political and geographical contexts which both positively and negatively influence adolescent health and wellbeing across rural and urban populations (WS3), b) Examine and understand the current status of adolescent health and wellbeing, and how this is influenced by water, sanitation and hygiene (WASH), sexual and reproductive health rights (SRHR) and community engagement (WS3-6), c) Co-design, test and evaluate context appropriate intervention strategies to improve adolescent health and wellbeing (WS4-6), d) Co-develop recommendations through community engagement to inform evidence based adolescent health and wellbeing strategies (WS2, 4-6), e) Co-create and implement a capacity building programme to provide increased research and partner institutional capacity in Malawi (WS1). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Strathclyde UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Malawi Medical research Research and Innovation 473957 747276 742440 672008 364173 2999854 GB-GOV-10-GHRG_3_133128 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Strathclyde 118489 GB-GOV-10-GHRG_3_133128 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Strathclyde 177734 GB-GOV-10-GHRG_3_133128 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Strathclyde 215650 GB-GOV-10-GHRG_3_133128 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Strathclyde 325590 GB-GOV-10-GHRG_3_133128 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Strathclyde 74478 GB-GOV-10-GHRG_3_133128 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Strathclyde 210883 GB-GOV-10-GHRG_3_133128 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Strathclyde 43073 GB-GOV-10-GHRG_3_133128 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Strathclyde 149692 GB-GOV-10-GHRG_3_133128 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Strathclyde 187644 GB-GOV-10-GHRG_3_133128 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Strathclyde 149987 GB-GOV-10-GHRG_3_133128 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Strathclyde 289307 GB-GOV-10-GHRG_3_133128 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Strathclyde 250526 GB-GOV-10-GHRG_3_133128 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Strathclyde 53100.24 GB-GOV-10-GHRG_3_133128 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Strathclyde GB-GOV-10-GHRG_3_133135 UK - Department of Health and Social Care (DHSC) Each year 5 million people die due to injuries like road traffic accidents, burns, falls, or violence. Of these deaths, 90% occur in low- or middle-income countries (LMICs) and 40-50% of people who survive are disabled or unable to work. Delays that occur in accessing quality healthcare contribute substantially to death or disability after injury. The World Health Organization has stated that strong health systems that provide quality care for injured people are needed to prevent death and disability. Evidence is urgently required to understand how best to improve health systems to provide quality care after injury. In this project, we will partner with colleagues from Ghana, South Africa, Rwanda, and Pakistan, to collect and analyse data from injured persons to understand what the delays to equitable access of quality care after injury are and how can these be overcome to reduce death or disability. We will also collect information on costs of care. These data will be used to develop an injury pathway map to show where it is most beneficial to intervene to reduce delays in accessing quality care after injury. In partnership with stakeholders in each country, we will develop solutions for future study in these, and other similar countries. Additionally, we will research how to bring multiple different stakeholder groups together to influence policy to improve access to quality care after injury and embed research findings into policy. In each country to: 1. Collect data to inform whether post-injury care is of high quality and equitable. 2. Develop an injury pathway map to show points of intervention to improve equitable access to quality healthcare after injury. 3. Develop a road map to bring stakeholders together to improve policy for improving equitable access to quality healthcare after injury. 4. Work with multiple stakeholders to co-develop solutions to test in future studies to improve equitable access to quality healthcare after injury. 5. Conduct community engagement and involvement work to ensure that communities are informed about and inform our work. 6. Deliver capacity building to build research capacity in partner countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Birmingham UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 739725 807035 73761 905409.05 458825.37 2954235 GB-GOV-10-GHRG_3_133135 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Birmingham 99269 GB-GOV-10-GHRG_3_133135 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 148903 GB-GOV-10-GHRG_3_133135 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 491553 GB-GOV-10-GHRG_3_133135 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 807035 GB-GOV-10-GHRG_3_133135 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 73761 GB-GOV-10-GHRG_3_133135 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 208837 GB-GOV-10-GHRG_3_133135 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 30520.42 GB-GOV-10-GHRG_3_133135 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Birmingham 262144 GB-GOV-10-GHRG_3_133135 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 125360 GB-GOV-10-GHRG_3_133135 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 206683 GB-GOV-10-GHRG_3_133135 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 373971.6 GB-GOV-10-GHRG_3_133135 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham GB-GOV-10-GHRG_3_133144 UK - Department of Health and Social Care (DHSC) The Shire Valley Vector Control Project (Shire-Vec) will address the balance between food security and infectious disease in expanding irrigated land in southern Malawi. The goal of Shire-Vec is to reduce the burden of endemic vector-borne diseases (VBDs) while maintaining or improving equitable economic benefits for smallholder farming communities. We will focus our research on a new 40,000-hectare irrigation scheme in southern Malawi; the Shire Valley Transformation programme (SVTP). Construction on the SVTP began in 2020 and will continue throughout the decade. This provides a real-time natural longitudinal experiment to determine i. the impact of land-use transformation on vector-borne diseases ii. how local smallholder farming practices will change on the ground and how this influences risk of vector-borne infection iii. practical solutions for integration across both public health and agriculture Our primary diseases of interest are malaria and schistosomiasis due to the unequivocal link between irrigation and their host-vector life cycle, but we include provisions to look at the impact on emerging VBDs such as arboviruses. Objectives: 1. Strengthen vector-borne disease surveillance and research capacity between the agriculture and public health sector. We will bring together stakeholders from across public health and agriculture via the Technical Vector Control Advisory Group of the Ministry of Health in Malawi. We will achieve real impact by engaging with local farming communities of the lower Shire Valley via a dedicated Community Engagement and Involvement team and the establishment of a Community Advisory Group. Finally, a cohort of pre- and post-doctoral Malawian trainees will be recruited and integrated into Shire-Vec to strengthen the future capacity of vector-borne disease research and control in Malawi. 2. Determine the risk of vector-borne disease inside and outside of the irrigation catchment area. We will conduct insect vector and epidemiological surveillance in selected sentinel sites around irrigated farms. Ethnographic research will study behavioural practices in the farming communities and the influence on vector-host contact. 3. Pilot locally tailored interventions which tackle either single or multiple vectors, determine their acceptability to the community and establish their value for money. 4. Integrate vector control into agricultural and irrigation policy, using the evidence generated through Shire-Vec to provide recommendations for mitigating vector-borne disease in future planned extensions of the SVTP beyond 2025 and other national agricultural development schemes. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Malawi Medical research Research and Innovation 280751 645240 754532 592572 333229 40107 GB-GOV-10-GHRG_3_133144 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 120322 GB-GOV-10-GHRG_3_133144 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 120322 GB-GOV-10-GHRG_3_133144 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 2606324 GB-GOV-10-GHRG_3_133144 COMMITMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 40127 GB-GOV-10-GHRG_3_133144 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 133689 GB-GOV-10-GHRG_3_133144 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 107204 GB-GOV-10-GHRG_3_133144 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 308153.92 GB-GOV-10-GHRG_3_133144 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 94861 GB-GOV-10-GHRG_3_133144 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 237922 GB-GOV-10-GHRG_3_133144 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 157632 GB-GOV-10-GHRG_3_133144 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 163493 GB-GOV-10-GHRG_3_133144 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 51495.58 GB-GOV-10-GHRG_3_133144 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 189337.42 GB-GOV-10-GHRG_3_133144 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 210945.91 GB-GOV-10-GHRG_3_133144 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 106364.89 GB-GOV-10-GHRG_3_133144 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 295259 GB-GOV-10-GHRG_3_133144 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 98772.08 GB-GOV-10-GHRG_3_133144 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-GHRG_3_133205 UK - Department of Health and Social Care (DHSC) A syndemic approach to the prevention of diet- and activity-related NCDs (GDARSpaces) project of the Global Diet and Activity Research Network Progress on achieving the Sustainable Development Goal 3 non-communicable disease (NCD) targets has been inadequate. Despite requiring more ambitious, comprehensive and intersectoral approaches to prevention, strategies to address unhealthy diets and physical inactivity have been largely developed by the health sector, without the government-wide and society-wide engagement required to comprehensively address these NCD risks. The global diet and activity (GDAR) Network address the rising NCD burden in low- and middle-income countries (LMIC) by generating evidence for sustainable, resilient NCD prevention related to healthy diets and physical activity. We recognise that urbanisation acts alongside and synergistically with the impacts of climate change, posing risks to health by influencing diet and physical activity. Collectively we refer to these risks as ‘syndemic hazards’. The concept of a ‘syndemic’ (from ‘synergistic epidemic’) describes the co-occurrence of 2 or more interacting risks. The interaction of urbanisation, climate change, and diet and physical activity behaviours is one such example. Together these forces increase the risks of NCDs. Without considering all these forces, we cannot create effective, sustainable interventions to improve health in LMICs now and in the future. Our syndemic approach aims to develop interventions that will work in 2 ways: first by reducing the exposure of individuals in cities to these syndemic hazards, and second by reducing the vulnerability of the wider built and food environments to these hazards. As the urban poor are most affected by these hazards, we will build understanding of individual exposures by examining how the hazards cluster with household and neighbourhood deprivation. The broader questions will be approached by exploring the ways that policy, community and commercial forces shape the built and food environments in these growing cities. This way we can understand exactly how and which environments are most vulnerable. Research methods will be varied and tailored to contexts. For example, audits of built and food environments, surveys and focus groups, reviews of policy documents and practice, and collection of household and neighbourhood-level data on diet, PA and NCD risk. We will work in Cameroon, South Africa, Kenya and Jamaica, as well as collaborating with UN Habitat, the University of Lagos, Nigeria, the Federal University of Minas Gerais, Brazil and Imperial College’s South Asia study. Contributions of non-academic stakeholders will guide activities throughout the research process and co-design of syndemic interventions. This co-design will draw on existing community and policy actions being taken in response to COVID-19, which is an example of disruption to diet and PA that is made worse by urbanisation and climate change. This will help to identify the policy and community actions and characteristics that can support future interventions. Objectives: 1. Identify and characterise exposure to syndemic hazards. 2. Understand the adaptive capacity of community, policy and commercial institutions and actors that shape the syndemic. 3. Evaluate the role of COVID-19-mitigation actions by policy and community actors in shaping the food and built environment and the diet and physical activity choices residents can access. 4. Co-design adolescent-focused, syndemic-resilient interventions that promote healthy diets and physical activity. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Cambridge UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 452559 725040 733436 677196 408715 64651 GB-GOV-10-GHRG_3_133205 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 193954 GB-GOV-10-GHRG_3_133205 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 193954 GB-GOV-10-GHRG_3_133205 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 2996946 GB-GOV-10-GHRG_3_133205 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 78998 GB-GOV-10-GHRG_3_133205 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 185194 GB-GOV-10-GHRG_3_133205 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 363880.11 GB-GOV-10-GHRG_3_133205 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 171124 GB-GOV-10-GHRG_3_133205 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 265939 GB-GOV-10-GHRG_3_133205 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 72687 GB-GOV-10-GHRG_3_133205 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 168769 GB-GOV-10-GHRG_3_133205 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 189674.65 GB-GOV-10-GHRG_3_133205 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 251495 GB-GOV-10-GHRG_3_133205 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge 457866 GB-GOV-10-GHRG_3_133205 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cambridge GB-GOV-10-GHRG_3_133208 UK - Department of Health and Social Care (DHSC) Clinicians and the Ethiopian Government urgently seek the development of a Hepatitis C Virus (HCV) strategy for Ethiopia. They have identified the need for implementation and scale-up of testing and treatment, and development of effective preventive strategies. The DESTINE project is a collaboration of experts from the Universities of Dundee and Bristol, 4 Ethiopian Medical schools (Universities of Addis Ababa, Gondar, Jimma and Mekele) together with the Ethiopian Public Health and Armauer Hansen Institutes on behalf of the Ethiopian government. The team will investigate the extent of HCV infection in Ethiopia using epidemiological and modelling techniques. It will design pathways of care based around treatment pathways designed in the UK but moulded to suit the Ethiopian context. Ethiopian stakeholders and community members will be intrinsic to the project, ensuring that any outputs take account of local attitudes to provisions of services, stigma, regional and ethnic issues around services. The work of the project will inform Ethiopian government strategic planning for HCV. It will also enhance associated research skill sets within the 4 major Ethiopian Medical schools, thereby enhancing the research infrastructure in the country. Objectives: 1. To estimate how common Hepatitis C virus (HCV) infection is in 4 regions across Ethiopia, namely Addis Ababa, Gondar, Mekelle and Jimma. 2. To collect demographic data on age, sex, route and stage of infection. 3. To estimate the risk of new infection, based on route of infection data and surveys of health care practices and other risk factors. 4. To discover the molecular epidemiology of HCV by region. 5. To estimate the causal contribution of HCV to incidence of Lymphoma and HCC. 6. To model the ongoing HCV epidemic in Ethiopia and the health consequences for those infected. 7. To model the impact and cost-effectiveness of different testing and treatment strategies. 8. To model the health economic impacts of different care pathways. 9. To develop sustainable public health strategies to prevent further HCV transmission. 10. To develop models of care suitable for Ethiopian HCV strategy and health care system, utilising learning from international best practice. 11. To pilot the efficacy and effectiveness of models of care to inform modelling in different environments in Ethiopia. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Dundee UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Ethiopia Medical research Research and Innovation 241308 547372 578528 501172 355802 120654 GB-GOV-10-GHRG_3_133208 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 120654 GB-GOV-10-GHRG_3_133208 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 2224182 GB-GOV-10-GHRG_3_133208 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Dundee 7135 GB-GOV-10-GHRG_3_133208 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Dundee 114821.01 GB-GOV-10-GHRG_3_133208 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Dundee 164721 GB-GOV-10-GHRG_3_133208 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Dundee 200942 GB-GOV-10-GHRG_3_133208 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 5741.82 GB-GOV-10-GHRG_3_133208 2023/24 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Dundee 46244 GB-GOV-10-GHRG_3_133208 2023/24 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Dundee 302731 GB-GOV-10-GHRG_3_133208 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 54742 GB-GOV-10-GHRG_3_133208 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 117703.65 GB-GOV-10-GHRG_3_133208 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 148409.35 GB-GOV-10-GHRG_3_133208 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 225343 GB-GOV-10-GHRG_3_133208 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 34939 GB-GOV-10-GHRG_3_133208 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 124710 GB-GOV-10-GHRG_3_133208 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 77792 GB-GOV-10-GHRG_3_133208 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 85069 GB-GOV-10-GHRG_3_133208 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee 18979.17 GB-GOV-10-GHRG_3_133208 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Dundee GB-GOV-10-GHRG_3_133231 UK - Department of Health and Social Care (DHSC) By 2030, about 24 million people worldwide will develop cancer each year. Most cases will occur in low- and middle-income (LMIC) countries, which may be attributed to aging societies, high prevalence of cancer risk behaviours, as well as the epidemiologic transition and socio-economic inequalities. While more people are getting cancer, services to diagnose and to treat cancer are often not widely available, and there are huge differences in care-seeking and quality of care. Cancer outcomes can be improved by early detection and timely diagnosis. Our team includes researchers from Queen Mary University London, University of Cape Town in South Africa, University of Zimbabwe and Kings College London. We aim to advance the early diagnosis of cancer in Southern Africa by developing and evaluating e-Tools to improve care-seeking and reduce healthcare delays in two countries: Zimbabwe and South Africa. We will focus on cervical and breast cancer in women and colorectal cancer in men and women as these are common cancers and have relatively easy methods for detecting and treating the cancers, especially in the early stages. This research programme will run for 4 years from October 2021. The research aims to answer important questions about how to encourage appropriate help-seeking among people with possible cancer symptoms and how to deliver high-quality, accessible and equitable cancer referral and diagnosis services in lower level facilities. It will be undertaken mainly in local clinics and secondary health facilities that are the first place that people go for health services in these countries. Studies will include materials in local languages to increase awareness and access to the services. We will also have a major focus on quality training for junior researchers. The questions to be answered include: Can we improve timely symptom appraisal and help-seeking among people with possible symptoms of cancer? Can we develop and evaluate an effective digital e-Tool for local primary care workers which will support their service, including patient management and referrals? Can we provide an acceptable and user-friendly e-Tool for patients to promote early diagnosis of breast, cervical and colorectal cancer? To answer these questions we will map current primary care and hospital services for breast, cervical and colorectal cancer in the two Southern African countries. We will then identify key factors influencing patient pathways, from symptom awareness through to referral and diagnosis, and develop two interventions. One will be a symptom assessment and management e-Tool for primary care providers and the other a symptom appraisal and help-seeking e-Tool for the public. We will evaluate the feasibility, acceptability and effectiveness (including cost-effectiveness) of these e-interventions. Importantly, we will draw on community engagement and involvement at all stages of the research, and emphasize interventions that are affordable and socio-culturally acceptable to African women and men and local healthcare providers. This research will help health authorities plan how new approaches can be integrated into existing health services in countries like Zimbabwe and South Africa. It will demonstrate which resources are needed to provide accessible, good quality, cost effective services that successfully help people to have a more timely diagnosis of breast, cervical and colorectal cancer. To advance early diagnosis of breast, cervical and colorectal cancer cancers in Southern Africa we will: 1. In Workstream 1, assess the current time intervals from breast, cervical and colorectal cancer symptom awareness to referral and diagnosis and the factors influencing these intervals among adult (age 18 and over) men and women in Zimbabwe (low-income country) and South Africa (upper middle-income country) representing Southern African countries at different levels of economic development; 2. In Workstream 2, develop two e-Tools that promote more timely presentation and referral for breast, cervical and colorectal cancer: i. A symptom assessment and management e-Tool for primary care providers to enable efficient diagnosis ii. A symptom appraisal and help-seeking e-Tool for the public; 3. In Workstream 3, evaluate the e-Tools across local settings in Zimbabwe and South Africa, to ensure that they are operationally and economically feasible and equitable, socio-culturally acceptable and support timely referral. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Queen Mary University of London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 400458 377044.21 544203 694342.27 599930.53 375758.99 200229 GB-GOV-10-GHRG_3_133231 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 200229 GB-GOV-10-GHRG_3_133231 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 2991737 GB-GOV-10-GHRG_3_133231 COMMITMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 146598.71 GB-GOV-10-GHRG_3_133231 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 103929 GB-GOV-10-GHRG_3_133231 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 126516.5 GB-GOV-10-GHRG_3_133231 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 91832 GB-GOV-10-GHRG_3_133231 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 131557 GB-GOV-10-GHRG_3_133231 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 257612 GB-GOV-10-GHRG_3_133231 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 63202 GB-GOV-10-GHRG_3_133231 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 156149 GB-GOV-10-GHRG_3_133231 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 186342.12 GB-GOV-10-GHRG_3_133231 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 184196.09 GB-GOV-10-GHRG_3_133231 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 167655.06 GB-GOV-10-GHRG_3_133231 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 155334.53 GB-GOV-10-GHRG_3_133231 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 670768.14 GB-GOV-10-GHRG_3_133231 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London GB-GOV-10-GHRG_3_133232 UK - Department of Health and Social Care (DHSC) In Sierra Leone, 1 in every 17 women will die during pregnancy or childbirth. It is one of the most dangerous places to give birth in the world. This NIHR Global Health Research Group is a partnership between the University of Sierra Leone and King’s College London to develop and implement life-saving maternal health interventions and build research capacity in Sierra Leone. Within our programme of research our main objectives are: 1. To determine the impact of scaling up the CRADLE Vital Signs Alert (VSA) device in rural Sierra Leone. 2. To improve health, psycho-social, educational, and economic outcomes for pregnant under-18-year-olds in Sierra Leone, under the 2 Young Lives mentoring scheme. 3. To determine whether shock index (heart rate divided by systolic blood pressure, as measured by the CRADLE VSA device) is a better predictor of poor pregnancy outcomes than conventional vital signs in women who are bleeding or have severe infection. 4. To validate a point of care creatinine device, to detect acute kidney injury in women with bleeding, severe infection or high blood pressure during pregnancy. 5. To conduct a cost benefit analysis of the CRADLE VSA device to inform subsequent adoption and policy pathway. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) King's College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Sierra Leone Medical research Research and Innovation 564261 650520 1179823.93 379898.93 195811.25 156332.37 80609 GB-GOV-10-GHRG_3_133232 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 241826 GB-GOV-10-GHRG_3_133232 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 241826 GB-GOV-10-GHRG_3_133232 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 2977854 GB-GOV-10-GHRG_3_133232 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) King's College London 37493 GB-GOV-10-GHRG_3_133232 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) King's College London 257310 GB-GOV-10-GHRG_3_133232 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) King's College London 323544 GB-GOV-10-GHRG_3_133232 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) King's College London 32173 GB-GOV-10-GHRG_3_133232 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 140131.93 GB-GOV-10-GHRG_3_133232 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 375291 GB-GOV-10-GHRG_3_133232 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 370885 GB-GOV-10-GHRG_3_133232 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 293516 GB-GOV-10-GHRG_3_133232 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 234097 GB-GOV-10-GHRG_3_133232 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 30968.93 GB-GOV-10-GHRG_3_133232 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 114833 GB-GOV-10-GHRG_3_133232 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 54457.44 GB-GOV-10-GHRG_3_133232 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 148793.48 GB-GOV-10-GHRG_3_133232 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) King's College London 148793.18 GB-GOV-10-GHRG_3_133232 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London GB-GOV-10-GHRG_3_133314 UK - Department of Health and Social Care (DHSC) Conflict resulting in serious, life changing injuries is widespread and accidental injuries through road traffic accidents (RTAs) are increasing in prevalence in Low- and Middle-Income Countries (LMICs). iPrOTeCT focuses on saving limbs after these injuries (surgery and technology), and where limbs cannot be saved, ensuring the best possible functional outcomes for amputees (prosthetics). This provision of the best healthcare and rehabilitation to physical trauma patients saves lives, increases functional outcomes, provides independence, and enhances quality of life. iPrOTeCT will work to benefit those injured in Gaza, Lebanon, Rwanda, Sri Lanka, and Syria initially, but in the longer-term, we will expand the reach of the programme to benefit those in the East, Central and South of Africa and other LMICs who are, or have, experienced conflict or significant increases in accidental injuries. The project is led by partners in the UK (Imperial College London), and Rwanda (University of Global Health Equity), with additional partners in Rwanda (University of Rwanda), Lebanon (American University of Beirut) and Sri Lanka (University of Moratuwa). We will explore the patterns of injuries from conflict situations (blast, gunshots), and other trauma (RTAs and non-conflict blast injuries). This knowledge will inform the understanding of the impacts on healthcare services and will influence policy and practice changes. We will use our clinical engineering expertise based on frugal principles to 1) identify technology need, 2) design, develop and test solutions that can be implemented and manufactured locally within the partner countries, and 3) develop a clinical translational plan for sustainability that is relevant and unique to the partner countries. We will create, evaluate and improve capacity building opportunities which will help to improve opportunities and provide long-term benefits for those in research and research management. We will work closely with community groups formed of patients, their families, rehabilitation service practitioners and clinicians. The groups will be facilitated by the Legacy of War Foundation. Their insights will help the team to better understand concerns about treatments, devices and socioeconomic needs and the main outcome will be to help reduce stigma, raise awareness, and support changes in policy. 1. Establish a global picture of the clinical burden of accidental, conflict and post-conflict injuries and the resulting societal issues. o Target Sector/Group: Those affected by traumatic injury (conflict and non-conflict trauma) and healthcare providers. o Expected Outcome: Policy development, Improved medical practice, future healthcare and rehabilitation. Provide rehabilitation/medical recovery roadmap for countries post-conflict. 2. Identify, develop, and share appropriate healthcare technologies. o Target Sector/Group: Healthcare practitioners in LMICs, o Expected outcomes: Expand and teach the use of the following technologies:  Surgical bone reconstruction technologies  Bone regeneration medicine  Prosthetic and rehabilitation technologies 3. Co-create, evaluate and improve capacity building opportunities in research, education, global clinical collaboration and research management. o Target sector/group: Surgeons, clinician, engineers and scientists, research management and administration in LMIC locations o Expected outcomes: Improved capacity within LMIC institutions on all levels. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 522925 937672 733092 476080 321178 2990947 GB-GOV-10-GHRG_3_133314 COMMITMENT UK - Department of Health and Social Care (DHSC) Imperial College London 130731 GB-GOV-10-GHRG_3_133314 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) Imperial College London 196097 GB-GOV-10-GHRG_3_133314 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) Imperial College London 22424 GB-GOV-10-GHRG_3_133314 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 208999 GB-GOV-10-GHRG_3_133314 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 193492 GB-GOV-10-GHRG_3_133314 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 44444 GB-GOV-10-GHRG_3_133314 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 151055.47 GB-GOV-10-GHRG_3_133314 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 156810.26 GB-GOV-10-GHRG_3_133314 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 229493 GB-GOV-10-GHRG_3_133314 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 216431.85 GB-GOV-10-GHRG_3_133314 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 243320.69 GB-GOV-10-GHRG_3_133314 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 229477 GB-GOV-10-GHRG_3_133314 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 258085.91 GB-GOV-10-GHRG_3_133314 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London GB-GOV-10-GHRG_3_133333 UK - Department of Health and Social Care (DHSC) The aim of The Partnerships for Resilience Group is to develop and strengthen the evidence base for how to improve effective community-led responses to environment-related public-health crises. To do this the Group will establish and capacity strengthen an international partnership to conduct excellent research to inform policy and practice. Human health and wellbeing face severe, interconnected threats from increasingly frequent and disruptive shocks, including outbreaks (some pandemic) of zoonotic infections (e.g. Ebola, Covid19) as well as severe environmental change, heightened by climate change, that lead to changes in food security, disease patterns and disasters. Social science work has shown that resilience for responding to such shocks is most effectively built at community level. However, no good quality data exist on the mechanisms by which effective health responses to crises can be built. The Group will gather evidence with local partners in Ethiopia, Madagascar, Sierra Leone and Uganda, which have experienced – and responded to – a range of public health crises. Central to our approach is the “co-production” of research actions with affected communities. We will gather evidence and conduct case study analyses to develop prototype approaches to developing community-led approaches to emergency-response. We will then test and evaluate these using participatory methods. We will refine and finalise our Prototypes in the light of our findings and then widely disseminate them to key decisions makers in governments and international agencies in order to improve the resilience and effectiveness of responses to public health crises. Our overarching strategic aim is to develop and strengthen a newly expanded international partnership to conduct research to inform policy and practice that improves effective community-led responses to public-health crises. Our five objectives, are to: 1) Synthesise evidence on how communities, local health systems and other formal and informal entities have responded to health crises, and with what effect: 2) Develop effective approaches for public health crisis-response at grassroots: 3) Evaluate models for effective community-led responses to public-health crises. 4) Formulate guidance and create dialogue with stakeholders on how to strengthen local resilience for effective responses to public health crises. 5) Strengthen and consolidate sustainable partner research and management capacities to strengthen policy and practice in crisis-response. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 367460 622328 615804 576200 358004 52494 GB-GOV-10-GHRG_3_133333 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 157483 GB-GOV-10-GHRG_3_133333 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 157483 GB-GOV-10-GHRG_3_133333 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 2539796 GB-GOV-10-GHRG_3_133333 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 98113 GB-GOV-10-GHRG_3_133333 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 116544.84 GB-GOV-10-GHRG_3_133333 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 225652 GB-GOV-10-GHRG_3_133333 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 187184.04 GB-GOV-10-GHRG_3_133333 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 179434 GB-GOV-10-GHRG_3_133333 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 197743 GB-GOV-10-GHRG_3_133333 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 104385.79 GB-GOV-10-GHRG_3_133333 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 198157.77 GB-GOV-10-GHRG_3_133333 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 137100.96 GB-GOV-10-GHRG_3_133333 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 69125.75 GB-GOV-10-GHRG_3_133333 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 112694 GB-GOV-10-GHRG_3_133333 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 239487 GB-GOV-10-GHRG_3_133333 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 76678.72 GB-GOV-10-GHRG_3_133333 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-GHRG_3_133382 UK - Department of Health and Social Care (DHSC) Cancer care is an increasing burden on the limited health resources in Kenya and improved early detection could decrease both mortality and complex treatment costs. The Christie NHS Foundation Trust and The University of Manchester have signed Memoranda of Understanding to support a long-term partnership with Kenyatta University Teaching, Referral and Research Hospital and Ministry of Health, Kenya to improve cancer outcomes with a specific focus on early detection within Kenya and East Africa. This programme of work supports a joint partnership to improve early detection of oesophageal squamous cell carcinoma (OSCC). In Kenya, OSCC is the 3rd most common cancer with the highest mortality of all cancers at 4400 deaths per year. Although present-day therapeutic interventions of surgery, chemotherapy and radiotherapy can positively influence disease prognosis, OSCC remains a highly lethal disease in Kenya with 99% case fatality rate due to late recognition of symptoms by the patient and general practitioner and advanced disease presentation. OSCC therefore needs better early detection strategies to diagnose cancers at a much earlier stage whereby 40-50% of Kenyan patients could potentially be cured with surgery. Potentially influenced by a combination of genetics, lifestyle, socio-economic and environmental factors, striking variations in incidence and survival exist across geographic confines whereby Western and Central Kenya have the highest OSCC incidence. Cancer survival also varies as a function of geography within Greater Manchester (GM) with great variation in the proportion of GM’s cancer patients that present with late-stage disease across different locales and poor survival. The similarities in needs of Nairobi and Manchester to reach out to at-a-distance and socially deprived communities allows for reciprocal learning and research co-creation. This includes an unmet need to use African-specific genomics to improve our understanding of OSCC carcinogenesis to offer bespoke cancer aetiologic information to aid long-term prevention strategies. The latter approach is currently blocked by the preponderance of non-African genomic OSCC data in which risk factors may differ in the Western world. Our programme of work will benefit from engaging with a range of communities and stakeholders across the clinical cancer care ecosystem in Kenya. Partnering with and complementing the work of key local patient and community partners such as the Kenyan Network of Cancer Organisations will help to reduce the stigma associated with cancer, and inform best future joint actions through a Kenyan lens. This programme will lead to the earlier reporting and understanding of symptoms leading to better treatment and enhanced survivorship. Together, with the personnel and infrastructure build for research diagnostics and pathology at KUTRRH, this will start important stepchanges needed to embed a system-wide and research-driven earlier detection programme for all cancers. This project sets out an initial and systematic approach to understand and engage the communities we seek to support, with long-term goals for improving cancer care. With strong partners, there is clear succession planning to enable sustainable success beyond this 3-year grant. 1. Engagement: Co-develop enhanced community engagement strategies to establish equipollent partnerships and improve county-level access to cancer early detection services for OSCC. 2. Digital Transformation: Co-create a research-based digital 'hub and spoke outcomes unit' with inward OSCC clinical data from counties to KUTRRH hub and outward harmonised OSCC care protocols to distant spoke counties. 3. Molecular Pathology and Biology: Co-build a pathologist and pathology capacity to support early detection programmes and inform on bespoke Kenyan cancer biology relevant to future prevention studies. 4. In year 3, submit an application to become an NIHR Global Health Research Unit. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Manchester UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Kenya Research for prevention and control of NCDs Research and Innovation 581969 1050697.83 602253.16 415207 139480.01 2789607 GB-GOV-10-GHRG_3_133382 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 232788 GB-GOV-10-GHRG_3_133382 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) The University of Manchester 349181 GB-GOV-10-GHRG_3_133382 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) The University of Manchester 65841.83 GB-GOV-10-GHRG_3_133382 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 551430 GB-GOV-10-GHRG_3_133382 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 433426 GB-GOV-10-GHRG_3_133382 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 405856 GB-GOV-10-GHRG_3_133382 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 196397.16 GB-GOV-10-GHRG_3_133382 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 415206.66 GB-GOV-10-GHRG_3_133382 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester GB-GOV-10-GHRG_3_133384 UK - Department of Health and Social Care (DHSC) African Youth in Mind (AYMI) will bring together researchers, youth and a range of government and non-government stakeholders to learn how best to treat depression and anxiety in youth aged 15-24 in Ghana and Zimbabwe. We will build capacity on youth-focussed mental health interventions in these two countries and also in Malawi. Depression and anxiety prevent youth from productivity and innovation and from reaching their full educational and social potential. This is critical in African countries, where 60% of the population are aged under 25. Depression and anxiety are key risk factors for self-harm and for suicide, which is the third leading cause of death globally in this age group. Various treatments which help with thinking, behaviour and emotions are known to be able to restore health and functioning for depressed and anxious youth. These could feasibly be delivered by non-specialists in low-resource settings. Our plan is to work with youth and caregivers to adapt and test a stepped care intervention for youth with depression and anxiety, which is tailored to the needs of communities in Ghana and Zimbabwe. We will build on lessons from African innovation, especially the Zimbabwean Friendship Bench. Based on country priorities and context, we will shape the intervention in Ghana for those aged 15-18 enrolled in Ghana’s free senior high school system and in Zimbabwe for youth aged 15-24 in schools, colleges and community health settings including sexual health services. We will then evaluate the clinical and economic benefits of the intervention through running a clinical trial in senior high schools in Ghana. By the end of our program, we aim to have four completed PhDs for African early career researchers in youth mental health (in Zimbabwe, Ghana, and Malawi), two post-doc fellowships completed, and ten publications in open access journals, with at least 80% of these to be first or senior authored by an African researcher. Our longer-term vision is a strong interdisciplinary group of African-UK researchers in youth mental health, and for our stepped care intervention to be taken up by governments and NGOs to improve youth mental health. 1. To provide essential context about needs and strengths of youth and of organisations and systems supporting youth in our research communities. 2. Develop and agree implementation theory for delivering youth mental health interventions, and the pathway to primary mental health care and specialist care for youth with more complex needs. 3. Inform content and implementation of relevant interventions, and measurement of clinical outcomes. 4. Learn about youth and caregiver views of mental health and mental health interventions. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) King's College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 305680 443127 558760.62 604360.79 693743.94 137140.65 152840 GB-GOV-10-GHRG_3_133384 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 152840 GB-GOV-10-GHRG_3_133384 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 2742813 GB-GOV-10-GHRG_3_133384 COMMITMENT UK - Department of Health and Social Care (DHSC) King's College London 43435 GB-GOV-10-GHRG_3_133384 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) King's College London 68442 GB-GOV-10-GHRG_3_133384 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) King's College London 173981 GB-GOV-10-GHRG_3_133384 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) King's College London 157269 GB-GOV-10-GHRG_3_133384 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 24038.62 GB-GOV-10-GHRG_3_133384 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 140856 GB-GOV-10-GHRG_3_133384 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 225417 GB-GOV-10-GHRG_3_133384 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 168449 GB-GOV-10-GHRG_3_133384 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 124678 GB-GOV-10-GHRG_3_133384 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 243745.54 GB-GOV-10-GHRG_3_133384 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 235937.25 GB-GOV-10-GHRG_3_133384 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 223903 GB-GOV-10-GHRG_3_133384 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 204404 GB-GOV-10-GHRG_3_133384 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 102893 GB-GOV-10-GHRG_3_133384 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 119234.48 GB-GOV-10-GHRG_3_133384 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 43309.46 GB-GOV-10-GHRG_3_133384 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London GB-GOV-10-GHRG_3_133391 UK - Department of Health and Social Care (DHSC) The largest proportionate growth of people aged over 60 is occurring in low- and middle-income countries (LMICs), such as those in sub-Saharan Africa (SSA). Already coping with a large burden of infectious diseases they now face a large increase in age-related diseases such as dementia and Parkinson’s disease (PD). There are very few medical specialists. We estimate half the people with PD (PwP) in the world are not diagnosed. Effective symptomatic drug treatment is available, though not a cure, but access is very limited in SSA. People undiagnosed, and others not treated, will have a much poorer quality of life and a significantly reduced life expectancy. We have treated people in SSA who were virtually bed bound and within days were back working on their farm. We showed similarly dramatic short term impacts for a physiotherapy cueing intervention before drug treatment was available locally. There is a lack of awareness about PD among the general public and health professionals, so people often don’t recognise symptoms or access medical help and, even when they do, may not be correctly diagnosed. Some PwP see traditional, or faith, healers and many seek no help at all, mistaking the symptoms for old age and feeling nothing can help. Even those diagnosed face the challenge of obtaining affordable and sustainable drug treatment. This research will enable us to gain important information on PD and effectiveness of treatment in Africa. We will test ideas for helping diagnosis and management, and develop support including patient and carer information. We will strengthen research capability in PD in Africa. We are linking with a current research study looking at the genetics of PD worldwide, including Africa. We plan to work with colleagues in Tanzania, Kenya, Ghana, Nigeria, South Africa, Ethiopia and Egypt to: Improve Diagnosis 1. Develop aids to diagnosis for non-specialist doctors, such as questionnaires appropriate for LMIC settings, and equipment that measures slowness of movement and tremor, the two major symptoms of PD. We will utilise new techniques such as scripted videos recorded on smartphones and then analysed by movement disorder specialists in Africa, UK or Europe, and also investigate chemicals in blood, sweat and urine as early signs of PD. 2. Provide training for doctors, nurses and therapists to improve diagnosis and management. 3. Develop and trial services for diagnosis and management of PD by non-specialists. 4. Undertake community based studies of the number of people with PD (prevalence) in Tanzania, Ghana, Nigeria and Kenya, testing different diagnostic methods. Improve care 5. Develop a database of PD outpatients in sites in the different countries to enable description of their characteristics. 6. Look at the effectiveness and side-effects of preparations of Mucuna pruriens (MP), a tropical plant, compared to Levodopa (standard drug treatment) in Tanzania. Evidence from an on-going Ghana study suggests MP is affordable, effective and side-effects are limited. 7. Assess the response to drug treatment, with low-cost home monitoring with wearable movement sensors in PwP who consent. 8. Work with patient and carer support groups to understand lived experience, raise public awareness via standard media techniques and social media. 9. Collaborate with the Investigators on a large genetic project to collect blood and saliva samples for genetic analyses, as well as stool samples for microbiome analysis. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Newcastle University UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 476766 748404 724068 678624 372043 2999905 GB-GOV-10-GHRG_3_133391 COMMITMENT UK - Department of Health and Social Care (DHSC) Newcastle University 119192 GB-GOV-10-GHRG_3_133391 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) Newcastle University 178787 GB-GOV-10-GHRG_3_133391 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) Newcastle University 173818 GB-GOV-10-GHRG_3_133391 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 239669 GB-GOV-10-GHRG_3_133391 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 271152 GB-GOV-10-GHRG_3_133391 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 50750 GB-GOV-10-GHRG_3_133391 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 126489 GB-GOV-10-GHRG_3_133391 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 213714.01 GB-GOV-10-GHRG_3_133391 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 191075.12 GB-GOV-10-GHRG_3_133391 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 146435.18 GB-GOV-10-GHRG_3_133391 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 155958.62 GB-GOV-10-GHRG_3_133391 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 185982.31 GB-GOV-10-GHRG_3_133391 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 284109 GB-GOV-10-GHRG_3_133391 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 201779.49 GB-GOV-10-GHRG_3_133391 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University 144480.63 GB-GOV-10-GHRG_3_133391 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Newcastle University GB-GOV-10-GHRG_3_133712 UK - Department of Health and Social Care (DHSC) There is an urgent need to improve children's and adolescents' wellbeing in sub-Saharan Africa. The mental wellbeing of children and adolescents is poor, and their educational attainment is low. Little is being done to improve their mental wellbeing, and there are few services for those in need. The WHO recommends preventative mental health interventions in schools. Mindfulness has proven to be an acceptable and effective use of resources in countries like the UK. Mindfulness involves a combination of breathing exercises, visualisation, body awareness, and relaxation. Practising mindfulness makes children and adolescents happier. It improves their attention span, helps them manage stress, increases their sense of wellbeing, improves their communication skills and their school performance. Teaching mindfulness also improves the mental wellbeing of teachers. There is a need to know if mindfulness improves the wellbeing of children and adolescents in Sub-Saharan Africa, and if it would be a good use of government resources. We will deliver the project in Ethiopia and Rwanda between 2022 and 2026. Rwanda and Ethiopia are two of the poorest countries in the world. The wellbeing of children is poor in both countries, and school attainment is low. Researchers from Ethiopia, Rwanda, and the UK will collaborate on the project. Our research team includes health experts, social scientists, and teacher educators. We have an international advisory board, including government officials from both countries. Community members, including parents, teachers, children, and adolescents, will help us design the mindfulness intervention. We will research ways of providing an affordable and acceptable mindfulness intervention that improves children's and adolescents' wellbeing. We will work with parents and policymakers to agree on delivering and testing it. Teacher-educators working with primary school teachers will develop an appropriate mindfulness intervention and these will train other teachers in their schools. Teachers will deliver the intervention as part of the primary school curriculum so that it reaches all children. We will test the intervention to provide policymakers with high-quality evidence on how well it works, and the costs and benefits of delivering it in all schools. The testing will include talking to children and adolescents, their teachers, and parents about their experiences of the intervention. We will also test children's and adolescents' mental wellbeing before we deliver the intervention and after, to see what improvement it makes. We will compare children who received the mindfulness training with similar children who did not to control for the effects of other simultaneous changes in children’s lives. We will provide feedback on all our findings to policymakers in Rwanda and Ethiopia. This will include the findings from an 'economic model' showing the potential cost savings and benefits of introducing mindfulness practices in all schools. We will tell international organisations such as the WHO and the United Nations Children's Fund about our findings. We will disseminate the findings through our website and social media in French and English. We will invite relevant organisations from across Sub-Saharan Africa to regular webinars disseminating information about the project. A training programme will educate the next generation of researchers in transdisciplinary health research. Early career researchers will be involved in every stage of the research, from design to publication of the findings. Improving children's and adolescents' wellbeing will enable them to enjoy their childhood and develop to their full potential. It will also improve their lives as adults, making them happier, less likely to develop mental and physical illnesses and better able to play a full role in society. Also, it reduces healthcare expenditure. 1. Identify policies for promoting the well-being of children and adolescents in Ethiopia and Rwanda, and examining how they are being implemented and their effectiveness. 2. Identify and build networks of policy actors, teacher educators, teachers, parents, and community members that have a stake in improving the well- being of children and adolescents. 3. Train teacher educators and teachers in mindfulness and in teaching it to children. 4. Develop a mindfulness intervention led by Rwandan and Ethiopian educators for delivery in schools. The intervention to be designed designed to promote the wellbeing of children and adolescents, and to be acceptable to policy actors, teachers and communities, including children and adolescents. 5. Evaluate the intervention's effectiveness, including its acceptability to communities, children and their families, and teachers. 6. Generate evidence on the intervention's affordability and effectiveness and how it can be scaled up. 7. Sustainably build capacity and capabilities for interdisciplinary applied health research for delivering interventions to improve the well-being of CYP. 8. Provide an enhanced understanding of the distinct mental health challenges that face adolescent girls and boys and how these challenges are affected by gender-based discrimination. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Aberdeen UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 341786 626700 752624 764996 395390 2881496 GB-GOV-10-GHRG_3_133712 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of Aberdeen 85446 GB-GOV-10-GHRG_3_133712 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) The University of Aberdeen 128170 GB-GOV-10-GHRG_3_133712 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) The University of Aberdeen 6295 GB-GOV-10-GHRG_3_133712 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Aberdeen 218764.21 GB-GOV-10-GHRG_3_133712 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Aberdeen 240453 GB-GOV-10-GHRG_3_133712 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Aberdeen 177429 GB-GOV-10-GHRG_3_133712 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Aberdeen 318920 GB-GOV-10-GHRG_3_133712 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Aberdeen 286455.46 GB-GOV-10-GHRG_3_133712 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Aberdeen 78599 GB-GOV-10-GHRG_3_133712 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Aberdeen 712590 GB-GOV-10-GHRG_3_133712 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Aberdeen 230743 GB-GOV-10-GHRG_3_133712 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Aberdeen 253556.53 GB-GOV-10-GHRG_3_133712 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Aberdeen GB-GOV-10-GHRG_3_133850 UK - Department of Health and Social Care (DHSC) Background: More than 600,000 patients die after surgery in Africa each year, a death rate which is twice the global average. Those patients who develop complications after surgery but survive, have a reduced overall life expectancy, reduced quality of life and significant financial hardship. Poor patient outcomes primarily result from failings in perioperative care and critical care (before, during and after surgery) rather than surgery itself. Meanwhile, a three-fold increase in procedures is required to meet the needs of 1.2 billion people across Africa who cannot access safe affordable surgical treatment. As health systems work to increase the number of surgical procedures, we anticipate a further increase in complications and deaths after surgery. Without effective perioperative care, the positive impact of increasing provision of surgery will be limited, as will any net improvements in health for individuals and societies. We will establish sustainable research infrastructure in Africa and build on our world-leading applied research in a range of health-system contexts to develop effective solutions to this problem. Aim: To develop centres of research excellence in four African nations within the African Perioperative Research Group (APORG) of 705 hospitals in 42 countries, creating equitable partnerships to deliver an international research programme and improve the safety and quality of perioperative and critical care across Africa. Impact: Our research findings will inform changes in healthcare which could reduce deaths after surgery to the global average across Africa, saving 300,000 lives each year, improving long-term health and reducing financial hardship. 1. Develop research leadership and capacity in four African nations Establish research hubs in four African universities with managerial, financial and governance infrastructure to become centres of research excellence, with a pan-African research design centre to lead international clinical trials. We will develop current and future research leaders and research professionals through training programmes, mentoring and PhD fellowships. Ultimately these hubs will become training centres for future African research professionals in our field. 2. Delivering research to improve outcomes after surgery across Africa Building on our successful international global health research, we will deliver a programme of observational studies of patient care, interviews with patients, staff and other stakeholders, large dataset research and large clinical trials across four key themes: 1) Developing realistic and sustainable models of Essential Critical Care 2) Improving identification of patients with life-threatening complications after surgery 3) Preventing and treating life-threatening bleeding after childbirth 4) Building linked national health data platforms (health registries) to assess the impact of Projects 1 to 3 and improve patient outcomes after surgery through international clinical audit and research 3. Engage patients, communities and policy-makers Led by teams in Africa, we will establish meaningful community engagement at local, national and pan-African levels allowing us to work together to produce the research which is most relevant to patients. We will develop links with civil society, policy-makers and health professionals across partner nations and to ensure our research impacts patient care. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Queen Mary University of London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 495646 725652 718292 538852 287894 2766336 GB-GOV-10-GHRG_3_133850 COMMITMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 123912 GB-GOV-10-GHRG_3_133850 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 185867 GB-GOV-10-GHRG_3_133850 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 155608.14 GB-GOV-10-GHRG_3_133850 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 92680 GB-GOV-10-GHRG_3_133850 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 39093 GB-GOV-10-GHRG_3_133850 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 168413 GB-GOV-10-GHRG_3_133850 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 71539 GB-GOV-10-GHRG_3_133850 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 172680 GB-GOV-10-GHRG_3_133850 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 169530.97 GB-GOV-10-GHRG_3_133850 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 151984.24 GB-GOV-10-GHRG_3_133850 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 135888 GB-GOV-10-GHRG_3_133850 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 173798 GB-GOV-10-GHRG_3_133850 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 187811 GB-GOV-10-GHRG_3_133850 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 209299 GB-GOV-10-GHRG_3_133850 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 147202.69 GB-GOV-10-GHRG_3_133850 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 442713.16 GB-GOV-10-GHRG_3_133850 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London GB-GOV-10-GHRG_3_134325 UK - Department of Health and Social Care (DHSC) In HOPE, we will seek to address the needs of people experiencing homelessness and severe mental illness (SMI) in Ethiopia, Ghana and Kenya. People with SMI are over-represented in homeless populations globally, but this is a major concern in low- and lower middle-income countries. However, there is no high-quality evidence to show which interventions are effective in these settings. In HOPE, we will create a new partnership of researchers, policy makers, community members and people with lived experience of SMI and homelessness. We will work in a capital city (Addis Ababa) in Ethiopia, a regional city (Tamale) in Ghana, and a rural county (Makueni) in Kenya to understand the different approaches needed across varied settings. In phase 1, we will carry out a number of activities to understand priorities, needs and opportunities for intervention. We will map existing contexts, conduct a survey and ethnographic study with people who are homeless and have SMI, interview stakeholders, synthesise global evidence and experience on interventions for this group, and prioritise potential interventions. In phase 2, we will work with stakeholders to select, co-produce and test intervention packages to optimise feasibility and acceptability. We will support and empower people with lived experience of SMI and homelessness to participate. The intervention package will seek to address a range of needs, from basic needs, to mental and physical health, family support, livelihoods and social inclusion. A cornerstone will be peer support. In phase 3, we will test the intervention package with 350 people per site who experience homelessness and SMI. We will follow up participants over six months to see whether they benefit in terms of physical and mental health, experience of discrimination and abuse, housing status, family reintegration, functioning and social inclusion. We will identify ways to implement at scale and ensure sustainability. By the project end, we will have: (1) developed evidence-supported interventions to improve the lives of people who are homeless and experience SMI; (2) collaborated with the World Health Organization to produce a manual on how to adapt and implement the programme in low-resource settings; (3) developed methods and the capacity of early career researchers and other stakeholders; and (4) built a strong collaboration of multi-sector partners to sustain in-country work and longer-term high-quality future research on this neglected topic. 1) Establish a partnership of researchers, implementers, policymakers and people with lived experience working collectively to improve the lives of people who are homeless and have SMI. 2) Synthesise global evidence on existing initiatives and obtain global expert consensus on priority actions and approaches. 3) Work in distinctive settings in Ethiopia (capital city), Ghana (regional capital) and Kenya (rural county) to: a. Identify the priority needs and valued outcomes of those who are homeless and have SMI, and opportunities and challenges for effective intervention. b. Integrate global and local evidence to select and co-produce interventions that target priority needs, and pilot test for acceptability and feasibility. c. Evaluate the impact of interventions on the human rights and diverse outcomes valued by people who are homeless and experience SMI, and generate evidence on intervention costs, implementation processes and outcomes. d. Pioneer the development of methods and ethical frameworks for research engaged with people who are homeless and have SMI. 4) Impact global policy and practice through translation of evidence into a WHO ‘how-to’ guide to adapt and implement programmes for people who are homeless and have SMI in diverse low-resource contexts. 5) Build sustainable capacity across partners that responds to local priorities, enhances existing capabilities, supports south-south and south-north exchange of expertise and develops both individuals and systems. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Edinburgh UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 522504 703084 702564 694824 376998 2999974 GB-GOV-10-GHRG_3_134325 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 130626 GB-GOV-10-GHRG_3_134325 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 195939 GB-GOV-10-GHRG_3_134325 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 75283.77 GB-GOV-10-GHRG_3_134325 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 173483 GB-GOV-10-GHRG_3_134325 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 257986 GB-GOV-10-GHRG_3_134325 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 113227 GB-GOV-10-GHRG_3_134325 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 444122.8 GB-GOV-10-GHRG_3_134325 2024/25 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The University of Edinburgh -67010.79 GB-GOV-10-GHRG_3_134325 2024/25 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The University of Edinburgh 62107.52 GB-GOV-10-GHRG_3_134325 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 173164.36 GB-GOV-10-GHRG_3_134325 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 66327.94 GB-GOV-10-GHRG_3_134325 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 211434 GB-GOV-10-GHRG_3_134325 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 213130.78 GB-GOV-10-GHRG_3_134325 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 115559.17 GB-GOV-10-GHRG_3_134325 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh GB-GOV-10-GHRG_3_134342 UK - Department of Health and Social Care (DHSC) Invasive fungal infections are a growing global threat to human health, affecting >150 million people and accounting for up to 1.5 million deaths per year. However, this burden is under-appreciated and medical mycology is chronically underfunded. Research into improvements in diagnosis and treatment and implementation of this research are essential to reduce death and disability. HIV remains a leading cause of morbidity and mortality in low- and middle-income countries (LMICs) causing an estimated 500,000 to 1 million deaths annually, the majority in sub-Saharan Africa and South East Asia. Four HIV-associated fungal infections - cryptococcal meningitis, talaromycosis, Pneumocystis pneumonia (PCP), and histoplasmosis - are responsible for 250,000 deaths per year, and up to 20% of all HIV-associated mortality. The World Health Organization (WHO) has recognized that HIV deaths cannot be further reduced until these major fungal complications of advanced HIV disease are effectively addressed. Our NIHR Global Health Group aims to capitalise on the opportunities presented by recent clinical research advances in cryptococcal meningitis to improve the diagnosis and treatment not just of cryptococcal meningitis, but also the three other major HIV-associated mycoses of public health importance. Our group brings together leading academic researchers, clinical and public health leaders, non-governmental organisations (NGOs) including Médecins Sans Frontières and the Drugs for Neglected Diseases initiative, and community and patient representatives, to improve the diagnosis and treatment of these HIV-associated fungal infections and ensure that these improvements are made widely available to populations most commonly affected in Africa (Democratic Republic of Congo, Mozambique, Guinea, Malawi, Botswana, South Africa), and South East Asia (Vietnam). Our partnership will be equitable, with leadership shared across six work packages delivered over 4 years from 2022 through to 2026, insights from qualitative research, guidance from a steering committee and community advisory boards, and priorities set at initial meetings led by LMIC partners. In addition to the direct impact of the work, we will liaise with national, regional, and international bodies (ministries of health, major NGOs, UNITAID, WHO) in order to effectively scale the results and impact of our work. 1. TREATMENT: To implement novel, short-course treatment for HIV-associated cryptococcal meningitis in routine care in African and South East Asian countries, building on the results of two landmark trials, ACTA and AMBITION-cm, completed by partners in our consortium, both of which demonstrated improved survival with regimens that are practical and affordable in resource-limited settings. And to support preliminary work using a single high-dose liposomal amphotericin B treatment approach in talaromycosis and to lay the foundations for future studies in histoplasmosis. 2. PREVENTION: To optimize the screen-and-treat strategy, to identify and treat early cryptococcal disease, before it becomes clinically apparent, in Africa and South East Asia. Semi-quantitative tests will be evaluated for cryptococcal antigen screening, and the pharmacokinetics of pre-emptive treatment with sustained-release flucytosine will be determined, within the ongoing EFFECT trial. Screening will be evaluated to prevent talaromycosis, cryptococcosis and histoplasmosis in South East Asia and histoplasmosis and emergomycosis in Africa. 3. HEALTH ECONOMICS: To generate essential economic data to support the different screening and treatment approaches being investigated for cryptococcosis, histoplasmosis and talaromycosis. These individual and, if appropriate, combined analyses will be crucial evidence in our efforts to effect the policy changes needed to reduce mortality from HIV-associated fungal infections. 4. DIAGNOSTICS: To initiate a programme of earlier-stage, laboratory-based work on HIV-associated Pneumocystis pneumonia (PCP), and to develop a clinical cohort and sample bio-bank as a resource to develop and test novel diagnostic tests for PCP, which constitutes the major barrier to reducing PCP deaths. 5. TRAINING: As integral to the work proposed, to support a comprehensive training and capacity strengthening programme in clinical (epidemiology, health economics and/or public health), and laboratory research, and including 3 laboratory MSc, 2 taught MSc and 3 PhD places. Training will be enabled by a recent strategic UK-African partnership based at the University of Cape Town (UCT), South Africa between the UK MRC Centre for Medical Mycology and UCT, and will build on our extensive experience of training and capacity strengthening within existing multinational projects. Our goal is to train and mentor clinicians and researchers who will help drive and develop this partnership beyond the initial 4-year period. 6. ENGAGEMENT: To ensure that the voices of people living with advanced HIV disease and community representatives are meaningfully included and heard across the entire scope of work, we will develop strategies and tools to increase patient health literacy around HIV-associated fungal infections, collect qualitative data to learn from the experience of patients with HIV-associated fungal infections and facilitate meaningful engagement through our community advisory boards. We acknowledge and affirm that successful implementation of our work is dependent on the engagement of patients and communities. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 551510 840276 830480 499944 262130 2984340 GB-GOV-10-GHRG_3_134342 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 137878 GB-GOV-10-GHRG_3_134342 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 206816 GB-GOV-10-GHRG_3_134342 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 3651 GB-GOV-10-GHRG_3_134342 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 17794 GB-GOV-10-GHRG_3_134342 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 249443 GB-GOV-10-GHRG_3_134342 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 68072 GB-GOV-10-GHRG_3_134342 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 177070 GB-GOV-10-GHRG_3_134342 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 81917 GB-GOV-10-GHRG_3_134342 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 181812 GB-GOV-10-GHRG_3_134342 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 183735 GB-GOV-10-GHRG_3_134342 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 178165 GB-GOV-10-GHRG_3_134342 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 275262 GB-GOV-10-GHRG_3_134342 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 166062.08 GB-GOV-10-GHRG_3_134342 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 160893.95 GB-GOV-10-GHRG_3_134342 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-GHRG_3_134440 UK - Department of Health and Social Care (DHSC) This research aims to develop ways for people in sub-Saharan Africa to receive palliative care if they need it, focusing on groups that we know are not getting the care they need. 1: In Uganda we want to improve the quality of palliative care for children and young people, by making sure that care focuses on what matters to them. We will work with health centres (a hospital, a clinic and a homecare team) and use a simple checklist that helps children (with their families) identify the problems and concerns that are affecting them most. 2: In Zimbabwe, we want to ensure that adults with cancer, who are not expected to be cured, can receive palliative care as part of their cancer care at the hospital. Patients, families and their health care team will design together a new way of working that will focus on patients’ symptoms and concerns. 3: In South Africa, we want to make sure that adults with long term illness and who have pain, breathlessness, and fatigue, can benefit from palliative care and rehabilitation to optimise function and independence. We will work with patients, families and physiotherapists/ occupational therapists to develop simple ways for patients and families to self-manage their symptoms at home. Why is this being done? Palliative care is for people who are living with incurable illness that is likely to shorten their lives. Because palliative care can reduce suffering and improve wellbeing for patients and families, it is now seen as an essential part of healthcare for all. But although most people who need palliative care live in poorer countries, that is also where there is less availability of palliative care. We have found that people with incurable illness in poorer countries have a lot of unnecessary suffering, and the numbers of people suffering is rising rapidly. We have found three groups of people who could benefit from better access to palliative care in sub-Saharan Africa: children and young people, patients living with cancer, and people with long-term illnesses using community-based care. The additional challenge is that palliative care has not had enough attention in research and universities, and we must build our skills and networks to address these growing challenges. Who is doing it? We have consulted with patients and families on developing this research, and they have inputted to our plans. In each partner country, our Advisory Group (of both adults and children) will be part of the research team. Their specific roles will be to help us design the recruitment plans, to promote the study, to design information and consent forms, to help design interventions, to interpret the findings, input to design of the materials that come from our research, and to present study findings. We will ensure each group has a training programme to support their personal development. We will work together to evaluate the impact of their involvement to continually improve our approach. The project leads are King’s College London and the University of Cape Town UK. Our other partners are the African Palliative Care Association, Makerere University, Mildmay, University of Zimbabwe, and Island Hospice. When is it being done? We will be delivering this project for 4 years from August 2022. Workstream 1 (integrated child- and family-centred outcome measurement) Aim To integrate a child- and family-centred outcome measure (i.e. Children’s Palliative Outcome Scale, C-POS) into routine children’s palliative care at three demonstration sites in Uganda, developing implementation and data usage plans for quality improvement, and to deliver a manual for regional adoption. Objectives i) To develop a child expert group to advise and act as peer promoters. ii) To refine C-POS for implementation across age groups and diagnoses. iii) To develop a quality improvement team within each of our three demonstration sites and identify site-specific integration plans. iv) To develop a Decision Support Tool (DST) specifying appropriate and feasible clinical responses to real-time data that are feasible and effective within local resources. v) To implement C-POS for quality improvement cycles within routine practice in three demonstration sites. vi) To determine stakeholder views on quality improvement mechanisms and impact. vii) To develop an implementation manual with consortium partners for the region. Workstream 2 (integrated cancer palliative care) Aim To develop a model of integrated cancer palliative care that is tailored to the context of Zimbabwe, and to determine the feasibility of evaluating it using an RCT design. Objectives Phase 1 Develop the intervention (MRC: “Development”) i. Identify patients’, families’ and clinical staff views on acceptable model of integrated cancer palliative care, and on trial methods ii. Develop a theory of change and manualised intervention programme to standardise delivery iii. Adapt an existing palliative care costing tool using qualitative data from objective i on formal and informal care costs Phase 2 Assess feasibility of a hybrid cluster randomised controlled trial (MRC: “Feasibility”) iv. Determine trial recruitment rates to a RCT for patients and family members v. Measure completion of potential family and patient outcome & staff cost data, intervention implementation, and determine staff and family views of the intervention and its processes vi. Confirm primary outcome measure and potential effect size, identify contamination, and develop full trial protocol if full trial is warranted vii. Develop methodological guidance for palliative care trials in LMIC & intervention manual adaptation to partner countries Workstream 3 (symptom self-management) Aim This workstream aims to develop, then assess the acceptability and feasibility of implementing symptom self-management for people living with chronic organ failure (lung, heart, renal, liver disease) attending primary care in South Africa, focusing on the high prevalence symptoms of pain, breathlessness and fatigue. Objectives Intervention development and modelling objectives: i) Identify the active components of the intervention (core and optional), distinct patient sub-groups using systematic review findings ii) Refine salient components of intervention delivery, receipt, implementation and outcomes with key stakeholders iii) Develop a logic model with contents, mechanism of action and outcomes for the self-management intervention Acceptability and feasibility testing objectives: iv) Assess the acceptability and feasibility of intervention delivery focusing on process and implementation measures v) Understand experiences of intervention delivery and receipt, including barriers and facilitators, and utility to patients and professionals vi) Explore the impact on candidate outcomes for clinical (symptom burden, function, quality of life) and cost effectiveness vii) Synthesise data to inform the eligibility criteria, primary outcome, sample size and resource requirements for a definitive trial. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) King's College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 392771 645596 667956 642732 345247 2694302 GB-GOV-10-GHRG_3_134440 COMMITMENT UK - Department of Health and Social Care (DHSC) King's College London 98193 GB-GOV-10-GHRG_3_134440 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) King's College London 147289 GB-GOV-10-GHRG_3_134440 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) King's College London 357873 GB-GOV-10-GHRG_3_134440 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 181353 GB-GOV-10-GHRG_3_134440 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 151394 GB-GOV-10-GHRG_3_134440 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 256784 GB-GOV-10-GHRG_3_134440 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 25066 GB-GOV-10-GHRG_3_134440 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 69624 GB-GOV-10-GHRG_3_134440 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 526452.64 GB-GOV-10-GHRG_3_134440 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 312680 GB-GOV-10-GHRG_3_134440 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 51424.2 GB-GOV-10-GHRG_3_134440 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 257553.97 GB-GOV-10-GHRG_3_134440 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London GB-GOV-10-GHRG_3_134482 UK - Department of Health and Social Care (DHSC) There is substantial evidence from high-income countries that infection prevention, hydroxyurea and blood transfusions can reduce mortality and morbidity in sickle cell disease (SCD) These are not widely used in sub-Saharan Africa where most patients are not diagnosed and die before 5 years of age. We will put patients in Nigeria, Ghana and Zambia at the centre of our research, involving them in every aspect and empowering them, in collaboration with health workers, to find solutions to, and overcome, the barriers they face in accessing care for SCD. This will be complemented by research in health facilities to optimise the implementation of standards of care for SCD. Our research and complementary capacity strengthening activities will use the implementation research methods of participatory action cycles and standards-based audit. Our research is underpinned by a realist evaluation to understand what worked (or not), why, for whom and in what context, and a comprehensive dissemination and engagement strategy to share with, and learn from, communities, policy-makers and journalists. TBC during start-up UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 422190 673104 740144 761064 403232 2999734 GB-GOV-10-GHRG_3_134482 COMMITMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 105548 GB-GOV-10-GHRG_3_134482 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 158321 GB-GOV-10-GHRG_3_134482 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 35136 GB-GOV-10-GHRG_3_134482 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 91596.03 GB-GOV-10-GHRG_3_134482 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 137168 GB-GOV-10-GHRG_3_134482 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 207614 GB-GOV-10-GHRG_3_134482 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 68316 GB-GOV-10-GHRG_3_134482 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 144841 GB-GOV-10-GHRG_3_134482 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 194970.43 GB-GOV-10-GHRG_3_134482 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 22793 GB-GOV-10-GHRG_3_134482 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 335423 GB-GOV-10-GHRG_3_134482 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 51257.91 GB-GOV-10-GHRG_3_134482 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 274962.99 GB-GOV-10-GHRG_3_134482 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 319695 GB-GOV-10-GHRG_3_134482 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 219908.67 GB-GOV-10-GHRG_3_134482 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 264829 GB-GOV-10-GHRG_3_134482 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-GHRG_3_134531 UK - Department of Health and Social Care (DHSC) Vaccination is a central public health intervention: key to smallpox eradication, polio elimination, and control of Ebola outbreaks and the COVID-19 pandemic. But not everyone benefits equally. Some vaccines give weaker protection in people from rural, tropical settings than in those from high income settings: for example, BCG for tuberculosis and oral polio vaccine for polio. Some new vaccines also elicit weaker responses in people living in low-income, rural settings. The biological reasons for this are not fully understood. Also, some people benefit less from vaccines for socioeconomic reasons, such as the social context of the communities they live in, including limited access to accurate information to aid vaccine choices. Social and biological factors can interact to make communities “vulnerable” in terms of vaccine impact. For example, poor people in rural communities with limited vaccine access may also be undernourished or exposed to infections that alter immune responses to vaccination. This needs to be addressed to promote health equity, but also to secure maximum global benefit from vaccines: non-immune communities are foci for recurrent disease outbreaks. VAnguard brings together African and UK experts in vaccine research, implementation and stakeholder and community engagement, to work in Uganda and Kenya to 1. Investigate how biological factors (such as infections, nutrition) influence vaccine responses 2. Explore how communities perceive and access vaccines, what influences them to take up vaccines for themselves and their families, and how this relates to social vulnerability, biological health status and vaccine information 3. Bring together biological and social data, and engage communities, to work out how vaccination can best be optimised for vulnerable communities, thereby also benefitting entire populations. First, we shall work with national stakeholders (such as Ministries of Health, and vaccine-related non-governmental organisations), review literature, and work on samples from previous studies, to identify Ugandan and Kenyan communities likely to have most difficulty in getting the best out of vaccination programmes (“vulnerable communities”). Then, with stakeholders and communities, we shall co-design the VAnguard Community Study, and implement it to investigate in detail which biological and social factors most influence vaccine impact in vulnerable communities. Data and economic modellers will study the results to identify which factors could usefully be modified, and we shall work with the communities to explore ways in which this could be done. Hence we shall co-develop strategies which national stakeholders may be able to implement straight away, or which can be tested in future studies. The work will be led by young African scientists, supported by local and international experts, to build capacity for African vaccine research. Biological, social, and implementation scientists and experts will work closely together to understand each other’s disciplines, establishing a culture of collaboration that will foster sustainable pathways to the desired impact: healthy communities. VAnguard’s goal is to identify modifiable structural, social and biological determinants of impaired vaccine impact in vulnerable African communities, and hence to develop integrated strategies to address them and to drive health equity. VAnguard brings together East African leaders in vaccine research, implementation and community engagement, with UK experts in vaccine biology and the social anthropology of vaccine hesitancy. Our specific objectives are, in Uganda and Kenya, to 1. Investigate biological drivers and mechanisms of population differences in vaccine response 2. Understand how social and biological determinants of vaccine response interrelate to determine vaccine impact 3. Identify and model integrated strategies to inform development of future interventions to optimise vaccine impact among vulnerable populations First, we shall work with national stakeholders (such as Ministries of Health, and vaccine-related non-governmental organisations), review literature, and work on samples from previous studies, to identify Ugandan and Kenyan communities likely to have most difficulty in getting the best out of vaccination programmes (“vulnerable communities”). Then, with stakeholders and communities co-design the VAnguard Community Study, and implement it to investigate in detail which biological and social factors most influence vaccine impact in vulnerable communities. Based at the UVRI, VAnguard will initiate a new multidisciplinary Group comprising the London School of Hygiene & Tropical Medicine (LSHTM), East African partners at the forefront of building vaccine research capacity in the region: UVRI and Kenya Medical Research Institute (KEMRI) Wellcome Trust Research Programme. Additional contributions will be made by the Medical Research Council (MRC)/UVRI and LSHTM Uganda Research Unit (MUL), Makerere University, Uganda Christian University (UCU), the Ugandan and Kenyan Ministries of Health (MoH) and expert collaborators. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 526856 818740 820048 669576 0 149227 2984447 GB-GOV-10-GHRG_3_134531 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 131714 GB-GOV-10-GHRG_3_134531 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 197571 GB-GOV-10-GHRG_3_134531 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 234750 GB-GOV-10-GHRG_3_134531 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 163670 GB-GOV-10-GHRG_3_134531 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 411072 GB-GOV-10-GHRG_3_134531 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 416886 GB-GOV-10-GHRG_3_134531 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 209991 GB-GOV-10-GHRG_3_134531 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 271753 GB-GOV-10-GHRG_3_134531 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 255500 GB-GOV-10-GHRG_3_134531 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 306181 GB-GOV-10-GHRG_3_134531 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 134985 GB-GOV-10-GHRG_3_134531 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 56777.95 GB-GOV-10-GHRG_3_134531 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-GHRG_3_134544 UK - Department of Health and Social Care (DHSC) Many people live with high blood pressure in Sub-Saharan Africa (SSA), where the rate is amongst the highest in the world. In SSA, high blood pressure occurs at young ages, few people are treated, and high blood pressure causes severe complications and premature deaths. This is a serious health concern particularly in SSA where there is little knowledge of, or treatment for this condition. The causes of the high impact of high blood pressure in rural SSA are multiple including lack of clear symptoms; restricted access to healthcare; and competing demands on time which may prevent people from going to clinics and seeking care. One suggested approach to improve the management of people with high blood pressure in rural SSA is to use a community-centred approach, where care is more actively promoted and brought into the community to remove obstacles in accessing it. Our proposed NIHR Group will develop and assess a community-based approach to improve the identification and management of high blood pressure in rural SSA (in Kilifi, Kenya and Kiang West, the Gambia). The research will be divided into three linked work packages that match the specified objectives. We will adopt a multidisciplinary research approach including document reviews; in-depth interviews, focus groups with patients living with high blood pressure, healthcare workers and other key stakeholders; cross-sectional studies; a co-creation design to develop the intervention; and, a cluster feasibility trial to test it. The work is being developed in partnership by the KEMRI-Wellcome Trust Research Programme in Kenya, MRC the Gambia and The London School of Hygiene & Tropical Medicine. Within the core research team, there is a strong expertise in high blood pressure research. There is support from other key stakeholders including existing local community health organisations and the Ministries of Health in Kenya and the Gambia. Community engagement and involvement are key to this work. Existing community health worker organisations and patients have been consulted in the development of this work and will contribute throughout the research as part of interviews, focus groups and the co-creation process. In addition to the research, we will provide a training programme in hypertension research in SSA. Dissemination: The research team involved in this work includes staff closely linked with the local community and community health workers, collaborators from non-governmental and governmental organisations who will ensure grassroots dissemination and sustained implementation of the findings beyond the research period. We will also pursue traditional dissemination routes including publishing results in academic journals and presenting the results at international conferences. 1) To understand what is currently done (and what needs to be done) at all levels from patients to the whole healthcare system. To understand how the current healthcare system operates, and what changes need to be made, from patients upwards. 2) To improve the way community workers can decide whom to treat for high blood pressure. 3) To co-create, with patients and health workers, and test a new community-based programme for treating high blood pressure. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 651747 797844 685940 479544 137633 2752708 GB-GOV-10-GHRG_3_134544 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 162937 GB-GOV-10-GHRG_3_134544 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 244405 GB-GOV-10-GHRG_3_134544 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 193984.52 GB-GOV-10-GHRG_3_134544 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 237425 GB-GOV-10-GHRG_3_134544 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 154531 GB-GOV-10-GHRG_3_134544 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 138879 GB-GOV-10-GHRG_3_134544 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 215090 GB-GOV-10-GHRG_3_134544 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 209399.11 GB-GOV-10-GHRG_3_134544 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 269436 GB-GOV-10-GHRG_3_134544 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 178103 GB-GOV-10-GHRG_3_134544 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 231982 GB-GOV-10-GHRG_3_134544 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 173764 GB-GOV-10-GHRG_3_134544 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 205136.97 GB-GOV-10-GHRG_3_134544 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-GHRG_3_134629 UK - Department of Health and Social Care (DHSC) The mental health and psychosocial (MH) consequences of precarity experienced by migrants is widely acknowledged as a global health challenge. Migrants inhabiting and moving across ‘precarious situations’ are at high risk of Gendered Violence (GV), at both the interpersonal and structural level. Combined with the inability to report or access healthcare and other systems of protection, and invisibility in policy and planning results in excess burden and entrapment in a damaging cycle of GV and MH. In order to inform the design of appropriate interventions that address these burdens, it is necessary to improve our understanding of the relationship between drivers of risk among migrants in precarious situations. Responding to conceptual, empirical and intervention gaps affecting this global public health crisis, we build on existing interdisciplinary expertise and prior collaborations to establish a Global Health Research Group on GEndered violence & Poor Mental health among Migrants in precarious Situations’ (GEMMS). GEMMS brings together clinical, psychosocial, sociological and public health expertise within the University of Essex with expertise from South Asia and Southern Africa to advance this agenda. Aims: Working in four precarious situations with diverse migrant groups in India, Myanmar, South Africa and Zimbabwe, we aim to create the necessary conceptual and methodological tools and actions that may create solutions to disrupt the damaging cycle of GV and poor MH and improve migrants' wellbeing WP1: Situational Assessment And Data Appraisal – evaluate existing evidence and service gaps to inform the design of research and intervention tools and conceptual framework to advance other WPs. WP2: Lived Experiences – conduct research with migrants, health providers using mixed methods integrated with Participatory Action Research to generate new knowledge about: • burden and lived experiences of the intersecting risks of GV and poor MH • socio-economic determinants and contextual mechanisms • distribution and accessibility of resources that support resilience and well-being. WP3: Actions & Interventions - Drawing on WP1 &2, develop a participatory approach to co-design actions and a training and support intervention for healthcare workers and service providers UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Essex UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 362101 627892 617956 609940 333928 2551817 GB-GOV-10-GHRG_3_134629 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Essex 90525 GB-GOV-10-GHRG_3_134629 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Essex 135788 GB-GOV-10-GHRG_3_134629 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Essex 210439.64 GB-GOV-10-GHRG_3_134629 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Essex 60606 GB-GOV-10-GHRG_3_134629 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Essex 230864 GB-GOV-10-GHRG_3_134629 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Essex 234197 GB-GOV-10-GHRG_3_134629 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Essex 29755.37 GB-GOV-10-GHRG_3_134629 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Essex 356938.05 GB-GOV-10-GHRG_3_134629 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Essex 124924.37 GB-GOV-10-GHRG_3_134629 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Essex 231436.12 GB-GOV-10-GHRG_3_134629 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Essex 198513 GB-GOV-10-GHRG_3_134629 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Essex 199765.66 GB-GOV-10-GHRG_3_134629 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Essex 231000.4 GB-GOV-10-GHRG_3_134629 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Essex GB-GOV-10-GHRG_3_134638 UK - Department of Health and Social Care (DHSC) Depression and anxiety are common mental health problems, affecting large numbers of people around the world. Depression and anxiety affect 14 million people in Indonesia, and this country has one of the highest rates of depression in the South-East Asia region. Depression and anxiety can affect how people feel and how communities function. These disorders can worsen physical health conditions and significantly increase healthcare costs. This can challenge sustainable development in low-middle income countries. Depression and anxiety are treatable but there is a shortage of trained professionals. Many people in Indonesia, and across the world, are not getting the help they need. Talking treatments can help people with depression and anxiety to recover. These treatments can be delivered by people without a mental health qualification and are recommended by the World Health Organization's for areas where mental health services are limited. Training lay workers to deliver talking treatments is cheaper and more feasible than training a smaller number of highly skilled professionals. It can reduce the stigma of mental health treatment and make treatment more accessible. Similar approaches have been tested in other countries, but the best way to organise and support these services is unknown. This means that we do not know how best to deliver these interventions in Indonesia, how acceptable they will be or what benefits they will have. Our group will use information from existing national surveys in Indonesia to identify where rates of depression and anxiety are highest and where talking treatments are needed the most. We will find out which groups of people have the greatest difficulties accessing talking treatments and explore what effects this has. We will work directly with patients and professionals to understand their experiences of, and preferences for, receiving and delivering treatments and the types of challenges they face. Once we understand the problem, we will work with patients, lay workers, professionals and policy makers to culturally adapt talking treatments, produce locally relevant delivery plans and provide workforce training. We will explore the impact of our intervention on individuals, communities and health service use. We will talk to patients and professionals about their experiences of our intervention and identify any other needs. We will measure the cost of delivering our intervention and identify the geographical areas and patient groups that should be prioritised for treatment roll out. We will compare and contrast findings from different regions within Indonesia to help us understand how best to support treatment availability and uptake in the longer term and deliver new learning to help us enhance the delivery of talking treatments in other global settings. We will hold collaborative, faceto-face engagement events to engage individuals, families and communities in our programme and deliver applied health services research training programs to Indonesian health researchers and public representatives to enable further high quality work. We will work with government, academic and public representatives to tell patients, professionals and policy makers what we find. Where is it being done? Java, Indonesia (South-East Asia) When is it being done? August 2022-July 2026 Who is doing it? Our research team represents an international partnership between mental health professionals and health researchers at the Universities of Manchester and Manchester Metropolitan University, UK and The University of Indonesia, The Indonesian Research and Innovation Agency within the Ministry of Health and non-governmental organisations in Indonesia. 1. Explore nationally representative and publicly available datasets to assess the distribution, determinants and socio-economic consequences of depression and anxiety for adults in Indonesia, providing a robust evidence base for the development and evaluation of primary care and community mental health services in this country. 2. Understand, through interviews with health professionals and decision makers, the different contexts in which psychological interventions may be used in Indonesia, and culturally-adapt a low intensity psychological intervention (Guided Self-Help) to treat depression and anxiety in Indonesian adults. 3. Work with local community and clinical partners to develop local strategies for intervention implementation, including culturally sensitive workforce training programmes. 4. Deliver and evaluate, through a mixed method research, the costs, reach and health impacts of our low-intensity psychological intervention. 5. Combine and disseminate our findings to inform policy and support sustainable service scale-up. 6. Work in partnership with national and local governmental, non-governmental and public stakeholders to engage communities, promote mental health advocacy and stimulate demand for effective, efficient mental healthcare. 7. Build equitable research partnerships and strengthen research capacity, research management and public and community involvement in mental health research in Indonesia. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Manchester UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Indonesia Medical research Research and Innovation 393125 785484 739088 659840 365940 2943477 GB-GOV-10-GHRG_3_134638 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 98281 GB-GOV-10-GHRG_3_134638 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 147422 GB-GOV-10-GHRG_3_134638 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 154962 GB-GOV-10-GHRG_3_134638 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 160884.18 GB-GOV-10-GHRG_3_134638 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 177552 GB-GOV-10-GHRG_3_134638 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 278448 GB-GOV-10-GHRG_3_134638 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 231958 GB-GOV-10-GHRG_3_134638 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 133712.99 GB-GOV-10-GHRG_3_134638 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 192964.91 GB-GOV-10-GHRG_3_134638 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 51736 GB-GOV-10-GHRG_3_134638 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 286336 GB-GOV-10-GHRG_3_134638 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 145245 GB-GOV-10-GHRG_3_134638 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 160015 GB-GOV-10-GHRG_3_134638 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 370997 GB-GOV-10-GHRG_3_134638 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 32822.83 GB-GOV-10-GHRG_3_134638 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester GB-GOV-10-GHRG_3_134663 UK - Department of Health and Social Care (DHSC) In small island countries of the Caribbean, South East Asia and the Pacific, around two thirds of the food consumed is imported. Most of the imported food is of low nutritional value. At the same time, local food production has been steadily declining, made worse by increasingly frequent extreme weather events associated with climate change. All of these countries have high burdens of nutrition related ill-health, including non-communicable diseases associated with overweight and obesity and deficiencies of some micronutrients, especially iron. We are public health, agricultural and social scientists and civil society stakeholders who aim to improve the nutrition, health, social and economic well-being of populations in low- and middle- income small island countries by applying approaches that develop healthy, resilient and environmentally sustainable community-based food production. We come from the Universities of the West Indies, South Pacific, Western Philippines, Exeter (UK), Cambridge (UK), McGill (Canada), and the Danish Technical University. We include scientists from the James Hutton Institute (UK) and community engagement and development specialists from the Foundation for Rural Integrated Enterprises and Development (FRIEND) in Fiji. We will work in island countries and settings in the Caribbean, Pacific and Philippines to provide evidence on how to improve human and ecosystem health for better nutrition. The work will be guided by the UN Food and Agriculture Organization’s 10 elements of agroecology. We will work with local communities to assess their needs and develop ‘living labs’ to work together to increase local food production and improve household nutrition. The project will inform national and regional policy goals of developing sustainable and healthy food systems. The project is organised into four work packages (WP), which are summarised below. 1. To critically appraise and synthesize published evidence on diet, nutrition, their health impacts, and on community-based food production in small island countries, with a specific focus on the project islands in the Caribbean, Pacific and Philippines. 2.Guided by the findings from objective 1 and in consultation with local communities and stakeholders, to select geographically and ecologically defined settings within each project island, and as needed undertake new data collection on: 3.To create ‘communities of practice’ and ‘living labs’ for the design of interventions in the project settings. These will bring together community food producers, other stakeholders across the food value chain, consumers, policy makers and researchers in order to: 4.To undertake qualitative (non-mathematical) and quantitative (mathematical) modelling to assess, compared to business as usual, the potential human and ecosystem health impacts if the interventions designed as part of objective 3 are more widely adopted: The objectives related to the continuation of the programme are: 5.To develop a web-based resource and repository of materials, case studies and guidance to support dissemination and further applied research to support the further development of sustainable community-based food production and human nutrition. 6.To build the breadth and depth of research capacity across and within the project settings to maintain and further develop this programme of work UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Exeter UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 452437 719036 739932 692952 371906 2976263 GB-GOV-10-GHRG_3_134663 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Exeter 113109 GB-GOV-10-GHRG_3_134663 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Exeter 169664 GB-GOV-10-GHRG_3_134663 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Exeter 41406.66 GB-GOV-10-GHRG_3_134663 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 150856 GB-GOV-10-GHRG_3_134663 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 268663 GB-GOV-10-GHRG_3_134663 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 213553 GB-GOV-10-GHRG_3_134663 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 19743 GB-GOV-10-GHRG_3_134663 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 219102.08 GB-GOV-10-GHRG_3_134663 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 180658 GB-GOV-10-GHRG_3_134663 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 95637 GB-GOV-10-GHRG_3_134663 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 255955 GB-GOV-10-GHRG_3_134663 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 273526 GB-GOV-10-GHRG_3_134663 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 164751 GB-GOV-10-GHRG_3_134663 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 220986 GB-GOV-10-GHRG_3_134663 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 406421 GB-GOV-10-GHRG_3_134663 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter GB-GOV-10-GHRG_3_134694 UK - Department of Health and Social Care (DHSC) We are developing new “digital” diagnostic tests for infectious diseases. Our approach uses a handheld electronic device where the test is performed on a microchip. The tests have similar accuracy to large laboratory machines, but are rapid, low cost, and portable. The test results are immediately linked to a smartphone which enables data transmission, so that we can monitor the detection of different diseases in different locations. This project is being undertaken by more than 40 researchers from African institutions, the UK, and the Netherlands. The researchers have a wide range of expertise, from electronic and design engineering, through to clinical medicine and health systems research. We will recruit 10 African PhD students to receive training and undertake research on digital diagnostics. Projects will be based in Burkina Faso, The Gambia, Ghana, Kenya, Sudan, and Zambia, with some technology development in the UK. The project will run between 1st August 2022 and 31st July 2026. The project addresses the unmet need for access to accurate diagnostics in low and middle income countries. At present, less than half of the population of Africa have access to essential diagnostics. Without accurate diagnostics, the correct treatments cannot be given, and public health interventions cannot be targeted to where they are most needed. We will evaluate the potential of digital diagnostic technology to tackle common problems including malaria and other childhood infections. Our overall aim is to generate evidence to support the development and implementation of new “digital diagnostic” tests to tackle infectious diseases in Africa. The digital diagnostics are hand-held analysers, using a microchip to detect different organisms causing infection, connected to a smart phone to provide instantaneous data transfer for disease surveillance. The specific objectives underpinning the project are: 1. Evaluate the perceptions of users and stakeholders about the new diagnostic technology, including community members, patients, clinical staff, healthcare managers, and policy makers in different African countries 2. Evaluate the usability and diagnostic performance of digital diagnostic tests for the detection of malaria parasites, and detection of mutations in the parasites which make them resistant to current treatments 3. Evaluate the usability and diagnostic performance of digital diagnostic tests to determine the cause of illness in unwell children with suspected infection 4. Evaluate the usability and diagnostic performance of digital diagnostic tests to detect contamination of water or food with organisms which can cause illness in humans 5. Develop a user-friendly interface for the digital diagnostic tests by working with the people who would use the new diagnostic tests 6. Understand the conditions necessary for these new diagnostic tests to bring greatest impact to healthcare systems, at local, national, and international levels 7. Train a network of researchers, including a cohort of 10 African PhD Fellows, to be future leaders in the development, evaluation, and implementation of digital diagnostic technology UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 961938.3 172788 832206.27 708385.22 301483.47 156673.75 2999952 GB-GOV-10-GHRG_3_134694 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Imperial College London 172105 GB-GOV-10-GHRG_3_134694 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Imperial College London 258158 GB-GOV-10-GHRG_3_134694 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Imperial College London 531675.3 GB-GOV-10-GHRG_3_134694 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 69020 GB-GOV-10-GHRG_3_134694 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 66344 GB-GOV-10-GHRG_3_134694 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 37424 GB-GOV-10-GHRG_3_134694 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 63022 GB-GOV-10-GHRG_3_134694 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 233726.77 GB-GOV-10-GHRG_3_134694 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 281191.19 GB-GOV-10-GHRG_3_134694 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 254266.31 GB-GOV-10-GHRG_3_134694 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 39873.53 GB-GOV-10-GHRG_3_134694 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 204801.69 GB-GOV-10-GHRG_3_134694 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 239202 GB-GOV-10-GHRG_3_134694 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 224508 GB-GOV-10-GHRG_3_134694 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 133523.01 GB-GOV-10-GHRG_3_134694 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Imperial College London 80076.17 GB-GOV-10-GHRG_3_134694 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London GB-GOV-10-GHRG_3_134717 UK - Department of Health and Social Care (DHSC) National malaria control programmes (NMCPs) need effective tools to monitor resistance to control measures and to provide early warning that their interventions are causing resistance to rise to unacceptable levels so they can change strategy. Advances in genome surveillance revolutionised the UK response to the COVID pandemic and demonstrated the power of this tool across the world. Proof-of-concept work being carried out as part of this programme of research at the University of Ghana (UG) and the MRC Unit in The Gambia at the London School of Hygiene and Tropical Medicine (MRCG) of malaria genetic surveillance in West Africa has included engagement with NMCPs. Knowledge of genetics, genetic markers and genetic epidemiology is outside the domain of expertise of most NMCPs. Therefore, subject matter experts need to work with NMCPs to bridge the gap and support implementation. Discrete but connected hubs can support NMCP managed activities in different countries and integrate data generated into regional analyses. Hub leaders also serve as advocates to connect these data to a global data sharing network by forging strong relationships in both directions and acting as stakeholder representatives. Bringing malaria genetic surveillance data across the world benefits public health. If a new form of parasite drug resistance or mosquito insecticide resistance emerges elsewhere in the world, it will greatly help an NMCP to monitor and manage the problem if the global genomic data for malaria surveillance is continually updated to incorporate the most useful genetic markers, which are likely to have been discovered elsewhere. However, those new to sharing data openly benefit from working closely with subject matter experts who are knowledgeable and sensitive to cultural, operational and technical challenges in achieving this. Rapid advances building on malaria genomic surveillance in West Africa have the potential to catalyse relationships and advancement in malaria. For example, building on capacity for malaria genetic surveillance, scientists at the University of Ghana utilised capacity built for malaria surveillance to develop sequencing tools to analyse the SARS-CoV-2 virus from confirmed cases in Ghana. Combined with local leadership, genomic surveillance tools can be applied to pathogens and viruses for both endemic and pandemic infectious disease. Following the implementation of genomic surveillance of malaria using Amplicon sequencing, the teams at UG and MRCG will strengthen their own discrete but complementary regional networks. The Wellcome Sanger Institute will support UG and MRCG in building capacity for managing multi-partner collaborations and scaling up sequencing operations. Hub leaders will work with their collaborators to provide training from sample collection through to the translation of genomic data into actionable knowledge. By the end of this project, we aim to be integrating these systems into the routine working practices of NMCPs in countries that are part of the regional networks of Ghana and The Gambia, and to provide a working example of how such systems could be deployed at other locations in Africa. 1. Implement amplicon sequencing tools to address specific use cases in malaria control. 2. Enable the regional sequencing hubs to achieve reliable production of genomic surveillance data. 3. Establish a sampling framework for genomic surveillance of parasites and vectors in selected locations. 4. Start to integrate genomic surveillance into national and regional malaria control initiatives. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Genome Research Limited UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 379954 677187 865516.11 1030455 155427.43 2981004 GB-GOV-10-GHRG_3_134717 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Genome Research Limited 379954 GB-GOV-10-GHRG_3_134717 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 111698 GB-GOV-10-GHRG_3_134717 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 124677 GB-GOV-10-GHRG_3_134717 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 440812 GB-GOV-10-GHRG_3_134717 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 31132 GB-GOV-10-GHRG_3_134717 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 251414.22 GB-GOV-10-GHRG_3_134717 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 267231.09 GB-GOV-10-GHRG_3_134717 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 315738.8 GB-GOV-10-GHRG_3_134717 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 194428 GB-GOV-10-GHRG_3_134717 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 127535.54 GB-GOV-10-GHRG_3_134717 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Genome Research Limited 714868.69 GB-GOV-10-GHRG_3_134717 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited 121158.76 GB-GOV-10-GHRG_3_134717 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Genome Research Limited GB-GOV-10-GHRG_3_134781 UK - Department of Health and Social Care (DHSC) Most maternal deaths occur in Sub-Saharan Africa. Nearly all are preventable with good quality maternal healthcare. Both Malawi and Zambia are committed to improving maternal and neonatal health outcomes but are not making fast enough progress. The aim of the NIHR Safe Motherhood Research Programme is to improve maternity outcomes in Malawi and Zambia by improving the quality of care. The senior leadership of the research team are all based in Malawi and Zambia, hosted by the Malawi-Liverpool-Wellcome Research Programme in Blantyre, Malawi. The four-year (August 2022 – July 2026) programme of work described here builds upon previous work of the NIHR DIPLOMATIC research group in Zambia and Malawi. We will leverage the team research strengths and network, and initiate new work to ensure meaningful impact on maternal and neonatal health outcomes. The NIHR Safe Motherhood group’s aim will be delivered through 4 themes, which operate alongside the cross-cutting domains of capacity building in institutions in both countries, communicating widely across professional and public settings for impact, and community engagement and involvement. We will ensure the research is centred on the needs of users and their families, and focusseson sustainable improvements that can be implemented within resource constrained health systems. 1. Data driven improvement – we will report key maternal and neonatal health data to improve the quality of pregnancy care in Zambia and Malawi 2. Placing users at the centre of change – we will use qualitative methods to understand the experience of vulnerable service users, in particular adolescents and women with mental health problems 3. Prioritisation and co-design – we will engage stakeholders in prioritisation and train health professionals in methods for co-designing interventions 4. Implementing and evaluating change – we will implement the behaviour change interventions co-designed with stakeholders in Zambia and Malawi, starting with management of sexually transmitted infections during pregnancy 5. Capacity building and communicating for impact – all programme activities aim to improve the knowledge and skills of health professionals in Zambia and Malawi, including effective communication of findings for policy impact UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 456440 684876 710024 741708 400088 2993136 GB-GOV-10-GHRG_3_134781 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 114110 GB-GOV-10-GHRG_3_134781 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 171165 GB-GOV-10-GHRG_3_134781 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 93771 GB-GOV-10-GHRG_3_134781 2023/24 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Liverpool 141145 GB-GOV-10-GHRG_3_134781 2023/24 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Liverpool 247294 GB-GOV-10-GHRG_3_134781 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 125112 GB-GOV-10-GHRG_3_134781 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 396667.83 GB-GOV-10-GHRG_3_134781 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 137227 GB-GOV-10-GHRG_3_134781 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 219598 GB-GOV-10-GHRG_3_134781 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 288303 GB-GOV-10-GHRG_3_134781 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 105148 GB-GOV-10-GHRG_3_134781 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 94028 GB-GOV-10-GHRG_3_134781 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 282104 GB-GOV-10-GHRG_3_134781 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool GB-GOV-10-NIHR_GHRG4 UK - Department of Health and Social Care (DHSC) The NIHR's fourth Global Health Research call for Groups. UK universities and research institutes were invited to submit applications, working in equitable partnerships with researchers in low- and middle-income countries (LMICs) eligible to recieve Official Development Assistance (ODA), to develop their ambitions to deliver world-class applied global health research to address under-funded or under-researched global health areas specific to those countries. The partnerships support both identified training and capacity needs for academy research and programme support functions in low resource settings. Together these provide an important, sustainable platform for future research and resilience in those countries. Global Health Reseach Group funding is available to research groups either new to delivering applied health research globally or that wish to expand an existing partnership. Through this call, awards up to £3 million over a period of up to four years are available to NIHR Global Health Research Groups. The project has three objectives: 1. Adapt an existing treatment for people with severe mental illness to stop using all forms of tobacco, including smokeless tobacco, via an updated and refined intervention package consisting of treatment materials and training resources. 2. Identify, evaluate and refine strategies to deliver Smoking cessation for people with severe mental illness in South Asia (SCIMITAR-SA) in mental health facilities, and develop a shortlist of relevant strategies for its wider rollout in Bangladesh, India and Pakistan. 3. Deliver the intervention to people with severe mental illness via a randomised controlled trial to compare tobacco use and severe mental health between recipients and non-recipients at 6 and 12 months. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Oxford Queen Mary University of London University College London University of Birmingham Queen Mary University of London University of Oxford University of Exeter The University of Edinburgh University of Birmingham Liverpool School of Tropical Medicine London School of Hygiene and Tropical Medicine University of Liverpool University of Sussex University of Warwick University of Kent Roehampton University London School of Hygiene and Tropical Medicine London School of Hygiene and Tropical Medicine Imperial College London University of Southampton Liverpool School of Tropical Medicine The University of Manchester The University of Edinburgh King's College London University of Birmingham UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-GHRG_4_155559 UK - Department of Health and Social Care (DHSC) Injuries are the leading cause of death in people aged between 10-49 years. More people die from injuries than from HIV, malaria, and tuberculosis combined. For every person who dies, up to 50 people survive but become disabled. Broken bones account for most of these injuries, and disproportionately affect people living in poorer regions, such as countries in Africa. Little is known about how many individuals in Africa sustain a broken bone, what healthcare services are available to treat them, how the injury affects individuals and their families, or ways to improve their recovery. Across three African countries (Malawi, Tanzania, and South Africa) we aim to: 1. Develop the ability to undertake research into the care of broken bones. 2. Determine the number of people affected by a broken bone. 3. Describe the healthcare resources available for the treatment of broken bones and identify factors that help or hinder the delivery of services. 4. Assess the impact of a broken bone on the life and livelihoods of those affected. 5. Improve the recovery of patients who have experienced a broken bone. Methods: Our project has four themes: 1. Capacity: Doctors, nurses, and healthcare workers involved in the care of patients with broken bones have limited training in how to conduct research and poor access to the basic resources to do research, making it difficult to improve the care for their patients. We will assess current levels of research training and organisation, designing educational resources to fill gaps in the current understanding and ability to undertake research. 2. Mapping: We will create a network of collaborating hospitals, in our partner countries, to perform a study to determine how often different types of broken bones occur. We will look at five broken bones that the World Health Organisation (WHO) have identified to cause the most disability and describe the resources (people and equipment) available to treat these injuries and find out how patients make use of these services. 3. Outcome: We will examine how patients recover from their injury and the impact on their lives and livelihoods for each of the five types of broken bones. 4. Change: Through our network of collaborating hospitals, we will undertake a multi-centre study to ‘test’ if it is possible to do large-scale research studies. Our goal is to run similar studies throughout Africa to assess new treatments for patients with broken bones. This project will help us understand the number of broken bones that occur in Africa, what treatments are available and how these injuries affect patients. It will develop research capacity and lay the foundations to attract future research funding, enabling us to work towards our vision that the care for broken bones in poor countries can be safe, accessible, and appropriate to the resources of local health systems. This project will run from September 2024 to August 2028. Community engagement and involvement: We have engaged with local patients and healthcare workers, whose opinions have informed our work so far. We will continue to integrate patients and community leaders to co-produce our research. Dissemination: Patients, clinicians and methodologists will co-develop publications, social media, and events. We will work alongside policy makers in national government ministries and strengthen our relationship with leaders within the WHO to ensure that we disseminate our findings effectively and influence policy to drive improved patient care. This project has 4 objectives: 1. Evaluate the available resources for conducting clinical research & develop research capacity and leadership. 2. Quantify the incidence of musculoskeletal (MSK) injuries & define the healthcare resources currently available for MSK injury care. 3. Assess MSK injury treatment pathways, clinical & quality of life outcomes, and economic impact. 4. Implement a multi-centre feasibility study to inform a randomised control trial. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Oxford UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 299367.95 793546.14 951880.91 644564.38 337350.38 3026709.76 GB-GOV-10-GHRG_4_155559 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Oxford 42766.85 GB-GOV-10-GHRG_4_155559 2024/25 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Oxford 128300.55 GB-GOV-10-GHRG_4_155559 2024/25 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Oxford 221946 GB-GOV-10-GHRG_4_155559 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 173003.9 GB-GOV-10-GHRG_4_155559 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 172662 GB-GOV-10-GHRG_4_155559 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 1470.79 GB-GOV-10-GHRG_4_155559 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 241250.65 GB-GOV-10-GHRG_4_155559 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford GB-GOV-10-GHRG_4_155974 UK - Department of Health and Social Care (DHSC) Ukraine, like other eastern European countries, had started to move from inpatient-based to community mental health care before the outbreak of the war in February 2022. However, the war has changed the situation with increasing problems of mental distress, serious trauma, disruption to social support and context, and the destruction of the critical clinical infrastructure, with 6 psychiatric hospitals annihilated, over 10 million people displaced and healthcare and research workers increasingly leaving Ukraine. Little is known about the best models of mental health care during wars. One model that shows considerable promise is Mobile Community Mental Health Teams (MCMHTs), which provide services to people with severe mental health problems at home. MCMHTs are currently being implemented in Ukraine using government funding. Eighty-eight MCMHTs are already in operation as a result of an unprecedented collaboration between the authors of this application and the World Health Organization (WHO). A total of around 200 MCMHTs are planned. The teams should comprise a range of mental health, social care and primary care specialists. MCMHTs should primarily work with service users (18 to 65 years) with severe psychiatric disorders, but could include 16 and 17 year old users. These teams could improve access to healthcare, although current evidence is limited. It is also possible that these teams could provide an alternative to inpatient treatment for those service users who would traditionally be referred for hospital treatment due to a significant worsening of their disorder, but this remains untested. Finally, there is an urgent need to train MCMHT professionals in overcoming the consequences of the war on the mental health of service users. The current project, Developing And Integrating Mobile community mental health Services In Ukraine (DAISI Ukraine) will complement, enhance and inform the development of innovative community mental health care during and after the war in Ukraine, as well as informing appropriate mental health responses in other conflict areas. DAISI Ukraine will aim to evaluate, improve, fine-tune and embed MCMHTs in Ukraine culminating in the establishment of the national service standard for these teams. Specifically, DAISI Ukraine’s aims are to provide: 1. Locally relevant evidence to underpin, guide and shape the implementation of MCMHTs. 2. Improved local research capacity. 3. A global network of researchers interested in community care. 4. Appropriate training programmes for staff. 5. Involvement of service users and their families in service development and research. Service users and their families have been involved in the development of this proposal from day one. In DAISI Ukraine, they will be a part of the research team and core to its activities – they will be co-researchers and co-developers rather than simply being the objects of study. This process of engagement will change how service users feel about and manage their conditions. We will create a service users panel for research and engagement before the beginning of DAISI Ukraine. This will allow DAISI Ukraine service user researchers to support and mentor one another, giving them translational skills beneficial for employment and education. To our knowledge, DAISI Ukraine is the first example of co-developed and co-produced research in mental health services in Ukraine. The project will be implemented between 2024 and 2028. The project has 5 objectives: 1. Provide locally relevant evidence to underpin, guide and shape the implementation of Mobile Community Mental Health Teams (MCMHTs). 2. Improve local research capacity. 3. Create a global network of researchers interested in community care. 4. Deliver appropriate training programmes for staff. 5. The involvement of service users and their families in service development and research. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Queen Mary University of London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Ukraine Medical research Research and Innovation 276487.9 653694.66 758228.04 777951.7 547630 3013992.3 GB-GOV-10-GHRG_4_155974 COMMITMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 138243.95 GB-GOV-10-GHRG_4_155974 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 52588 GB-GOV-10-GHRG_4_155974 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 123084 GB-GOV-10-GHRG_4_155974 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 35536 GB-GOV-10-GHRG_4_155974 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 86705 GB-GOV-10-GHRG_4_155974 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 133364 GB-GOV-10-GHRG_4_155974 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London GB-GOV-10-GHRG_4_156011 UK - Department of Health and Social Care (DHSC) Globally, there are around 1.3 million deaths each year due to infections that are resistant to antibiotics (so-called AMR infections). Respiratory infections such as pneumonia account for ~15% of deaths in children under 5 years, many of these deaths are in sub-Saharan Africa (SSA), and most can be prevented with vaccines. Frequently and understandably, fear of bad outcomes leads to inappropriate antibiotic use which increases the threat of AMR. This is even when fever or respiratory infections are caused by viruses like influenza, respiratory syncytial virus (RSV) & COVID-19, which do not need antibiotics. As a result, Governments and the World Health Organization (WHO) have declared AMR a world threat. Over the next 4 years (2024-2028), we aim to achieve Africa-led transformation of the long-term impact of vaccines, targeting high burden respiratory infections & limiting AMR. We will bring together well-established research institutions in Kenya (KEMRI-Wellcome) and Malawi (Malawi-Liverpool-Wellcome Programme, Kamuzu University of Health Sciences), with less-well-resourced institutions in Ghana (Navrongo Health Research Centre) and Nigeria (Nigeria Centre for Disease Control and Nigerian Institute of Medical Research) in new South-South partnerships across Africa. We will develop new interdisciplinary multimodal interventions, supported by improved diagnostics, and more robust measurement of immune protection. With communities and policymakers, we will identify target microbes within those prioritised by WHO; evaluate ways to control respiratory infections and AMR through evidence analysis & stakeholder consultation; and test the feasibility of a multimodal intervention package. We will improve the detection of infection and AMR through cutting-edge diagnostic technologies. By identifying better ways to measure immune protection, we will enhance the evaluation of interventions to control respiratory pathogens and AMR. This work will be underpinned by four cross-cutting themes: community engagement & involvement, understanding behaviour and risk perception, evidence to policy, and leadership development for Africa-based mic-career researchers. This project has 6 objectives: 1. Identify multimodal interventions to reduce AMR, developing the evidence base, co-creating interventions, modelling impact & prioritising methodologies. The intended outcomes of this objective are to produce an interdisciplinary intervention assessment platform; community of community engagement groups; and comprehensively trained Africa-based leadership. 2. Accelerate implementation of diagnostic approaches to support AMR intervention evaluation. The intended outcomes of this objective are to target diagnostic platforms identified with Africa CDC; field test diagnostics to support intervention; host local training in Wole Genome Sequencing (WGS) analysis; and produce open-access protocols. 3. Evaluate candidate immune markers of protection to support intervention & outcome evaluation. The intended outcomes of this objective are to select immunological tools; test protective immunity tools, and develop models; and produce open-access protocols. The intended impact is to have innovative intervention evaluation using immune biomarkers as secondary endpoints. 4. Strengthen evidence-to-policy translation. The intended outcome of this objective is to support African leadership in the global AMR pandemic response, involving communities and policymakers. 5. Engage communities to evaluate AMR risk & identify behaviour change interventions. The intended outcome of this objective is to create a community of engagement groups from across Africa with a focus on vaccines and AMR. 6. Empower Africa-based leadership & innovation in AMR. The intended outcome of this objective is to support African leadership in the global AMR pandemic response, involving communities and policymakers. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 528699.36 781819.03 811021.36 615901.67 288934.97 3026376.39 GB-GOV-10-GHRG_4_156011 COMMITMENT UK - Department of Health and Social Care (DHSC) University College London 176233.12 GB-GOV-10-GHRG_4_156011 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 176233.12 GB-GOV-10-GHRG_4_156011 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 389574.5 GB-GOV-10-GHRG_4_156011 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 75810.3 GB-GOV-10-GHRG_4_156011 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 288496.57 GB-GOV-10-GHRG_4_156011 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 35822.24 GB-GOV-10-GHRG_4_156011 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London GB-GOV-10-GHRG_4_156087 UK - Department of Health and Social Care (DHSC) Climate change is an emergency and communities are worried about its impact on their health. World leaders are committed to reducing carbon emissions, including in healthcare, which contributes to 4.6% of global carbon emissions. The National Institute for Health and Social Care Research (NIHR) has identified this area as a research priority, which we will address. Our proposed Group will focus on reducing the carbon “footprint” of operating theatres in lower- and middle-income countries (LMICs) and then apply these lessons to other hospital areas. Starting with operating theatres is easier than changing the whole hospital at once, increasing the chances of success. Also, operating theatres produce the most carbon and waste compared to any other hospital area. This research project will run from July 2024 to August 2028. We looked at published research, gathered initial data, consulted with lots of different stakeholders, and held two global community engagement workshops. Our proposal addresses 8 of 10 priorities identified by patients and stakeholders for “greener” operating theatres. We have prioritised three areas for testing: 1. Reusable drapes and gowns in theatres: Instead of using disposable drapes and gowns that create a lot of waste, we want to test using ones that can be washed and reused multiple times. This will help reduce the amount of waste generated in the operating rooms, but we need to prove it will not increase the number of infections first. 2. Reducing the use of harmful anaesthetic gases: Some of the gases used during surgery are harmful to the environment. We want to find ways to reduce the amount of these used or find alternatives that are more environmentally friendly. 3. Improving what happens to recyclable waste: We want to make sure that recyclable waste, such as plastic packaging or containers used in the operating rooms, is managed properly and sent for recycling, instead of ending up in landfills or the ocean. We aim to learn how to reduce carbon emissions from operating theatres across Ghana, India, Nigeria and Rwanda. Via experienced policymakers in Pakistan, we aim to put this research quickly into everyday practice and learn how to work with the World Health Organization (WHO). This Group will bring new senior leadership into the NIHR Global Health family, and train new junior researchers for the future. 1. We will scope communities’ understanding of “Net Zero” and carbon-related concepts, to develop ways to communicate this in local, lay language. 2. We will create a toolkit of resources that our teams can use to communicate Net Zero concepts and our research results to the community, including policymakers, media, and hospital managers in each country, and beyond. 3. We will design, with input from the community, three research studies across our three prioritised topics, ranging from large and simple (e.g. 80 hospitals) to small and detailed (e.g 4 hospitals). The project on waste management will be spread across the whole hospital. 4. We will train a new generation of scientific researchers to tackle environmentally sustainable healthcare in the future and organise community advocates for “greener” surgery. 5. We will build links to senior policymakers from the very start of this research, so they can influence its design, and act quickly upon the results. This includes learning how to work with the WHO on this topic. This project has 4 objectives: 1. Create a pool of community representatives, scope their understanding of Net Zero/carbon footprint, and identify their training needs. 2. Build context-specific training toolkits, using suitable non-specialist language to create grassroot advocates. 3. Involve communities in research design for projects in Workstreams 3 and 4. 4. Use our large trial as a learning platform to test Community, Engagement and Involvement (CEI)-led dissemination to communities, media, and policymakers in each country. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Birmingham UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 521227.38 759731.44 738520.79 672051.87 313936.06 3005467.54 GB-GOV-10-GHRG_4_156087 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 347484.92 GB-GOV-10-GHRG_4_156087 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 28799 GB-GOV-10-GHRG_4_156087 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 20862 GB-GOV-10-GHRG_4_156087 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 104667.63 GB-GOV-10-GHRG_4_156087 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 76575.46 GB-GOV-10-GHRG_4_156087 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham GB-GOV-10-GHRG_4_156161 UK - Department of Health and Social Care (DHSC) Long term conditions such as heart disease, diabetes and kidney disease are the leading causes of death in Thailand. It is estimated that reducing the number of people living with high blood pressure in Thailand can prevent 14,000 deaths, 27,000 strokes, and 18,000 heart attacks over the next five years. In Thailand, computerised medical records are used by the Ministry of Public Health to understand how whole regions deliver care. However, this information is not available to healthcare providers in a format that helps them identify people in need of earlier or more active management. Learning Health System approaches turn computerised medical data into information that allows healthcare teams to provide better health care and reduce inequalities. We will work alongside healthcare providers, decision-makers, researchers, and the public to co-develop a data supported quality improvement approach for the management of diabetes, high blood pressure, and kidney disease in primary care settings. We will begin by hosting a series of workshops to identify challenges that healthcare teams face when managing individuals living with these long-term conditions and what kinds of data tools and ways of working might help address these challenges. Building on the recommendations made in the workshops, our team of computer scientists will develop computerized tools to support healthcare teams to better manage individuals with diabetes, high blood pressure, and kidney disease. These tools will be tested in two primary care units before being rolled out to all 16 primary care units participating in our study. The rollout of the computerised tools will be accompanied by training and ongoing support by our team of clinical nurse facilitators, clinical, and community champions who will support healthcare teams to incorporate the new computerised tools into their quality improvement activities. We will evaluate the intervention using formal statistical approaches which will measure improvements in control of blood pressure, diabetes, and kidney disease over time and compare our 16 intervention practices to other practices in the region. We will also conduct a realist evaluation which will involve interviews with the healthcare teams and observation of meetings and workflows to understand which components of the quality improvement intervention have worked, under what circumstances, and for which populations. This project will run from July 2024 to July 2028 and is led by Queen Mary, University of London, and Chiang Mai University in partnership with the London School of Hygiene and Tropical Medicine and the Thai Ministry of Public Health. The project has 5 objectives: 1. Engage with healthcare providers, decision makers, researchers, and the public to co-design a Learning Health System, for the management of hypertension, diabetes, and kidney disease, and develop computerised data systems, decision support tools, and training materials in 16 randomly selected primary care units across two provinces in Thailand. 2. Train multidisciplinary healthcare teams, data scientists, and researchers in the design, delivery, analysis, and evaluation of a Learning Health System, and establish a cohort of clinical and community champions to support the intervention. 3. Pilot the delivery of a Learning Health System, for improving management and clinical outcomes of hypertension, diabetes, and kidney disease and generate robust new evidence around the acceptability and effectiveness of Learning Health System approaches and delivery of clinical care. 4. Compare outcomes between intervention and control practices and conduct a health economic evaluation of the costs of implementing the Learning Health System versus routine care. 5. Conduct a mixed-methods evaluations to identify provider and patient barriers and facilitators to implementing a Learning Health System to inform subsequent approaches to embedding quality improvement for hypertension, diabetes, and kidney disease care in Thai primary care settings and more widely across the region. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Queen Mary University of London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Thailand Research for prevention and control of NCDs Research and Innovation 340415.91 460697.58 549777.55 607015.13 265271.07 2223177.24 GB-GOV-10-GHRG_4_156161 COMMITMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 113471.97 GB-GOV-10-GHRG_4_156161 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 113471.97 GB-GOV-10-GHRG_4_156161 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 112438 GB-GOV-10-GHRG_4_156161 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 121794 GB-GOV-10-GHRG_4_156161 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 122953 GB-GOV-10-GHRG_4_156161 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 120242 GB-GOV-10-GHRG_4_156161 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 145982.9 GB-GOV-10-GHRG_4_156161 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 124922.84 GB-GOV-10-GHRG_4_156161 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London GB-GOV-10-GHRG_4_156179 UK - Department of Health and Social Care (DHSC) Childhood injuries are a leading cause of death and disability, with 90% of injury burden reported in low- and middle-income countries. Being the leading cause of death for children aged 5 and above, injuries kill more than half a million children every year. Children with non-fatal injuries are frequently left with disabilities adversely impacting their development and quality of life. Childhood injuries contribute to a loss of economic productivity at individual, family, societal and national levels; they lead to catastrophic health expenditures, time off school and work, and impose a significant burden on healthcare systems. Sub-Saharan Africa has a high burden of childhood injury, which may be preventable through simple, cost-effective interventions instituted at family and community levels. This proposal, co-led by the University of Oxford and University of Zimbabwe, aims to reduce the burden of disease from injuries among children aged 6 to 12 years in Tanzania and Zimbabwe. Addressing childhood injuries within community settings has been identified as a national priority by decision-makers in both countries, but policymakers in the two countries lack the necessary information for evidence-based resource allocations. The lack of published childhood injury data in the region prevents a comprehensive understanding of factors associated with childhood injuries, care processes, and outcomes; all of which would support the development of interventions to prevent injury occurrence, and improve post-injury care and long-term rehabilitation. This study, funded by the National Institute for Health and Care Research, seeks to fill this knowledge gap over four years, between 2024 and 2028. Our research programme will address the World Health Organization’s World Report on Child Injury Prevention recommendations: 1) enhance the quality and quantity of data for child injury prevention. 2) research on the causes, consequences, costs, and prevention of child injuries. 3) implement specific actions to prevent and control child injuries. 4) strengthen health systems to address child injuries. The project has 4 objectives: 1.1. Undertake a meso-level study of select locations within both nations to assess the trauma burden in children, including its drivers, care pathways, outcomes, and economic implications in Tanzania and Zimbabwe. 1.2. Assess access to health services for injured children in Tanzania and Zimbabwe. 1.3. Understand specific child road safety risks in Tanzania and Zimbabwe. 2.1. Develop cost-effective strategies to reduce the burden of trauma experienced by children across Tanzania and Zimbabwe. 2.2. Test the feasibility and acceptability of strategies developed to reduce the burden of childhood injuries. 2.3. Inform policymaking regarding child injury prevention. 3.1. Assess resource use, costs, and hospital-system efficiencies in the delivery of paediatric trauma care across networks of referral and district hospitals. 3.2. Support value-based resource allocation for optimised delivery of paediatric trauma care in Tanzania and Zimbabwe. 4.1. Develop a sustainable, community-led quality improvement initiative that introduces baseline standards for access and outcomes of paediatric trauma care (The Paediatric Trauma - Extension for Community Healthcare Outcomes: PT-ECHO) in Tanzania and Zimbabwe. 4.2. Implement and evaluate the impact of the PT-ECHO initiative on improving access, quality, and outcomes of paediatric trauma care within the targeted communities. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Oxford UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 487888.71 824286.29 797258.05 621685.51 294427.38 3025545.94 GB-GOV-10-GHRG_4_156179 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Oxford 162629.57 GB-GOV-10-GHRG_4_156179 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 162629.57 GB-GOV-10-GHRG_4_156179 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 18944.08 GB-GOV-10-GHRG_4_156179 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 56503.2 GB-GOV-10-GHRG_4_156179 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 13941.6 GB-GOV-10-GHRG_4_156179 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford GB-GOV-10-GHRG_4_156184 UK - Department of Health and Social Care (DHSC) Over 20 million people live with type 2 diabetes (T2D) in sub-Saharan Africa (SSA). This number will increase by 134% by 2045, the largest expected increase of all regions in the world. A key challenge for managing T2D in SSA is the lack of local data to inform appropriate management. Increasing evidence shows that diabetes presents differently in SSA compared to high-income countries (HICs). One important difference is that those diagnosed with T2D in SSA are often young and lean, in stark contrast to its classical presentation in older and more obese individuals in high-income countries. These observations raise important questions, such as: 1. What is making lean individuals susceptible to diabetes, and do lifestyle factors play a role? 2. What is the best way to identify people at risk of T2D in SSA, as most current risk scoring tools rely on age and obesity? 3. Are the traditional approaches to prevention and treatment of T2D that focus on weight loss and/or metformin (to treat insulin resistance associated with obesity) as effective in this population where a high proportion (40-60%) of those living with T2D are lean? Collaborators from Uganda (Medical Research Council (MRC) / Uganda Virus Research Institute (UVRI) and London School of Hygiene and Tropical Medicine (LSHTM) Research Unit), Cameroon (University of Yaoundé 1), Malawi (Malawi Epidemiology and Intervention Research Unit, MEIRU), South Africa (University of Cape Town) and the UK (University of Exeter) aim to improve outcomes for people with T2D in SSA by addressing these questions. In a four-year project (July 2024 - 2028), the group will do this through three work packages using a combination of existing data and new research studies undertaken Uganda, Cameroon and Malawi. The group will also focus on developing leaders in diabetes research and building research capacity through studentships and training and capacity strengthening across clinical, laboratory, epidemiology, social and implementation science. The project has 5 objectives: 1. Determine whether lifestyle behaviours (diet and physical activity) contribute to lean type 2 diabetes (T2D) and explore whether current national guidelines for lifestyle change have the same effect in lean and obese individuals. 2. Use data from our research in objective 1 and the literature to co-develop and pilot a new structured education intervention for T2D, incorporating appropriate lifestyle education including for those with the lean phenotype. 3. Investigate whether commonly used low-cost T2D drugs work as well in lean patients as they do in individuals with obesity in sub-Saharan Africa (SSA). 4. Use existing data from different countries to comprehensively identify the risk factors for lean T2D and integrate these into tools to improve identification of at-risk individuals who should be screened. 5. Strengthen the capacity to undertake multidisciplinary diabetes research that leads to policy translation and practice in SSA. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Exeter UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 567796.26 801853.96 749061.28 607559.78 292939.91 3019211.19 GB-GOV-10-GHRG_4_156184 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Exeter 189265.42 GB-GOV-10-GHRG_4_156184 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 189265.42 GB-GOV-10-GHRG_4_156184 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 144290.76 GB-GOV-10-GHRG_4_156184 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 38813.92 GB-GOV-10-GHRG_4_156184 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 238246.7 GB-GOV-10-GHRG_4_156184 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter 121561.31 GB-GOV-10-GHRG_4_156184 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Exeter GB-GOV-10-GHRG_4_156234 UK - Department of Health and Social Care (DHSC) The improving equity in respiratory disease (RD) outcomes in Africa using data-driven tools (EQUI-RESP-AFRICA) Global Health Group aims to reduce the number of deaths, disabilities and wider health and societal impacts from respiratory diseases in the most disadvantaged populations across Africa. Combined, respiratory conditions including pneumonia, chronic obstructive pulmonary disease, influenza, asthma, tuberculosis, lung cancer and COVID-19 are the leading causes of death and disability both in Africa and globally. Despite this, knowledge and awareness of respiratory diseases are low, and they do not get the priority attention they need from health systems, policymakers and funding agencies. An interdisciplinary group of academics, policymakers, representatives of non-governmental organisations (NGO), patients and civil society will implement a 4-year programme starting in Sept 2024 to address key respiratory diseases in five African countries where morbidity and mortality from respiratory diseases are very large: Nigeria, Kenya, Cameroon, Cote d’Ivoire, and South Africa. This is a collaboration co-led by the University of Edinburgh, UK and the University of Lagos, Nigeria, that is supported by a wide network of institutions and organisations in Africa and internationally. EQUI-RESP-AFRICA will build strong, equitable partnerships and develop capacity with research groups in African partner countries. It will focus on several lines of work based on local research priorities, which will be supported by cross-cutting platforms. These activities will generate new knowledge and use it to improve healthcare for the most underprivileged and support the development of appropriate health policies. The cross-cutting platforms will focus on knowledge exchange and capacity building in data science, digital health and innovation; then, on strong stakeholder and community engagement; and on data-driven formulation of health policies based on tools. It will prioritise the implementation of equitable interventions appropriate to each African context and tailored to patients’ needs. Strong community engagement and Involvement (CEI) strategies, and wide networks covering policy makers, local healthcare providers and NGOs will be developed to improve the relevance and impact of our research and reduce health inequity. We will focus on the problems of the poorest and underprivileged groups and on opportunities to improve gender equity in our network of partner countries. This project has 6 objectives: 1. Synthesise the existing knowledge to map the landscape of respiratory medicine in African partner countries. The focus will be on life-threatening respiratory infections, such as pneumonia and influenza, and also on chronic conditions silently present in many Africans: chronic obstructive pulmonary disease (COPD), asthma, and tuberculosis. 2. Assess how much the health systems in African partner countries are prepared for dangerous emerging respiratory infections, such as COVID-19 and possible pandemic strains of influenza and other diseases. This line of work will study the factors that could undermine a decisive epidemic response and assess the capacity and security for providing oxygen treatment. It will then explore how local health workers adhere to internationally accepted guidelines for diagnosis and treatment. 3. To conduct a study on the feasibility of introducing a programme of pulmonary rehabilitation and its effectiveness. This line of work will also evaluate the role of preventable risk factors for respiratory conditions, e.g. tobacco smoking and exposure to indoor and outdoor air pollution, which underlie millions of deaths globally each year. 4. To build capacity in research methods, data science, digital health, AI and innovation among researchers in African partner countries. 5. To engage relevant in-country stakeholders and community representatives and to raise awareness of respiratory health. 6. To translate quality evidence to health policy using specific, evidence-based, data-driven tools to identify priorities and improve equity. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Edinburgh UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 447868.68 786494.02 699306.87 615001.86 399969.14 2948640.57 GB-GOV-10-GHRG_4_156234 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 63981.24 GB-GOV-10-GHRG_4_156234 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 191943.72 GB-GOV-10-GHRG_4_156234 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 19489.84 GB-GOV-10-GHRG_4_156234 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 153389 GB-GOV-10-GHRG_4_156234 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 217550.12 GB-GOV-10-GHRG_4_156234 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 170514.94 GB-GOV-10-GHRG_4_156234 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 162574.21 GB-GOV-10-GHRG_4_156234 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh GB-GOV-10-GHRG_4_156261 UK - Department of Health and Social Care (DHSC) This research programme addresses the problem of poor and inequitable access to quality primary healthcare for chronic obstructive pulmonary disease (COPD) patients in South America. COPD is the fourth leading cause of death in the continent, with a high hospital healthcare and societal burden, disproportionately affecting the poor. More than 75% of cases remain undiagnosed, therefore untreated. Building on a previous Global Health Research Group in Brazil, the aim of the programme is to develop primary care research capacity in South America (specifically Argentina, Brazil, and Peru) to improve earlier identification and management of COPD. It is co-led by the University of Birmingham (UoB) and the Universidad Cientifica del Sur (UCSUR) in partnership with CRONICAS Centre of Excellence in Chronic Diseases in Peru. The co-leads work in an equitable partnership with the Institute for Clinical Effectiveness and Health Policy (IECS) in Argentina and the University of São Paulo (USP) in Brazil. The three partner Institutions (‘hubs’) in South America will work with and build capacity amongst colleagues from 2-3 less-experienced institutions (‘spokes’), situated in contrasting geographical/economic areas which include the most disadvantaged populations. Over four years, starting in July 2024, Breathe Well partners will develop a set of COPD quality indicators, and an identification pathway for COPD patients in primary care. They will test the feasibility of these in different settings, and model the preliminary cost-effectiveness of the pathway and its potential impact on health inequalities. Based on the outcomes of the work, partners will then submit funding applications for full trials of the developed interventions. The project has 8 objectives: 1. Develop sustainable research infrastructure and research leaders, in order to deliver high quality COPD research in primary care in South America. This will involve training individuals on a range of generic, clinical and research skills and methods, and engaging with academic, clinical and funding institutions to sustain future research. 2. Develop sustainable engagement with community members, clinical leaders and policy stakeholders, to ensure research is rooted in local, national and regional needs with clear pathways to impact on health and healthcare. The core project partners will provide training and mentoring for local teams to identify, engage, influence and work with relevant stakeholders, in order to ensure sustainability of impact. 3. Assess the current quality of COPD primary care in Argentina, Brazil and Peru. This assessment will cover governance and the policy context, foundations, processes, quality and inequities, as well as the quality of electronic healthcare records (EHR). 4. Develop a set of COPD quality indicators. These indicators will be used to monitor and improve the quality of care. 5. Co-develop/adapt a pathway of identification and management of COPD patients in primary care, from early diagnosis through management and self-management. The pathway will be based on locally-appropriate, team-based, task-sharing implementation. 6. Test feasibility of implementation. The pathway will be tested, including a comparison of different settings to evaluate its potential impact in different segments of society. 7. Model preliminary cost-effectiveness of the pathway and potential impact on health inequalities. The pathway will be assessed using exploratory decision model-based health economic analyses from both healthcare and societal perspectives. 8. Submit funding applications for full trials of the developed interventions. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Birmingham UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 413127.75 741203.11 760881.22 765352.12 344163.02 3024727.22 GB-GOV-10-GHRG_4_156261 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 137709.25 GB-GOV-10-GHRG_4_156261 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 137709.25 GB-GOV-10-GHRG_4_156261 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 104438 GB-GOV-10-GHRG_4_156261 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 123298 GB-GOV-10-GHRG_4_156261 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 151472 GB-GOV-10-GHRG_4_156261 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 94736 GB-GOV-10-GHRG_4_156261 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 175427.04 GB-GOV-10-GHRG_4_156261 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 162742.86 GB-GOV-10-GHRG_4_156261 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham GB-GOV-10-GHRG_4_156297 UK - Department of Health and Social Care (DHSC) Antimicrobial resistance (AMR) is a global health security priority that is expected to severely impact health outcomes in low-income countries with inappropriate use of antibiotics being a key driver. Antibiotic prescribing and use (ABU) must be optimised to ensure patients with life-threatening illnesses receive appropriate medication while decreasing unnecessary prescriptions. This challenge is complicated by the lack of affordable, accurate and rapid diagnostics to support antibiotic stewardship by local health systems. Our focus is on community-based facilities where clinicians have limited time for therapeutic decision-making and where the emergence of AMR is a marker of failure of the health system to deliver quality care (QoC). Our Research Group comprises research institutions in the UK, Liverpool School of Tropical Medicine (LSTM), Uganda (Makerere University and doctors for Africa CUAMM (Collegio Universitario per Aspiranti Medici Missionari)), Zambia (Centre for Infectious Disease Research in Zambia - CIDRZ) and Malawi (Malawi Liverpool Wellcome Trust Centre). In Uganda, Zambia, and Malawi, we will rapidly assess the QoC for febrile children under 5-years of age to understand drivers of inappropriate ABU and support quality improvement at the health system level. To contribute to understanding drivers of AMR, we will develop a method for sentinel surveillance of key pathogens to identify regional differences in AMR prevalence and ABU in local health facilities and ABU in local communities. Using community data at two time points we will assess and develop local solutions to address inappropriate ABU and prescribing practices. Our aim is to understand the AMR-ABU linkage and improve practices exacerbating AMR using a new surveillance system which can be locally sustained. Our project is located in three sub-districts in each country with assessments taking place at two time points to assess progress improving ABU and reducing AMR. The project will take place from August 2024 to July 2028. This project has 4 objectives: 1. Develop a surveillance system for tracking antibiotic use (ABU) and antimicrobial resistance (AMR) in three districts in Uganda, Malawi, and Zambia, assessing clinical care quality in lower-level health facilities for febrile illnesses. 2. Investigate the relationship between quality of clinical care (QoC) in health facilities and AMR to key antibiotics by sampling febrile children to measure AMR prevalence and resistance patterns. 3. Explore community-level drivers of ABU and AMR focusing on childhood febrile illnesses through surveys measuring caregivers' knowledge and practices, complemented by qualitative analysis for insights into health perceptions. 4. Assess the risk of AMR development by analysing genomic traits from swab samples, detailing circulating resistance genes, and experimentally evolving bacterial isolates to evaluate potential resistance emergence. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 482806.9 658876.36 721912.21 749516.7 396968.42 3010080.59 GB-GOV-10-GHRG_4_156297 COMMITMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 301754.31 GB-GOV-10-GHRG_4_156297 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 213360.92 GB-GOV-10-GHRG_4_156297 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 167314 GB-GOV-10-GHRG_4_156297 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 178003.74 GB-GOV-10-GHRG_4_156297 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 149600.86 GB-GOV-10-GHRG_4_156297 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 185121 GB-GOV-10-GHRG_4_156297 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-GHRG_4_156363 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership to address the sexual and reproductive health rights (SRHR) of young migrants, by creating lasting interventions with young people to raise awareness of their eligibility for SRHR and promote the responsiveness of services in Zambia and South Africa. We aim to build resilient mobile adolescent and young people’s social networks that enhance visibility and solidarity, as well as inform policy and practice on building responsive SRHR services for mobile adolescent and young people in southern Africa. Between 2024 and 2028, we will take a theory-based and systems perspective to synthesise two complementary concepts: candidacy and the framing of health systems’ responsiveness. This will place mobile adolescent and young people’s experiences of engaging with systems/services at the centre of addressing their needs, emphasising the importance of a deeper understanding of context at individual, community, institutional, and systems levels. Central to our approach is the involvement of mobile adolescent and young people in all stages, from problem identification, selection of interventions, approaches to delivery, monitoring and evaluation, results dissemination, and planning next steps. This project will approach capacity strengthening in a comprehensive way, by nurturing the careers of early and mid-level researchers and ensuring community engagement and involvement throughout. This will contribute to enhancing and sustaining individual skills and expertise; relevant organisational systems and processes and group/network-level partnerships. By the end of the project, we will have developed interventions to improve mobile adolescent and young people’s access to SRHR services; co-created systems to monitor service responsiveness; supported identifiable youth-led approaches which enhance mobile adolescent and young people’s visibility; and established early/mid-career African researchers as research leaders. The project has 5 objectives: 1. Synthesise evidence that examines causation in youth-led health research to identify effective approaches and emergent processes that enhance health systems responsiveness and improve access to SRHR services for mobile adolescent and young people (mAYP) in southern Africa. 2. Anchored by youth-led social mobilisation, to co-develop and implement interventions with young people that support mAYP to recognise their candidacy and access sexual and reproductive health services, working with health-care stakeholders to identify ways to make care more responsive to mAYP requirements. 3. Co-produce and use a participatory monitoring and evaluation process in the piloting of the co-developed interventions, assessing their feasibility (including resource needs), acceptability, and equitable reach. 4. Continuously engage and involve communities and other stakeholders to encourage and facilitate youth-led mobilisation to nurture their resilience and support facility/provider responsiveness to the health and well-being needs of mAYP. 5. Consolidate and strengthen South African and Zambian researcher’ skills and agency to navigate the inequitable power dynamics in health research, promoting their visibility and shared intellectual leadership across Zambia, South Africa, and in the UK, to influence practice and policy in relation to the health and wellbeing needs of mAYP. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 511890.96 767206.63 741073.76 682554.09 318324.42 3021049.86 GB-GOV-10-GHRG_4_156363 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 170630.32 GB-GOV-10-GHRG_4_156363 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 170630.32 GB-GOV-10-GHRG_4_156363 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 43820 GB-GOV-10-GHRG_4_156363 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 111722 GB-GOV-10-GHRG_4_156363 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 189811.95 GB-GOV-10-GHRG_4_156363 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 120309.18 GB-GOV-10-GHRG_4_156363 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-GHRG_4_156365 UK - Department of Health and Social Care (DHSC) Acute fever is a leading cause of child mortality in sub-Saharan Africa, responsible for 40% of child deaths (1.2 million fatalities) annually. Children presenting with acute fever are frequently assumed to have malaria or bacterial infections, leading to inappropriate treatments. A significant portion of these children likely suffer from zoonotic infections—diseases transmitted from animals to humans. Diagnosing these infections is challenging because healthcare professionals often lack training, and testing for zoonotic diseases is limited in much of Africa. Our Global Health Research Group aims to address this issue by: 1. Determining which zoonotic infections are most prevalent in the region. 2. Developing effective, new diagnostic tests for these infections. 3. Establishing evidence-based guidelines to aid healthcare professionals in diagnosing and treating zoonotic infections. Our research group unites experts from the UK (University of Liverpool and Liverpool School of Tropical Medicine) and Africa (Kabale University and Makerere University in Uganda; University of Nairobi and the International Livestock Research Institute [ILRI] in Kenya; and Addis Ababa University and ILRI in Ethiopia). Our methodology includes: • Conducting studies in rural and urban areas of Uganda, Kenya, and Ethiopia to understand the symptoms, causes, and risk factors of fever in children. • Developing and assessing new tests for zoonotic infections to determine their feasibility for use in clinical or research settings. • Engaging with communities and healthcare providers to understand their perceptions of the causes of fever and the challenges they face in treatment, as well as how healthcare is accessed by those who are sick. Through these studies we aim to develop tools and guidelines for diagnosing and treating acute fever in children in our target countries. Additionally, we will focus investment and training to enhance the capabilities of our partner institutions in detecting zoonotic infections and nurturing future leaders in zoonotic disease research. During the project lifespan (July 2024 - June 2028), our group will improve the local capacity to diagnose zoonotic infections and introduce new diagnostic tests. In the medium to long term, better detection and reporting of zoonotic infections will lead to more accurate treatment of fever, thereby reducing childhood mortality and curbing the misuse of antimalarial and antibiotic treatments. The project has 4 objectives: 1. Determine the common zoonotic causes of acute febrile illness and associated factors in paediatric patients living in urban and rural areas of Uganda, Kenya and Ethiopia. 1.1 Quantify the burden of non-malarial fever and identify the major zoonotic aetiologies. 1.2 Identify risk factors for and clinical indicators of infection with specific zoonotic pathogens. 2. Develop and test novel technologies and approaches for diagnosing zoonotic causes of acute febrile illness that are suitable for use in low- and middle-income countries and field settings. 2.1 Evaluate point-of-care tests and pilot prototype molecular diagnostic platforms for key zoonotic pathogens. 2.2 Determine the best sequence of tests to optimise diagnosis of fever. 3. Involve communities and the health sector in Uganda, Kenya and Ethiopia in defining improved approaches to diagnosis and management of zoonotic causes of acute febrile illness. 3.1 Identify community perceptions on the causes of acute febrile illness and care seeking behaviours for fever. 3.2 Develop and validate a decision support tool for diagnosis and management of zoonotic causes of acute febrile illness in clinical settings. 4. Strengthen capacity and capability for research on diagnosis and management of zoonotic diseases in Uganda, Kenya and Ethiopia. 4.1 Develop and implement evidence-based capacity strengthening plans to ensure that all partner-affiliated laboratories have the capability to perform quality-assured molecular diagnostics research for zoonotic infections. 4.2 Develop a cohort of clinical and laboratory scientists with expertise in zoonotic causes of acute febrile illness. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 526852.8 763323.75 798509.26 477498.5 232125.32 2798309.63 GB-GOV-10-GHRG_4_156365 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 175617.6 GB-GOV-10-GHRG_4_156365 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 175617.6 GB-GOV-10-GHRG_4_156365 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 166605 GB-GOV-10-GHRG_4_156365 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 197613 GB-GOV-10-GHRG_4_156365 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 48900 GB-GOV-10-GHRG_4_156365 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 104807 GB-GOV-10-GHRG_4_156365 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 144696.25 GB-GOV-10-GHRG_4_156365 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 62214.08 GB-GOV-10-GHRG_4_156365 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool GB-GOV-10-GHRG_4_156442 UK - Department of Health and Social Care (DHSC) Ear disease and hearing loss are common and under-recognised disorders, with 80% of the 1.6 billion people with hearing loss living in lower- and middle-income countries (LMICs). Hearing loss affects individuals, society, and the economy, through effects on health, education, employment, and community. Recent advances in developing a low-cost high-performance hearing aid could help many, but will fail to support two of the most disadvantaged groups: those with persistent or recurrent ear discharge due to a hole in the ear drum (a disorder called chronic suppurative otitis media, CSOM) and those who are born deaf. CSOM affects predominantly those in LMICs, and it is thought that 250 million people are affected. In CSOM, a hole in the ear drum leads not only to hearing loss, but also to intermittent or continuous discharge of pus that is stigmatising and precludes use of a conventional hearing aid. For those born deaf, hearing aids cannot help as the loss is too severe. In many LMIC communities, these children are erroneously assumed to lack intelligence, so denied access to education or means of communication. Our team has pioneered and undertaken feasibility studies for three novel solutions that enable community-led self-care for ear and hearing disorders in LMICs: 1. Iodine antiseptic washout for active ear discharge in children and adults with CSOM. Iodine has the potential to treat infection, is widely available in LMICs, and is not toxic to the ear. 2. Low-cost bone-conduction aids for hearing loss in children and adults with CSOM. Bone conduction sends sound through vibration of the skull and so circumvents the diseased ear drum. 3. Web and app-based digital sign-language dictionaries to connect deaf children, their parents and communities, and empower the deaf community. This software has been developed and optimised over the past 8 years for Pakistani sign language by project partner Deaf Reach, and could be adapted to sign languages in other countries. Almost all existing research partnerships in ear and hearing care are based in high-income countries, despite the large burden of disease in LMICs. This will be a four-year project from September 2024 to August 2028, to develop an international team to instigate and support these and other future trials in the field of ear and hearing care in LMICs, partnering with local clinical teams and universities. We will develop capacity in research, in ear and hearing care in three low-income countries: Zambia, Cambodia and Malawi. Our project is focused on developing community-based solutions, so it has and will continue to include community members in developing and steering the project. Our solutions, we hope will enable people to stop their ear discharge and/or recover functional hearing, leading to improvements in self-confidence, socialisation, education and employability, with advantages to community and society as well as individuals. The project has 4 objectives: 1. To evaluate the lived experience of individuals living with chronic suppurative otitis media (CSOM) and children who are deaf, and the attitudes knowledge and beliefs of their families, teachers and community, to ensure current and future interventions are sensitive to their needs. 2. To evaluate the effectiveness and uptake of interventions for community-based ear and hearing care: topical iodine for ear discharge in people with CSOM, low-cost bone conduction headsets for people with CSOM, and digital sign-language dictionaries for empowering deaf culture. 3. To train four PhD researchers in our partner countries (Malawi, Cambodia, Zambia) to become the academic leaders of the future in this field. 4. To develop a global academic team that will lead future research in ear and hearing, focused on real world change, through impact on healthcare policy and practice. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Sussex UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 635031.55 782475.78 508561.73 495050.26 352682.03 2773801.35 GB-GOV-10-GHRG_4_156442 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Sussex 362875.17 GB-GOV-10-GHRG_4_156442 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 185580.15 GB-GOV-10-GHRG_4_156442 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 237883.74 GB-GOV-10-GHRG_4_156442 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 151215.39 GB-GOV-10-GHRG_4_156442 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex GB-GOV-10-GHRG_4_156467 UK - Department of Health and Social Care (DHSC) The application of genomics to the analysis and interpretation of virus outbreaks is now widely adopted in disease response, as was the case in the COVID-19 pandemic. However, the effective use of genomic science is contingent on having relevant technical capacity closely linked to national and local public health systems. These two components are often not established or indeed integrated. This project will produce optimised genomics analysis protocols for investigating past and future virus outbreaks in Central/East Africa and will strengthen links between technological developments, reference testing laboratories and public health authorities. The key aim is to develop more effective public health responses. The different data types/sources collected from outbreaks will be converged in new mathematical models to forecast the potential impact of various intervention scenarios. The project will closely link with health systems in each of the countries involved. The lead institutes in this study are the University of Warwick, UK, and KEMRI-Wellcome Trust Research Programme, Kenya, for the mathematical modelling and genomics development/analysis, respectively. At its conclusion, we aim to have set up (a) critical sequencing/bioinformatics protocols in at least three regional reference laboratories (one in each of Kenya, Comoros and Democratic Republic of Congo), (b) enhanced local virus outbreak response expertise in genomics and modelling through purposive research mentorship opportunities and short courses on current cutting-edge approaches, and (c) relevant structures to support the rapid translation of genomics insights to outbreak responses. At all the key project implementation phases, we aim to adequately consult critical community and public health stakeholders to identify local priority infections and co-develop best practices in genomics/modelling evidence requirements and presentation for optimal intervention impact. The project will be implemented between 2024-2027. This project has 7 objectives: 1. Create a suite of optimised readily accessible and adaptable virus genome sequencing and bioinformatic protocols for priority outbreak pathogens in Central/East Africa - these will be made available for rapid deployment in reference labs for improved outbreak public health response. 2. Transfer sustainable technical capacity in virus sequencing and bioinformatic analysis to three collaborating reference laboratories (in Kenya, Comoros and Democratic Republic of the Congo) - this will include mentorship of identified individuals in these labs to oversee future application of virus genomics in outbreak response of their labs. 3. Investigate pathogen aetiology for select previous disease outbreaks with unknown aetiology by applying broad diagnostics/agnostic sequencing methods on samples archived in our partner labs - specific pathogen positive samples will be henceforth whole genome sequenced to provide data for elucidating the origins, dispersal patterns, and evolution of endemic and emerging viruses that have caused virus outbreaks in Central and East Africa. 4. Through integrated epidemiological analysis of genomic and case data, we will advance understanding of the nature of past and prospective virus outbreaks during the project lifetime - we will develop and apply the mathematical models that converge these data types for improved insights and better public health response. 5. Generate wider involvement in sequencing, genomics analysis and outbreak modelling within the Central/East Africa region by naturing local human resource capacity through targeted training, and mentorship of budding expertise - we will offer a competitive and closely mentored Research Fellowship scheme for growth of expertise in the region. 6. Strengthen the collaborative link between the University of Warwick and KEMRI-Wellcome Trust Research Programme for enhanced synergy of their areas of strength, genomics and epidemiological modelling, respectively. 7. Improve understanding, and potentially, uptake of genomics and mathematical modelling insights in outbreak response among key stakeholders in local/country level health systems. We will have an end-to-end involvement of relevant community stakeholders impacted by disease outbreaks in implementing the modern genomics/modelling advances. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Warwick UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 527185.32 807679.88 806387.63 853025.66 2994278.49 GB-GOV-10-GHRG_4_156467 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Warwick 351456.88 GB-GOV-10-GHRG_4_156467 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 341931.73 GB-GOV-10-GHRG_4_156467 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 212855.25 GB-GOV-10-GHRG_4_156467 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 245054.38 GB-GOV-10-GHRG_4_156467 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick GB-GOV-10-GHRG_4_156517 UK - Department of Health and Social Care (DHSC) This research is going to explore the questions of how racism and social disadvantage impact the mental health of Black Brazilians and how capacity can be built in research and healthcare around intersectional, anti-racist mental healthcare provision in Brazil. Brazil is a highly socio-racially unequal society where Black communities are characterised by extreme poverty, racial and social discrimination, and restricted access to health services. Brazil has high levels of unmet mental health problems in Black communities, leading to significant impact on quality of life, poor health outcomes and reduced educational/employment opportunities. There is a significant gap both in research and interventions on racism in mental health, notably from an intersectional approach. The aims are to establish an urgently needed evidence base on racism and mental health in Brazil, and co-design effective, context-bespoke and culturally acceptable interventions to address mental health needs in underserved Black Brazilian communities. The objectives are to produce intersectional knowledge on racism and mental health; to conduct research with Black Brazilians; to co-develop community mental health interventions and training packages; to influence mental health policy in Brazil and the wider region; and to build sustainable research capacity. This is a 4-year multidisciplinary mixed-methods study informed by a participatory action approach and underpinned by robust community engagement and involvement (CEI). Research through 4 case studies in quilombola and favela communities and mental healthcare services in the states of Bahia and São Paulo in Brazil. Completion: research by mid-2026; interventions and evaluation by early 2028; dissemination by mid-2028. The strength of the project lies in the collaboration with 12 project partners from the health community, civil society, government, and international science community, which will aid rapid dissemination and achieve high impact. The project 'Mental Health Policy Network' will disseminate the new evidence on racial and social discrimination in mental health through presentations, open access publications, podcasts, videos, and a bilingual website. The project will establish a sustainable platform for future global mental health researcher-leaders and healthcare professionals. The project directly addresses the UN Sustainable Development Goals (SDGs) by promoting health and well-being for all. The project has 6 objectives: 1. To produce intersectional knowledge on the effects of racism on mental health in Brazil. 2. To conduct socially engaged research with underserved Black communities in Brazil. 3. To co-develop, with community members and stakeholders, community mental health interventions and training packages. 4. To recommend and influence mental health policy at municipal, state and national levels in Brazil. 5. To foster cross-cultural learning on racial and social inequalities in relation to mental health care in the Latin American and Caribbean (LAC) region. 6. To build sustainable research capacity on inequalities in mental health through the group on racism and social inequalities (ORI) partnership. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Kent UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Brazil Medical research Research and Innovation 244982.59 518081.93 760771.92 758334.12 734137.23 3016307.79 GB-GOV-10-GHRG_4_156517 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Kent 244982.59 GB-GOV-10-GHRG_4_156517 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Kent -40471.84 GB-GOV-10-GHRG_4_156517 2025/26 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Kent 213160.95 GB-GOV-10-GHRG_4_156517 2025/26 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Kent 246007.35 GB-GOV-10-GHRG_4_156517 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Kent 163694.77 GB-GOV-10-GHRG_4_156517 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Kent GB-GOV-10-GHRG_4_156521 UK - Department of Health and Social Care (DHSC) Pregnancy can be a particularly difficult time for women facing adversity or mental health issues. These challenges can affect the mother's well-being, employment, and community engagement. As the mother is at a higher risk of poor birth outcomes and postnatal depression, potentially impacting her ability to care for her child after birth. The child of a woman with antenatal depression, anxiety or stress during pregnancy is at twice the risk of cognitive, social, emotional, and behavioural problems. Delivering universal preventive interventions has the potential for broad impact and long-lasting consequences for mothers and their children, offering a scalable solution for improving maternal mental health without the need for screening, which is often unfeasible in resource-constrained settings. Working with pregnant women and local women’s groups in The Gambia, we co-developed a music based intervention, CHIME (Community Health Intervention through Music Engagement) that involves pregnant women meeting for 6 weeks to make music together, drawing on community songs, adapting lyrics to give messages around maternal health and support, lifting mood and creating a supportive network. Building on outcomes from our published feasibility trial, researchers and academics from The Gambia, South Africa, Lesotho and UK will work with local communities, those with lived experience and other stakeholders to test effectiveness and cost-effectiveness in the Gambia via a full trial; test generalisability to an urban context in South Africa via a co-development process and feasibility trial and explore the potential uses of music for maternal mental health promotion in Lesotho, a rural context with rich culture around traditional and popular music, but where capacity around health promotion strategies is lacking. The project and research will be conducted over a 4 year period from September 2024 to August 2028. Measures of effectiveness will focus on maternal mental health, wellbeing and functioning, as well as collected clinic data (antenatal care attendance, institutional delivery, birthweight, birth complications, breastfeeding success, vaccination uptake) and infant outcomes, via a parental self report. Through community and stakeholder partnership building, we will explore pathways for the CHIME intervention to be scaled and implemented. The primary target for impact is improvement in mental health and well-being of antenatal women, with cascading effects for their children, families, community and society. The project has 8 objectives: 1. Mentor, train and collaborate with researchers and non-academic partners across all sites to build capacity for research, both relevant to Community Health Intervention through Music Engagement (CHIME), and to advancing expertise and skills relating to maternal mental health, public mental health and community-based interventions. 2. Engage with perinatal women, their families and communities as well as other stakeholders across all three sites to equip, engage and empower them to play a significant and sustainable role in the project. 3. Comprehensively describe, through stakeholder input, how the CHIME intervention works in context, at both a cross-country and country-specific level, to inform intervention development, trial design, outcome measures and scenarios for implementation. 4. Explore opportunities and develop partnerships for the future expansion of CHIME with a view to planning for its implementation in Lesotho. 5. Adapt and conduct the CHIME intervention in Khayelitsha, South Africa in partnership with community members and service providers and test the feasibility of evaluating it through a cluster RCT. 6. Test the effectiveness, cost effectiveness and asses the proposed mechanisms of action of CHIME in the Gambia. 7. Co-develop plans for scaling CHIME and assess their budget impacts and return-on investment in the Gambia and South Africa. 8. Utilise the knowledge generated through the CHIME research activities to influence policy and practice in the development and implementation of participatory-music based interventions for maternal mental health in the study countries and regions. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Roehampton University UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 373119.86 690704.76 693592.45 646723.44 403017.96 2807158.47 GB-GOV-10-GHRG_4_156521 COMMITMENT UK - Department of Health and Social Care (DHSC) Roehampton University 373119.86 GB-GOV-10-GHRG_4_156521 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Roehampton University 122255.81 GB-GOV-10-GHRG_4_156521 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Roehampton University 134355 GB-GOV-10-GHRG_4_156521 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Roehampton University 181817.95 GB-GOV-10-GHRG_4_156521 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Roehampton University 70554.61 GB-GOV-10-GHRG_4_156521 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Roehampton University GB-GOV-10-GHRG_4_156579 UK - Department of Health and Social Care (DHSC) This Global Health Research Group (GHRG) aims to develop a simple, cheap imaging solution to screen for tuberculosis (TB). The World Health Organization strategy to "End TB” by 2035 requires more people to be screened, diagnosed, and treated for TB. Current screening guidelines include chest x-ray, but this is inaccessible to many of the poorest people worldwide who are most in need of screening for TB. Ultrasound may be an alternative, as it is a simple and safe procedure that can be used for adults and children. Portable ultrasound probes (“Point-of-care” ultrasound, POCUS) that can connect to mobile phones could be placed at the lowest levels of the health care system in countries most affected by TB. Initial research is promising, but highly trained health workers able to interpret ultrasound images are not widely available. Therefore, artificial intelligence (AI) could provide a solution. This GHRG will bring together researchers from the London School of Hygiene and Tropical Medicine (LSHTM) and Imperial College in the UK with researchers from four high TB burden countries; Centro de Investigacao em Saude de Manica (CISM) in Mozambique, Zambart in Zambia, Prisma in Bolivia and Peru, alongside Delft Imaging to develop an AI-supported POCUS tool. The project will conduct research over 4 years (2024-2028) to co-design an AI-POCUS tool. We will collect clinical, microbiological and imaging data to determine whether it is an effective tool for TB screening. To develop the AI reading, large numbers of images and data are needed, posing challenges with data privacy and ownership if data is transferred to a central source. The GHRG will therefore conduct research around the broader ethics of data privacy and transfer, and will pilot a “federated machine learning approach”, which involves all sites retaining full ownership of their data and concurrently training a general machine learning model on-site, before combining these models into a centralised one. Clinical performance and costs of a final version of an AI-supported POCUS product will then be assessed across the four sites in adults and children being investigated for TB. The GHRG will finally present the findings and discuss the roadmap to the further development of the product with communities affected by TB and policy makers. We will also produce a training package for health workers to facilitate adoption beyond the facilities and countries in this GHRG. This project has 5 objectives: 1. To create a network of multi-disciplinary researchers, clinicians, communities affected by TB, industry partners, and policy makers for integrated capacity strengthening, co-design and evaluation of an artificial intelligence-supported point-of-care ultrasound (AI-POCUS) for TB screening in children and adults. Using a model of equitable research partnerships the group will jointly make decisions on the best protocols to answer the research questions and evaluate the final product. We will include community-led research to understand the user perspective of AI-POCUS. We will build capacity in research and in the generation and ethics of artificial intelligence. 2. To optimise different point-of-care ultrasound (POCUS) acquisition protocols and training methodologies in different epidemiological contexts. We will conduct formative studies, including qualitative research, in the four countries to assist in the design of the final AI-POCUS model. 3. To automate the reading of point-of-care ultrasound by contextualizing the AI-POCUS approach at health facility level in low- and middle-income countries, broaden the understanding around the ethics of data sharing in artificial intelligence (AI) and pilot a distributed collaborative machine learning approach. We will establish a federated learning network with each country using its own data to train a machine-learning algorithm which will be shared across the network. Maximizing learning while minimizing the risks of data sharing. The outcome of objectives 2 and 3 will be a functional AI-POCUS model. 4. To evaluate the clinical performance, acceptability and costs of implementing AI-POCUS. The AI-POCUS model developed from objectives 2 and 3 will be evaluated through a unified protocol in the 4 country sites. 5. To disseminate research findings to maximise uptake of an AI-POCUS for TB. Dissemination will involve local, national, and international dissemination and publication of main outcomes in scientific journals. We will develop a training kit for users and work with our industry partner to package and promote a successful AI-POCUS tool more widely. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 591428.28 743487.16 655845.31 536973.94 266043.48 2793778.17 GB-GOV-10-GHRG_4_156579 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 197142.76 GB-GOV-10-GHRG_4_156579 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 197142.76 GB-GOV-10-GHRG_4_156579 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 17241 GB-GOV-10-GHRG_4_156579 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 91272 GB-GOV-10-GHRG_4_156579 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 136982 GB-GOV-10-GHRG_4_156579 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 162932 GB-GOV-10-GHRG_4_156579 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 200741.74 GB-GOV-10-GHRG_4_156579 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 112093.55 GB-GOV-10-GHRG_4_156579 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-GHRG_4_156644 UK - Department of Health and Social Care (DHSC) Around 150 million people alive today have survived Tuberculosis (TB), but many will still suffer from the post-TB consequences. Almost all TB survivors live in countries where there is limited or no care available, which leads to much suffering. Our Post-TB Centre for Assessment and Research Excellence (CARE) project will help us to understand what care TB survivors need, and what care can be provided in places where options are very limited, but the needs are high. In our Post-TB CARE project, we will first look at how TB survivors still suffer the consequences from TB after their medication is completed. Then we will ask TB survivors, doctors, and nurses what they think is the best way to provide post-TB care in their community. This information will help us to design studies to assess potential methods for improving the lives of TB survivors and their families. Finally, we are building a team and centre in South Africa to lead post-TB research. We, at the London School of Hygiene & Tropical Medicine, Stellenbosch University, KHANA Center for Population Health Research and TB Proof are a group of researchers, doctors, care providers and TB survivors working together to make post-TB care better in the places where TB survivors live. We will be working with communities in South Africa and Cambodia with support from the United Kingdom. The study will start in August 2024, and we hope to have completed our work in 4 years. The project has 4 objectives: 1. What is needed: Develop an operational multidimensional assessment tool, which can quantify impairment in TB survivors to accurately assess post-TB care needs. We will take a patient-centred approach by creating patient listening groups to determine the reported needs of TB survivors and inform scope of development of the operational and reference assessment tools, followed by recruitment of TB survivor cohorts in South Africa and Cambodia. The data will be used to inform the tests of post-TB impairment we will apply, and how we identify the operational assessment tool based on simple and low-cost diagnostics. 2. How do we provide care: Design an effective, appropriate and sustainable post-TB care package for resource-limited settings, using good clinical governance. We will complete a pathway to understand preferences, combining qualitative and health economics methodology. We will conduct group discussions with TB survivors to identify care package components, followed by interviews with TB survivors and care providers in South Africa and Cambodia. These will inform attributes and levels for Discrete Choice Experiments (DCEs), where we can enumerate what patients and providers prefer in an effective, appropriate, and sustainable post-TB care package, evaluated with final interviews. 3. Share what we know: Create a knowledge sharing and advocacy platform for post-TB in high-burden TB settings. We will build knowledge sharing networks both online and in-person, within and across geographical regions. TB survivor and post-TB care provider led, we will conduct stakeholder mapping in South Africa and Cambodia to identify relevant groups and existing networks, develop an online hub for activities and train a new cadre of TB champions. 4. Future research leaders: Develop a multi-disciplinary centre of excellence for post-TB research, care and community engagement in South Africa to enable sustainable, collaborative south-south and north-south research partnerships in post-TB. We will develop a self-sustaining centre of post-TB excellence at Stellenbosch University (SU) through the work in Obj 1 to 3. TB survivor community perspective will be a leading voice, through an independent community advisory group. Financial sustainability of the centre will come via new funding applications, led by SU and Global South partners. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 643746.88 781512.29 688175.32 584091.15 328771.45 3026297.09 GB-GOV-10-GHRG_4_156644 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 402341.8 GB-GOV-10-GHRG_4_156644 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 92686 GB-GOV-10-GHRG_4_156644 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 214487 GB-GOV-10-GHRG_4_156644 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 178724 GB-GOV-10-GHRG_4_156644 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 119890.4 GB-GOV-10-GHRG_4_156644 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 258966 GB-GOV-10-GHRG_4_156644 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-GHRG_4_156700 UK - Department of Health and Social Care (DHSC) An estimated 10.6 million people develop tuberculosis (TB) disease each year, with a quarter of cases occurring in Africa. TB is damaging to the lives and livelihoods of patients and their families, often causing increased poverty and poor long-term health outcomes even after treatment. There is a strong overlap between the symptoms, presentation, and needs of patients with chronic respiratory diseases and TB disease. Both groups experience cough and breathlessness, and their first point of contact with health services is often through TB services. Risk factors for respiratory diseases and TB are similar and include smoking, occupational exposures, and HIV. TB can directly cause lung damage, and similar interventions are used to care for patients with respiratory diseases and post-TB lung disease, including pulmonary rehabilitation and inhaled medications. Despite this overlap, TB and respiratory care in low-resource settings are delivered separately. TB care is provided via strong and well administered National TB Programmes (NTPs), but respiratory care is provided via less well defined and poorly resourced health systems. As a result, patients with TB do not receive good respiratory care, and those with lung diseases are either undiagnosed and untreated, or given un-necessary TB treatment and antibiotics for their symptoms. Our previous work with patients, health care workers, and policy makers in Africa has shown a wish to develop integrated TB-respiratory care to improve patient outcomes. However, there are no models of how this might be achieved, and this has prevented services from being implemented on the ground. In this project we will develop a novel model of patient-centred integrated TB-respiratory care for implementation and evaluation in urban sites in three African countries: Nigeria, Kenya, and Tanzania. This work will be delivered by research partners in the UK (National Heart and Lung Institute at Imperial College London, University of Warwick), The Netherlands (Vrije Universiteit Amsterdam), Kenya (Centre for Respiratory Disease Research, Kenya Medical Research Institute), Tanzania (Kibong'oto Infectious Disease Hospital), and Nigeria (University of Lagos). The work will be completed together with local stakeholders and communities, to ensure that the services developed are suitable for local use. The project will run from July 2024 to July 2028. The project has 7 objectives: 1. To complete a literature review to understand potential models of integrated care, the impact of these, and approaches to evaluation. 2. To describe the burden of non-TB respiratory disease amongst patients presenting to TB services, to inform a diagnostic pathway for lung conditions. 3. To work with TB patients to understand the respiratory exposures they face, and how they address these, and to co-develop tools to empower them to improve their own respiratory health. 4. To understand the changes which would be needed to health systems in order to deliver integrated TB- respiratory care, and what the challenges and impact of this might be. 5. To understand the potential economic costs and benefits of integrated approaches to TB-respiratory care, and to develop a framework for formal economic evaluation of these models of care. 6. To map and engage with stakeholders and community members with interest or influence in TB and respiratory care. 7. To deliver sustainable research capacity strengthening in each site. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 525112.77 829606.93 840594.59 561397.92 269275.93 3025988.14 GB-GOV-10-GHRG_4_156700 COMMITMENT UK - Department of Health and Social Care (DHSC) Imperial College London 175037.59 GB-GOV-10-GHRG_4_156700 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 175037.59 GB-GOV-10-GHRG_4_156700 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 227344.29 GB-GOV-10-GHRG_4_156700 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 149317 GB-GOV-10-GHRG_4_156700 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 188296.89 GB-GOV-10-GHRG_4_156700 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 259816.59 GB-GOV-10-GHRG_4_156700 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 188693.91 GB-GOV-10-GHRG_4_156700 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London GB-GOV-10-GHRG_4_156746 UK - Department of Health and Social Care (DHSC) Globally, there are high rates of death among pregnant women and newborn babies due to poor quality of care. Reviewing deaths of mothers and babies helps health workers, governments and community members identify and solve issues in access and quality of care. This process, known as Maternal and Perinatal Death Surveillance and Response (MPDSR), can reduce deaths by a third. However, in many countries, MPDSR has not had the expected impact due to weak health systems with poor leadership, exclusion of communities from the process, insufficient resources, and lack of training. Fear of blame and punishment discourages people from reporting deaths or providing complete information, so discussions do not address the main issues, and the necessary actions are not taken. A lack of change demotivates health workers and communities. More evidence is needed on how to build a cost-efficient, acceptable MPDSR process, adapted and integrated within local country health systems. The project aims to improve reporting, review and response to deaths of mothers and babies in Ethiopia, Ghana and Uganda, and to evaluate the effect of doing this on death rates of babies. This 4-year project will work with community members and stakeholders in Uganda, Ghana, and Ethiopia to study how deaths of mothers and babies are currently identified, reported and reviewed, and what changes are made in response. This project is led by the University of Southampton in collaboration with the University of Ghana School of Public Health (Ghana), Haramaya University (Ethiopia), Mbarara University of Science and Technology (Uganda), University of Cape Town (South Africa), the World Health Organization, Liverpool School of Tropical Medicine, and Leiden University (the Netherlands). During phase 1 and 2 of the research (2024-2025), we will conduct in-depth research on current MPDSR practices and develop tools to address the main barriers to MPDSR implementation. In phase 3 (2026-2028), each country will introduce an intervention package of the tools developed in phase 2 into 3 districts, starting at different times. We will count deaths of women and babies before and during implementation. We estimate that the number of babies dying can be reduced by 30%. If this approach reduces deaths, and is cost-effective, countries will be supported to scale it up. Our materials will be made available online. This will help to reduce preventable deaths and improve quality of care for women and their babies. This project has 8 objectives: 1. To build strong relationships between researchers and community members. The intended outcomes of this objective are to establish community advisory boards (CABs) in each country; to ensure that research plans are relevant and meaningful to the community by incorporating feedback from CABs; and to improve understanding of the motivations and influence of different stakeholders in the MPDSR process. 2. To reduce fear of blame amongst for health workers, by improving laws and regulations. The intended outcomes of this objective are to make recommendations on changes to laws/regulations, so that information in MPDSR cannot be used as evidence against health workers; and to develop a complaints system that is separate from the MPDSR process. 3. To develop standardised tools for reporting and collecting information on deaths of pregnant women and babies. The intended outcomes of this objective are to produce standard tools for reporting maternal and perinatal deaths, and for collecting information about them; to create a system for tracking implementation of recommendations; and to improve the quality of data from health facilities. 4. To improve skills of health workers in conducting MPDSR. The intended outcome of this objective is to produce updated training packages that equip health workers and nursing/midwifery/medical students with the knowledge and skills needed to effectively implement MPDSR. 5. To monitor how well MPDSR is being carried out, what the process costs, and develop sustainable ways of financing it. The intended outcomes of this objective are to produce a standardised form to monitor the implementation of MPDSR; to estimate the cost of implementing MPDSR; and to create a novel mechanism to fund recommendations from MPDSR. 6. To empower communities to prevent the deaths of pregnant women and babies. The intended outcomes of this objective are to create a community death reporting system to provide comprehensive data on deaths in communities; produce standard simplified questionnaires on deaths for community health workers; create a community system for discussing deaths and making recommendations; and to create a training package for community health workers on bereavement counselling. 7. To develop a customised “toolbox” in each country through consultation with stakeholders on each of the tools developed under objectives 2-6, to improve the implementation of MPDSR. 8. To test the effectiveness of the “toolbox” by undertaking clinical trials in three districts in each country, with stagared start dates to allow for comparison. The intended outcome of this objective is to produce high-quality evidence on cost-effectiveness of the "toolbox" to improve the implementation of MPDSR. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Southampton UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 539116.74 756095.85 725870.32 684532.14 320161.77 3025776.82 GB-GOV-10-GHRG_4_156746 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Southampton 179705.58 GB-GOV-10-GHRG_4_156746 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 179705.58 GB-GOV-10-GHRG_4_156746 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 62197 GB-GOV-10-GHRG_4_156746 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 139125.21 GB-GOV-10-GHRG_4_156746 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 162481 GB-GOV-10-GHRG_4_156746 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 193133.74 GB-GOV-10-GHRG_4_156746 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 157479.16 GB-GOV-10-GHRG_4_156746 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 76191.49 GB-GOV-10-GHRG_4_156746 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton GB-GOV-10-GHRG_4_156750 UK - Department of Health and Social Care (DHSC) Dengue and other viruses transmitted by the mosquito 'Aedes aegypti' are a growing problem in West Africa, with increasingly frequent outbreaks. Control of the mosquito is the most effective way to protect humans. This project, which will run from 2024 to 2028, is based in Ouagadougou, Burkina Faso, where regular dengue epidemics have occurred in recent years. To carry out the research project, we have formed a collaboration between Liverpool School of Tropical Medicine (LSTM, UK), Université Joseph Ki-Zerbo (Burkina Faso), Institut de Recherche en Sciences de la Santé – Direction Régionale de l'Ouest (Burkina Faso), Spanish National Research Council (Spain), Institut de Recherche pour le Développement (France), University of Glasgow (UK) and King's College London (UK). We propose to develop a community-based approach for arbovirus outbreak prevention and response. We will collect data on the abundance and distribution of Aedes aegypti in different environments, their genetics and behaviour, human exposure to bites and circulating virus levels to model the forces governing dengue dynamics and to develop an improved index for virus transmission risk. Additional work will test the effectiveness of digital surveillance of mosquitoes using a mobile app to determine a potential role for citizen science. Trials will be conducted of different tools to control adult mosquitoes and immatures, including a large-scale community-embedded programme to determine the effectiveness of reducing mosquito breeding sources. Capacity building is embedded throughout, with the aim of developing skills in trial design and analysis, social science, community-based programme development and implementation, genetic diagnostics and genomics, serosurveillance, entomology and statistical modelling. Community engagement and involvement activities will play a crucial role throughout the project activities and have a dedicated work package supported by researchers based both in Burkina Faso and in Northern partner institutes. We believe that new evidence on arbovirus epidemiology in sub-Saharan Africa and a new generation of local specialists is urgently needed to fill the skills gaps from the bottom upwards and to equip African health systems with the experience, knowledge, and motivation to respond effectively to arbovirus outbreaks. The project has 5 objectives: 1. To develop improved indices for estimating arbovirus transmission risk through integrated modelling of adult Aedes aegypti abundance, distribution, and behavior, including factors such as genomic admixture, environmental covariables, human behavior, immunological biomarkers, and mosquito biting patterns. 2. To implement community-based surveillance for immature mosquito development sites, adult occurrence, and perceptions of mosquito biting using the Mosquito Alert mobile app, while cross-validating data through entomological monitoring of adult mosquitoes and larval sites, as well as bite biomarkers. 3. To conduct community-embedded interventions that include a large-scale cluster randomised controlled trial focused on larval source management and a phased suite of adult-targeted interventions tailored to local Aedes aegypti bionomics, culminating in a household-level randomised controlled trial of the most effective intervention strategies. 4. To enhance the capacity of researchers from Burkina Faso and extend this capacity to the wider West African region by integrating PhD topics within all project activities, along with outreach initiatives aimed at the broader West African research and vector control community. 5. To explore the interactions between human behaviour and mosquito biology, empowering citizens with knowledge and practical skills for mosquito control, thereby facilitating the successful implementation of relevant activities. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Burkina Faso Medical research Research and Innovation 701465.64 768384.8 668520.96 576945.06 287999.34 3003315.8 GB-GOV-10-GHRG_4_156750 COMMITMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 467643.76 GB-GOV-10-GHRG_4_156750 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 133255.91 GB-GOV-10-GHRG_4_156750 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 148605 GB-GOV-10-GHRG_4_156750 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 197041.25 GB-GOV-10-GHRG_4_156750 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 168968.24 GB-GOV-10-GHRG_4_156750 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 113236 GB-GOV-10-GHRG_4_156750 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-GHRG_4_156801 UK - Department of Health and Social Care (DHSC) We aim to set up the National Confidential Inquiry into suicide deaths, suicide ideation and suicide attempts for India (India Inquiry) by adapting the national confidential inquiry into suicide and safety in mental health (NCISH) from the UK to improve data capture and understanding of risk factors to inform suicide prevention and improve services for survivors in India. This research will focus on understanding of risk factors for suicide deaths from the administrative data at individual-level, and risk factors for suicide ideation and suicide attempt cases from the mental health services, identify gaps in this documentation, and will build consensus on a minimum data requirement and shared operational definitions for risk factors for these data to be utilised to plan, monitor and improve India’s response to suicide prevention. The project is a collaboration between the University of Manchester (UK), Public Health Foundation of India (New Delhi, India), the All India Institute of Medical Sciences (New Delhi, India), the Jawaharlal Institute of Postgraduate Medical Education & Research (Puducherry, India) and the Sisters Living Works (Mumbai, India). Between July 2024 and June 2028, we will contextually adapt the NCISH as India Inquiry, pilot and refine the India Inquiry approach, test the India Inquiry model in two states, one each in the north and south of India, and then present an adaptable model for use across India. This project aims to address the high burden of suicide deaths in India. An estimated 195,000 people died by suicide in 2019 in India, the highest number of suicide deaths globally. Furthermore, for every death by suicide in India, there are more than 200 people with suicidality and more than 15 suicide attempts. With the impulsive nature of suicide, and because hanging is increasingly the common method of suicide in India, there is an urgency to act upon suicide prevention. Suicide is the leading cause of death in the 15-39 age group in India, and the suicide death rate in Indian women is twice that of the global average for women. This research will contribute towards a comprehensive response to suicide prevention in India, which is to ensure that suicide does not continue to cost lives and adversely affect many millions through the loss of loved ones. This research is therefore anticipated to have substantial population health benefits. This project has 4 objectives: 1. To set-up India Inquiry by adapting the national confidential inquiry into suicide and safety in mental health (NCISH) in the UK for India to include suicide deaths captured in the police system and suicide ideation and suicide attempts in contact with mental health services. 2. To test the India inquiry model to document and analyse the common factors associated with suicide deaths, suicide ideation, and suicide attempts through the confidential inquiry. 3. To assess the validity of risk factors documented for suicide death cases in the police records at the time of filling report of suicide death with the police. 4. To disseminate the findings of India inquiry, recommendations for capacity-building for improved documentation of common factors associated with suicide deaths, suicide ideation, and suicide attempts, and explore barriers and facilitators for broader adaptation of the India inquiry. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Manchester UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU India Medical research Research and Innovation 295315.53 482629.61 529288.74 432163.02 199473.77 1938870.67 GB-GOV-10-GHRG_4_156801 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 98438.51 GB-GOV-10-GHRG_4_156801 2024/25 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The University of Manchester 98438.51 GB-GOV-10-GHRG_4_156801 2024/25 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The University of Manchester 88201 GB-GOV-10-GHRG_4_156801 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 73087 GB-GOV-10-GHRG_4_156801 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 41081 GB-GOV-10-GHRG_4_156801 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 25859.52 GB-GOV-10-GHRG_4_156801 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 17193.9 GB-GOV-10-GHRG_4_156801 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester GB-GOV-10-GHRG_4_156820 UK - Department of Health and Social Care (DHSC) Non-communicable diseases (NCDs) and the climate crisis jointly pose unequal burdens on the health of citizens, with implications for economies and sustainable development. Most of the premature death and disease from these causes happens in low- and middle-income countries (LMICs) and falls most heavily on the poorest and most vulnerable communities within them. Among the key drivers of these harms are global industries that manufacture and distribute unhealthy products, including tobacco, alcohol, unhealthy food and drink products and fossil fuels. Their diverse impacts on health and their activities in shaping policies to protect and advance their interests constitute “the commercial determinants of health”. The substantial evidence-base about these impacts and about how to regulate such industries to promote health is largely confined to high-income countries. In sub-Saharan Africa (SSA), the relationship between such commercial actors and public health is not well understood. The entire region is strategically important to commercial actors both as a source of raw materials and as key markets for future growth. The region confronts particular challenges in seeking to regulate business impacts on health, including resource constraints, competing priorities, the influence of donors and international organisations, and the power of global corporate actors. In an ambitious programme of research in South Africa, Ghana and Kenya, our team will undertake research to inform policies to address these challenges, focusing on the alcohol, unhealthy food and fossil fuel industries. This Group brings together leading researchers from the University of the Witwatersrand, South Africa; Kwame Nkrumah University of Science and Technology, Ghana; African Population Health Research Centre, Kenya; and the University of Edinburgh, UK. Working across diverse disciplines, via partnerships and with key stakeholders, this research will address national priorities, strengthen research capacity, and promote South learning. Based on high quality academic outputs and by engaging with communities, advocacy organisations, government ministries and international organisations, we will promote positive impacts on health and development and produce accessible learning materials, good practice guidance and model policies. The project will be implemented between 2024 and 2028. The project has 4 objectives: 1. To map the health impacts of commercial actors and show how strategic links between alcohol, food and fossil fuel industries influence policies to advance their interests. 2. To use economic modelling and evaluation to inform policies to effectively regulate unhealthy commodity industries. 3. To examine how health policy processes can be strengthened to manage conflicts between health goals and the interests of these three industries. 4. To explore how such research can inform efforts to tackle inequalities in health and in power distribution, working in collaboration with communities and civil society. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Edinburgh UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 442680.42 730847.59 705244.4 683554.2 314958.43 2877285.04 GB-GOV-10-GHRG_4_156820 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 147560.14 GB-GOV-10-GHRG_4_156820 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 147560.14 GB-GOV-10-GHRG_4_156820 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 141483.22 GB-GOV-10-GHRG_4_156820 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 84946.48 GB-GOV-10-GHRG_4_156820 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 71930 GB-GOV-10-GHRG_4_156820 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 145685.63 GB-GOV-10-GHRG_4_156820 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 167237.04 GB-GOV-10-GHRG_4_156820 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh GB-GOV-10-GHRG_4_156828 UK - Department of Health and Social Care (DHSC) The number of women and babies dying due to pre-eclampsia in lower- and middle-income countries (LMICs) compared to the UK is one of the starkest, avoidable health injustices in the world. Although prompt detection and appropriate management of pre-eclampsia were highlighted in the Sustainable Development Goals (SDGs), progress has been inadequate. Globally, 30,000 women and 500,000 babies die every year due to pre-eclampsia. A woman in Sierra Leone is over 2000 times more likely to die from pre-eclampsia than in the UK. Pre-eclampsia is diagnosed by high blood pressure (BP), with one of: the presence of protein in the urine, problems with liver, kidney or clotting function, eclampsia (fits) in the mother, or growth problems for the baby. It is challenging to diagnose and difficult to predict life-threatening complications, especially in resource-poor settings where BP monitors, blood/urine tests, and ultrasound scans may be scarce. The only definitive treatment is delivery of the baby and premature birth is often necessary. Recently, a new blood test for pre-eclampsia has been developed, called placental growth factor (PlGF). This test is better at diagnosing pre-eclampsia than all other commonly used tests combined. It accurately predicts which women and babies are likely to become seriously unwell and need premature birth, and which women can be safely reassured and continue their pregnancy. A large trial in the UK demonstrated that PlGF helps doctors diagnose pre-eclampsia faster and reduces severe complications, including eclampsia and stroke. PlGF is now recommended in national guidance in the UK. This new test needs to reach locations where it is most needed, where stillbirth, maternal death and severe complications are at least 100 times greater, and resources are limited. We have recently shown that, in pre-eclampsia between 34 and 37 weeks of pregnancy, early birth reduces stillbirth by 75%. However, given the challenges associated with limited resources, it is critical to get the diagnosis right to justify early delivery. Premature delivery in the absence of pre-eclampsia would cause harm, especially in LMICs where neonatal care may be limited. PlGF will enable accurate diagnosis to ensure that the correct babies are delivered early to save lives. We propose an extensive investigation of the impact of PlGF on making a diagnosis of pre-eclampsia and timing birth, through a cross-continent research group in Sierra Leone, Zambia, India and Brazil. • Workstream 1 will be an observational study of existing care pathways and management strategies for pre-eclampsia, including cost implications. • Workstream 2 will be a randomised controlled trial investigating the impact of PlGF on clinical outcomes, including diagnosis, timing of birth and complications. • Workstream 3 will be a randomised controlled trial of planned early birth, compared to watchful waiting, in women with pre-eclampsia between 34 and 37 weeks of pregnancy, with diagnosis informed by PlGF. The primary outcome for this trial will be stillbirth or early neonatal death. Throughout all phases, we will build local research capacity and run a training programme to develop research leaders of the future and promote education on the management of pre-eclampsia. Our group has a wealth of experience and proven track record. We are well placed to conduct this important and necessary research, to save lives and improve clinical outcomes for women and their babies where it is vitally needed. This project will run from July 2024 to June 2027. This project has 4 objectives: 1. Describe care pathways for preterm pre-eclampsia, identify barriers to, and facilitators of placental growth factor (PlGF) testing in lower- and middle-income countries (LMICs). 2. Assess clinical and cost effectiveness of PlGF testing in suspected preterm pre-eclampsia. 3. Evaluate clinical and cost effectiveness of planned early delivery in late preterm pre-eclampsia with diagnosis incorporating PlGF testing. 4. Sustainably build local research capacity at individual and institutional levels. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) King's College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 713714.43 878845.06 873957.01 361504.46 2828020.96 GB-GOV-10-GHRG_4_156828 COMMITMENT UK - Department of Health and Social Care (DHSC) King's College London 237904.81 GB-GOV-10-GHRG_4_156828 2024/25 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) King's College London 237904.81 GB-GOV-10-GHRG_4_156828 2024/25 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) King's College London 26974 GB-GOV-10-GHRG_4_156828 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 84043 GB-GOV-10-GHRG_4_156828 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 325289.39 GB-GOV-10-GHRG_4_156828 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 253477.18 GB-GOV-10-GHRG_4_156828 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London GB-GOV-10-GHRG_4_156915 UK - Department of Health and Social Care (DHSC) Violence against women and children (VAW/C) are human rights violations that affect many women (one in three) and children (around one billion) worldwide. There aren't many other violations that affect such a large part of the global population and have such devastating effects on people's well-being and lives. To address VAW/C, there's a group called the Lancet Commission on VAW/C, of which the applicants are members. The group is made up of policy makers, researchers, and individuals who have experienced violence themselves, many of whom are from low- and middle-income countries (LMICs). As part of our work, we have seen that there is a lot of information about preventing VAW/C in high income countries, but not as much in LMICs. This is a problem because it's important to understand the country specific context to effectively address the issue. We have identified five anchor countries who are engaged to address these concerns and provide recommendations to support other Southern Hemisphere nations. The aim of the project is to work across South Africa (University of Cape Town), Mexico (Instituto Tecnológico y de Estudios Superiores de Monterrey), Peru (Universidad Peruana Cayetano Heredia), Brazil (Universidade Federal de Pelotas) and Sri Lanka (University of Jaffna) to co-produce (with survivors of VAW/C) research using a trauma informed framework which will help us understand the effects of violence across different contexts, provide recommendations to prevent violence and build local research capacity. The research will include developing diverse, representative, and inclusive survivor panels; describing the economic cost of inaction; finding out what works to prevent violence and developing novel solutions; knowledge exchange; and impact and dissemination activities across five streams of work or work packages (WP). WP1 on development of the survivor panels including focus groups and evaluation will be completed by February 2028. WP2 on the healthcare burden and impact of VAW/C will be completed by September 2026. WP3 will focus on the economic impact and social burden and will be done by November 2027. The subsequent work around identification and evaluation of interventions and policies to prevent VAC/W will form part of WP4 and will be completed by May 2028. The final work package (WP5) focusing on capacity building and knowledge exchange will run in parallel to the other work packages and will be completed by the end of the project. The project has 5 objectives: 1. Engage with the affected community and develop working groups (panels) of diverse survivors that are linked into local healthcare networks, and assess impact of this approach. The intended outcome of this objective is to empower those affected by violence by integrating their voice into local healthcare systems and sharing best practices for other countries to learn from. 2. Map country level data and carry out epidemiological studies to describe the burden of harm particularly in marginalised and underserved communities. The intended outcomes of this objective are to produce an openly accessible data directory to facilitate further research; to discover new undocumented harms associated with violence; and to produce novel survey data describing the intersection between experiences of violence and subsequent ill health. 3. Identify the economic impacts and social burden associated with VAW/C. The intended outcome of this objective is to produce an economic toolkit summarising the economic harms of violence, including those previously undocumented, as well as a total cost of inaction. 4. Optimise approaches to finding out what works to prevent VAW/C in LMICs. The intended outcomes of this objective are to produce a policy toolkit summarising effective and promising population based interventions and policies which can be implemented to prevent harm, and to directly benefit residents in Sri Lanka who will be part of a pilot trial of a primary prevention service. 5. Build research capacity in the LMICs and an open-access knowledge exchange and training programme. The intended outcome of this objective is to generate sustainable and well-trained communities of researchers, students (through 10 PhD/Master’s level degree sponsorships) and survivors who will be able to further independently expand this field of research, particularly to help their local communities. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Birmingham UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 507093.24 734762.44 783320.16 686388.78 313991.5 3025556.12 GB-GOV-10-GHRG_4_156915 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 169031.08 GB-GOV-10-GHRG_4_156915 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 169031.08 GB-GOV-10-GHRG_4_156915 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 401240 GB-GOV-10-GHRG_4_156915 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham GB-GOV-10-NIHR_GHRG5 UK - Department of Health and Social Care (DHSC) The NIHR's fifth Global Health Research call for Groups. UK universities and research institutes were invited to submit applications, working in equitable partnerships with researchers in low- and middle-income countries (LMICs) eligible to receive Official Development Assistance (ODA), to develop their ambitions to deliver world-class applied global health research to address under-funded or under-researched global health areas specific to those countries. The partnerships support both identified training and capacity needs for academy research and programme support functions in low resource settings. Together these provide an important, sustainable platform for future research and resilience in those countries. Global Health Research Group funding is available to research groups either new to delivering applied health research globally or that wish to expand an existing partnership into new themes and geographies. Through this call, awards up to £3 million over a period of up to four years are available to NIHR Global Health Research Groups. The Global Health Research Groups programme has six key strategic aims: 1. Build global research capacity by supporting specialist UK researchers to pivot to global health through new equitable and diverse UK and low- and middle-income country (LMIC) partnerships. 2. Support UK-LMIC partnerships seeking to scale-up or expand research programmes into new health areas and/or geographies. 3. Deliver programmes of high quality applied global health research targeted at the needs of people in LMICs, including e.g., scoping studies, needs analyses, economic and/or health system analyses, pilot studies and potentially trials. 4. Generate robust new scientific evidence that will improve health outcomes for people in low resource settings through improving practice and informing policy. 5. Create pathways to develop research leaders of the future. 6. Strengthen research management capability and institutional sustainability in partner countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London Manchester Metropolitan University Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-GHRG_5_163709 UK - Department of Health and Social Care (DHSC) The STOP-HBV project (A Simplified Screen-and-Treat-All Prophylaxis Approach in Pregnant Women to Stop Hepatitis B Virus Mother-to-Child Transmission) is a multi-country research project funded by the UK Department for Health and Social Care (DHSC) through its National Institute for Health and Care Research (NIHR). The project aims to develop and evaluate a simplified strategy to prevent mother-to-child transmission (MTCT) of hepatitis B virus (HBV) in Malawi and The Gambia, where HBV prevalence remains high and access to screening and treatment during pregnancy is limited. STOP-HBV addresses these challenges by evaluating a simplified “screen-and-treat-all prophylaxis” approach integrated within routine antenatal care services. The project combines clinical research, implementation science, and health systems strengthening to test whether simplified screening pathways and prophylactic antiviral treatment during pregnancy can reduce HBV transmission to infants born to HBV-positive mothers while remaining feasible and scalable in resource-limited settings. The research includes clinical cohort studies, health systems evaluation, community engagement, and policy-relevant implementation research. The project will generate evidence on the clinical effectiveness, feasibility, cost-effectiveness, and acceptability of the proposed strategy, while also strengthening research capacity and collaborative networks between UK institutions and partner organisations in Africa. The project will be undertaken by Kamuzu University of Health Sciences Malawi, MRC Unit the Gambia, University of Liverpool UK and Canterbury Christ Church University UK in Malawi and The Gambia between March 2026 and February 2030. Chronic HBV infection is a major global health challenge, particularly in low- and middle-income countries, where vertical transmission during pregnancy and childbirth is a key driver of lifelong infection. Infants infected at birth have a very high probability of developing chronic HBV infection, which substantially increases the risk of liver cirrhosis and hepatocellular carcinoma later in life. Despite the availability of effective prevention strategies, implementation barriers including limited diagnostics, complex treatment algorithms, and gaps in antenatal care continue to hinder effective prevention of mother-to-child transmission in many endemic settings. By producing actionable evidence for policymakers and national hepatitis programmes, STOP-HBV seeks to inform scalable strategies for eliminating HBV transmission at birth, contributing to the World Health Organization’s goal of eliminating viral hepatitis B as a public health threat by 2030. This project has 8 objectives: 1. Evaluate the effectiveness of a simplified screen-and-treat-all prophylaxis strategy during pregnancy to reduce mother-to-child transmission of hepatitis B virus (HBV) in endemic settings. 2. Assess the feasibility and acceptability of integrating HBV screening and prophylactic treatment into routine antenatal care services in Malawi and The Gambia. 3. Identify optimal screening strategies for detecting HBV infection among pregnant women in resource-limited healthcare systems. 4. Determine the clinical outcomes of maternal antiviral prophylaxis, including safety for both mothers and infants and effectiveness in preventing vertical transmission. 5. Evaluate implementation barriers and facilitators affecting the uptake and delivery of HBV prevention interventions within existing maternal health systems. 6. Assess the cost-effectiveness and scalability of simplified HBV prevention strategies to inform national and international hepatitis elimination policies. 7. Strengthen research capacity and collaborative networks between UK and African institutions through training, data sharing, and joint research activities. 8. Generate policy-relevant evidence to support the development of national and regional guidelines for preventing HBV mother-to-child transmission in low- and middle-income countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Infectious disease control Research and Innovation 63222.85 760027.99 776533.41 768972.7 449713.34 148340.54 2966810.83 GB-GOV-10-GHRG_5_163709 COMMITMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health 63222.85 GB-GOV-10-GHRG_5_163709 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health 189668.54 GB-GOV-10-GHRG_5_163709 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health GB-GOV-10-GHRG_5_163838 UK - Department of Health and Social Care (DHSC) East Africa AMR-STOP (Africa AMR-STOP) is a transnational, interdisciplinary initiative addressing antimicrobial resistance (AMR), a critical threat to human, animal, and environmental health. Our goal is to combat AMR. We will do this by improving monitoring and surveillance and implementing innovative aerated constructed wetlands interventions. We will enhance AMR knowledge and build capacity for community health volunteers/village health teams, communities at village level, and professionals in water and environment sectors. We will also develop an online central service platform for training, management, and sharing of AMR data and tools, explore community engagement and involvement for reducing AMR spread, and assess the economic cost and cost-effectiveness of interventions. The project will be undertaken by Makerere University in Uganda, Masinde Muliro University of Science and Technology in Kenya, South African Medical Research Council in South Africa, and University of Pretoria in South Africa. The main aim is to co-develop a one health approach to mitigate and manage environmental AMR for enhancing health and wellbeing in Kenya and Uganda between February 2026 to January 2030. AMR is a critical global public health issue that can lead to fatal outcomes if not controlled. Low- and middle-income countries (LMICs) bear a disproportionate burden of AMR due to weak monitoring and wastewater treatment plants that don't work but are known to be major sources of antibiotic residues, antibiotic-resistant bacteria and antimicrobial resistance genes (ARGs) in the environment. In East Africa, untreated wastewaters from hospitals, pharmaceuticals, households, and industries are discharged into water sources, leading to widespread AMR. This is aggravated by poor separation of human waste depositions and potable drinking water sources in rural and informal settlements. Our UK-Africa partnership has recently identified the presence of high antibiotic residues and ARGs in wastewaters and drinking water in the region, underscoring the health risks to the population. The AMR burden not only threatens the health sector, but also prevents poor countries from investing in crucial areas like sanitation, education, food security, and infrastructure development, hindering the achievement of Sustainable Development Goal 3 (SDG 3) - Health and Human Wellbeing, and SDG 6 - Water and Sanitation. The proposed research aligns with these SDGs by delivering high-quality applied health research to meet the needs of people in Kenya and Uganda, which can be scaled up to benefit other LMICs in East Africa. The project will also continue to generate surveillance data on antibiotic use, pathogens on the World Health Organization (WHO) watch list, which will be made available for all LMICs through the digital AMR online hub. This will enhance the contribution of the East and South African regions in sharing AMR data with the WHO Global AMR and Use Surveillance System. At the hospital, county, national, and regional levels, this data can influence existing antibiotic policy needs and more rational use of antibiotics among patients and health practitioners. This project has seven objectives: 1. To investigate the influence of abiotic and biotic factors on antibiotics and antimicrobial resistance genes levels in aquatic environments. 2. To co-design a surveillance and monitoring system to facilitate effective reduction strategies for antimicrobial resistance (AMR) in clinical, animals and environmental settings. 3. To optimise an eco-hydro wetland to remove antibiotics, antimicrobial resistance genes and multidrug-resistant pathogens from wastewater in a cost-effective and sustainable way. 4. To co-develop a digital AMR online hub for training, management and regulation of AMR. 5. To estimate the economic cost of AMR. 6. To co-design avenues of community engagement and involvement for reduction of AMR. 7. To build human capacity for sustainable AMR research and management. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Manchester Metropolitan University UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 128697.41 747617.95 632883.25 664336.38 515960.54 141552.4 2831047.93 GB-GOV-10-GHRG_5_163838 COMMITMENT UK - Department of Health and Social Care (DHSC) Manchester Metropolitan University 128697.41 GB-GOV-10-GHRG_5_163838 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Manchester Metropolitan University 193046.12 GB-GOV-10-GHRG_5_163838 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Manchester Metropolitan University GB-GOV-10-GHRG_5_Reimbursements UK - Department of Health and Social Care (DHSC) This activity captures the reimbursements made to seven applicants to Global Health Research Groups call 5. These applicants had received a letter signalling DHSC’s intend to fund their proposals but these offers were then retracted following the February 2025 announcement that UK Official Development Assistance (ODA) would reduce from 0.5% GNI to 0.3%. When DHSC notified recipients of this change, they were advised that reasonable costs incurred since receipt of "intent to fund" letters would be reimbursed, provided applicants could demonstrate these were directly related to the call and were ODA eligible. This was in appreciation of the significant time and energy invested in application and contracting stages, recognising that applicants may have begun work following assurances provided in the “intend to fund” letter. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 169346.28999999998 169346.28999999998 GB-GOV-10-GHRG_5_Reimbursements COMMITMENT UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 44155.76 GB-GOV-10-GHRG_5_Reimbursements 2025/26 Q4 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 24835.73 GB-GOV-10-GHRG_5_Reimbursements 2025/26 Q4 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 27593.48 GB-GOV-10-GHRG_5_Reimbursements 2025/26 Q4 EXPENDITURE (3) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 26484.17 GB-GOV-10-GHRG_5_Reimbursements 2025/26 Q4 EXPENDITURE (4) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 19816.53 GB-GOV-10-GHRG_5_Reimbursements 2025/26 Q4 EXPENDITURE (5) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 20082.19 GB-GOV-10-GHRG_5_Reimbursements 2025/26 Q4 EXPENDITURE (6) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 6378.43 GB-GOV-10-GHRG_5_Reimbursements 2025/26 Q4 EXPENDITURE (7) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified Recipients of GHR Groups Call 5 Reimbursements are reimbursed expenditure that has already been incurred to facilitate the timely commencement of research, subject to the following conditions being met: a) the expenditure qualifies as Official Development Assistance (ODA)-eligible b) it is directly incurred in relation to the proposed research, and c) it aligns with conditions outlined in the Letter of Intent. GB-GOV-10-NIHR_GHRU2 UK - Department of Health and Social Care (DHSC) The NIHR's second Global Health Research call for Units. UK universities and research institutes were invited to submit applications, working in equitable partnerships with researchers in low- and middle-income countries (LMIC), to develop their ambitions to deliver world-class applied global health research to address under-funded or under-researched global health areas specific to those countries. Global Health Research Units are defined as a well-established research partnership or network of universities and research institutes in LMICs and the UK: 1. With an existing track-record of delivering internationally recognised applied global health research addressing unmet health needs in ODA-eligible countries; 2. Who wish to consolidate and expand this work, supporting and developing thematic research and capacity strengthening networks, through regional and global hubs; 3. Who will deliver a large scale, ambitious programme of applied health research through a range of trials and studies; 4. Who are able to leverage the strength of the existing partnership consortium to improve practice and inform policy based on scientific evidence; 5. Who will set up and deliver a substantial and sustainable programme of capacity and capability strengthening at individual and institutional level. The strategic aim across the Global Health Research Units programme is to: 1. Address locally-identified challenges in LMICs through equitable research partnerships between researchers and institutions in the UK and ODA-eligible countries 2. To generate the scientific evidence that can improve health outcomes for people in low resource setting through improving practice and informing policy. 3. Strengthen research and research management capacity and capability to support future sustainability of research in partner countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Sussex Liverpool School of Tropical Medicine The University of Edinburgh Imperial College London University of York University of Oxford University of Birmingham University of Liverpool The University of Manchester University of Glasgow UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-GHRU_2_131996 UK - Department of Health and Social Care (DHSC) Since 2017, the NIHR Global Health Research Unit (GHRU) on Neglected Tropical Diseases (NTDs) at Brighton and Sussex Medical School has carried out a highly successful needs-driven research programme in partnership with Addis Ababa University and the Armauer Hansen Research Institute in Ethiopia, and the Mycetoma Research Centre, University of Khartoum, Sudan. Our GHRU has focused on three conditions considered severely neglected in terms of research, public attention and political will: 1. podoconiosis (a progressive, disabling form of leg swelling seen in barefoot farmers) 2. mycetoma (a destructive infection of the skin and underlying tissues) 3. scabies (a profoundly irritating skin condition caused by burrowing mites) Our studies have spanned wide-ranging disciplines to address questions directly relevant to national and global NTD elimination agendas. This research has been conducted within a strong framework of capacity strengthening which has developed infrastructure and financial management at partner institutions and trained 11 PhD students and five post-doctoral researchers. All early career researchers have benefitted from training opportunities within and beyond their countries, and from the NIHR Global Health Academy. We will build on these strong foundations in the next five years and expand the partnership to include the University of Rwanda. We will use a range of methods to investigate new research questions clustered into four interrelated themes: 1. mechanisms of disease 2. geospatial mapping 3. diagnostics and drug development 4. implementation research The questions have been prioritised through a process of: 1. identifying the areas in which our GHRU has had the most impact 2. participating in WHO and disease-group identification of research gaps in these areas 3. consulting with stakeholders including patients, communities, implementers and policy makers. Our research will contribute evidence important to disease treatment and prevention strategies and continue to enhance research capacity to ensure sustainability. Scientific Objectives: 1. investigate pathogen genetic diversity and/or host susceptibility to each condition 2. improve understanding of the disease burden and distribution of each condition through a combination of field-based mapping and geo-spatial modelling 3. identify new diagnostics and treatments for scabies 4. evaluate services to improve prevention, diagnosis and care of these conditions, in particular integrating these with other skin-NTDs Strategic Objectives: 1. develop a network of researchers studying podoconiosis, mycetoma and scabies across three DAC countries 2. increase societal awareness and expand the evidence base for national and international policy relating to these three NTDs Capacity Strengthening Objectives: 1. support endemic-country PhD and postdoctoral training posts so that capacity for research into NTDs is expanded 2. strengthen the research environment in which our collaborators and trainees work UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Sussex UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 670986 1310320 1407376 1458040 1265920 887017 335493 GB-GOV-10-GHRU_2_131996 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 335493 GB-GOV-10-GHRU_2_131996 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 6999659 GB-GOV-10-GHRU_2_131996 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Sussex 150314 GB-GOV-10-GHRU_2_131996 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Sussex 258763 GB-GOV-10-GHRU_2_131996 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Sussex 392379.87 GB-GOV-10-GHRU_2_131996 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 270462 GB-GOV-10-GHRU_2_131996 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 227242 GB-GOV-10-GHRU_2_131996 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 443932 GB-GOV-10-GHRU_2_131996 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 363155 GB-GOV-10-GHRU_2_131996 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 444727 GB-GOV-10-GHRU_2_131996 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 402293.94 GB-GOV-10-GHRU_2_131996 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 291198.59 GB-GOV-10-GHRU_2_131996 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 341483 GB-GOV-10-GHRU_2_131996 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 520699.09 GB-GOV-10-GHRU_2_131996 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 353518 GB-GOV-10-GHRU_2_131996 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 399721 GB-GOV-10-GHRU_2_131996 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 518208.98 GB-GOV-10-GHRU_2_131996 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 418307.53 GB-GOV-10-GHRU_2_131996 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex GB-GOV-10-GHRU_2_132027 UK - Department of Health and Social Care (DHSC) The NIHR Global Health Unit on the Prevention and Management of Stillbirths and Neonatal Deaths in Sub-Saharan Africa and South Asia, led from the Centre for Childbirth, Women’s and Newborn Health at Liverpool School of Tropical Medicine UK, is an established equitable multidisciplinary partnership between Africa, Asia and UK-based researchers. As an international centre of research excellence, our goal is to end preventable stillbirths and newborn deaths, ensure adequate support for parents and families whose baby dies and reduce associated stigma. Using a whole systems approach, we work across high burden settings in India, Kenya, Malawi, Pakistan, Tanzania, Uganda, Zambia and Zimbabwe. We aim to develop, test and implement sustainable and cost-effective solutions to strengthen maternity and newborn care, reducing mortality and morbidity through high-quality, respectful and compassionate maternity and newborn care. Activities cover the entire spectrum of maternal and newborn health from preconception to post/neonatal care, with a strong focus on meaningful community and stakeholder partnerships. We co-produce research with women, families, front-line health workers and policy makers. Working across 10 work streams, we are drawing on the team’s methodological expertise to deliver impactful findings from evidence syntheses, exploratory studies (qualitative and quantitative approaches), core outcomes sets, clinical trials and implementation research. Capacity strengthening for maternal and newborn health research, across all partner countries is embedded throughout the Unit. We have a particular, but not exclusive, interest and experience in developing midwifery and nursing research capacity to address global shortages in these disciplines. Our development programmes spans 3 masters students, 9 PhD placements and 3 post-doctoral fellowships as well as project specific and institutional skills training. 1. Develop and evaluate sustainable, cost-effective solutions to strengthen maternity and newborn care and reduce stillbirths and neonatal deaths in high-burden settings (Kenya, Malawi, Tanzania, Uganda, Zambia, Zimbabwe, India, Pakistan). 2. Determine how best to support parents, families, attending health providers and communities who experience a stillbirth or neonatal death. 3. Strengthen research capacity with particular (but not exclusive) emphasis on midwives and nurses. 4. Create and embed mechanisms of knowledge-transfer in high-burden settings. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 893649 1297456 1490644 1819762.45 1122679.82 644191.63 297883 GB-GOV-10-GHRU_2_132027 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 297883 GB-GOV-10-GHRU_2_132027 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 297883 GB-GOV-10-GHRU_2_132027 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 6972834 GB-GOV-10-GHRU_2_132027 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 115329 GB-GOV-10-GHRU_2_132027 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 242002 GB-GOV-10-GHRU_2_132027 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 508338 GB-GOV-10-GHRU_2_132027 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 431787 GB-GOV-10-GHRU_2_132027 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 282998 GB-GOV-10-GHRU_2_132027 2023/24 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 333577 GB-GOV-10-GHRU_2_132027 2023/24 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 556135 GB-GOV-10-GHRU_2_132027 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 317934 GB-GOV-10-GHRU_2_132027 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 367974 GB-GOV-10-GHRU_2_132027 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 440604 GB-GOV-10-GHRU_2_132027 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 451996.45 GB-GOV-10-GHRU_2_132027 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 559188 GB-GOV-10-GHRU_2_132027 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 97594.82 GB-GOV-10-GHRU_2_132027 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 367793 GB-GOV-10-GHRU_2_132027 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 365464 GB-GOV-10-GHRU_2_132027 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 295548.9000000004 GB-GOV-10-GHRU_2_132027 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 291828 GB-GOV-10-GHRU_2_132027 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 280772.49 GB-GOV-10-GHRU_2_132027 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-GHRU_2_132826 UK - Department of Health and Social Care (DHSC) Vision: To improve quality of life and reduce the number of deaths from respiratory disorders by expanding research infrastructure, capacity and capability to conduct outstanding applied respiratory research, creating an Asian respiratory translational research network of excellence. The aim of RESPIRE (Phase 2) is to deliver low-cost, scalable policy and clinical interventions which address locally-identified problems. We aim to act as a source of expertise and resource to policymakers, ministries of health, health workers and communities in our 7 ODA eligible partner countries across Asia (Pakistan, Sri Lanka, Bangladesh, India, Indonesia, Bhutan, Malaysia). Our Unit aims to build on the capacity development, research outputs and relationships from RESPIRE (Phase 1: 2017-2022) to contribute to improving global respiratory health. In so doing, RESPIRE aims to disseminate knowledge on existing evidence-based interventions that can be adapted for Asian settings, promote innovation to generate and evaluate new interventions and approaches, provide technical support to implementation of respiratory health programmes and identify/develop and promote innovative new approaches and delivery mechanisms. Our overarching objectives include: Building research and research management capacity in our Asian partner countries; ensuring research is driven by the needs/priorities of LMIC populations and is based on equitable/respectful partnerships; strengthening capacity to translate research findings into impact; engaging stakeholders, involving patients and communities, where appropriate, as key partners at all stages; and considering the context of COVID-19, where relevant. Short-term (year 1): • Promote respectful and equitable partnerships and shared values on research governance and ethical conduct of research across RESPIRE; • Establish RESPIRE governance and administrative arrangements (including due diligence, research contracts and financial reporting), ensuring deliverables and reports are completed on time; • Set up and commence agreed programmes of work (including submitting governance (sponsorship) and ethics applications where needed) within the Unit research programmes and platforms. Medium-term (years 2-3): • Maintain close monitoring of and support to research programmes giving assistance in problem solving and taking risk mitigation action, where necessary; • Ensure translational platforms are having an impact on the work of the Unit in the areas of stakeholder engagement, education/capacity building, data science and digital health and innovation; • Ensure the Translational Platforms Coordination Group is working effectively to integrate Unit outputs and these are being used effectively to have an impact on respiratory health policy and practice in partner countries; • Ensure study findings are communicated to local communities and consultation takes place to co-develop plans for follow on actions; • Submit collaborative follow-on grants to extend work and tackle gaps that have been identified; • Develop plans for longer term sustainability. Long-term (years 3-4): • Ensure the Translational Platforms Coordination Group is maximising the local, regional and global impact from the new knowledge and experience generated by RESPIRE; • Communicate RESPIRE-2 findings to policymakers, health professionals and communities through publication in respected journals, presentation at national/regional and global meetings and publication in social media; • Submit collaborative follow-on grants to sustain RESPIRE activities into the future. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Edinburgh UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 1210840 2232864 1777640 1321048 456963 6999355 GB-GOV-10-GHRU_2_132826 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 220153 GB-GOV-10-GHRU_2_132826 2022/23 Q2 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) The University of Edinburgh 330229 GB-GOV-10-GHRU_2_132826 2022/23 Q2 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) The University of Edinburgh 109923.07 GB-GOV-10-GHRU_2_132826 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 39776 GB-GOV-10-GHRU_2_132826 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 435108 GB-GOV-10-GHRU_2_132826 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 652233 GB-GOV-10-GHRU_2_132826 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 273611 GB-GOV-10-GHRU_2_132826 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 734650 GB-GOV-10-GHRU_2_132826 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 356454.19 GB-GOV-10-GHRU_2_132826 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 775166.42 GB-GOV-10-GHRU_2_132826 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 609695.65 GB-GOV-10-GHRU_2_132826 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 316858 GB-GOV-10-GHRU_2_132826 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 445044 GB-GOV-10-GHRU_2_132826 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 333650.57 GB-GOV-10-GHRU_2_132826 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh GB-GOV-10-GHRU_2_132960 UK - Department of Health and Social Care (DHSC) Theme 1. Understanding the drivers of diabetes and cardiovascular disease in South Asia South Asians (SAs) are recognised to be at increased risk of both cardiovascular disease (CVD) and type 2 diabetes (T2D) compared to European populations. Data from the UK, Europe and North America suggests that the high risk of CVD and T2D in SAs is not explained by differences in traditional cardiovascular or metabolic risk factors. We will advance understanding of the lifestyle, environmental and molecular factors influencing T2D and CVD and provide much needed new insight into the determinants of T2D and CVD in SA populations. The results will inform development of effective personalised, policy based, environmental and public health interventions. Theme 2. Digital interventions for prevention of T2D and CVD in South Asians. Our Non-Communicable Diseases (NCD) Surveillance study reveals that >30% of SAs have established diabetes or CVD and that a further >30% have obesity, prediabetes or are at high CVD risk. Quality of care is poor and there is major inequality between socio-demographic groups. Our programme of digital health research aims to understand how technology platforms can be used to improve prevention of diabetes and CVD in SA in a scalable, sustainable and equitable fashion. Informed by the results of the trial data, we will make digital interventions available for wider use by community users and healthcare providers. In collaboration with the theme 3 work strand, we will use trial data to build decision trees that help prioritise the applications to people who will benefit most. The decision support algorithms will be incorporated into the theme 3 community-facing ‘Health hub’ as a demonstration of a scalable model for integrated end-end digital care co-ordination. Theme 3. Accelerating the digital transformation of NCD management in South Asia Digital technologies offer the potential to transform primary healthcare (PHC) systems in LMICs and improve both access to and quality of healthcare. The emergence of the COVID-19 pandemic has intensified the need for digital technologies to support decentralised NCD care. We will advance understanding of how digital platforms can be used to strengthen prevention and control of T2D, CVD and their risk factors in SA. Our PHC collaborators in Bangladesh and Sri Lanka are already committed to strengthening health information systems for PHC teams and are working to national solutions. We will bring learnings from demonstration projects to support these efforts and scale up the digital care coordination tools we have developed. This will be facilitated by the implementation toolkits and inter-operable frameworks we will establish in conjunction with the WHO. Successful demonstration projects will thus lead to a high likelihood of sustainable scale-up of our digital training and care-co-ordination modules. Theme 4: Policy and environmental interventions for primary prevention of NCDs Among the most important actions to reverse the epidemics of T2D and CVD are to understand the built environment around people’s everyday life and to develop population-based interventions. Published evidence to support the effectiveness of policy and environmental interventions for improving health behaviours and prevention of cardio-metabolic disease comes mainly from high-income countries. It remains unclear whether such ‘whole of society’ approaches are acceptable, feasible or effective in SA settings, where resources are limited, the priorities of individuals are different, and the burden of disease is high and increasing. Our overarching goal is to implement and evaluate a community-based intervention for prevention of T2D and CVD, at national scale in Sri Lanka, and to provide evidence that other countries in SA can learn from in. The insights from the research will be used to develop policy recommendations in South Asian countries for health promotion and prevention of T2D and CVD. Theme 1. We will advance understanding of the lifestyle, environmental and molecular factors influencing T2D and CVD in South Asia. We will: 1. Ascertain health outcomes over four years for the ~150,000 South Asian men and women participating in our NCD Surveillance study, to identify new onset CVD and T2D 2. carry out molecular profiling of the baseline samples, including lipid profile and other measures of metabolic risk, and genome-wide genotyping with whole exome sequencing. 3. analyse the data to determine the age- and gender-specific incidence for T2D and CVD amongst South Asians in different settings; identify the behavioural, environmental and genomic exposures that underlie T2D and CVD in South Asians; strengthen approaches for identification of South Asian individuals and communities who are at increased risk for CVD Theme 2. We will test whether digital intervention with AI driven education or gamification for behaviour change reduces weight (primary endpoint) and improves quantitative measures of cardiometabolic health, amongst South Asian men and women aged 30-60 years with overweight or obesity, compared to usual care over 2 years. Theme 3. We will advance understanding of how digital platforms can be used to strengthen prevention and control of T2D, CVD and their risk factors, in South Asia. We align with the Principles for Digital Development and collaborate with WHO. We will: 1. adapt our ‘Co-ordinate’ platform for use in wider South Asians settings. Extend functionality to include digital training and to empower self-management by community users 2. demonstrate and evaluate platform performance in diverse South Asian settings to provide objective assessment of utility for care co-ordination 3. modularise and generalise the platform, align to global digital health standards, and collaborate with WHO, to make our approaches available to the global health technology ecosystem Theme 4 Our overarching goal is to implement and evaluate a community-based intervention for prevention of diabetes and cardiovascular disease, at national scale in Sri Lanka, and to provide evidence that other countries in South Asia can learn from in formulation of policy. Our specific aims are: 1. comprehensively assess drivers of health risky behaviours linked with T2D and CVD through the linkage of surveillance and exposure to the built environmental data 2. implement the ‘Happy Village Plus’ intervention (including community-based and school- based components) in 75 surveillance sites across Sri Lanka and evaluate the effectiveness of the intervention using a cluster randomised trial design 3. benchmark government policies aimed at tackling NCDs in India, Pakistan and Bangladesh, applying the INFORMAS (International Network for Food and Obesity/Non-Communicable Diseases (NCDs) Research, Monitoring and Action Support) framework, extended to physical activity and tobacco policies. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 719658 671888.15 1395701 1274120.83 1428148.53 871424.82 716990.28 102808 GB-GOV-10-GHRU_2_132960 2021/22 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Imperial College London 308425 GB-GOV-10-GHRU_2_132960 2021/22 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Imperial College London 308425 GB-GOV-10-GHRU_2_132960 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 7000000 GB-GOV-10-GHRU_2_132960 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Imperial College London 66369 GB-GOV-10-GHRU_2_132960 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Imperial College London 445114 GB-GOV-10-GHRU_2_132960 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Imperial College London 160405.15 GB-GOV-10-GHRU_2_132960 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 76885 GB-GOV-10-GHRU_2_132960 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 500403 GB-GOV-10-GHRU_2_132960 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 725198 GB-GOV-10-GHRU_2_132960 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 93215 GB-GOV-10-GHRU_2_132960 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 258323 GB-GOV-10-GHRU_2_132960 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 675404 GB-GOV-10-GHRU_2_132960 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 111028 GB-GOV-10-GHRU_2_132960 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 229365.83 GB-GOV-10-GHRU_2_132960 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 735820.59 GB-GOV-10-GHRU_2_132960 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 360133.63 GB-GOV-10-GHRU_2_132960 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 332194.31 GB-GOV-10-GHRU_2_132960 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 77931.61 GB-GOV-10-GHRU_2_132960 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Imperial College London 217856.16 GB-GOV-10-GHRU_2_132960 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London GB-GOV-10-GHRU_2_133252 UK - Department of Health and Social Care (DHSC) Universal health coverage (UHC) is where all people have access to the health services they need, when and where they need them, and without financial hardship. UHC is an objective shared by countries worldwide. Many low- and middle-income countries (LMICs) have made progress towards UHC, but large challenges remain (owing to COVID-19, the current war in Ukraine, climate change related natural disasters, and other crises). At the same time, the COVID-19 pandemic has highlighted at the global level the social and economic importance of health and UHC. There is, therefore, a critical opportunity for change that we embrace in this Unit: to strengthen progress to UHC in such challenging times, using the tools and perspectives of health financing and economics. The Unit will use these tools and perspectives to carry out in-depth, policy-relevant analyses on specific health finance-related topics, engage with communities and stakeholders, and conduct capacity building. The Unit’s research will comprise the analysis of existing data, modelling, primary data collection and policy evaluation. This will be shared across four policy themes and four cross-cutting methodological areas. The policy themes revolve around a set of national and international challenges identified through extensive stakeholder consultations: (1) raising money for health; (2) allocating money for health; (3) ensuring healthcare access for left-behind groups; and (4) the role of governance, including the interaction between the health system and other sectors. The methodological areas will feed into the policy themes by ensuring the application and development of rigorous, innovative methods to address the challenges identified. They cover (1) methods of evaluating the impact of policies, (2) the analysis of distributional (“equity”) effects, (3) ways of assessing value-for-money of the policies in question, and (4) aspects of political economy. The collaborative research programme builds directly on the work of the University of York’s NIHR Global Health Econometrics and Economics Group (GHE2), which focussed upon Brazil, Indonesia and South Africa. For the Unit, India is included as an additional research location. These four ‘middle-income’ countries comprise nearly two billion people and 45% of the world’s population living in absolute poverty. The countries are characterised by substantial within-country economic and health inequalities, hosting large marginalised and left-behind populations (e.g. geographically-isolated populations, slum dwellers, socially marginalised castes, and ethnic or religious minorities). Understanding how to advance UHC in these contexts, and among diverse vulnerability profiles, provides significant opportunities for mutual, between-country learning and knowledge spill-over benefits to other low- and middle-income countries. The long-term aim of the Unit is to strengthen countries’ ability to adapt health financing policies and programmes for resilient, equitable and sustained progress towards UHC. It will be achieved by the production of rigorous evidence on the key health financing and resource allocation challenges. Through the work it plans to do over a five year period, the Unit aims to inform national and international policy agendas, in particular to support national and regional governments in Brazil, India, Indonesia and South Africa in developing, implementing and evaluating health financing reforms, with a view to accelerating progress towards UHC. 1)Produce policy-relevant, actionable research, applying and developing innovative health economics methods to address major health financing challenges that impede UHC progress. 2)Strengthen and expand research capability in using health economics/financing for decision-making in partner countries among both academic researchers and policy practitioners (including via south-south knowledge exchange network). 3)Strengthen and develop stakeholder coalitions with policymakers, civil society partners and the public in partner countries to improve the relevance and quality of policymaking in health financing, and foster a greater use of health economic evidence in decision-making. 4)Engage with international organisations / stakeholders / policymakers (e.g. WHO, PAHO, the World Bank, bilateral donors) to share findings, foster global uptake and influence global UHC policies. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of York UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 886149 1370944 1242248 1274280 1314168 898467 6986256 GB-GOV-10-GHRU_2_133252 COMMITMENT UK - Department of Health and Social Care (DHSC) University of York 126593 GB-GOV-10-GHRU_2_133252 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of York 379778 GB-GOV-10-GHRU_2_133252 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of York 70412.71 GB-GOV-10-GHRU_2_133252 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 392590 GB-GOV-10-GHRU_2_133252 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 255860 GB-GOV-10-GHRU_2_133252 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 367676 GB-GOV-10-GHRU_2_133252 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 189473 GB-GOV-10-GHRU_2_133252 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 327514 GB-GOV-10-GHRU_2_133252 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 304321.53 GB-GOV-10-GHRU_2_133252 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 351704.24 GB-GOV-10-GHRU_2_133252 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 392810.57 GB-GOV-10-GHRU_2_133252 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 234071.53 GB-GOV-10-GHRU_2_133252 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 308514.65 GB-GOV-10-GHRU_2_133252 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 359071.97 GB-GOV-10-GHRU_2_133252 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 430668.38 GB-GOV-10-GHRU_2_133252 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 202627.69 GB-GOV-10-GHRU_2_133252 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York GB-GOV-10-GHRU_2_133307 UK - Department of Health and Social Care (DHSC) Antimicrobial resistant (AMR) bacterial infections are a rising global cause for concern. AMR is increasingly being predicted to significantly affect health and wellbeing on an international scale, and new technologies and greater understanding are required to reduce resistance to effective treatments. Monitoring how AMR progresses and increasing our understanding into how, when and where AMR emerges are essential to respond to the growing crisis and assess how effective local, national and international interventions are. Whole Genome Sequencing (WGS) is a technology becoming more frequently used in public health communities and offers the ability to provide information at an individual level, as well as at a regional, national and international scale due to its digital nature. Using this surveillance combined with rapid data reporting, will strengthen the evidence base of research, which is crucial for public health decision makers and their capacity to respond. Progress is being made in technical support for practical uses. However, the remaining major problem is how to rapidly and routinely link data and its interpretation to provide the greatest value at all levels. Our global multi-institutional partnership unit brings together established collaborations between the UK (Centre of Pathogen Genomic Surveillance -CGPS, Oxford University), Philippines (Research Institute for Tropical Medicine - RITM), Ibadan (University of Ibadan), India (KIMS Hospital and Research Centre) and Colombia (Colombian Agriculture Research Corporation AGROSAVIA) to continue to combat this growing problem. Capacity for WGS of AMR at each key site has been established or embedded into developing and existing national surveillance initiatives and has already helped outbreak detection and tracking of AMR populations. Building upon this foundation, the data landscape now needs to be put into use to guide public health policies and practices. Through our partnerships we aim to reduce AMR bacterial infections through bettering WGS and surveillance across each site. Our main goals and objectives are detailed below. The project will leave a legacy of engineering, data science and data driven surveillance by using WGS and achieving the highest value of the data on policy. It will have a direct impact on patient lives and well-being and the prevention of infection at a very local level, with a strong focus on capacity building. Outputs will highly impact public health strategies for reducing the impact of AMR in our fight against infectious diseases and infection control to curb the threat of AMR. (1) Country Specific: To operationalise a data-driven WGS-enhanced surveillance model for priority AMR pathogens i) Increase capacity at sentinel sites in Nigeria for WGS-enhanced surveillance to progress an emergent national public health surveillance system ii) Enhance detection and ceasing of hospital outbreaks in real-time by operationalising local and governmental stakeholder delivery in the Philippines iii) Embed data-enhanced surveillance across OneHealth sectors with stakeholder reporting in Colombia iv) Deliver reporting and enhanced surveillance for monitoring interventions (eg vaccines) in India v) The UK will collaboratively develop, test and validate work packages with country sites and transfer capacity for data science/engineering while optimising additional technical support for WGS and training. (2) Research: Deliver transformational capacity for data engineering, data-driven sampling strategies and technological advances in response to analysis of information architecture and stakeholder needs i) Model national data landscapes across all countries to identify common practice, bottlenecks, and develop an architectural plan within which to enhance surveillance ii) Develop a stakeholder landscape and reporting framework for key local, national and international infection prevention and antimicrobial policy questions. iii) Transform the collection, linkage, interpretation and reporting of data to stakeholders via training and deployment of data science and engineering methods and tools. iv) Develop a rational sampling framework for surveillance and targeted outbreak investigation through leveraging routinely collected laboratory AMR data to intelligently prioritise and maximise the value of WGS. iv) Innovate novel solutions to enhance data and WGS driven surveillance for rollout in country and regionally. (3) Implementation: Support regional networks in developing laboratory, bioinformatic, data and institutional capacity to build, maintain and sustain WGS-enhanced AMR surveillance. i) Optimise and minituarise standardised laboratory process for microbiological and multiple sequencing technologies for operational use across surveillance networks ii) Optimise and support local ownership of bioinformatics for assaying risk from genomic data and contextualising within the global landscape iii) Transfer capacity and ownership of expertise in data science and engineering to equip networks to rapidly deploy data solutions and implement the delivery of research for action iv) Enhance institutional financial and grant management to conduit practice and sustainability. (4) Regional Centres of Excellence: Create Regional Centres of Excellence linked to WHO for technical support and institutional capacity, building on previous genomic surveillance of AMR (i) Enhance regional networks through engagement, training and transfer of expertise tailored to regional priorities (ii) Work with national agencies, regional WHO offices and international agencies to deploy owned expertise regionally UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Oxford UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 881149 1370944 1242248 1274280 1314168 898467 6981256 GB-GOV-10-GHRU_2_133307 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Oxford 230297 GB-GOV-10-GHRU_2_133307 2022/23 Q2 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) University of Oxford 345446 GB-GOV-10-GHRU_2_133307 2022/23 Q2 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) University of Oxford 588189 GB-GOV-10-GHRU_2_133307 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 472912 GB-GOV-10-GHRU_2_133307 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 480305 GB-GOV-10-GHRU_2_133307 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 1571.02 GB-GOV-10-GHRU_2_133307 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 899413 GB-GOV-10-GHRU_2_133307 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 414733.64 GB-GOV-10-GHRU_2_133307 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 254489 GB-GOV-10-GHRU_2_133307 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 525579.37 GB-GOV-10-GHRU_2_133307 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford GB-GOV-10-GHRU_2_133364 UK - Department of Health and Social Care (DHSC) The NIHR Global Health Research Unit on Global Surgery (GSU) initially funded in 2017, established seven surgical research Hubs (Benin, Rwanda, Ghana, India, Nigeria, Mexico, South Africa), coordinating research through more than 70 ‘spoke’ hospitals across three continents, prioritised through LMIC led Delphi processes (2016-20). In this funding envelope we will seek excellence through a new body of prioritised primary research, equitable partnerships through transfer of research leadership to the Hubs, sustainability through new Hub-based training centres. Research Objectives: 1. Generate randomised evidence to support sustainable expansion of surgical workforces. 2. Accelerate and sustain a pipeline of research to improve outcomes after surgery in LMICs. 3. Develop evidence to create resilient surgical systems. 4. Generate evidence to support resource allocation decisions through trial and model based economic evaluation alongside the primary research. Education and Training Objectives: 1. Facilitate staged transfer of research leadership to LMIC Hub Directors. 2. Establish sustainable training in surgical research methods. 3. Develop data management and analysis capability. 4. Develop new cohort of surgical research leaders. 5. Facilitate development of clinical research management teams. 6. Create and utilise sustainable South to South learning pathways. Community Engagement and Inclusion (CEI) Objectives: 1. Establish a flexible and sustainable LMIC led CEI steering group in each partner country. 2. Develop an LMIC led CEI strategy for research project, with an integrated South to South feedback loop. 3. Bespoke training through South to South learning. 4. Make CEI steering group advocates for surgical research through engagement with key stakeholders (communities, relevant policy makers). Impact Objectives: 1. To connect research outputs to multiple stakeholders (patients, clinicians, policy makers). 2. To establish and maintain two-way pathways for stakeholder engagement. 3. To establish local and global pathways to policymakers. 4. To create a sustainable framework for Impact assessment around the 6 domains of healthcare quality. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Birmingham UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 872770 1699224 1602936 1324176 920716 580178 436385 GB-GOV-10-GHRU_2_133364 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 436385 GB-GOV-10-GHRU_2_133364 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 7000000 GB-GOV-10-GHRU_2_133364 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 242193 GB-GOV-10-GHRU_2_133364 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 335903 GB-GOV-10-GHRU_2_133364 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 581079 GB-GOV-10-GHRU_2_133364 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 110090 GB-GOV-10-GHRU_2_133364 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 371097 GB-GOV-10-GHRU_2_133364 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 436453 GB-GOV-10-GHRU_2_133364 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 220040 GB-GOV-10-GHRU_2_133364 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 231027 GB-GOV-10-GHRU_2_133364 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 494638 GB-GOV-10-GHRU_2_133364 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 367805 GB-GOV-10-GHRU_2_133364 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 491163 GB-GOV-10-GHRU_2_133364 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 468516 GB-GOV-10-GHRU_2_133364 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 353318 GB-GOV-10-GHRU_2_133364 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 549571 GB-GOV-10-GHRU_2_133364 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 479932.15 GB-GOV-10-GHRU_2_133364 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 44404.85 GB-GOV-10-GHRU_2_133364 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham GB-GOV-10-GHRU_2_134530 UK - Department of Health and Social Care (DHSC) Globally 3.8 billion people rely on polluting fuels (e.g. wood, charcoal, kerosene) for cooking. Household air pollution (HAP) from burning these fuels caused 2.3 million premature deaths in 2019 (more than HIV/AIDS, malaria and tuberculosis). With 695,000 premature deaths and 38 million Disability-Adjusted-Life-Years (DALYs) in 2019, Sub-Saharan Africa (SSA) bears a disproportionate fraction (30%) of the global HAP-related disease burden. To reduce the dangers of reliance on these fuels, the UN established Sustainable Development Goal 7 (SDG7) has set a deadline of 2030 for “universal access to clean, modern energy”. Unfortunately, data show that the world is not on track to meet SDG7, particularly in Sub-Saharan Africa. Increasing use of liquefied petroleum gas (LPG), a clean burning fuel with much lower air pollution than traditional fuels and wide availability, is the best short to medium term solution promoted by most countries for its rapid scale-up potential. The NIHR CLEAN-Air(Africa) Global Health Research Unit aims to inform national strategies to help achieve SDG7 through scaled adoption of LPG for clean cooking in Kenya, Uganda, Rwanda, Tanzania and Cameroon to address the negative health, gender, environment and climate impacts from reliance on polluting cooking fuels. The Unit is a partnership of leading academic, research, health and public institutions in the UK and SSA and has an ambitious 5-year program of implementation research, capacity building and health systems strengthening across its five focus countries 1. The Unit will establish the first Air Pollution Centre of Excellence in SSA to be located at the Kenya Medical Research Institute (KEMRI) in Nairobi. The Centre will include state-of-the-art air monitoring equipment and measuring capabilities becoming a training hub from East Africa. It will support research to elucidate relationships between exposure to HAP, acute health symptoms and respiratory disease and cardiovascular health, while also supporting the Kenyan Government in setting new air quality standards. 2. The Unit will initiate a program of HAP related disease prevention (including promotion of clean household energy) leveraging expertise of community health workers (CHWs) as front-line workers in health promotion through implementation of standardised national Ministry of Health (MoH) led training of CHWs in HAP, health and prevention. This will include (i) provision of curricula/ job aids in Cameroon, Rwanda and Uganda with piloting of training, (ii) creation of a digital platform for CHW training and health surveillance to maximise reach of training and (iii) monitoring and evaluation of rollout of the training in Kenya to 140,000 CHWs, initiated as part of the CLEAN-Air(Africa) Global Health Research Group. 3. To inform national policies relevant to SDG7 the Unit will collaborate with several international organisations (e.g. WHO, World Food Programme) to investigate innovations that have potential to facilitate rapid scale of LPG for clean cooking in SSA. This will comprise five randomised controlled trials to test technological (pay-as-you-cook LPG smart meters and pressure cookers), nutritional (pre-cooked, vitamin enhanced beans) and behavioural (cooking classes) innovations for addressing barriers to adoption and exclusive use of clean cooking fuel for households and schools in East Africa (Kenya, Tanzania and Rwanda). The focus on schools is novel and important with widespread reliance on wood and charcoal for cooking school meals leading to a high degree of HAP exposure for school cooks and pupils. In addition an in depth mixed-methods evaluation will be conducted of a successful social entrepreneur company in Kenya providing LPG access to rural women (over 20,000 current users) to understand their ability to facilitate microfinance for clean cooking. 4. The Unit will also seek to describe hidden burdens from reliance on polluting solid fuels and kerosene for household energy including gender inequity (time poverty from fetching firewood and ill health/ lost time from cooking with these fuels through survey based research in Kenya, Rwanda and Tanzania) and the occurrence of fuel related burns/ scalds (establishment of surveillance systems at specialist hospitals and in the community in Cameroon and Uganda). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 1331722 1479372 1448284 1222092 1078880 438944 6999294 GB-GOV-10-GHRU_2_134530 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 242131 GB-GOV-10-GHRU_2_134530 2022/23 Q2 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) University of Liverpool 363197 GB-GOV-10-GHRU_2_134530 2022/23 Q2 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) University of Liverpool 270402 GB-GOV-10-GHRU_2_134530 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 427768 GB-GOV-10-GHRU_2_134530 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 238002 GB-GOV-10-GHRU_2_134530 2023/24 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Liverpool 409726 GB-GOV-10-GHRU_2_134530 2023/24 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Liverpool 401433 GB-GOV-10-GHRU_2_134530 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 299072 GB-GOV-10-GHRU_2_134530 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 344435 GB-GOV-10-GHRU_2_134530 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 403223 GB-GOV-10-GHRU_2_134530 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 312342 GB-GOV-10-GHRU_2_134530 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 402210 GB-GOV-10-GHRU_2_134530 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 357575 GB-GOV-10-GHRU_2_134530 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 320559 GB-GOV-10-GHRU_2_134530 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 367309 GB-GOV-10-GHRU_2_134530 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 367459 GB-GOV-10-GHRU_2_134530 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 258202.95 GB-GOV-10-GHRU_2_134530 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool GB-GOV-10-GHRU_2_134702 UK - Department of Health and Social Care (DHSC) Global Health Research Unit: Neurodevelopment and AutisM in South ASia Treatment and Evidence (NAMASTE) is an ambitious programme which aims to develop a flexible evidenced pathway towards universal health coverage for young children with Autism, focused on four regions in South Asia. Autism a severe neurodevelopmental disability has a significant impact on a child’s developmental trajectory into adulthood with profound long-term consequences on the individual and their families. About five million families in India alone live with a young autistic child, the great majority with no access to services. Over a 10-year collaboration, Sangath, an Indian public health research not-for-profit, and the University of Manchester have carefully adapted an early intervention, tested in the UK with evidence for improving long-term autism outcomes for non-specialist delivery in South Asia. The resulting 'Parent-mediated Autism Social Communication Intervention for Non-Specialists Plus (PASS Plus)’, is the first of its kind having shown real-world effectiveness in low resource settings. Sangath has in parallel, also developed an extensive digital training and supervision platform for health workers to support non-specialist delivery of a range of psychosocial interventions. NAMASTE will extend this work, with additional collaboration with the World Health Organization’s group-delivered 'Caregiver Skills Training' (CST) for more general neuro-disability, into a comprehensive detection care pathway, which will include a novel, flexible digitally enabled, two-level screening protocol (for young children with neurodevelopmental difficulty); combined with a complimentary evidenced intervention protocol embedded in the health system where possible. NAMASTE will develop a training, research and capacity building hub across India, Sri Lanka and Nepal over 5 years. Initial workforce development will build clinical and research capacity across each country; including masters, doctoral, and post-doctoral training from the UK for future health leadership. In each region and at each stage, community partners, self-advocates and co-applicants will help co-design awareness materials and advise on tool and protocol development. Evaluation of this program will be disseminated in international scientific and policy forums. This NIHR Global Health Research Unit will generate a hub for high quality research in autism and other developmental disorders in South Asia. 1. To develop and evaluate a stepped detection pathway for a broad range of Neurodevelopmental Disorders (NDDs) including autism. This will include a system of universal screening and surveillance for developmental delays as well as autism risk, for young children. Outcome: A community administered questionnaire which is sensitive and specific in identifying young children with neurodevelopmental disabilities including autism. 400 Public health midwives (PHM) in Sri Lanka; 155 frontline workers in India and 14 Female Community Health Volunteers (FCHV) sensitized to neurodevelopmental disorders and to administer the questionnaire. 2. To digitize the training for non-specialist to deliver two evidenced interventions, including the World Health Organization Caregiver Skills Training (WHO-CST); and the Parent-mediated Autism Social Communication Intervention for non-Specialists Plus (PASS Plus), a developmental intervention supporting social communication for autism. The programme will develop linked competency assessments for each intervention, ensuring a scalable certification process. Outcome: 10 PHMs in Sri Lanka, 8 frontline workers in India and 4 non-specialist in Nepal trained to competency to deliver the two intervention packages. 3. To digitize a supervision platform for the PASS Plus intervention. This digital platform will allow remote access to non-specialist delivered sessions to allow supervision and quality checks and facilitate peer supervision in groups. Outcome: A digital platform which will be evaluated for use in building and supporting peer supervision skills of non-specialist health workers in delivering the PASS Plus intervention. 4. To develop and capacity build a training and supervision cascade to deliver both interventions. Outcome: A minimum of four Master trainers for both interventions will be established within each country team. 5. To evaluate the effectiveness of the data pipeline from detection to intervention across the sites, using process indicators, elucidating the accuracy of the detection pathway, the engagement with the interventions being delivered and the acceptability, feasibility and quality of non-specialist delivery of the two interventions. Outcome: A scalable model for a district level service provision for young children with neurodevelopmental disorders 6. To evaluate service use and organisational costs in the implementation areas; and developing relevant health economic quality of life outcomes. Outcome Development of joint policy briefs with government partners for dissemination and scale up of services. 7. To develop research and clinical capacity in partnership regions coupled with an extensive postgraduate training and supervision programme. This will include four PhD students registered at the University of Manchester, and embedded within local site activity. These individuals will develop capacity in key areas of need and supported to act as a nucleus to lead future clinical research within South Asia. Additionally, six Masters courses and bespoke training and professional development activities to further build capacity within local teams. Outcome Research and clinical capacity to deliver NAMASTE objectives and to develop and sustain a South Asia Neurodevelopmental Disabilities Research Hub extending beyond the project timelines 8. To develop a public engagement campaign through participatory and collaborative methods, to help increase the awareness of neurodevelopmental disorders and autism in the implementation communities. Outcome: A customised toolkit for each site for advocacy and awareness raising. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Manchester UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 1237467 1429804 1405252 1376584 1071192 434725 6955024 GB-GOV-10-GHRU_3_134702 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 176781 GB-GOV-10-GHRU_2_134702 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) The University of Manchester 530343 GB-GOV-10-GHRU_2_134702 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) The University of Manchester 104712 GB-GOV-10-GHRU_2_134702 2023/24 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The University of Manchester 310416 GB-GOV-10-GHRU_2_134702 2023/24 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The University of Manchester 470721 GB-GOV-10-GHRU_2_134702 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 29567 GB-GOV-10-GHRU_2_134702 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 39602 GB-GOV-10-GHRU_2_134702 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 262346 GB-GOV-10-GHRU_2_134702 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 308122 GB-GOV-10-GHRU_2_134702 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 249131 GB-GOV-10-GHRU_2_134702 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 238515 GB-GOV-10-GHRU_2_134702 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 296653 GB-GOV-10-GHRU_2_134702 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 512308.38 GB-GOV-10-GHRU_2_134702 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 423257.81 GB-GOV-10-GHRU_2_134702 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester 6929 GB-GOV-10-GHRU_2_134702 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Manchester GB-GOV-10-GHRU_2_134801 UK - Department of Health and Social Care (DHSC) Brazil and Ecuador are Latin American countries that show marked inequalities in health. Although there are many potential causes of health differences between different social groups, it is reasonable to assume that these are largely due to the social determinants of health – the conditions in which people are born, grow, work, live, age and die. At the same time, there are many environmental factors that can impact individual and population health, including the built environment and climate change. Such environmental considerations tend to have the most harmful impacts on the most deprived in society. In an attempt to reduce the impact of social conditions such as poverty, governments sometimes have introduced policies such as providing small cash payments to or building houses for the very poor. Similarly, in an attempt to protect the environment and to mitigate their harmful effects on the conditions in which people live, governments may introduce environmental policies. While such policies may have health improvement as the primary target, they may still have a notable influence on health. Our Unit will focus on discovering whether these policies, when implemented, had any impact on health, whether they had a bigger impact on disadvantaged groups (defined by income, ethnicity, sex, geography, migrant status and deprivation), and the extent to which the health impacts have been modified by the provision and organisation of health services, particularly regarding coverage, access and quality. Over the next five years, we plan to lead globally, with particular reference to Latin America, in terms of using the full potential of existing databases by combining them to find out whether social and environmental policies have had an impact on health and health inequalities, and the extent to which these can be affected by health service provision. 1. Building, developing and linking national databases covering health, social (e.g. welfare) and environmental registers in Brazil and Ecuador; 2. Studying the impacts of social and environmental policies, and the effects of large scale population movement on health and health inequalities; 3. Creating indicators of deprivation for small areas covering the whole of Brazil and Ecuador; 4. Determining how best to organise health services to improve health for all social groups and to respond to social and environmental threats in a way that minimises the damage they do to health; 5. Focusing on health outcomes that are considered priorities in Brazil, Ecuador and the Latin American region, in which our research team has particular expertise: non-communicable diseases including mental health and asthma; maternal and child health; reproductive and sexual health; COVID-19, infectious diseases and emerging health threats; neglected tropical diseases; and violence; 6. Monitoring progress towards the United Nations’ 2030 Agenda for Sustainable Development (particularly Goal 3: Ensure healthy lives and promote well-being for all at all ages); 7. Working with stakeholders, communities and the public to decide which policies we should evaluate, set priorities for our research, and tell different audiences about our results, particularly those who are making policies; and 8. Training researchers from Brazil, Ecuador and other low and middle-income countries in global health research methods by developing a research hub in Ecuador, and providing training programmes and mechanisms to share researchers’ experiences. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Glasgow UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 1288463 1509956 1375680 1253696 1128972 443208 6999975 GB-GOV-10-GHRU_2_134801 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 234266 GB-GOV-10-GHRU_2_134801 2022/23 Q2 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) University of Glasgow 351399 GB-GOV-10-GHRU_2_134801 2022/23 Q2 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) University of Glasgow 324737 GB-GOV-10-GHRU_2_134801 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 93148 GB-GOV-10-GHRU_2_134801 2023/24 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Glasgow 239730 GB-GOV-10-GHRU_2_134801 2023/24 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Glasgow 456299 GB-GOV-10-GHRU_2_134801 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 192559 GB-GOV-10-GHRU_2_134801 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 405493 GB-GOV-10-GHRU_2_134801 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 401225 GB-GOV-10-GHRU_2_134801 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 504277.3 GB-GOV-10-GHRU_2_134801 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 166173.47 GB-GOV-10-GHRU_2_134801 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 402869.64 GB-GOV-10-GHRU_2_134801 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 480763.86 GB-GOV-10-GHRU_2_134801 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 494235.57 GB-GOV-10-GHRU_2_134801 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 207900.15 GB-GOV-10-GHRU_2_134801 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow GB-GOV-10-HPSR UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR has identified health policy and systems research (HPSR) as a strategic global health research priority. Through a process of stakeholder consultation, NIHR aims to develop a portfolio of activities that will support health policy and systems research for the direct and primary benefit of people in low- and middle-income countries (LMIC). 1) Support applied and implementation research that promotes the coverage, quality, efficiency and equity of health systems in LMICs. 2) Leverage NIHR expertise in health services and health systems research, and work with leading health research funders to develop initiatives that complement the existing global HSR funding landscape. 3) Contribute towards the achievement of Universal Health Coverage (SDG 3.8). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Oxford Imperial College London King's College London London School of Hygiene and Tropical Medicine Liverpool School of Tropical Medicine Queen Mary University of London The University of the West of England, Bristol The Queen's University of Belfast University of Birmingham University of Essex London School of Hygiene and Tropical Medicine The University of Sheffield The University of Edinburgh Imperial College London London School of Hygiene and Tropical Medicine London School of Hygiene and Tropical Medicine University of Leeds Liverpool School of Tropical Medicine University of Sussex Queen Margaret University Loughborough University Liverpool School of Tropical Medicine Imperial College London The University of the West of England, Bristol University of Cape Town LVCT Health BRAC University University of Plymouth Universidad Peruana Cayetano Heredia Imperial College London Universities UK UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-HPSR_CA_130812 UK - Department of Health and Social Care (DHSC) Essential technologies could improve quality and outcomes of care if they are successfully adopted but benefits in poorer countries are threatened by workforce shortages and a failure to consider all the obstacles to their use up and down the system. Thus, many technologies fail, for example it is reported there are over 200,000 failed mHealth apps. This wastes valuable resources, or can even worsen care quality. Our proposal addresses this key emerging issue in Kenya. In doing this we address the priority areas of Quality of Care, including families’ experiences of care; Health Workforce Management and Planning, as we explore how technologies can support or undermine routine work in settings with few staff; and Integrating Health Services & Improved Data Quality and Use, by exploring how information technologies might best support post-discharge care for sick babies.This research has the direct and primary aim of improving the health, wellbeing and economic development of people in low and middle income countries. We have two broad objectives: 1. To learn how technologies can be better designed and introduced in weak health systems to yield benefits and reduce harms and waste. 2. To build capacity of government and researchers for these difficult but important evaluations so they help poorer countries strengthen their health systems. To achieve these in Work-package 1 we will design and conduct an evaluation using multiple approaches of a large existing hospital technology intervention programme. We will deliberately change staff numbers to explore how this affects quality and technology adoption. In Work-package 2, we focus on using methods that involve staff and families to co-design an approach that helps schedule the care sick babies need after hospital discharge and ensures all health staff and families have access to key information needed for follow up care. This work will produce an outline technology for testing with new funding. In Work-package 3 we tackle cross-cutting issues including how technologies are changing the jobs people do and the skills they need individually and as teams to give quality care and explore what oversight mechanisms are needed to gain good evidence on the effects of introducing technologies in health. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Oxford UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 417596 938496 1048728 959931 230478 208798 GB-GOV-10-HPSR_CA_130812 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 3595229 GB-GOV-10-HPSR_CA_130812 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Oxford 208798 GB-GOV-10-HPSR_CA_130812 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 3581 GB-GOV-10-HPSR_CA_130812 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 178464 GB-GOV-10-HPSR_CA_130812 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 265286 GB-GOV-10-HPSR_CA_130812 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 293156 GB-GOV-10-HPSR_CA_130812 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Oxford 73364.36 GB-GOV-10-HPSR_CA_130812 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Oxford 252476 GB-GOV-10-HPSR_CA_130812 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Oxford 352024 GB-GOV-10-HPSR_CA_130812 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 218224.49 GB-GOV-10-HPSR_CA_130812 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 214811 GB-GOV-10-HPSR_CA_130812 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 297197 GB-GOV-10-HPSR_CA_130812 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 17467 GB-GOV-10-HPSR_CA_130812 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 505791 GB-GOV-10-HPSR_CA_130812 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 144998 GB-GOV-10-HPSR_CA_130812 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 99547 GB-GOV-10-HPSR_CA_130812 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 81484 GB-GOV-10-HPSR_CA_130812 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford GB-GOV-10-HPSR_CA_131145 UK - Department of Health and Social Care (DHSC) Affordable, good quality medicines are a bedrock of strong health systems, something governments aspire to deliver as they expand health care to more citizens, especially the poorest. But budgets don't always match political aspirations or patient demand, and health authorities have to squeeze down spending on medicines or services. If prices are pushed too low, drug manufacturers sometimes cut corners, compromising quality. Hospitals also protect profits by pushing patients towards medicines not covered by insurance. Poor patients then buy on the internet or in street markets, where they are easy targets for criminals who sell fake medicines. So while expanding health systems are delivering more medicines, poorer people may be getting "medicines" that don't actually work, and which can cause real harm. The World Health Organization says substandard and falsified medicines are a major problem in poorer countries with rapidly-growing markets, but no-one knows how bad the problem really is. Some prefer to turn a blind eye, worrying that quality enforcement could reverse progress towards wider access. And with no reliable numbers, it's easy for politicians to ignore the threat, at least for a while. Over time, though, bad quality medicines hurt patients, waste money, drive out responsible companies and undermine confidence in the whole health system. And if sub-par antibiotics don't deliver full doses to patients, they'll kill only the weaker bugs, allowing resistant infections to spread. We want to help countries understand and measure the problem, so that they can plan effective action and track change over time. That's hard to do, because the market for medicines is huge and complex. We've been working in Indonesia to use information about price, sales outlet and company history to try and predict which medicines are most likely to be substandard or fake. We believe our model could be used to improve the efficiency of surveillance systems, helping governments to save money by sampling from the market and testing the medicines most likely to be poor quality. We also want to build simple tools to estimate the overall size of the problem in a country, and the toll it takes on health and on the economy. We'll work with WHO to make these methods useful for many countries. First, we want to try the system in Indonesia, the world's fourth most populous country, where 106 million people live on less than £1.25 a day. In the last 5 years most of them have joined another 116 million citizens as members of the national health insurance scheme, which carries a deficit of £1.9 billion. Medicine prices have been slashed, and several recent scandals, as well as our research, suggest that poor quality medicines are common. Working with the regulator, we plan to sample and test medicines from categories our model predicts are at risk (e.g. expensive medicines with recent shortages sold on the internet; or products sold for under 20% of a benchmark price). We'll work in 9 districts in 4 market regions, and use the results, together with assumptions based on market volumes, insurance claims and discussion with our policy partners, to estimate the prevalence, impact and cost of poor quality medicines in Indonesia. Those policy discussions can provide a springboard for action needed to ensure that quality is built in to medicine procurement, while the methods we develop will provide a blueprint for other countries facing similar challenges. We aim to support national efforts to ensure that Indonesians, especially the poorest who rely on insurance or informal markets, have consistent access to quality medicine. We will do this by working with the medicine regulator and intersectoral partners to better understand and quantify the prevalence and distribution of substandard and falsified medecines nationally. In the process, we will: 1. Trial new methods for risk-based sentinel surveillance for substandard and falsified medecines. 2. Develop robust, adaptable tools to estimate the prevalence, health impact and cost of substandard and falsified medecines. 3. Pioneer the use of the tools, making the first national estimates of substandard and falsified medecines in any low and middle-income country (LMIC). 4. Engage continuously with policy partners to facilitate appropriate intersectoral responses in Indonesia, and to adapt tools for other LMICs. 5. Promote institutionalisation of academic-policy partnerships to support the ongoing production and use of medicine policy research in Indonesia. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Indonesia Medical research Research and Innovation 352971 821971 659182 148007 176486 GB-GOV-10-HPSR_CA_131145 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 1982131 GB-GOV-10-HPSR_CA_131145 COMMITMENT UK - Department of Health and Social Care (DHSC) Imperial College London 176486 GB-GOV-10-HPSR_CA_131145 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 34180 GB-GOV-10-HPSR_CA_131145 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 154926 GB-GOV-10-HPSR_CA_131145 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 291808 GB-GOV-10-HPSR_CA_131145 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 198730 GB-GOV-10-HPSR_CA_131145 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Imperial College London 275026.43 GB-GOV-10-HPSR_CA_131145 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Imperial College London 120043 GB-GOV-10-HPSR_CA_131145 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Imperial College London 94499 GB-GOV-10-HPSR_CA_131145 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 226525.24 GB-GOV-10-HPSR_CA_131145 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 135344 GB-GOV-10-HPSR_CA_131145 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 57638.97 GB-GOV-10-HPSR_CA_131145 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 101338 GB-GOV-10-HPSR_CA_131145 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London GB-GOV-10-HPSR_CA_131207 UK - Department of Health and Social Care (DHSC) As the Syrian conflict enters its ninth year, 13.2 million Syrians are in need of health assistance. Displacement continues to be a major challenge for the country with 5.6 million refugees and 6.6 million internally displaced persons (IDPs) according to UNHCR as of April 2019. The conflict has caused a severe disruption in health services leading to a collapse of the health system in the most conflict-affected areas. Attacks on healthcare have been a major threat in Syria, in what has been described as a weaponisation of health care. The UN estimates that half of the health facilities in Syria are either only partially functional or destroyed. Physicians for Human Rights have documented 588 attacks on health facilities and 914 medical personnel killed between March 2011 and November 2019. Essential health services have been further disrupted by the increasing number of health professionals fleeing the country. This has left populations with limited access to healthcare leading to increased vulnerability to communicable and non-communicable diseases. Recently, there have been three distinctive territories in Syria corresponding to the different areas of control. About 60% of the Syrian territories, including the capital Damascus and most central and southern areas, are controlled by Assad regime. Kurdish armed groups, supported by the US, control around 25% of north east Syria, with a population of approximately 4 million. The remainder of opposition armed groups, supported by Turkey, control around 15% in the north west with a population of approximately 3.5 million. The health system in each territory developed different adaptation mechanisms to the conflict. For example, after the collapse of the health system in north west Syria, local medical networks - relying on limited local resources, the remanence of health infrastructure and equipment, and the humanitarian health resources - adopted a new bottom up approach to build a hybrid and kinetic health system that is currently functioning as an autonomous local health authority in the region. Whereas, the health system in north east Syria maintained a level of functionality throughout the conflict with a similar structure to the pre-conflict health system and some ties to the Damascus Ministry of Health. Little is understood about how contemporary conflicts shape emergent health ‘systems’. It is important to study these different adaptation mechanisms and explore various strategies to strengthen these health systems and ways to integrate them into a national health system in what will now be the post conflict phase. Throughout the Syrian conflict, research has been focused largely on Syrian refugees in neighbouring countries and in Europe with very little focus on health issues within the country. Our project will study the experience of health systems in north west and north east Syria in relation to four elements of health system adaptation and strengthening; provision of health services – by comparing different models of health service provision, health education and medical training, health financing, and the use of digital solutions in health information system to inform future post conflict systems strengthening (SDG 3 and 6). The main aim of Research for Health System Strengthening in northern Syria is to produce a model on health system strengthening in conflict settings which could be applied in other contexts affected by protracted and complex conflicts. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) King's College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Syrian Arab Republic (the) Medical research Research and Innovation 654599 1070896 996894 1011567 253962 327299 GB-GOV-10-HPSR_CA_131207 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 3987918 GB-GOV-10-HPSR_CA_131207 COMMITMENT UK - Department of Health and Social Care (DHSC) King's College London 327299 GB-GOV-10-HPSR_CA_131207 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 279358 GB-GOV-10-HPSR_CA_131207 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 162234.03 GB-GOV-10-HPSR_CA_131207 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) King's College London 155923.26 GB-GOV-10-HPSR_CA_131207 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) King's College London 307062 GB-GOV-10-HPSR_CA_131207 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) King's College London 249526 GB-GOV-10-HPSR_CA_131207 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 497683 GB-GOV-10-HPSR_CA_131207 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 612950 GB-GOV-10-HPSR_CA_131207 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 267112 GB-GOV-10-HPSR_CA_131207 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 126426 GB-GOV-10-HPSR_CA_131207 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 337523 GB-GOV-10-HPSR_CA_131207 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 138126.97 GB-GOV-10-HPSR_CA_131207 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London GB-GOV-10-HPSR_CA_131237 UK - Department of Health and Social Care (DHSC) Every year 2.5 million newborns die. Most of these deaths happen in hospital and could be prevented. Babies in their first 28 days of life represent some of the most vulnerable users of the health system, as they can die quickly. Malawi was one of the fastest progressing countries in Africa for newborn survival, but progress has stalled. Now that most births happen in health facilities, there is an urgent need to improve hospital care for newborns and their families. There is strong evidence that health technologies (e.g. drugs, equipment) are a necessary ingredient for improving survival of small and sick babies. However, in practice, babies do not always get these clinical interventions even when resources are available. Commonplace problems, such as drug stockouts, absent staff, and power outages, are due to organisational failings that are rooted in poor management. Improving management practices – so that hospitals effectively manage staff, drugs and medical supplies, have sound financial management and are data-driven in how they make decisions – offers the potential to turn the situation around. Building on an existing platform, Newborn Essential Solutions & Technologies (NEST360), we will identify practical ways to enhance management practices in the 36 largest hospitals (43,000 babies admitted per year) in Malawi, to improve quality of care and reduce newborn deaths. We will address what are three fundamental gaps in knowledge. First, until recently, we did not have the tools to measure the extent to which hospitals adopt management practices. Building on recent advances, we will adapt and validate tools for Malawi to measure management practices. Second, no interventions to enhance hospital management practices have been rigorously evaluated in low-resource settings. Working in partnership with the Ministry of Health, experts and other key partners, we will design a management intervention and then evaluate it using the gold-standard of a randomised controlled trial and other complementary methods. This will inform scale up to the entire country and generate findings that can inform policy in other countries. Third, it is rarely possible to measure lives saved in such health systems research. By building on the existing NEST360 network of 36 hospitals with detailed patient level information on newborns admitted to hospital, we will examine which management practices matter most for quality of care. At the core of the research is an equitable partnership between College of Medicine, University of Malawi and London School of Hygiene & Tropical Medicine. A multi-disciplinary team of health system researchers, epidemiologists, health economists, social scientists, clinicians, implementation scientists and statisticians will partner with the Ministry of Health to generate high quality evidence that has direct relevance for policy and practice in Malawi, the African region, and beyond. At all stages of the research, from the design through to the communication of the findings, we will engage with the local community. Our goal is to enhance the management of hospitals, ultimately for the benefit of small and sick neonates admitted to hospital. The research aims to examine whether enhanced management practices can improve health outcomes and clinical quality for newborns in hospitals in Malawi. A multi-disciplinary team from College of Medicine, University of Malawi, and London School of Hygience & Tropical Medine will address the following interlinked objectives: 1. Adapt and validate measures of hospital and district management practices. 2. Examine the association between management practices and quality of clinical care, and its variation by facility characteristics. 3. Co-design a problem-focused hospital management intervention and scalable delivery model. 4. Evaluate effectiveness of the intervention on neonatal mortality and secondary outcomes (including hospital-acquired infections) through a cluster randomised trial. 5. Assess the intervention’s acceptability, fidelity, and mechanisms through qualitative research and estimate its cost-effectiveness. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Malawi Medical research Research and Innovation 295826 311745 494108.81 488693 397509.16 97695.48 109767.23 147913 GB-GOV-10-HPSR_CA_131237 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 2092305.36 GB-GOV-10-HPSR_CA_131237 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 147913 GB-GOV-10-HPSR_CA_131237 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 20256 GB-GOV-10-HPSR_CA_131237 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 63041 GB-GOV-10-HPSR_CA_131237 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 228448 GB-GOV-10-HPSR_CA_131237 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 96052.81 GB-GOV-10-HPSR_CA_131237 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 139627 GB-GOV-10-HPSR_CA_131237 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 258429 GB-GOV-10-HPSR_CA_131237 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 134533 GB-GOV-10-HPSR_CA_131237 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 177467 GB-GOV-10-HPSR_CA_131237 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 176693 GB-GOV-10-HPSR_CA_131237 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 250966 GB-GOV-10-HPSR_CA_131237 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 103039.32 GB-GOV-10-HPSR_CA_131237 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 54980.56 GB-GOV-10-HPSR_CA_131237 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 128417.72 GB-GOV-10-HPSR_CA_131237 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 60840 GB-GOV-10-HPSR_CA_131237 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-HPSR_CA_131273 UK - Department of Health and Social Care (DHSC) We are the NIHR Group on the Management and Prevention of HIV-infection, Diabetes and Hypertension. In our NIHR Group award we had an ambitious objective to bring together vertically delivered HIV services (generally well-resourced and protected) and diabetes and hypertension care (currently less structured and poorly resourced), under one roof in Tanzania and Uganda. This approach was innovative, unique and risky. With support and in partnership with policy makers and disease control programme managers, we have successfully established and are currently evaluating this “integrated care clinic” model. However, the prevalence of chronic conditions is so high that clinic-based care alone cannot meet demand. Our NIHR Group is being urged by health services to evaluate decentralising integrated care to the community-level. Our primary research question for the proposed research is: How can we design community-based integrated management of HIV-infection, diabetes and hypertension, and what is its effectiveness in comparison to clinic-based integrated management of these conditions in terms of patient outcomes? Moreover, we want to know how an effective model of community-based integrated management can be scaled up and sustained across different country contexts in Africa. The proposed research will likely be more challenging than clinic-based integration, in part, because examples of community management, particularly of an integrated nature, are rare. The agenda has been defined after almost 2 years of discussions with African health policy makers in Tanzania and Uganda, and with input from patient and community representatives. Our primary question is: How can we design community-based integrated management of HIV-infection, diabetes and hypertension, and what is its effectiveness in comparison to clinic-based integrated management of these conditions in terms of patient outcomes? Moreover, we want to know how an effective model of community-based integrated management can be scaled up and sustained across different country contexts in Africa. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 737216 470568 349632 1256379 1274208.37 215158.07 368608 GB-GOV-10-HPSR_CA_131273 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 3991107.1 GB-GOV-10-HPSR_CA_131273 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 368608 GB-GOV-10-HPSR_CA_131273 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 47762 GB-GOV-10-HPSR_CA_131273 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 422806 GB-GOV-10-HPSR_CA_131273 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 349632 GB-GOV-10-HPSR_CA_131273 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine -111310 GB-GOV-10-HPSR_CA_131273 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 837008 GB-GOV-10-HPSR_CA_131273 2023/24 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 424758 GB-GOV-10-HPSR_CA_131273 2023/24 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 105923 GB-GOV-10-HPSR_CA_131273 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 588656 GB-GOV-10-HPSR_CA_131273 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 312054.34 GB-GOV-10-HPSR_CA_131273 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 197050.03 GB-GOV-10-HPSR_CA_131273 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 201789 GB-GOV-10-HPSR_CA_131273 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 54239 GB-GOV-10-HPSR_CA_131273 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 134424 GB-GOV-10-HPSR_CA_131273 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-HPSR_DA_129848 UK - Department of Health and Social Care (DHSC) Safe and affordable surgery is a global health priority. For surgical procedures to effectively improve patient outcomes, health systems must also provide high-quality perioperative care (the care before, during and after surgery). There is now strong evidence that health systems failures around the time of surgery are a key factor limiting the net improvements in health which could be achieved through greater worldwide access to surgery. In this proposal, we will build the foundations of a major global health research unit to study and improve perioperative health systems. We will map perioperative care pathways in different resource limited hospitals. We will co-produce a list of research priorities, and a core dataset for quality assurance, clinical trials and implementation research. We will perform initial community engagement work, a research capacity needs analysis and develop the dissemination plans essential for a major research programme in perioperative care. 1) Establish partnerships with five higher education institutions in low- and middle-income countries (LMICs) 2) Map perioperative care pathways in different LMIC hospitals and identify common research themes, using literature review, observation and interviews with healthcare staff and patients 3) Co-produce priority questions with patients, healthcare staff and policy-makers for future mixedmethods research, using surveys and stakeholder workshops 4) Co-produce a patient dataset which is relevant and feasible to collect in resource limited hospitals, and build a simple online database to capture this information 5) Complete a research capacity needs assessment at local and national levels in LMICs and a workforce plan for research delivery 6) Develop a pathways to policy impact plan for future research UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Queen Mary University of London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 99523 12677 GB-GOV-10-HPSR_DA_129848 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 17483.25 GB-GOV-10-HPSR_DA_129848 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 99523 GB-GOV-10-HPSR_DA_129848 COMMITMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 5470 GB-GOV-10-HPSR_DA_129848 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 34212 GB-GOV-10-HPSR_DA_129848 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 19728.75 GB-GOV-10-HPSR_DA_129848 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 9952 GB-GOV-10-HPSR_DA_129848 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London GB-GOV-10-HPSR_DA_129877 UK - Department of Health and Social Care (DHSC) The death rate for road traffic injuries in Nepal is now estimated at 22.7/100 000, ranking Nepal as 30th of 195 countries worldwide (Global Burden of Disease 2019). This study will identify the priorities for road safety research that would support the development of a multi-sectoral ‘safe system’ for road users in Nepal. The World Health Organization has identified five ‘pillars’ of road safety; road safety management, safe roads, safe people, safe vehicles and having an effective post-crash response. Through existing networks we will engage up to 25 stakeholders for each of the five pillars. Interviews with each stakeholder will identify individual views on the evidence gaps. At a series of five workshops collated issues for each pillar will be discussed and ranked. The output will be consensus on the priorities for a programme of road safety research in Nepal. 1) Identify what research needs to be done, and what information needs to be found, to create a safe system for road users in Nepal. 2) Identify 20-25 stakeholders whose experience and knowledge is relevant to each of the five pillars of road safety. 3) Interview each stakeholder to identify what they think are the main gaps in our knowledge. 4) Collate the ideas from the stakeholders and present them at a workshop to which all of the stakeholders will be invited. Support participants to rank the evidence gaps in order of importance and share the results and give everyone the chance to rank the list again. 5) Generate a prioritised programme of research to reduce road traffic deaths and injuries in Nepal. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 79486.95 19861 GB-GOV-10-HPSR_DA_129877 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 79486.95 GB-GOV-10-HPSR_DA_129877 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 2295 GB-GOV-10-HPSR_DA_129877 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 13061 GB-GOV-10-HPSR_DA_129877 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 12231.95 GB-GOV-10-HPSR_DA_129877 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol GB-GOV-10-HPSR_DA_129915 UK - Department of Health and Social Care (DHSC) Mongolia has the highest cancer death rates in Asia-Pacific and cancer incidence is expected to double by 2040. The proposed study represents the first step of a health policy and systems research (HPSR) programme aiming to reduce cancer burden in Mongolia by strengthening its health care system and supporting evidence-based service planning and policy development. Collaborative preliminary work identified cancer prevention and early detection as the early focus of the HPSR Programme. In this developmental phase we will work with local stakeholders to describe current early detection and cancer prevention initiatives in Mongolia, and to identify and develop plans for future HPSR research and capacity building activities. We will conduct a scoping review, undertake a needs-and-gaps analysis, use consensus-elicitiation techniques to identify priorities, provide capacity-building training in Mongolia and the UK, and co-develop plans to advance our collaborative HPSR programme. 1) Conduct a review of published and grey literature regarding early detection and cancer prevention in Mongolia 2) Undertake a needs-and-gaps analysis (key informant interviews, online survey, consensus workshop) to identify, refine and prioritise research questions 3) Design an interdisciplinary collaborative research programme focusing on improving early detection and cancer prevention in Mongolia 4) Establish a community advisory steering group to contextualise and sustain the partnership and assist with dessimination of research results into usable findings 5) Develop and expand (according to HSPR Programme needs) the current Queens University Belfast (QUB)-National Cancer Centre of Mongolia (NCC) partnership 6) Contribute to capacity building, skill development and knowledge transfer 7) Formulate and sign a Memorandum of Understanding between QUB and NCC. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 93487.41 18644 GB-GOV-10-HPSR_DA_129915 2020/21 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 1974 GB-GOV-10-HPSR_DA_129915 2020/21 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 93487.41 GB-GOV-10-HPSR_DA_129915 COMMITMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 6742 GB-GOV-10-HPSR_DA_129915 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 28500 GB-GOV-10-HPSR_DA_129915 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast 28278.41 GB-GOV-10-HPSR_DA_129915 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast -8748.47 GB-GOV-10-HPSR_DA_129915 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Queen's University of Belfast GB-GOV-10-HPSR_DA_130036 UK - Department of Health and Social Care (DHSC) Deaths from trauma, especially due to road traffic collisions, are prevalent in lower and middle income countries (LMICs); trauma causes a substantial burden of disability in survivors. Equitable access to quality health care is essential to treat trauma patients. Expanding on our preliminary work in Rwanda, this project will: - Convene workshops with providers and policy makers to delineate barriers, knowledge, and priorities in access to care in three contrasting countries - Map access to trauma care as a complex health system problem - Collect data from patients on their experiences of barriers to and quality of care - Build research capacity in partner countries to enable further work - Develop a network of trauma researchers - Convene a meeting of investigators, patient representatives, and policy makers to discuss findings and, in combination with ongoing studies and literature review results, identify and agree upon priorities for a programme for future research 1) Develop an evidence-based approach, drawing on existing global evidence to decision making (EtD) frameworks, to guide the adaptation of the WHO EDL to national health system needs and establish a Research Initiative for Evidence-based diagnostics in Africa. 2) Engage with decision makers in health policy and practice in East Africa to jointly decide on information needs and the development of methods, skills and capacity required. 3) Conduct a systematic stakeholder analysis to identify local, national, regional and international stakeholders responsible for the EDL in Kenya and Uganda. 4) Conduct a needs analysis thorough literature review and engagement with the identified stakeholders to identify the desired and current status of the EDL lists, decision-making and health system barriers to their adaption and implementation, desired local decision-making approaches and finally refine our proposed research question and study methods. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Birmingham UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 99997 8363 GB-GOV-10-HPSR_DA_130036 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 99997 GB-GOV-10-HPSR_DA_130036 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 12556 GB-GOV-10-HPSR_DA_130036 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 22921 GB-GOV-10-HPSR_DA_130036 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 22710 GB-GOV-10-HPSR_DA_130036 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 23447 GB-GOV-10-HPSR_DA_130036 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 5456.86 GB-GOV-10-HPSR_DA_130036 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham GB-GOV-10-HPSR_DA_130041 UK - Department of Health and Social Care (DHSC) This project will build partnerships towards developing selected health system interventions to address the impact of urban violence on youth access to health services in South Africa and Brazil. The objectives are: 1) Build collaborations with South Africa and Brazil, as countries affected by urban violence particularly in low-income neighbourhoods 2) Carry out a scoping review of the evidence on the influence of urban violence on treatment seeking and health systems and interventions to address this 3) Engage with stakeholders in local health services and socio-economic development, and youth in affected communities, to increase understanding of health systems issues and interventions to decrease the impact of urban violence on youth healthcare access 4) Through collaborative partnerships, work towards developing context appropriate specific health systems micro and meso interventions in South Africa and Brazil for proof-of-concept testing in a future proposal 1) Develop a collaboration between University partners in UK, South Africa and Brazil who together have expert knowledge and/or experience in violence, health systems research, health policy and public engagement. 2) Carry out a scoping review of the evidence on urban violence’s influence on treatment seeking and health systems and potential interventions that may help. 3) Engage with multilevel stakeholders in different sectors in Cape Town, São Paulo and Porto Alegre to identify health systems-related issues and possible interventions. This will include developing an advisory group in each site as well as interviews and workshops with youth groups and healthcare providers in affected communities, health and development policy makers and non-governmental organisations 4) Develop further research plans for a proof-of-concept intervention study to see if the interventions would be feasible and could work. This would include both social and health system elements. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Essex UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 99987.68 11310 GB-GOV-10-HPSR_DA_130041 2020/21 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Essex 19867 GB-GOV-10-HPSR_DA_130041 2020/21 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Essex 99987.68 GB-GOV-10-HPSR_DA_130041 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Essex 6408 GB-GOV-10-HPSR_DA_130041 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Essex 25645 GB-GOV-10-HPSR_DA_130041 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Essex 20996 GB-GOV-10-HPSR_DA_130041 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Essex 5762.68 GB-GOV-10-HPSR_DA_130041 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Essex 6849.64 GB-GOV-10-HPSR_DA_130041 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Essex GB-GOV-10-HPSR_DA_130086 UK - Department of Health and Social Care (DHSC) This project seeks to build a platform to enable and support higher education and research institutions within and beyond China to systematically advance health policy and systems research (HPSR) to generate evidence for health systems strengthening in the most disadvantaged settings in the region and beyond, with lessons learned from the partnership benefitting low resource countries elsewhere. 1) Establish a partnership between Sun Yat-sen University Global Health Institute (SGHI), China, and the London School of Hygiene & Tropical Medicine(LSHTM), UK 2) Develop a consortium of SGHI-LSHTM and research collaborators from disadvantaged provinces in China (Gansu, Inner Mongolia) and Nepal 3) Conduct a review of health system challenges for most disadvantaged populations across China (Tibetan, Muslim and Mongol) and Nepal 4) Work with local stakeholders and communities using structured workshops to identify policy and HPSR priorities at regional level 5) Prepare a grant proposal addressing identified priorities using rigorous, multidisciplinary HPSR methods and approaches. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 91866.5 15309 GB-GOV-10-HPSR_DA_130086 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 91866.5 GB-GOV-10-HPSR_DA_130086 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 18230 GB-GOV-10-HPSR_DA_130086 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 15740 GB-GOV-10-HPSR_DA_130086 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 33400.5 GB-GOV-10-HPSR_DA_130086 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine -21404.63 GB-GOV-10-HPSR_DA_130086 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-HPSR_DA_130103 UK - Department of Health and Social Care (DHSC) Many developing countries are experiencing rapid and unplanned urbanisation. Previous research has shown that this can create a variety of new health risks from communicable and noncommunicable diseases, and that newly-urbanised people can find it more difficult to access health services. Through this award, we will develop the research design, methods and partnerships for a large participatory project examining these issues in four countries across South Asia and sub-Saharan Africa. A pilot study in Nepal will be used to trial a series of participatory research methods (Participatory Video, Participatory Photo and Participatory Mapping) to capture the experiences and perceptions of both newly-urbanised people and providers of health services, to bring these into dialogue with health planners and policymakers, and to learn lessons for a larger-scale funding proposal. Meanwhile, preparatory work and network building will be carried out in Ghana, Bangladesh and one other African country. 1) Develop the partnerships and methods, and prioritise research questions, to inform a larger programme of research which will use a participatory approach to i) better understand lived experiences of the health costs/benefits of urbanisation; and ii) identify mechanisms to enhance the accountability and responsiveness of health systems to the needs of the newly-urbanised. 2) Develop and refine various participatory methods to enable newly-urbanised people, as well as health system stakeholders, to work with us to identify priority areas for research and action, through conducting a pilot study in Nepal 3) Involve partners from other countries in the pilot, enabling consideration of how the methods can be adapted and applied in Bangladesh, Ghana and one other country 4) Build relationships with municipal governments, service providers and other health system stakeholders in each country and determine their priorities for research 5) Build institutional and individual capacity and strengthen partnerships 6) Conduct systematic literature reviews and identify suitable study sites in Bangladesh and Ghana (plus one other country) 7) Develop the ethical protocols for the project’s participatory approach. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Sheffield UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 99649.69 5464 GB-GOV-10-HPSR_DA_130103 2020/21 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The University of Sheffield 15764 GB-GOV-10-HPSR_DA_130103 2020/21 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The University of Sheffield 99649.69 GB-GOV-10-HPSR_DA_130103 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 44217 GB-GOV-10-HPSR_DA_130103 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 11829 GB-GOV-10-HPSR_DA_130103 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 12410.69 GB-GOV-10-HPSR_DA_130103 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield 3102.97 GB-GOV-10-HPSR_DA_130103 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Sheffield GB-GOV-10-HPSR_DA_130125 UK - Department of Health and Social Care (DHSC) Equitable access to healthcare is a key element of emergency preparedness. However, in low-income countries, efforts to strengthen preparedness tend to be disconnected from actions to achieve universal health coverage (UHC). We aim to provide decision-makers with the evidence they need to pursue preparedness and equity goals in synergy. By establishing the Re_Emerge consortium, we aim to produce the evidence needed by key stakeholders working in disease outbreak-affected low-income countries (LIC), so that they can align their efforts, and advance preparedness and UHC through integrated governance and synergistic decision-making. The consortium will conduct research in four low-income countries (LICs) - Sierra Leone, Liberia, Guinea and the Democratic Republic of Congo (DRC) - which recently experienced (and, in DRC’s case, is currently experiencing) outbreaks of Ebola Virus Disease (EVD). We intend to use the development grant to lay the groundwork for this by consolidating an emerging multi-partner collaboration on achieving integrated approaches to health systems strengthening in Ebola-affected settings – led by the University of Edinburgh (UK) and the College of Medicine and Allied Health Sciences (Sierra Leone). 1) Establish arrangements for consortium governance 2) Set up an advisory board of key stakeholders 3) Define capacity needs of our partners 4) Conduct a synthesis of existing data to establish strategic priorities and key evidence needs 5) Construct an initial theory of change, setting out pathways from evidence needs to real-world impact 6) Draft and publish academic/policy outputs from the synthesis 7) Establish plans for a competitive funding application to the NIHR. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Edinburgh UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 92366.76 92366.76 GB-GOV-10-HPSR_DA_130125 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 44621.450000000004 GB-GOV-10-HPSR_DA_130125 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 17821 GB-GOV-10-HPSR_DA_130125 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 20688 GB-GOV-10-HPSR_DA_130125 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh -23882.91 GB-GOV-10-HPSR_DA_130125 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh GB-GOV-10-HPSR_DA_130136 UK - Department of Health and Social Care (DHSC) This project strengthens an existing collaboration between UK-Brazil and extends this to other Latin America countries. It will develop a policy-relevant research agenda to understand and address health system inadequacies in the region, including their impact on Universal Health Coverage (UHC). The main output will be a research proposal focused on health system fragmentation in Latin America, which is widespread in the region and has an especially negative impact on the health of low-income populations. To identify policy-relevant evidence gaps for the proposed research programme, we will undertake a needs assessment and research planning in Brazil and two other countries. This will involve: 1) active, fully integrated stakeholder involvement and engagement (involving policy-makers, non-governmental organisations and civil society); 2) a literature review; 3) identification and curation of data sources; 4) formulation of a research team, covering key methodological requirements; 5) capacity building. 1) Develop a research programme proposal focused on health system fragmentation in Latin America Countries. This setting affords valuable learning to policy-makers in many low- and middle-income countries (LMICs) wishing to advance UHC given fragmentation plagues even mature health systems despite policy innovations to address this. To identify policy-relevant evidence gaps for the proposed research programme, we will undertake a needs assessment and research planning in Brazil and two other countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 99493 6699 GB-GOV-10-HPSR_DA_130136 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 30611 GB-GOV-10-HPSR_DA_130136 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 99493 GB-GOV-10-HPSR_DA_130136 COMMITMENT UK - Department of Health and Social Care (DHSC) Imperial College London 10206 GB-GOV-10-HPSR_DA_130136 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 13172 GB-GOV-10-HPSR_DA_130136 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 31557.22 GB-GOV-10-HPSR_DA_130136 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 4600 GB-GOV-10-HPSR_DA_130136 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London GB-GOV-10-HPSR_DA_130180 UK - Department of Health and Social Care (DHSC) In South Africa(SA), stroke is a leading cause of death and disability and over 30,000 people have a stroke each year. Stroke incidence is increasing due to rising prevalence of risk factors such as obesity and hypertension. While efforts are made to prevent stroke, provision of stroke care remains largely unmet and where available, is limited in quality and accessibility. We will establish a SA-UK partnership to build a consortium, drawing together people with stroke, their families, rural communities, health professionals, researchers and policy planners, which can inform policy makers on context-appropriate stroke care for the new universal health coverage(UHC) bill in SA. Together, we will consider: (i)healthcare needs of people with stroke (ii)how the Health System can meet these needs through a people-centred approach. Our findings will identify priorities for research, generate recommendations for health system planners and inform a subsequent Research Program 1) Establish a Stellenbosch University (SU) and London School of Hygiene & Tropical Medicine (LSHTM) partnership to build a consortium (3-5 institutions) to identify and address research priorities to improve stroke care in SA 2)Determine the current provision of healthcare for people with stroke in SA 3)Identify appropriate economic evaluation methods for a future Research Program Within two provinces purposively selected for comparison, the Eastern Cape (the poorest) and the Western Cape (second wealthiest), our objectives are to: 4)Interrogate networks of health service provision for people with stroke 5)Determine the needs of people with stroke and their families in accessing health services UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 99557 13245 GB-GOV-10-HPSR_DA_130180 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 13604 GB-GOV-10-HPSR_DA_130180 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 99557 GB-GOV-10-HPSR_DA_130180 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 20491 GB-GOV-10-HPSR_DA_130180 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 27303 GB-GOV-10-HPSR_DA_130180 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 14958 GB-GOV-10-HPSR_DA_130180 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 9336.62 GB-GOV-10-HPSR_DA_130180 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 619.38 GB-GOV-10-HPSR_DA_130180 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-HPSR_DA_130201 UK - Department of Health and Social Care (DHSC) Health systems in many countries in the WHO Western Pacific Region (WPR) must respond to changing health needs driven by demographic and economic transition, demanding strengthening of universal health coverage and health system reforms. Yet there is limited health policy and systems research (HPSR) capacity to inform these changes. This project will build HPSR capacity, which is critical to strengthening health systems. A training programme based on global HPSR competencies will be implemented in Malaysia and extended to other WPR countries where there is buy-in, with the aim of creating an international community of practice and a body of policy-relevant research to support health reform. It will be delivered by a consortium comprising the Institute for Health Systems Research (IHSR), the United Nations University-International Institute for Global Health (UNU-IIGH), University of the Philippines Manila (UP Manila) and the London School of Hygiene & Tropical Medicine(LSHTM). 1) Design and field-test an HPSR training programme in Malaysia. An initial needs assessment will help tailor this to diverse audiences. Internationally agreed HPSR competencies will be adapted to the country context, creating a package that is supported by key actors and can be scaled up nationally. An innovative theory of change will be applied to track training outcomes and processes,documenting what works, where, and when. 2) Undertake HPSR capacity mapping in Malaysia and selected WPR countries where there is demand, to identify capacity gaps, national priorities and opportunities to align HPSR training with national health policies (e.g. the Philippines). 3) Learn from the Malaysian experience to develop locally-led, country-specific plans and strategies for scaling up HPSR capacity in these WPR countries. 4) Develop proposals for HPSR projects that address important health system or health service needs in Malaysia and elsewhere in WPR and seek national/regional endorsement and funding. 5) Document and disseminate Malaysian and WPR country experiences through Health Systems Global (HSG), providing a roadmap to accelerate the expansion of HPSR capacity in other low and middle-income countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 95162 13518 GB-GOV-10-HPSR_DA_130201 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 95162 GB-GOV-10-HPSR_DA_130201 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 5420 GB-GOV-10-HPSR_DA_130201 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 59953 GB-GOV-10-HPSR_DA_130201 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 6755 GB-GOV-10-HPSR_DA_130201 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 6624.05 GB-GOV-10-HPSR_DA_130201 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-HPSR_DA_130219 UK - Department of Health and Social Care (DHSC) Availability of affordable medicines is critical for any national health system to ensure equitable access to healthcare. Medicine prices in Ghana are high compared to international reference prices. Between 2012 and 2017, the Government of Ghana introduced four major policies to regulate and reduce medicine prices. These policies are at different stages of implementation and to-date have not yielded the anticipated outcome. Our core focus is to understand, together with policymakers, why these presumed effective policies are not producing anticipated effects on medicine price reduction. Then - drawing on available published evidence and our understanding of how and why the policies are not effective in Ghana – we will co-develop a feasible action plan to facilitate implementation of these policies and generate a policy-driven research agenda to inform and address the information needs of policy makers. Our core question is “Why are these presumed effective medicine price control policies not producing the anticipated effects in implementation in the Ghanaian context?” 1) Develop an in-depth understanding of major determinants of effectiveness of implementing medicine pricing policies in different contexts 2) Develop a shared understanding of main facilitators and barriers to the implementation of medicine pricing policies in the Ghanaian context 3) Drawing on the results of No1 and 2, facilitate: (a) development of a feasible action plan to improve implementation of the four key policies to improve access to essential medicines and (b) coproduction of policy-relevant research agenda to address the information needs of key policymakers UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Leeds UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 99808.6 15325 GB-GOV-10-HPSR_DA_130219 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds 99808.6 GB-GOV-10-HPSR_DA_130219 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Leeds 12177 GB-GOV-10-HPSR_DA_130219 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds 20455 GB-GOV-10-HPSR_DA_130219 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds 29570 GB-GOV-10-HPSR_DA_130219 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds 12300.6 GB-GOV-10-HPSR_DA_130219 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds 9981 GB-GOV-10-HPSR_DA_130219 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leeds GB-GOV-10-HPSR_DA_130222 UK - Department of Health and Social Care (DHSC) The World Health Organization (WHO) has set up the Essential Diagnostics List (EDL) to complement the established Essential Medicine List (EML). Point of care diagnostics are increasingly available and affordable and have great potential. WHO decisions can put tests on the agenda, but countries need to consider whether they wish to purchase them, their role in the health system, and the development of feasible and effective standardised care pathways. These decisions require a range of specific scientific and local knowledge to inform their decisions on policy changes. We aim to develop an evidence-based approach to guide the adaptation of the WHO EDL to national health system needs and establish a Research Initiative for Evidence-based diagnostics in Africa. We will start this process by engagement with decision makers in health policy and practice in East Africa to jointly decide on information needs, methods and capacity. 1) Map access to trauma care as a complex health system problem 2) Collect data from patients on their experiences of barriers to and quality of care 3) Build research capacity in partner countries to enable further work 4) Develop a network of trauma researchers 5) Convene a meeting of investigators, patient representatives, and policy makers to discuss findings and, in combination with ongoing studies and literature review results, identify and agree upon priorities for a programme for future research UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 56703.9 3673 GB-GOV-10-HPSR_DA_130222 2020/21 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 10209 GB-GOV-10-HPSR_DA_130222 2020/21 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 56703.9 GB-GOV-10-HPSR_DA_130222 COMMITMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 21913 GB-GOV-10-HPSR_DA_130222 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 17028 GB-GOV-10-HPSR_DA_130222 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 386.51 GB-GOV-10-HPSR_DA_130222 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-HPSR_DA_130250 UK - Department of Health and Social Care (DHSC) South Africa has some of the highest sexually transmitted infection (STI) and HIV rates globally. Syndromic treatment of STIs has poor sensitivity and specificity and could fuel antimicrobial resistance. STIs increase HIV transmission and acquisition; STIs and HIV disproportionately affect the most vulnerable groups in society resulting in poor health and economic burden. Taking advantage of the current roll-out of HIV Pre-Exposure Prophylaxis (PrEP) for adolescent girls and young women in South Africa, we aim to evaluate integrated models of diagnostic STI care using an individualised public health approach. We will 1) establish equitable research partnerships with a view to strengthening health system and research capacity for diagnostic STI care 2) engage policy makers, healthcare providers and patients in discrete choice experiments to establish preferences for diagnosis and treatment of STIs and assess the feasibility of integrating these within the South African health-system. 1) Set up equitable interdisciplinary partnerships to strengthen the health system, and build research capacity, in diagnostic STI care 2) Use novel research methods to engage policy makers, facility managers, providers and service users in choice experiments in order to understand gaps in STI care and elicit their preferences for diagnoses and treatment 3) Use interviews and focus group discussions to assess how feasible, acceptable and practical it would be to integrate a range of diagnostic and treatment approaches within the provision of PrEP. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Sussex UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 99963 14133 GB-GOV-10-HPSR_DA_130250 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 8570 GB-GOV-10-HPSR_DA_130250 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 99963 GB-GOV-10-HPSR_DA_130250 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Sussex 15728 GB-GOV-10-HPSR_DA_130250 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 15082 GB-GOV-10-HPSR_DA_130250 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 26853 GB-GOV-10-HPSR_DA_130250 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 9601 GB-GOV-10-HPSR_DA_130250 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex -8931.13 GB-GOV-10-HPSR_DA_130250 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex GB-GOV-10-HPSR_DA_130266 UK - Department of Health and Social Care (DHSC) Achieving Universal Health Coverage (UHC) is a global priority to ensure health for all and reduce health inequalities (SDG3.8). However, progress towards UHC is an inherently political process. Political Economy Analysis (PEA) is an essential tool in the field of health policy and system research to shed light on the barriers and facilitators of UHC reforms. Although recent work has been done to develop PEA frameworks for UHC and to apply PEA, francophone West Africa remains understudied and underrepresented in the research arena. This project aims to develop a strong, effective and equitable research partnership between research institutions in the UK and francophone West Africa (initially in Benin, to be expanded to other countries during the grant period), to strengthen research capacity and frameworks and to build networks with stakeholders and communities. This will enable us to launch cutting-edge research on UHC and collectively to improve progress towards it in this region. 1) Develop a research partnership to catalyse a formative, collaborative programme of work and to strengthen research management, dissemination capacity and research skills in the domain of PEA applied to UHC. 2) Establish an active and engaged programme of PEA research in francophone West Africa to support UHC progress, grounded in collaboration with a variety of stakeholders, from government bodies to civil society groups. 3) Develop a future research project focused on the application of PEA and the creation of a network of national observatories to generate prospective evidence on the political dynamics underlying UHC reforms UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Queen Margaret University UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 99879 11073 GB-GOV-10-HPSR_DA_130266 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 37148 GB-GOV-10-HPSR_DA_130266 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 99879 GB-GOV-10-HPSR_DA_130266 COMMITMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 15291 GB-GOV-10-HPSR_DA_130266 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 332 GB-GOV-10-HPSR_DA_130266 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University 26047 GB-GOV-10-HPSR_DA_130266 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University -1603.62 GB-GOV-10-HPSR_DA_130266 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Margaret University GB-GOV-10-HPSR_DA_130285 UK - Department of Health and Social Care (DHSC) This project aims to build capacity & strengthen understanding of stakeholder research needs to facilitate the effective functioning of the Baby Friendly Community Initiative (BFCI; a community-based public health programme supporting health, growth & development of infants) within African primary care health systems. Members of our team have shown the BFCI’s efficacy within a randomised controlled trial (RCT) in Kenya and the Kenyan government is committed to scaling the BFCI. The challenge of this transition from RCT to scale is to embed the programme effectively into the health system working with existing resources. Engage with community, national and regional stakeholders to; 1) Share understanding of the BFCI 2) Identify needs for research and develop a whole systems-based strategy for the BFCI uptake and dissemination in Kenya and into other African health systems 3) Build capacity in health economics and systems science between the UK & Kenyan teams. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Loughborough University UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 100000 10375 GB-GOV-10-HPSR_DA_130285 2020/21 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Loughborough University 664 GB-GOV-10-HPSR_DA_130285 2020/21 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Loughborough University 100000 GB-GOV-10-HPSR_DA_130285 COMMITMENT UK - Department of Health and Social Care (DHSC) Loughborough University 27592 GB-GOV-10-HPSR_DA_130285 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Loughborough University 13721 GB-GOV-10-HPSR_DA_130285 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Loughborough University 37648 GB-GOV-10-HPSR_DA_130285 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Loughborough University -15519 GB-GOV-10-HPSR_DA_130285 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Loughborough University GB-GOV-10-HPSR_DA_130307 UK - Department of Health and Social Care (DHSC) Current guidelines for tuberculosis (TB) management focus on microbiological cure and survival, with no follow-up of patients beyond TB treatment completion. However, data suggest that TB survivors have a high burden of disabling residual lung damage, recurrent TB disease, and increased rates of mortality. There is an unmet need to develop post-TB care pathways to improve the long-term wellbeing of TB survivors. Clinical tools for post-TB care are under development. However, existing health systems in East Africa are poorly equipped to deliver these services and there has been little planning of how post-TB care could be achieved. This project will build on the partnership between London School of Tropical Medicine (LSTM) and African Institute for Development Policy (AFIDEP) to engage stakeholders in Malawi and Kenya in order to review existing management practices, and outline potential models of post-TB care for the region. This work will form the basis of future large-scale funding applications, and policy and implementation work. 1. Consolidate the existing academic partnership between Liverpool School of Tropical Medicine (LSTM) and the African Institute for Development Policy (AFIDEP) 2. Develop relationships with the wider policy-making and academic community working in post-tuberculosis (TB) care in the region 3. Perform a systematic review of post-TB management guidelines and practices in the region 4. Engage in dialogue with in-country stakeholders in Kenya and Malawi to identify potential models of post-TB care, barriers to implementation, and existing data gaps. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 99926.86 6363 GB-GOV-10-HPSR_DA_130307 2020/21 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 11669 GB-GOV-10-HPSR_DA_130307 2020/21 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 99926.86 GB-GOV-10-HPSR_DA_130307 COMMITMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 25151 GB-GOV-10-HPSR_DA_130307 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 9454 GB-GOV-10-HPSR_DA_130307 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 6356 GB-GOV-10-HPSR_DA_130307 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 30940.86 GB-GOV-10-HPSR_DA_130307 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine -4131.07 GB-GOV-10-HPSR_DA_130307 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-HPSR_RL_150067 UK - Department of Health and Social Care (DHSC) The way different health systems in different countries are organised, financed, and managed have major implications for the healthcare services different people have access to, the quality and scope of these services, how much they have to pay, and how effective these services are at improving and protecting their health. In many low- and middle-income countries, health systems are fragmented. This means there may be separate health systems covering different populations, different organisations providing competing or overlapping services, different service packages offered to different people, and be diverse and complex mechanisms for paying for different services. Health system fragmentation affects how efficiently, effectively, and equitably health services function. This project will carry a broad range of research to understand health system fragmentation and how fragmentation affects the health system functioning. The research will include collecting and analysing data from four study countries (Brazil, Colombia, India and Mexico) as well as assessing fragmentation globally. It will examine whether different types of fragmentation affect how well health systems perform. The project will also involve a deep-dive analyses on specific policy reforms related to fragmentation in each country and will understand the impacts on services and population health. Surveys and bespoke data collection activities will support these analyses. It will also study the political and economics determinants of fragmentation and understand why different health systems are fragmented differently and what policy options are available to improve performance. This project is being jointly led by Imperial College London and the Institute for Health Policy Studies in Brazil with four collaborating institutions – the National University of Colombia, , the Center for Health Systems Research of the National Institute of Public Health in Mexico, O.P. Jindal Global University in India, and the University of York in the UK. These institutions cover the four main study countries where the work is being carried out (Brazil, Colombia, India and Mexico) with support from the UK. The project will run from Oct 2022 to Sept 2026. This work aims to generate knowledge and evidence to improve health systems and inform policies. In the long run, it aims to strengthen health systems to improve their functioning and improve population health and well-being. 1. Collate data from multiple sources to quantitatively measure the fragmentation of health financing systems in Brazil, Colombia, India and Mexico; 2. Understand the nature of health financing fragmentation and how this varies within and between health systems in the four countries; 3. Assess whether fragmentation is associated with progress towards health systems goals including universal health coverage, quality, improved health and financial protection; 4. Understand how factors such as local governance arrangements and major events such as COVID-19 have affected health system fragmentation and related achievement of health system goals; 5. Evaluate recent health system reforms in Brazil, Colombia, India and Mexico and measures health system and health impacts; 6. Document key political and institutional drivers of health financing fragmentation and identify enablers and hurdles for policy reform; 7. Strengthen collaborations between collaborating institutions and build capacity for longer-term health systems research; 8. Engaged communities and stakeholders throughout the research to foster uptake and increase policy relevance. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 419906.32 944450.56 1025323.88 889168.4 581401.28 3860250.44 GB-GOV-10-HPSR_RL_150067 COMMITMENT UK - Department of Health and Social Care (DHSC) Imperial College London 209953.16 GB-GOV-10-HPSR_RL_150067 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Imperial College London 209953.16 GB-GOV-10-HPSR_RL_150067 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 40776.12 GB-GOV-10-HPSR_RL_150067 2023/24 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Imperial College London 174152.77 GB-GOV-10-HPSR_RL_150067 2023/24 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Imperial College London 284908.76 GB-GOV-10-HPSR_RL_150067 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 233361.88 GB-GOV-10-HPSR_RL_150067 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 253047.7 GB-GOV-10-HPSR_RL_150067 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 126971.5 GB-GOV-10-HPSR_RL_150067 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 311866.26 GB-GOV-10-HPSR_RL_150067 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 198587 GB-GOV-10-HPSR_RL_150067 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 122711 GB-GOV-10-HPSR_RL_150067 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 304946 GB-GOV-10-HPSR_RL_150067 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 275293 GB-GOV-10-HPSR_RL_150067 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 482236 GB-GOV-10-HPSR_RL_150067 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 146262.05 GB-GOV-10-HPSR_RL_150067 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London GB-GOV-10-HPSR_RL_150089 UK - Department of Health and Social Care (DHSC) This programme of research aims to improve collaboration between health and other agencies to reduce road traffic deaths and injuries in Nepal. It is being conducted through a collaboration between the University of the West of England, Bristol UK and Kathmandu Medical College, Kathmandu, Nepal, together with; Safe and Sustainable Travel Nepal (a charity advocating for safer travel in Nepal), MIRA (a non-governmental organisation in Nepal that supports research), emergency care experts in Nepal and colleagues at Imperial College London. This research is important because road traffic injuries are the 12th most common cause of death globally, and the leading cause of death in 5-29 year olds. Approximately 1.3 million people die and over 50 million people are injured in road traffic crashes each year, with over 90% of victims being from low- and middle-income countries. Nepal, a low-income country, has recently had a big road-building programme and there has been a large increase in vehicle ownership. However, without good road safety leadership, coordination and funding, the number of road traffic injuries have increased and there is no national ambulance service to provide prehospital care to those injured. Road traffic injuries are one of the most preventable causes of death, injury and disability. A ‘Safe Systems’ approach, in which all agencies work together to create an environment which keeps road users safe, has been shown to lead to significant reductions in rates of road traffic injuries. Between 01/11/2022 and 31/10/2026 we will conduct three work packages that will support the development of a safe road system in Nepal and will map to two of the United Nations Sustainable Development Goals; 3.6 (halve global road traffic deaths and injuries) and 11.2 (provide access to safe, affordable, accessible and sustainable transport systems for all, and improving road safety). The work packages focus on: (1) Supporting leadership and action for road safety at local and provincial government levels; (2) Strengthening public transport safety (specifically bus travel); and (3) Improving the care of those with injuries following a traffic crash. A fourth work package will improve researcher’s awareness of how to keep research data safe whilst still maximising its use. The objectives of our four work packages are: Work Package 1: • To identify existing policies and programmes at local, provincial and national levels of government in Nepal that can be linked to evidence-based recommendations for safer road systems • To understand the current reach and implementation of these policies and programmes • To identify the barriers and enablers to further implementation of these policies and programmes • To develop a toolkit for those working at local and provincial government level to help them improve road safety Work Package 2: • To identify the factors that influence how bus transport is currently provided in Nepal, and how those factors affect bus safety • To establish how these factors affect the current provision of bus transport and which factors can best be used as levers towards safer buses and bus services • To identify which established, cost-effective, interventions are needed to shift current practice and policy • To generate agreement across sectors on recommendations to make bus travel safer Work Package 3: • To determine the health, social and economic impacts of being injured in a road traffic crash in Nepal. • To understand the facilitators and barriers to optimal handover of road traffic injured patients from prehospital carers to hospital emergency department staff • To establish stakeholder agreement on a best practice care pathway for road traffic injured patients to be used in hospital emergency departments Work Package 4: • To deliver five, seven-week online good data governance courses between 2023 and 2026 • To develop and make available training materials that enable the safe collection, use and storage of research data • To strengthen the capacity for peer-to-peer learning on good data governance within and between low and middle-income countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Nepal Medical research Research and Innovation 232234 540920 504784 533533 349703 113745 92893.7 GB-GOV-10-HPSR_RL_150089 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 2274919 GB-GOV-10-HPSR_RL_150089 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 139340.55 GB-GOV-10-HPSR_RL_150089 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 468029.81 GB-GOV-10-HPSR_RL_150089 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 72699 GB-GOV-10-HPSR_RL_150089 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 105801.38 GB-GOV-10-HPSR_RL_150089 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 146401.43 GB-GOV-10-HPSR_RL_150089 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 117454.37 GB-GOV-10-HPSR_RL_150089 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 198160.68 GB-GOV-10-HPSR_RL_150089 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 90189 GB-GOV-10-HPSR_RL_150089 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 165843.62 GB-GOV-10-HPSR_RL_150089 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 226035.23 GB-GOV-10-HPSR_RL_150089 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol 27657.36 GB-GOV-10-HPSR_RL_150089 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of the West of England, Bristol GB-GOV-10-HPSR_RL_150146 UK - Department of Health and Social Care (DHSC) India, Brazil and South Africa are countries with public health care systems with forms of citizen participation in health care institutionalised in different ways (for example health committees). These systems are pluralistic when relying on combining public and private provision of services. This proposal addresses the implications of both, community participation and pluralistic health systems, for the goals of improving population health and wellbeing. We assume that citizen participation helps to align bureaucracies, politicians and health professionals around these goals. Therefore, this research program aims to enhance understanding of a) How citizen participation is working in these systems; b) How is it adapting to ongoing changes; c) What is needed in term of resources, institutional design, community involvement and training of public officials to fulfil its potential contribution. Since the 2000’s, cities in these countries began to expand access to health care through private provision. Preliminary evidence suggests that models of purchasing public health care involving private and philanthropic providers hired to manage public facilities and deliver public services can, under certain conditions, help expand and improve access to care quickly in marginalised communities in urban areas. At the same time, there is much resistance to this development because it is seen to introduce a private logic in the public system. Moreover, if officials lack the skills or experience to negotiate contracts with private providers, there is a risk of fraud and dysfunction in the health system. Pluralistic models of public service provision may help improve the agility of systems but may simultaneously impact negatively population health interests given the influence of private interests. We propose a multi country study focused on mapping and improving the state of community participation mechanisms in selected districts in the cities of Mumbai, Bengaluru, São Paulo, Fortaleza, Gqebhera and Cape Town, where pluralistic models of managing and providing services are either in place or in the making. This research seeks to understand the crucial role community participation can play in pluralistic health systems and how it could strengthen and enhance Universal Health System, helping to create an accountable health system with democratic governance. It seeks to identify a model for effective and meaningful participation within the pluralistic health system. The overarching research question is “How can community participation, framed as a human right, facilitate the promotion of population health and wellbeing in pluralistic health systems?” Objectives: 1. Identify and characterise the existing international evidence on the extent of community participation mechanisms, processes and structures under plural health systems and reasons for success or failure; 2. Map the current national and provincial policy context for urban health committees in three countries; 3. Characterise the extent to which states are able to extend their human rights obligations to ensure meaningful social participation in health, to non-state providers 4. Describe the contexts and identify the mechanisms that impede or facilitate intensified community engagement in pluralized health systems aimed at UHSs. 5. Explore how communities’ views, needs and perceptions of health service adequacy are and/or could be more adequately incorporated into contracting arrangements under pluralized health systems 6. Co-develop, test, and implement participatory approaches pilots to empower community voice in the policy cycle. 7. Evaluation of capacity building and implemented participation pilots 8. Compare and synthesize findings across different sites with a view to dissemination. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Cape Town UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 424786 902002 963413 991290 505092 199293 212393.04 GB-GOV-10-HPSR_RL_150146 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 3985876 GB-GOV-10-HPSR_RL_150146 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 212393.04 GB-GOV-10-HPSR_RL_150146 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 36016 GB-GOV-10-HPSR_RL_150146 2023/24 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Cape Town 294906 GB-GOV-10-HPSR_RL_150146 2023/24 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Cape Town 84474 GB-GOV-10-HPSR_RL_150146 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Cape Town 164209 GB-GOV-10-HPSR_RL_150146 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Cape Town 346519.63 GB-GOV-10-HPSR_RL_150146 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 12813 GB-GOV-10-HPSR_RL_150146 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 221441 GB-GOV-10-HPSR_RL_150146 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 250848 GB-GOV-10-HPSR_RL_150146 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 209970 GB-GOV-10-HPSR_RL_150146 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 608010 GB-GOV-10-HPSR_RL_150146 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town GB-GOV-10-HPSR_RL_150178 UK - Department of Health and Social Care (DHSC) Timeline: 4 years (Oct 2022 – Sep 2026) Location: 4 counties in western Kenya (Homa Bay, Migori, Kisumu, Kakamega). Partners: • LVCT Health - the Lead Agency • Kenya Medical Research Institute (KEMRI) – Collaborator • Liverpool School of Tropical Medicine (LSTM) – Collaborator • GinD - Collaborator This research project aims to strengthen community health systems in Kenya by increasing antenatal care (ANC) uptake through a health systems strengthening approach. The approach will link digital data platforms and train community Work Improvement Teams (WITs) to use the data they collect to identify problems and develop local solutions. The project entails ‘seeing’ linked data (C-it) and ‘doing’ or acting on the data (DU-it). The study seeks to answer the question, “What is the effect of ‘C-it DU it’ on community health systems strengthening and what is required for effective transfer and scale-up?” The project will enable smooth integration of data collected at both facility and community levels to track individuals from the community to facilities and back again. The study will pilot in Homa Bay County so as to introduce “C-IT DU-it” and increase the number of pregnant women achieving eight scheduled ANC contacts with a healthcare provider. The project will, from year 3, be scaled-up to the other three Kenyan Counties as an ideal way of transferring lessons. The project will use mixed methods implementation research design with four components: a) Realist evaluation will generate, empirically test and refine a transferrable programme theory to understand the causal relationship between context, participant response and outcomes. b) A 3-arm, cluster-randomised controlled trial in Homa Bay County will determine the efficacy of ‘C-it’ and ‘C-it DU-it’ to increase ANC contacts when compared to the standard of care. c) Health economic evaluation and equity analysis will compare health expenditure of women accessing and engaging with ANC care and determine costs and cost-effectiveness of C-it Du-it from a health systems perspective. d) Qualitative interviews will assess transferability and iterative scale-up of C-it DU-it across the three remaining counties using toolkits developed in Homa Bay. The study objectives are: 1. To increase ANC uptake and quality in Western Kenya by a. linking community and facility digital ANC data systems, creating a system able to track an individual woman throughout pregnancy and schedule appointments (‘C-it’) b. strengthening the capacity of community work improvement teams to use ‘C-it’ data for quality improvement and of CHVs to deliver community-based ANC contacts (‘DU-it’). 2. To co-develop research strategies with county policymakers that address evidence gaps to scale-up community health systems strengthening through ‘C-it DU-it’: a. to evaluate what worked or did not work for whom and why b. to establish the real-world effectiveness of ‘C-it’ and ‘C-it DU it’ on the number of ANC contacts c. to determine the costs and cost-effectiveness of ‘C-it’ and ‘C-it DU it’ from different perspectives d. to assess the transferability of our approach to other counties, countries, and contexts 3. To strengthen the capacity of communities, county managers, Kenyan researchers, and institutions to set the community health research agenda and deliver major implementation research Target Population: Pregnant women in 4 counties in Western Kenya. These 4 counties (Homa Bay, Migori, Kisumu and Kakamega) have the highest maternal mortality rate in Kenya. Project Outcomes: This study aims to strengthen community health systems in Kenya through antenatal care (ANC) data linkage and use while learning lessons for other contexts. Through this study the researchers will: 1) determine how counties can use digital data to integrate community-based with facility-based delivery of ANC services; 2) demonstrate how to scale up data use alongside digital data linkage at the community-facility interface and 3) improve the global frameworks for using robust data to track progress towards Universal Health Care (UHC). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) LVCT Health UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Kenya Medical research Research and Innovation 442549 1013902 1106751 886098 350701 199999 221274.36 GB-GOV-10-HPSR_RL_150178 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) LVCT Health 4000000 GB-GOV-10-HPSR_RL_150178 COMMITMENT UK - Department of Health and Social Care (DHSC) LVCT Health 221274.36 GB-GOV-10-HPSR_RL_150178 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) LVCT Health 155414 GB-GOV-10-HPSR_RL_150178 2023/24 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) LVCT Health 320647 GB-GOV-10-HPSR_RL_150178 2023/24 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) LVCT Health 174970 GB-GOV-10-HPSR_RL_150178 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) LVCT Health 270936 GB-GOV-10-HPSR_RL_150178 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) LVCT Health 383500 GB-GOV-10-HPSR_RL_150178 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) LVCT Health 163150 GB-GOV-10-HPSR_RL_150178 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) LVCT Health 399326 GB-GOV-10-HPSR_RL_150178 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) LVCT Health 278417 GB-GOV-10-HPSR_RL_150178 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) LVCT Health 394307 GB-GOV-10-HPSR_RL_150178 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) LVCT Health 387650.62 GB-GOV-10-HPSR_RL_150178 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) LVCT Health GB-GOV-10-HPSR_RL_150232 UK - Department of Health and Social Care (DHSC) Although community health workers (CHWs) play a crucial human resource role in health systems of many low and middle-income countries, they are largely invisible, under supported and not adequately recognised. Lack of support generates many stressors for CHWs which are further exacerbated when delivering services in challenging contexts (e.g COVID-19, informal settlements, remote areas). Chronic job-related stressors can have a lasting impact on CHW wellbeing which ultimately affects their performance and capacity to effectively undertake their important role as frontline health workers. Drawing on wellbeing and resilience frameworks while considering the hardware (e.g. training) and software (e.g. community cohesion and support) components of the health system, we aim to identify the stressors, challenges, constraints and opportunities faced by CHWs and communities. We will utilise this evidence to co-develop, pilot and evaluate a holistic health systems support package for CHWs in two different LMIC contexts to support CHW wellbeing and agency, ultimately contributing to enhanced health systems resilience. We will focus specifically on integrating support for the mental wellbeing of CHWs, a previously neglected area. . Objectives: 1. To identify strategies and programmes to enhance CHWs’ wellbeing, with a specific focus on mental health that is equitable, sustainable and acceptable in LMIC settings. 2. To co-design and test innovative health system interventions that are responsive to the diverse personal and job-related stressors (social, material and human) experienced by CHWs. 3. To enhance the quality and equity of existing support approaches to ensure a focus on mental wellbeing that prioritises the diverse needs of CHWs. 4. To contribute evidence and knowledge to inform and advocate for support of CHWs mental wellbeing in future research and programme design in other health systems Methods: Our research will apply ‘Community Based Participatory Research’ (CBPR) situating CHWs and stakeholders as equitable partners and co-researchers who are central to data collection, analyses and co-designing solutions. We will: 1) Undertake analysis of existing global and national policies and practices that support CHWs wellbeing. 2) Conduct interdisciplinary research with CHWs, supervisors and key decision/policy makers using qualitative, participatory methods (photo-voice, stepping stones, body mapping), quantitative surveys, and embedded participatory evaluation to generate evidence on their experiences and challenges. 3) Utilize evidence to co-produce interventions with CHWs and key stakeholders, to support CHWs’ mental wellbeing, promoting their resilience and agency to strengthen health system resilience. 4) Pilot and evaluate interventions for cost, equity, feasibility, acceptability and scale-up. Team: Our interdisciplinary team comprises researchers, implementers, policy makers, with direct engagements and collaborations with CHWs, government, non-governmental organisations, or in each country. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) BRAC University UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 285759.13 843543.09 823231.64 839706.65 562685.34 176575.04 3531500.89 GB-GOV-10-HPSR_RL_150232 COMMITMENT UK - Department of Health and Social Care (DHSC) BRAC University 251498 GB-GOV-10-HPSR_RL_150232 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) BRAC University 115066 GB-GOV-10-HPSR_RL_150232 2023/24 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) BRAC University 306930 GB-GOV-10-HPSR_RL_150232 2023/24 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) BRAC University 137141 GB-GOV-10-HPSR_RL_150232 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) BRAC University 235055.26 GB-GOV-10-HPSR_RL_150232 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) BRAC University 347266.64 GB-GOV-10-HPSR_RL_150232 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) BRAC University 278890 GB-GOV-10-HPSR_RL_150232 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) BRAC University 190502 GB-GOV-10-HPSR_RL_150232 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) BRAC University 165759 GB-GOV-10-HPSR_RL_150232 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) BRAC University 289921 GB-GOV-10-HPSR_RL_150232 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) BRAC University 366675.85 GB-GOV-10-HPSR_RL_150232 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) BRAC University GB-GOV-10-HPSR_RL_150244 UK - Department of Health and Social Care (DHSC) Rehabilitation is care that can help people get back, keep, or improve functions that are needed for daily life. These may be physical, mental, and/or cognitive (thinking and learning) and is help is almost always needed following stroke or other physical illnesses. Unlike in the UK, where there are very effective recovery programmes, in the Philippines, these services are almost non-existent. We intend to design, with the help of patients, carers and health workers, a programme of activities to help people manage their recovery from physical illness, such as stroke, themselves. We are doing this because the evidence from research strongly supports this type of help, which will be given by trained municipal and barangay (village) health workers, alongside family carers, who work in the island areas of the Philippines, away from towns and cities. The joint team of researchers and health professionals from the UK and Philippines will work together with stroke survivors and families to develop recovery care delivered within the community setting. This programme is intended to be adapted for other physical conditions in the Philippines and other low to middle income countries. To do this we will use a mixture of approaches to find out about current services, what people want before designing a programme, jointly with patients, carers and health workers, that meets local needs. We will train local health workers and village people to help to deliver it. The University of Plymouth, in the UK, and De La Salle University, in the Philippines are leading this project, having spent time meeting with policy makers, clinicians, and patient/carer groups, as well as the Philippine Academy of Rehabilitation Medicine (PARM) and national therapy organisations to involve them in this work. The project will start in October 2022 and continue until 2026, when we hope to have this model approved as part of the Philippines’ Universal Healthcare Scheme, to help others to manage themselves after physical illness. This work will help the health system to improve patient and family health, using a sustainable model that reflects the diversity and culture of the Philippines. To work together with stroke survivors and families to develop a programme of activities to help people manage their recovery from physical illness, such as stroke, themselves. This will be delivered within rural community settings, by trained local health workers and village people. To do this we will: 1. Record current services, key people and organisations involved in the delivery of care following stroke and other physical illnesses at national, regional and local (village) levels. We want to find out about what current care following stroke is provided, with a focus on community delivery of care (not in towns and cities). We will also review the evidence about community-based rehabilitation in low to middle income countries. The outcome will be a report that includes initial recommendations that can be shared more widely in the Philippines and form the basis for discussions in the regions where the self-management programme will be developed, so we can make sure the new programme fits with what is currently available. 2. Find out what Filipinos want, by talking to stroke patients, carers and health professionals in the Philippines about their needs and experiences following stroke. The outcome will be a summary of needs that will be used in the co-design stage of the project. 3. Co-design a programme that meets their local needs of people following stroke. To do this we will work with around 3-6 stroke survivors per village (barangay) in three main regions of the Philippines. We will aim to train at least 60 barangay (village) workers across the three regions. The outcome of this work will be a report detailing the development of the self-management programme for stroke rehabilitation in community settings for delivery at local level, and a ‘teach the teachers’ toolkit/package of support for wider use. 4. Seek feedback to find out what worked well, what needed changing when we move to a new region of the Philippines and gather basic information about the costs of delivering the programme. To do this we will seek information from key people from the three regions who have already been involved in the research, including stroke survivors, carers, health workers and other officials. The outcome will be a report that describes the implementation and evaluation of the programme, which can be used by policymakers in the Philippines and other similar countries as well as a report that simply describes the costs of delivering the recovery support programme. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Plymouth UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Philippines (the) Research for prevention and control of NCDs Research and Innovation 207229.7 405054.64 441560.54 440027.66 296292.04 1790164.58 GB-GOV-10-HPSR_RL_150244 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Plymouth 103614.85 GB-GOV-10-HPSR_RL_150244 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Plymouth 103614.85 GB-GOV-10-HPSR_RL_150244 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Plymouth 37727.73 GB-GOV-10-HPSR_RL_150244 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Plymouth 176856.43 GB-GOV-10-HPSR_RL_150244 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Plymouth 110418.34 GB-GOV-10-HPSR_RL_150244 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Plymouth 22212.84 GB-GOV-10-HPSR_RL_150244 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Plymouth 100097.36 GB-GOV-10-HPSR_RL_150244 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Plymouth 149693.91 GB-GOV-10-HPSR_RL_150244 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Plymouth 168725.54 GB-GOV-10-HPSR_RL_150244 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Plymouth 54973.3 GB-GOV-10-HPSR_RL_150244 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Plymouth 174351.09 GB-GOV-10-HPSR_RL_150244 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Plymouth 172604.3 GB-GOV-10-HPSR_RL_150244 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Plymouth 164353.66 GB-GOV-10-HPSR_RL_150244 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Plymouth 47538.61 GB-GOV-10-HPSR_RL_150244 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Plymouth GB-GOV-10-HPSR_RL_150261 UK - Department of Health and Social Care (DHSC) The COmmunity HEalth System InnovatiON (COHESION) project was a 3-year project that started in 2016 as a collaboration between research teams from Mozambique, Nepal, Peru and Switzerland. It enabled formative research to be conducted at policy, health system and community levels using tracer chronic conditions that included non-communicable diseases (NCDs) (diabetes and hypertension), and a specific neglected tropical disease (NTDs) (Schistosomiasis in Mozambique, Leprosy in Nepal and Epilepsy resulting from neurocysticercosis in Peru). The results from this formative research were utilised as part of a process for identifying adequate interventions through a participatory approach with communities, primary healthcare (PHC) workers, and regional health authorities. Meetings with different stakeholders were carried out between 2017 and 2018 to propose context- relevant interventions oriented to address the challenges of providing care for people affected by NCDs and NTDs. During the meetings, participants provided feedback regarding problems and potential solutions for chronic care and health services in general and proposed possible areas of intervention. Upon completion of all the meetings, each country identified the main components to be included in their interventions that were focussed on communities, health workers and facilities. The suggested intervention components in Mozambique include: (i) radio and pamphlets to inform population about hypertension, (ii) development of facility based guideline/algorithm, training in hypertension and clear communication, and group discussions on challenges and opportunities to manage chronic diseases, and (iii) establishment of a medical appointment system for people with chronic diseases. Taking the work forward, this proposed project has two main objectives: first, the implementation and evaluation of the context specific co-created interventions in the three countries – Mozambique, Nepal and Peru (Component 1), and secondly, explore the possibilities to translate the experience and the lessons learnt to other countries (India) for adaptation of the COHESION approach in a different context (Component 2). The COHESION - I project had two objectives: (i) The implementation and evaluation of the context specific co-created interventions in three countries – Mozambique, Nepal and Peru (Component 1). (ii) Explore the possibilities to translate the experience and the lessons learnt to other countries (India) for adaptation of the project in a different context (Component 2) Component 1 We propose to work in six communities in Mozambique, Nepal and Peru. Two communities (A&B) where we worked between 20017 - 2019 as part of the formative work will receive the co-created/co-designed intervention encompassing activities with the community’s health service users and health providers. Two other communities (C&D) will receive a co-designed only intervention of the same duration, the idea being evaluate if interventions that were co-created in other communities will work in new communities with similar characteristics. Finally, two different communities (E&F) will receive no intervention (“usual care arm”) to enable meaningful comparisons between intervention arms and usual care. The current project will enable us to evaluate the impact of a co-designed strategy in terms of (a) improved responsiveness of primary healthcare and patient satisfaction, and (b) improved health care provision for chronic conditions. We will compare the impacts of the co-designed intervention to those of the non-co designed intervention and usual care in terms of two major outcomes, responsiveness and patient satisfaction, as well as other health system-related outcomes. Component 2 In India, we will follow the approach taken in COHESION study and conduct a policy analysis, health system assessment and community perception study. A co-creation process will follow this to develop context-relevant interventions to improve the provision of care for people affected by non-communicable diseases and neglected tropical diseases. The co-created interventions will be pilot tested in the field for feasibility, acceptability, and preliminary effectiveness. If the COHESION approach proved to be locally adaptable in India, a protocol for the COHESION methodology will be developed that can be adapted to different settings. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 311607 834270 1007576 987576 499928 191630 124642.62 GB-GOV-10-HPSR_RL_150261 2022/23 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 62321.31 GB-GOV-10-HPSR_RL_150261 2022/23 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 3832587 GB-GOV-10-HPSR_RL_150261 COMMITMENT UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 62321.31 GB-GOV-10-HPSR_RL_150261 2022/23 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 62321.31 GB-GOV-10-HPSR_RL_150261 2022/23 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 62321.31 GB-GOV-10-HPSR_RL_150261 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 62321.31 GB-GOV-10-HPSR_RL_150261 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 75473.33 GB-GOV-10-HPSR_RL_150261 2023/24 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 150946.66 GB-GOV-10-HPSR_RL_150261 2023/24 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 93242 GB-GOV-10-HPSR_RL_150261 2023/24 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 93242 GB-GOV-10-HPSR_RL_150261 2023/24 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 93242 GB-GOV-10-HPSR_RL_150261 2023/24 Q4 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 12449.86 GB-GOV-10-HPSR_RL_150261 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 12449.86 GB-GOV-10-HPSR_RL_150261 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 12449.86 GB-GOV-10-HPSR_RL_150261 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 43075.27 GB-GOV-10-HPSR_RL_150261 2024/25 Q2 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 43075.27 GB-GOV-10-HPSR_RL_150261 2024/25 Q2 DISBURSEMENT (4) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 43075.27 GB-GOV-10-HPSR_RL_150261 2024/25 Q2 DISBURSEMENT (5) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 79564.88 GB-GOV-10-HPSR_RL_150261 2024/25 Q2 DISBURSEMENT (6) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 79564.88 GB-GOV-10-HPSR_RL_150261 2024/25 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 198234.56 GB-GOV-10-HPSR_RL_150261 2024/25 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 118669.68 GB-GOV-10-HPSR_RL_150261 2024/25 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 118669.68 GB-GOV-10-HPSR_RL_150261 2024/25 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 91380 GB-GOV-10-HPSR_RL_150261 2024/25 Q4 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 91380 GB-GOV-10-HPSR_RL_150261 2025/26 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 45054.67 GB-GOV-10-HPSR_RL_150261 2025/26 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 45054.67 GB-GOV-10-HPSR_RL_150261 2025/26 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 45054.67 GB-GOV-10-HPSR_RL_150261 2025/26 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 109305.22 GB-GOV-10-HPSR_RL_150261 2025/26 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 76111.89 GB-GOV-10-HPSR_RL_150261 2025/26 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 76111.89 GB-GOV-10-HPSR_RL_150261 2025/26 Q3 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 152228 GB-GOV-10-HPSR_RL_150261 2025/26 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 152228 GB-GOV-10-HPSR_RL_150261 2025/26 Q4 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 152228 GB-GOV-10-HPSR_RL_150261 2025/26 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 102407 GB-GOV-10-HPSR_RL_150261 2026/27 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia 102407 GB-GOV-10-HPSR_RL_150261 2026/27 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Universidad Peruana Cayetano Heredia GB-GOV-10-HPSR_RL_150287 UK - Department of Health and Social Care (DHSC) Health systems in low- and middle-income countries are ill-equipped to cope with rapidly aging populations. Dementia is a particular problem in Peru and challenges the health system on many fronts. People with dementia often have other health problems as well (co-morbidities) which go untreated, cause suffering and cost money. There is little social care infrastructure and care is provided almost entirely by over-stretched family members. Our goal is to strengthen the health system in Peru to meet the challenges of dementia by using technology and trained community health workers to bring expert diagnosis, treatment and support right to where it is needed – to the homes of patients and carers. To achieve this, we will run four linked lines of work to: 1) assess whether the healthcare system can care for more people with dementia 2) improve the diagnosis of dementia 3) improve the care of people with dementia and their carers 4) evaluate the costs of dementia to society Health systems readiness: We will interview people with dementia, carers, health professionals and government officials. We will find out about current dementia care in Peru and what is needed to improve it Diagnosis: Dementia is hard to diagnose in people who live far from health centres or have little formal education. We will make an ‘app’ to help community health workers diagnose people with dementia. We will test how well this app works in 3200 people across four distinct regions of this diverse country. Care: Although there is no cure for dementia, support and advice, group-based activities and physical exercise all help people to live well with dementia. But this type of care is not readily available in Peru. A project in the USA has developed a way of providing this care with smartphones. Because most Peruvians have smartphones, we can use them to develop a similar service, testing whether providing this care is feasible in Peru. Costs: We will measure the cost of dementia and comorbidities in Peru. The health system needs to know how much dementia care will cost, so that it can introduce cost-effective plans for better care. We will work with dementia charities in Peru and around the world to keep our research focused on patients. We will collaborate with the Peruvian Ministry of Health to develop a National Plan for Dementia. We focus on Peru in order to understand the context in depth but are confident that our findings will be applicable much more widely in Latin America. The aim of IMPACT is to strengthen health systems in Peru, using dementia as a tracer condition, through sustainable, integrated, community-delivered, technology-enabled innovations. Specific research objectives, embedded in our five Work Packages are: 1. Evaluate health system readiness to diagnose, treat and support people with dementia and their carers a. To understand the needs of and resources available for people with dementia and their carers b. To assess the readiness of the Peruvian health system to implement innovative tools for the diagnosis of dementia, and an intervention for people with dementia and their carers c. To adapt and scale-up the health system readiness tools for use across Latin America 2. Develop and implement an mHealth-enabled system for diagnosis of dementia a. Design and develop an mHealth, task-shifting diagnostic system for dementia and co-morbidities b. Assess the accuracy and acceptability of the diagnostic system in four regions of Peru c. Integrate the dementia diagnostic system in primary health care across the four study regions. 3. Determine the feasibility of an intervention to support people with dementia and their carers a. Adapt an existing intervention from the USA aimed at improving health-related quality of life for people with dementia and their carers in Peru b. Assess the feasibility of delivering this intervention in Peru and its acceptability to people with dementia and their carers c. Identify appropriate ways to measure health-related quality of life and multimorbidity outcomes in people with dementia and their carers 4. Assess the economic burden of dementia in Peru and estimate the costs of rolling out the diagnosis tool at a national level a. Estimate the economic burden of dementia in Peru from a societal perspective and the additional costs of comorbidities b. Assess the health-related quality of life of people with dementia and their carers and its variation with additional comorbidities c. Determine the cost to the health system of implementing the diagnostic screen for dementia 5. Optimise internal and external communications to deliver health systems improvements in Peru a. Manage resources to deliver the project to plan, within time and budget, including risk management and quality control procedures b. Ensure effective communication and work dynamics with attention to interactions between work packages c. Engage with communities, healthcare workers, policy makers and other stakeholders UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 415630.94 274906 908038.36 1009506 739967.95 431648 198931.43 166252.38 GB-GOV-10-HPSR_RL_150287 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 3868869.73 GB-GOV-10-HPSR_RL_150287 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Imperial College London 249378.56 GB-GOV-10-HPSR_RL_150287 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 274906 GB-GOV-10-HPSR_RL_150287 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 128230.44 GB-GOV-10-HPSR_RL_150287 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 56504.15 GB-GOV-10-HPSR_RL_150287 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 302822.15 GB-GOV-10-HPSR_RL_150287 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 420481.62 GB-GOV-10-HPSR_RL_150287 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 49193 GB-GOV-10-HPSR_RL_150287 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 256953 GB-GOV-10-HPSR_RL_150287 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 387005 GB-GOV-10-HPSR_RL_150287 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 316355 GB-GOV-10-HPSR_RL_150287 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 109758.95 GB-GOV-10-HPSR_RL_150287 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Imperial College London 307071 GB-GOV-10-HPSR_RL_150287 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London GB-GOV-10-HPSR_HSR UK - Department of Health and Social Care (DHSC) To inform the development of a dedicated NIHR-led Health Policy and Systems Research (HPSR) programme and the co-creation of strategic partnerships addressing global HPSR, NIHR is undertaking outreach and consultation activities to establish areas where there is an unmet need or skill shortage, and areas which are under-funded or under-researched. Universities UK will undertake a research project to develop a community of interest to support engagement in NIHR Global HPSR programme calls, knowledge sharing and in the identification of research priorities for Global HPSR. Initial aims are to build interest and engagement in NIHR global health systems research opportunities and facilitate meaningful exchange, collaborations and learning, focusing on: Mobilising UK research interest via HSRUK’s (Health Services Research UK) membership and academic networks; Deploying the whole community to contribute priority research themes and wider insights; encouraging uptake of funding and collaborative opportunities; supporting researchers to answer policy-relevant questions to improve health systems; sharing knowledge within and beyond the community to increase capacity and impact. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Universities UK UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Sectors not specified Research and Innovation 29276 2800 GB-GOV-10-HPSR_SYM 2018/19 Q4 EXPENDITURE UK - Department of Health and Social Care (DHSC) Universities UK 29276 GB-GOV-10-HPSR_HSR COMMITMENT UK - Department of Health and Social Care (DHSC) Universities UK 15600 GB-GOV-10-HPSR_HSR 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Universities UK 7800 GB-GOV-10-HPSR_HSR 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Universities UK 2100 GB-GOV-10-HPSR_HSR 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Universities UK GB-GOV-10-HPSR_Consortia UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR Global Health Policy and Systems Research (Global HPSR) programme funds health policy and systems research that is directly and primarily of benefit to people in low and middle income countries (LMICs), and to improve access to appropriate and affordable health services aligned with the aims of Universal Health Coverage and Sustainable Development Goal 3. The Global HPSR Consortia call supports broad ambitious programmes of health policy and systems research and capacity strengthening delivered through a consortium of partners. UK and LMIC universities and research institutes were invited to submit applications including two joint lead applicants, at least one of whom must be employed by a LMIC institution. To support broad ambitious programmes of health policy and systems research and capacity strengthening delivered through a consortium of partners which: 1) Include interrelated work packages involving applied research on health policy, services, or systems with a coherent theme. 2) Address priorities identified by and relevant to local stakeholders and policy makers, and deliver evidence and outcomes that will inform policy or change practice at local, regional and/or national levels, for example informing local, regional or national strategies. 3) Involve multidisciplinary teams to ensure that research objectives can be met. 4) Include an element of strengthening LMIC institutional capacity to undertake, manage and disseminate high-quality applied health research. 5) Strengthen research career pathways across LMIC partner institutions by including a minimum of three formal training posts for LMIC nationals. 6) Include appropriate project management and financial/administrative support. 7) Develop LMIC research leaders of the future through opportunities for developing leadership skills at all levels through effective mentoring and support. 8) Have clear and demonstrated institutional commitment and support for delivery of the research and for developing this field of research within the institution beyond the end of the award. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Birmingham London School of Hygiene and Tropical Medicine Northumbria University Liverpool School of Tropical Medicine London School of Hygiene and Tropical Medicine London School of Hygiene and Tropical Medicine University of the Western Cape Curatio International Foundation University of Cape Town University College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-HPSR_Consortia_158242 UK - Department of Health and Social Care (DHSC) A UK and lower- and middle-income country (LMIC) partnership (University of Ibadan, Bayero University, African Population and Health Research Center, Kenya Medical Research Institute, University of Birmingham, University of Edinburgh, University of Warwick, University of Exeter, Georgetown University) that aims to develop and then evaluate a service change to avoid delays in receiving cancer care. This study will take place over 54 months from November 2024 to April 2029. Cancer is the second largest cause of death in sub-Saharan Africa (SSA) and the outlook for cancer is much worse in SSA than in high-income countries, mostly because people already have late-stage, and therefore incurable, disease by the time they are diagnosed. Approximately half of the delay arises after the person has been to a clinic, and it is this delay within the health sector that we will study. We will build on our ongoing relationships with local governments in two countries: Oyo and Kano states in Nigeria, and Nairobi County in Kenya. These countries are increasingly using public messaging to encourage people with serious symptoms to attend health clinics, and they are upgrading specialist services. It is therefore crucial to close the gap and provide an effective, efficient, compassionate, and equitable pathway from presentation at a primary health clinic to receiving specialist treatment. We will study care for people with symptoms of seven ‘marker’ cancers; uterus (womb), colon, breast, stomach and gullet (oesophageal), lung, prostate/bladder/kidney, and head/neck. Working with patients, policymakers and civil society we will design interventions to reduce delay arising in primary health clinics by designing an educational programme and to reduce delays after referral by developing a programme of peer navigation assistance. To evaluate clinician education we will test knowledge through structured tests and the use of 'mystery shoppers' who will go into clinics to pose as patients with possible cancer symptoms. We will evaluate both interventions by monitoring referral rates, patient wellbeing and delay. To better understand factors that influence the successes of our interventions, we will study the broader system, including workforce, collaboration between organisations, leadership and governance. Community members and policymakers will work with us to disseminate findings and engage people across SSA and beyond so that they can learn from what we have done and advocate for similar services locally. The project has 1 objective: 1. To develop and then evaluate a service change to avoid delay in receiving cancer care. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Birmingham UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 223554.98 691222.78 985221.72 1015102.16 849585.66 265840.51 4030527.81 GB-GOV-10-HPSR_Consortia_158242 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 89421.99 GB-GOV-10-HPSR_Consortia_158242 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 134133 GB-GOV-10-HPSR_Consortia_158242 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 234506 GB-GOV-10-HPSR_Consortia_158242 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 260807 GB-GOV-10-HPSR_Consortia_158242 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 260713 GB-GOV-10-HPSR_Consortia_158242 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 202566.17 GB-GOV-10-HPSR_Consortia_158242 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 233152.7 GB-GOV-10-HPSR_Consortia_158242 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham GB-GOV-10-HPSR_Consortia_158462 UK - Department of Health and Social Care (DHSC) The research aims to ascertain if a community-based digitally supported care pathway, integrated into the existing primary health system in Zambia, will improve the coverage of Human Immunodeficiency Virus (HIV), sexually transmitted infections (STIs) and non-communicable disease (NCD) services among men. The project aims to demonstrate delivery of an integrated and co-designed system of providing equitable HIV/STI/Tuberculosis and NCD preventative and care services for men using a model of strengthened community and primary health systems in a high HIV burden urban community through an international collaboration between researchers, policymakers, and the community. The project will be run by Brighton and Sussex University Hospitals NHS Trust UK, Institute of Tropical Medicine Antwerp Belgium, Ministry of Health Zambia, University of Brighton UK, Zambart Zambia and Zambia's Men's Network between March 2025 and February 2030. Men are less likely than women to attend primary health services in much of Africa. This has led to men falling behind women on coverage of HIV testing and treatment services and in achieving HIV viral load suppression. This inequity in access presents a threat not only to men’s health but also to the continued success of HIV programmes due to ongoing HIV transmission. Furthermore, NCDs and STIs are increasing in countries like Zambia, yet there are few screening and prevention services offered, and opportunities to access them are particularly limited for men. The project has 5 objectives: 1. Co-develop an integrated, digitally supported care pathway (Yaba Guy Che) with men, community members, healthcare workers and policy-makers. 2. Deliver the Yaba Guy Che intervention and assess adoption, reach, fidelity, sustainability and scalability. 3. Create a men’s peer monitoring group to strengthen community health system accountability and document how men experience the Yaba Guy Che intervention. 4. Estimate the plausible impact of the Yaba Guy Che intervention on coverage of of Human Immunodeficiency Virus (HIV) and non-communicable disease services. 5. Measure the effect of the intervention across the six building blocks of the health system and assess the cost and economies of scope of implementing Yaba Guy Che to inform scalability and sustainability. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Zambia Medical research Research and Innovation 30449.53 381801.93 587938.54 859565.71 719322.23 417022 157689.47 3153789.41 GB-GOV-10-HPSR_Consortia_158462 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 230031 GB-GOV-10-HPSR_Consortia_158462 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 355 GB-GOV-10-HPSR_Consortia_158462 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 171658 GB-GOV-10-HPSR_Consortia_158462 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-HPSR_Consortia_158495 UK - Department of Health and Social Care (DHSC) The social participation for universal health coverage - evidence-informed networks advancing inclusion (SUNWAI) consortium seeks to institutionalise and deepen cross-regional research and action that advances the inclusion of key populations – specifically transgender communities in social participation for universal health coverage (UHC), and to understand its contexts, mechanisms, outcomes, and costs. The study will build within and cross-country partnerships between community (especially key populations), civil society, government and academic actors to understand the context of social participation for UHC, the mechanisms used, what these cost and what kinds of outcomes they yield. The study will also have a participatory action research (PAR) component, whereby it will promote mechanisms to improve inclusion of key populations in social participation for UHC. The study will be undertaken by Hanoi Medical University Vietnam, The George Institute for Global Health India, Mahidol University Thailand, and University of Essex England. The project will conduct 6 studies in Thailand, Vietnam and India between June 2025 and May 2030. Achievement of UHC, like other sustainable development goals (SDGs) targets, means that we “leave no one behind.” There is global recognition that this requires actual social participation of people affected by UHC policies. In Asia, sexual and gender minorities - that is transgender persons or men who have sex with men - have had variable involvement with health priority-setting: flagship UHC reforms, mostly related to insurance, rarely involves them. SUNWAI (Hindu/Urdu for “being heard”) is a consortium that will use participatory and realist research methods to enhance the inclusion of sexual and gender minorities (SGM) in UHC-related social participation platforms. In Vietnam, Thailand and India, it has taken approximately four decades for sexual and gender minorities to be recognised and granted entitlements, with potential for access to health under UHC reform. Yet, there are still gaps on what the role of SGM can be in UHC reform, what the related contexts, mechanisms, costs and outcomes could be. The project has 5 objectives: 1. To align, strengthen, evaluate, and sustain intra-and inter -country academic and civil society partnerships working on social participation of transgender populations for universal health coverage (UHC) with a specific emphasis on the “leave no one behind” agenda in Vietnam, India, and Thailand.​ 2. To understand the contexts, mechanisms, outcomes, and costs of involving transgender populations in social participation for health initiatives as well as social participation (of any group) in UHC reform initiatives at national and subnational levels in each country.​ 3. To co-produce country-specific as well as cross-country mechanisms intended to enhance meaningful inclusion of transgender populations in social participation for health geared towards achieving UHC.​ 4. To evaluate and or assess the relationship of these mechanisms to health system process goals from the perspective of community, civil society, government, and academic actors.​ 5. To catalyse exchange and expansion of the social participation for universal health coverage - evidence-informed networks advancing inclusion (SUNWAI) in the run-up to the endpoint of the sustainable development goals in 2030 and beyond​. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Northumbria University UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 488080.23 784362.98 836511.79 787646.55 786204.88 332072.34 4014878.77 GB-GOV-10-HPSR_Consortia_158495 COMMITMENT UK - Department of Health and Social Care (DHSC) Northumbria University 48808.02 GB-GOV-10-HPSR_Consortia_158495 2025/26 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Northumbria University 146424.07 GB-GOV-10-HPSR_Consortia_158495 2025/26 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Northumbria University 36249.42 GB-GOV-10-HPSR_Consortia_158495 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Northumbria University 303085.31 GB-GOV-10-HPSR_Consortia_158495 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Northumbria University GB-GOV-10-HPSR_Consortia_158627 UK - Department of Health and Social Care (DHSC) The climate crisis is the biggest threat to human health. It is resulting in extreme weather such as heatwaves, droughts, floods and landslides. These events are affecting people emotionally and physically. We are seeing malnutrition, respiratory illnesses, maternal and newborn complications, heat-related deaths, and the spread of diseases such as malaria, and the situation will only worsen. The climate crisis is impacting people’s ability to access health care and health systems’ ability to provide services. We need health systems that can withstand climate shocks and stresses, and the health workforce (HWF) is an important part of that response. If health workers (HWs) do not have the relevant knowledge, skills and support then it will have consequences for health. HWs are well-positioned to talk to people about the climate crisis and to act to protect health and respond to health needs. However, we know that they do not have enough knowledge about the climate crisis and its impact on health. This study aims to change that by developing interventions designed and produced with our chosen communities. Interventions will differ but each will help HWs respond to the health impacts of the climate crisis in their environment. This project will be joint led by Liverpool School of Tropical Medicine and Centre for Sexual Health and HIV AIDS Research Zimbabwe. They will work in partnership with HERD International Nepal from 1st November 2024 to 31st October 2028. Nepal and Zimbabwe are our country study settings, chosen because they are highly vulnerable to climate crisis. However, they differ in terms of the extreme weather they experience, how their health systems are organised, their geography, their social structures, and their policy frameworks. Together they offer the opportunity to learn different lessons about the climate crisis, its impact on health, and how we can help HWs develop and respond to that challenge - which are lessons useful in other countries facing similar issues. A mix of research tools will help us understand the issues communities face and co-create and implement appropriate interventions. By engaging locally and considering gender and equity we will create interventions that work for everyone. Also, throughout the study we will help those involved learn from their experiences of the research process, whether health systems actors, other stakeholders or researchers in Nepal, Zimbabwe and elsewhere. Together we aim to develop a resilient HWF which is better able to cope with the changing health impacts of the climate crisis, and which can ultimately help save lives. The project has 4 objectives: 1. To assess preparedness and capacities of health system actors (workers, managers, policymakers and community members including patients and vulnerable groups) to respond to climate crisis related health impacts in Nepal and Zimbabwe. 2. To collaborate with health system actors to co-create context sensitive and gender equitable intervention across both Nepal and Zimbabwe to address climate-related health issues. 3. To monitor and evaluate context-specific pilot intervention packages for equity, feasibility, effectiveness, cost, sustainability and scalability through a mixed-methods approach. 4. Throughout the project duration (2025-2028), facilitate quarterly learning sessions involving health system actors, stakeholders, and researchers in Nepal, Zimbabwe, and globally to share experiences, insights, and adaptations from the research, with the goal of documenting and disseminating at least five key learnings by the end of the project. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 354277.95 916068.03 1016951.31 993606.79 550521.41 201653.97 4033079.46 GB-GOV-10-HPSR_Consortia_158627 COMMITMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 141711.18 GB-GOV-10-HPSR_Consortia_158627 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 212566.77 GB-GOV-10-HPSR_Consortia_158627 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 33515.75 GB-GOV-10-HPSR_Consortia_158627 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 141366.92 GB-GOV-10-HPSR_Consortia_158627 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 110343.03 GB-GOV-10-HPSR_Consortia_158627 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 316579.57 GB-GOV-10-HPSR_Consortia_158627 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 139111.96 GB-GOV-10-HPSR_Consortia_158627 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-HPSR_Consortia_158646 UK - Department of Health and Social Care (DHSC) Governments' funding decisions for Universal Health Coverage include choosing health services among a wide range of options, varying in costs, health, and societal impacts, within a limited budget envelope. Collating locally relevant evidence on these services and involving key local stakeholders can help governments and national insurers prioritise the health services they fund and provide legitimacy to these choices. One approach to deciding which services to fund is to define ‘health benefit packages’ (HBPs). HBPs list the services to be publicly funded and guaranteed to the population. Several countries in Africa and elsewhere have begun adopting processes to assess and review a range of evidence to prioritise their HBPs, considering whether services provide value for money, improve equity, and are feasible to deliver at scale. This priority-setting process requires the creation of national structures that organise transparent, expert review of the evidence as well as stakeholder engagement that includes both public and patient representatives. Informing this process is challenging given the extent of evidence required; the complexity of engaging various stakeholders; and the challenge of ensuring HBPs are adopted by healthcare providers. Our consortium will explore and test approaches to defining HBPs from 2025-2029. Emphasis will be placed on producing evidence under real data, time, and capacity constraints; involving communities and patients; and ensuring linkage between HBPs and service delivery. This research will be embedded in HBP revision processes in Rwanda and Kenya, with the aim of informing the wider African region. Our novel methods will explore the risk of making decisions under weak evidence; acceptability of HBP design; and the implications of HBPs for the health system including challenges to existing interests. Our research will be undertaken by a partnership comprising University of Rwanda, University of Nairobi, KEMRI, London School of Hygiene and Tropical Medicine (LSHTM) and Radboud University. The work will strengthen capacity in health systems, economics, and policy analysis, facilitating institutions in Rwanda and Kenya to develop or expand research groups. We will engage communities and support national policy makers to identify technical and policy constraints affecting priority setting and we will work with Africa Center for Disease Control and the World Health Organisation to ensure lessons are shared regionally and globally. The project has 8 objectives: 1. To inform and design an approach to selecting the best evidence assessment method for evidence informed priority setting for health benefits packages (HBPs) in Rwanda and Kenya, based on an evaluation of the data, time and resource requirements, the cognitive demands and the risk associated with each method. 2. To inform and design strategies for effective patient and community involvement in HBP revision through the identification of the key stakeholders, and determining their interests and preferences. 3. To develop an approach to selecting which health systems functions and costs should be considered in HBP design to identify the implications of HBPs for the health system. 4. To assess whether HBPs achieve the procedural aims of evidence-informed priority setting processes in Rwanda and Kenya. 5. To assess the consequentialist outcomes of evidence-informed priority setting processes in HBP design in Rwanda and Kenya. 6. To understand how HBPs impact the allocation of resources and power between key actors, including how interests are contested, stated, aligned, and negotiated in Rwanda and Kenya. 7. To pilot a self-reflective evaluation for stakeholders involved in evidence-informed priority setting and HBPs to determine: how and why priority setting processes succeed or fail, how success or failure relates to underlying interests and what lessons other countries can learn from Rwanda and Kenya. 8. To strengthen training and capacity development and community engagement and involvement for HBP design process in Rwanda and Kenya. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 365776.08 898510.82 925218.02 938393.35 560671.62 194135.26 3882705.15 GB-GOV-10-HPSR_Consortia_158646 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 365776.74 GB-GOV-10-HPSR_Consortia_158646 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 66161 GB-GOV-10-HPSR_Consortia_158646 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 207564 GB-GOV-10-HPSR_Consortia_158646 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 332630 GB-GOV-10-HPSR_Consortia_158646 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-HPSR_Consortia_158706 UK - Department of Health and Social Care (DHSC) Many young children in lower- and middle-income countries (LMICs) become or remain blind because of a lack of eye care at the primary level of care. This means that some eye conditions are not being prevented, and children with treatable conditions are not being detected and treated early. We are addressing this by strengthening the health system at the primary level in Tanzania and Nepal. Our health system model has the following components: including eye care in the training materials of staff at the primary level who deliver the World Health Organization's (WHO) program, the Integrated Management of Newborn and Childhood Illness; improving staff supervision; providing staff with a device to test children’s eyes (Arclight); improving the referral of children who need to be seen by an eye specialist; adding eye conditions in the system staff use to document the conditions detected in children who attend the health facility, and improving awareness of the need for an eye test by including this in the booklet for parents. The project will start in November 2024 and run for five years. There will be five inter-connected studies: 1. Collecting baseline information on what is already in place in primary health facilities and whether there are other gaps to address in our model. 2. A randomised trial in which all the components outlined above will be rolled out at intervals in a randomised manner in selected districts. We will assess whether more children are identified with eye or vision problems and receive appropriate care after the elements have been rolled out compared with before. 3. Alongside the trial we will collect information from a range of different sources to find out what is working well, for whom and how (i.e., a process evaluation). 4. An analysis of the costs and effectiveness of the model using data from the trial. 5. A study to understand factors which might enable or hinder subsequent scaling-up of the model. Community engagement activities will take place throughout the project. The project is being led by the London School of Hygiene and Tropical Medicine, UK and Kilimanjaro Christian Medical College in Tanzania. The other partners are Muhibilli University Hospital and Allied Sciences in Tanzania, and Nepal Netra Jyoti Sangh and Kathmandu Medical College in Nepal. In each country the Ministry of Health and WHO representatives are actively involved. The project has 5 objectives: 1.In selected districts in Nepal and Tanzania we will collect information from primary level facility records, staff and parents, and districts supervisors and managers. We will also review relevant policy documents. The data will be analysed to find out whether the health systems strengthening model we have developed needs to be modified, and will provide baseline data for objectives 3 and 4. 2. The districts will be randomly allocated to different time periods when the health system strengthening model will be delivered to health facilities within the district. There will be four training phases and the trial will last 35 months. Data will be collected over 35 months from health facilities and referral hospitals. 3. During the trial, data will be collected from multiple sources to assess: how the intervention was implemented, the context of implementation and how the interventions brought about change. Findings will be used to recommend alterations to the model to be considered for scale up to other countries. 4. Data on the additional costs of delivering the health system strengthening model will be obtained from multiple sources (e.g., training costs). Data from the trial will provide measures of effectiveness. 5. Interviews will be conducted with key individuals in each country, regionally and globally to seek their views on scaling up the health systems strengthening model. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 428680.19 934345.58 769335.99 716073.35 649085.3 534013.23 4031533.64 GB-GOV-10-HPSR_Consortia_158706 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 171472.08 GB-GOV-10-HPSR_Consortia_158706 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 257208.11 GB-GOV-10-HPSR_Consortia_158706 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 7744 GB-GOV-10-HPSR_Consortia_158706 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 258237 GB-GOV-10-HPSR_Consortia_158706 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 188739 GB-GOV-10-HPSR_Consortia_158706 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 140067 GB-GOV-10-HPSR_Consortia_158706 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-HPSR_Consortia_158734 UK - Department of Health and Social Care (DHSC) The consortium aims to fill an urgent and widespread gap to understand the nature of workplace violence and its gendered dimensions experienced by the primary health care workforce in three countries (Burkina Faso, South Africa and Tanzania), where high proportions of women work as health workers and have reported high levels of violence. The objectives are to undertake policy-relevant research to document the nature of primary health care workplace violence and its gendered dimensions, and address the conceptual and intervention gaps in the three countries. Using desk reviews of policies, ethnographic and participatory action research methods and a survey (in one site), with approaches to engage communities to co-produce and co-design actionable interventions, they hope to iteratively implement and adapt interventions to address the problem in each site. They will invite health workers to be a part of the research team, thoughtfully navigating the sensitivities of researching violence within an active workplace and collecting data with a deep commitment to and practice of ethics. They plan to iteratively interrogate the data to deepen the insights, using emancipatory methods, like body maps and picture codes to get to the tacit and hidden scripts and meanings and co-design, with community engagement, actionable interventions for adaptive learning. The project take place from March 2025 to February 2023, and will be undertaken by Ifakara Health Institute Tanzania, Institut National de Santé Publique Burkina Faso, United Nations University - International Institute for Global Health Malaysia and University of the Western Cape South Africa and Recherche pour la Santé et le Développement (RESADE) Burkina Faso. The hope is that this research will generate compelling evidence and extrapolate it out to lessons learnt and actionable case studies on shifts in workforce management to take to other settings. The emphasis is on inclusive and equitable relationships, capacity building, sharing learning and facilitating exchange across the partners in order to seed the foundations of a strong consortium, the impact of which will go beyond geographic boundaries and the time bound nature of the funding. The project has 4 objectives: 1. To map public health sector human resource policies and assess how they recognise and respond to workplace violence and its gendered dimensions in Burkina Faso, Tanzania and South Africa to better understand the landscape of existing policies. 2. To document the nature of primary health care workplace violence and its gendered dimensions in Burkina Faso, Tanzania and South Africa from the perspective of health workers, managers and community members to reveal the power relations that underline its invisibility and normalisation. 3. To co-design and implement context specific system responses to address primary health care workplace violence and its gendered dimensions in Burkina Faso, Tanzania and South Africa. 4. To assess and reflect on the experiences of these system responses with stakeholders to sustain changes in policies for workplace violence and its gender dimensions in Burkina Faso, Tanzania and South Africa and beyond. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of the Western Cape UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 62595.72 743895.12 674905.08 795367.96 813932.56 747303.56 202000 4040000 GB-GOV-10-HPSR_Consortia_158734 COMMITMENT UK - Department of Health and Social Care (DHSC) University of the Western Cape 250382.88 GB-GOV-10-HPSR_Consortia_158734 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the Western Cape 209019 GB-GOV-10-HPSR_Consortia_158734 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the Western Cape 71691 GB-GOV-10-HPSR_Consortia_158734 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the Western Cape 259590 GB-GOV-10-HPSR_Consortia_158734 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the Western Cape 125233.95 GB-GOV-10-HPSR_Consortia_158734 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the Western Cape GB-GOV-10-HPSR_Consortia_158745 UK - Department of Health and Social Care (DHSC) Primary health care (PHC) is a community's first point of contact with the health system. Many countries are trying to improve PHC, especially as people are getting older and have more health problems. This is particularly important for countries such as Georgia where long-term health problems such as heart disease or diabetes are common and where PHC is under-developed. Georgia plans to change its PHC system to make it easier to access, especially for people in rural areas. Currently, some community members find it difficult to get to see a health worker because there are too few or they are overworked, while others are referred to specialists for care that could be provide at the primary level. Also, patients often have to pay directly for services, including for medicines. To address these challenges Georgia is introducing a package of reforms to improve PHC financing, organisation and quality. This project will investigate how well these changes are being conducted and whether they lead to better health services. It is well known from other countries, how challenging such comprehensive change can be. This project will systematically investigate in real-time how well these reforms are realised. This will give decision-makers and practitioners important information about how to adjust reform plans, ensure that the changes are accepted by the population, and that they will last. It will also generate new knowledge to help other countries that want to reform their PHC systems. The research will be carried out in three regions in Georgia that are experiencing different problems in accessing PHC. The project is undertaken by a team of researchers in Georgia (Curatio International Foundation, Ilia State University) and the UK (London School of Hygiene and Tropical Medicine). The team will be supported by the 'World Health Organisation’s European Centre for Primary Health Care'. The work will be carried out over four years, from November 2024 to October 2028. The project has 5 objectives: 1. To assess the experiences of individuals with diabetes, hypertension, and/or chronic respiratory diseases regarding their utilisation of primary health care (PHC) services, and to evaluate the extent to which PHC reform enhances the quality of care they receive. 2. To explore the experiences of healthcare providers with the new healthcare delivery methods introduced by the PHC reform, focusing on changes in their practices and their responses to new payment models for services rendered. 3. To examine the understanding of PHC reform among decision-makers, and to evaluate their readiness and commitment to adopting changes in their operational practices as a result of the reform. 4. To analyse the influence of the broader political and economic context in Georgia on the implementation and effectiveness of the PHC reform. 5. To investigate whether the reforms lead to improved equitable and affordable access to PHC services, and to identify variations in access across different regions of Georgia. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Curatio International Foundation UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 229383.55 520568.75 512270.4 478108.66 212542.96 102782.86 2055657.18 GB-GOV-10-HPSR_Consortia_158745 COMMITMENT UK - Department of Health and Social Care (DHSC) Curatio International Foundation 91753.42 GB-GOV-10-HPSR_Consortia_158745 2024/25 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Curatio International Foundation 137630.13 GB-GOV-10-HPSR_Consortia_158745 2024/25 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Curatio International Foundation 124392 GB-GOV-10-HPSR_Consortia_158745 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Curatio International Foundation 2851 GB-GOV-10-HPSR_Consortia_158745 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Curatio International Foundation 168804 GB-GOV-10-HPSR_Consortia_158745 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Curatio International Foundation 168326 GB-GOV-10-HPSR_Consortia_158745 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Curatio International Foundation 45531.59 GB-GOV-10-HPSR_Consortia_158745 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Curatio International Foundation GB-GOV-10-HPSR_Consortia_158821 UK - Department of Health and Social Care (DHSC) Harmful alcohol use is a substantial problem globally with negative impacts on health and wellbeing. The alcohol industry is a key driver of consumption or harms. It has responded to reduced consumption in many high-income countries (from increased regulation) by developing new sources of growth or profit in lower- and middle-income countries (LMICs) where harms are greater and policies are weaker. Expansion into Africa, with South Africa (SA) as a gateway, is an explicit part of this strategy. Many factors influence how much people drink, which vary from country to country: how easy or affordable is it to purchase alcohol, prevailing attitudes or ideas about drinking, and where or what type of alcohol people usually drink. It is usually the country’s alcohol policy (i.e. regulations about when/where alcohol can be sold) and enforcement that determine these factors. A research collaboration comprising the University of Cape Town, the South African Medical Research Council, Centre for the AIDS Programme of Research in South Africa, the London School of Hygiene and Tropical Medicine (LSHTM) and the University of Botswana will conduct the research in South Africa and Botswana from January 2025 to December 2029, focused on three sites in each of two provinces in South Africa (Khayelitsha, Klipfontein and Klapmuts in the Western Cape, and Atteridgeville, Olievenhoutbosch and Ga-Rankuwa in Gauteng) and three study sites in Botswana (Gaborone, Tlokweng and Francistown). We will review, consolidate, and synthesise existing literature on the influence of political, economic, and regulatory contexts on local alcohol environments, iteratively map alcohol supply chains through documentary review and stakeholder engagement, and conduct a desk-based review of national and selected provincial and local laws, regulations and policies. In each study site, we will also map and describe alcohol outlets, conduct interviews and focus groups with vendors, alcohol consumers and non-drinking community members, and in each South African study site household surveys to understand the relationship between drinking patterns/behaviour and health/social outcomes. We will apply modelled provincial alcohol harm estimates to derive harm reduction scenarios, provide consolidated and accessible evidence for communities/policymakers to inform potential prevention interventions and document the data requirements for effectively monitoring the alcohol environment. This project has 5 objectives: 1. Examine business and political strategies that the alcohol industry uses to influence policy and regulation at a global level before considering how these strategies are applied locally. 2. Describe the context in which people in South Africa and Botswana buy and consume alcohol and how these impact drinking patterns and behaviour. This will include mapping and visiting alcohol outlets, observing behaviour when buying/drinking, and interviewing people who sell and drink alcohol and those who do not. 3. Investigate how drinking patterns and behaviour impact health using existing data and data we collect in our study sites. By using mathematical models, we will explore the possible impact of proposed interventions and policy changes on alcohol-related harm, as well as consumption or sales in South Africa. 4. Harness community voices to influence alcohol policy by using research outputs that we co-create with community and policy stakeholders in South Africa and Botswana. 5. Strengthen capacity for both research through formal training (PhD and Master's students) and skills transfer, and through community engagement and involvement at the organisational and network levels. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Cape Town UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 142600.51 617640.75 795961.36 875343.84 792797.55 614277.98 202032.74 4040654.73 GB-GOV-10-HPSR_Consortia_158821 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 142600.51 GB-GOV-10-HPSR_Consortia_158821 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 94250 GB-GOV-10-HPSR_Consortia_158821 2025/26 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Cape Town 334265 GB-GOV-10-HPSR_Consortia_158821 2025/26 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Cape Town 259957 GB-GOV-10-HPSR_Consortia_158821 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 264253.99 GB-GOV-10-HPSR_Consortia_158821 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town GB-GOV-10-HPSR_Consortia_158910 UK - Department of Health and Social Care (DHSC) Intersectoral action is key to improving early childhood development, yet major knowledge gaps persist about how intersectoral policies interact with multi-level governance systems; how to engage communities, civil society, and children; and which factors enhance stakeholder coalitions and sustainability. Few models of intersectoral action have been developed from lower- and middle-income countries (LMICs). In a previous project called 'Children in All Policies', or CAP-2030, Argentina and Ghana explored intersectoral responses to shared challenges around early childhood development including child poverty, malnutrition, and limited participation of children in policy processes. These countries’ differing governance systems and levels of political prioritisation of early childhood development provide an opportunity to compare the development of intersectoral coalitions and their integration, coherence, and accountability. This prospective policy analysis will assess a participatory, data-driven intervention to improve intersectoral early childhood development policy for children aged 0-8 years at sub-national level in five localities each in Argentina and Ghana. The five-stage intervention is designed to redress common pitfalls of intersectoral action for health by using inclusive issue framing; deliberate co-production with public and non-public-sector actors, including children; and collaborative resource generation. The research will take place from November 2024 to October 2029 and will be undertaken by University College London (UCL, UK), UCL Institute for Global Health (UK), Ghana Health Services (Ghana), Ministry of Gender, Children and Social Protection (Ghana), Center for Learning and Childhood Development (Ghana) and the Latin American Faculty of Social Sciences (FLACSO, Argentina). The project has 4 objectives: 1. Explore how typologies of intersectoral action evolve in the context of differing political and fiscal power-sharing arrangements. 2. Investigate whether intermediate process indicators of collaboration and partnership are aligned with intersectoral policy coherence, and integration, and effects on early childhood development indicators. 3. Analyse how the engagement of non-governmental actors including civil society, communities and children can be maximised using inclusive issue framing and participatory data systems. 4. Promote institutionalised learning and increase stakeholders’ knowledge of and self-efficacy to engage in intersectoral policy processes. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 408491.92 870751.6 709568.2 678244.79 706681.95 458938.25 201719.83 4034396.54 GB-GOV-10-HPSR_Consortia_158910 COMMITMENT UK - Department of Health and Social Care (DHSC) University College London 163396.77 GB-GOV-10-HPSR_Consortia_158910 2024/25 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University College London 245095.15 GB-GOV-10-HPSR_Consortia_158910 2024/25 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University College London 60589.15 GB-GOV-10-HPSR_Consortia_158910 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 140979 GB-GOV-10-HPSR_Consortia_158910 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 203278.75 GB-GOV-10-HPSR_Consortia_158910 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 205342.98 GB-GOV-10-HPSR_Consortia_158910 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London GB-GOV-10-HPSR_Project_1 UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR Global Health Policy and Systems Research (Global HPSR) programme funds health policy and systems research that is directly and primarily of benefit to people in low- and middle-income countries (LMICs), to improve access to appropriate and affordable health services aligned with the aims of Universal Health Coverage and Sustainable Development Goal 3. Global HPSR Projects Call 1 supports applied health policy and systems research projects. UK and LMIC universities and research institutes were invited to submit applications including either a sole LMIC Lead Applicant, or two Joint Lead Applicants from either a LMIC or the UK, at least one of whom must be employed by a LMIC institution. To support applied Health Policy and Systems Research Projects which: 1) Will support new entrants to global health policy and systems research through smaller scale awards. 2) Have clearly defined questions which specifically target an identified health policy and/or system(s) challenge or evidence gap and set out how the outcome of the research will benefit vulnerable populations in LMICs. 3) Address priorities identified by and relevant to local stakeholders and policymakers, and deliver evidence and outcomes that will inform policy or change practice, for example informing local, regional or national strategies. 4) Have plans to involve relevant communities and stakeholders to ensure that research objectives address their needs. 5) Include research capacity development plans for LMIC partners that are proportionate and relevant to delivery of the proposed activities and include appropriate project management and financial/administrative support. 6) Support career development for research leaders of the future, e.g. through supporting less experienced researchers in LMICs to lead/jointly lead on the research proposal with effective mentoring and support from appropriate Co-Applicants. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Keele University Pancasila University Sangath Queen Mary University of London Institute for Clinical Effectiveness and Health Policy King's College London University College London Imperial College London Queen Mary University of London University of Cape Town London School of Hygiene and Tropical Medicine Universiti Malaya London School of Economics and Political Science American University of Beirut Lao Tropical and Public Health Institute UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-HPSR_Project_1_157653 UK - Department of Health and Social Care (DHSC) The emergent and re-emergent of global pandemics present significant challenges in lower- and-middle-income countries (LMICs) where health systems have limited capacity for timely identification and monitoring of the potential impact of pandemics. This project aims to strengthen health systems in LMICs via digitalisation to improve preparedness and responsiveness to pandemics. It has three interrelated workstreams: 1. An assessment of current capacity to use routinely collected data for healthcare decisions, including an illustrative analysis to showcase use of data to inform policy/practice. 2. Co-development and implementation of digital health and data analytics/visualisation tools and processes to facilitate data access and use for timely decisions. 3. Ploting and evaluating feasibility/process of digitalisation of healthcare data. The project is jointly led by two partners in Kenya and the UK: the Tropical Institute of Community Health and Development in Africa (TICH) in Kenya and Keele University - UK, in collaboration with the Kenyan Ministry of Health and the University of Sunderland - UK. It is a three-year project, starting in November 2024, being implemented in two counties of western Kenya: Kisumu and Siaya. Findings will inform the development of appropriate data digitalisation and visualisation/analytics tools to enhance evidence-based decision making for improved performance of the health systems with feedback loops at all levels. Potential impact extends beyond the study setting in Kenya to other LMICs. The project has 3 objectives: 1. Establish current capacity to use data/evidence for healthcare decisions, using Covid-19 and maternal, newborn and child health (MNCH) care/outcomes for illustration. 2. Develop digital health and intelligent data analytics/visualisation tools to facilitate and enhance data access/interpretation. 3. Pilot and assess feasibility of digitalisation of healthcare data for timely MNCH decisions. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Keele University UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Kenya Medical research Research and Innovation 104432.43 275077.16 326128.5 303991.25 1009629.34 GB-GOV-10-HPSR_Project_1_157653 COMMITMENT UK - Department of Health and Social Care (DHSC) Keele University 41772.97 GB-GOV-10-HPSR_Project_1_157653 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 62659.46 GB-GOV-10-HPSR_Project_1_157653 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 136893 GB-GOV-10-HPSR_Project_1_157653 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 77952 GB-GOV-10-HPSR_Project_1_157653 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 86683 GB-GOV-10-HPSR_Project_1_157653 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 95585.45 GB-GOV-10-HPSR_Project_1_157653 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University GB-GOV-10-HPSR_Project_1_157754 UK - Department of Health and Social Care (DHSC) Governments in many lower-income countries have recently set up health insurance systems aiming to provide affordable treatment for all citizens. These schemes are expensive, so governments try to impose procurement systems that reduce costs of the medicines and services covered. The World Health Organisation recommends a consolidated tender system where suppliers bid to provide large quantities of medicines at low prices. While this system appears effective, no independent academic studies have systematically evaluated its impact on medicine prices, availability, or governance. This project aims to fill that gap. Indonesia, the world's 4th most populous country, launched a national health insurance scheme in 2014 and adopted the WHO-recommended procurement system. Prices for medicines provided to insured patients fell significantly. However, in 2023, changes to procurement laws replaced this system with an Amazon-style platform, requiring thousands of health facilities to negotiate prices individually with hundreds of sellers. This fragmented the market and reduced transparency. This fragmented the market and reduced transparency. Later, the government re-introduced consolidated tenders for some medicines, but not others. The changes create a natural experiment: by comparing medicine availability and prices before and after the changes, we see which system works best. We have collected procurement and price data from the public system since 2016 and will gather additional data from hospitals and health centers in 13 districts across nine provinces. Interviews with buyers, sellers, pharmacists, and doctors will explore how these changes have influenced procurement practices. Using machine learning, we will analyse patterns of potential malpractice and examine the political and economic drivers of these reforms. The results will inform the further development of medicine procurement in Indonesia, and offer valuable lessons for other countries pursuing sustainable health coverage and will take place from January 2025 to December 2026. The project has 4 objectives: 1. Assess the impact of policy changes on medicine procurement outcomes. Analyse transaction-level data from public procurement systems and health facilities to examine changes in medicine prices, availability, and quality following Indonesia’s transition from a consolidated procurement system to a decentralised marketplace model. 2. Enhance data systems for medicine procurement. Analyse existing national and facility-level data systems to identify inefficiencies and opportunities for improvement. Integrate new data sources to create a comprehensive database on medicine procurement. 3. Understand the Political Economy of Procurement Policy to identify which interest groups most influence medicine procurement policy choices, through what mechanisms and to achieve what goals. 4. Contribute to the Global Evidence on Medicine Procurement. Share findings through national and international forums, publications, and seminars to inform global discussions on effective medicine procurement practices. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Pancasila University UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Indonesia Medical research Research and Innovation 118102.03 463488.52 377090.42 50456.89 1009137.86 GB-GOV-10-HPSR_Project_1_157754 COMMITMENT UK - Department of Health and Social Care (DHSC) Pancasila University 118102.03 GB-GOV-10-HPSR_Project_1_157754 2025/26 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Pancasila University 110170 GB-GOV-10-HPSR_Project_1_157754 2025/26 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Pancasila University 89944 GB-GOV-10-HPSR_Project_1_157754 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Pancasila University 117970 GB-GOV-10-HPSR_Project_1_157754 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Pancasila University 131349 GB-GOV-10-HPSR_Project_1_157754 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Pancasila University 147201 GB-GOV-10-HPSR_Project_1_157754 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Pancasila University GB-GOV-10-HPSR_Project_1_158115 UK - Department of Health and Social Care (DHSC) This project involves the development and roll out of a care model for depression in a rural setting in India. To achieve this, the project uses a 'participatory' approach i.e., involving members of the rural community; the doctors, nurses and village-level health workers who deliver routine primary care services; and the district and state health department officials to discuss their perspectives and beliefs on how such a model should be (e.g., its components, modes of delivery, expectations out of the care received). The project aims to check if this model will be effective to identify persons with depression in the clinics, and improve their mental health outcomes. This project is being implemented by Sangath, a mental health non-profit with 27 years of experience in India and twelve years of presence in the state of Madhya Pradesh in central India. A rural district in Madhya Pradesh has been selected for the project activities. Specifically, the depression care model will be implemented in nine primary care clinics with their catchment areas (villages), and nine other clinics will serve as the 'control group', which will receive routine health system support to deliver depression care. This will allow us to compare the effectiveness of the care model between these groups of clinics, on the percentage of people identified with depression, initiated on treatment, and those who improved their mental health outcomes (reduced depression severity) after receiving treatment. The project will be implemented from August 2025 to July 2028. Nearly 50 million people live with depression in India. There are very few depression care models in India that have focused on adequate integration of depression care into rural primary care clinics, where most healthcare is delivered. Efforts so far have had limited engagement of the rural community, doctors and nurses, and local health systems, to identify local needs and perceptions towards such a care model. Developing and implementing a care model for depression by involving these stakeholders will ensure the model is adopted and used by the persons who are identified (or living) with depression, and potentially scaled up across the district to serve the rural population's mental health needs. This project has 3 objectives: 1. To gather the perspectives of rural community members, care providers and health systems officials on suitable care models for people to seek care for depression, receive 'screening' tests (to identify depression), start treatments, and follow-up back at the clinic. 2. The insights will be used to conduct a workshop with various community representatives. This workshop will define the care model, its activities and stages and the expected changes as a result of the model. The model will be piloted with the community to make potential refinements and changes. The expected outcome will include a 'final' model that will be ready to be delivered. 3. This final model will be implemented and evaluated in nine rural primary care clinics in Madhya Pradesh in central India, against a control group of similar clinics. The two main parameters of evaluation of model effectiveness include: identifying cases of depression - to check if the percentage of people identified with depression is higher in the intervention group, and patient mental health outcomes - to check if the patients who receive treatment show lesser severity of their symptoms of depression in the intervention group compared to control group, at 3 months follow up time point. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Sangath UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU India Research for prevention and control of NCDs Research and Innovation 171755.84 282346.37 299362.6 200564.17 954028.98 GB-GOV-10-HPSR_Project_1_158115 COMMITMENT UK - Department of Health and Social Care (DHSC) Sangath 42938.96 GB-GOV-10-HPSR_Project_1_158115 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Sangath 35225 GB-GOV-10-HPSR_Project_1_158115 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Sangath 68052 GB-GOV-10-HPSR_Project_1_158115 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Sangath GB-GOV-10-HPSR_Project_1_158137 UK - Department of Health and Social Care (DHSC) Doctors in lower- and middle-income countries (LMICs) often work simultaneously in public and private clinical services, a phenomenon known as ‘dual practice’. Although such practice is credited with increasing doctors’ income and retention in the public sector, it is also accused of compromising availability of services in public hospitals. Regulating the practice is a complex health system issue, and little evidence exists on the effectiveness of regulatory options. We base this proposal on our previous research in Mozambique and South Africa and investigate physician dual practice within the context of urban and rural public hospitals. Our research questions focus on assessing the impact of current regulation in the two countries, as well as on identifying regulatory options to help achieve Universal Health Coverage (UHC) in LMICs. First, a mixed-methods enquiry will help us understand the current forms of dual practice in the two countries, doctors’ distribution of time across forms of dual practice, compliance with regulation, and interactions of relevant stakeholders. In 2025, we will use a combination of interviews, analysis of hospital service data, and doctors’ diaries to develop a metrics of dual practice and construct a picture of its impact on UHC. In the second part of the project in 2026, we will use discrete choice experiments (DCE) to reveal doctors’ preferences among public sector jobs with attributes including opportunities for forms of dual practice. Finally, in 2027 we will use Agent-Based Modelling to develop a theoretical model of the interactions of doctors and hospital managers in hospital contexts. Informed by the mixed-methods enquiry and DCE conclusions, we will model the influences on doctors’ job choices among alternative hospitals and the factors shaping managers’ decisions regarding stringency of regulation. Our study includes researchers and policymakers from the National Institute of Health of Mozambique, the University of Witwatersrand of South Africa, the Nossal Institute for Global Health, Australia, and Queen Mary University of London. We expect our project will: 1) develop health system research capacity in Mozambique and South Africa; 2) contribute to understanding the implications of different forms of regulation of human resources and health labour markets for the achievement of UHC, and; 3) engage with the development of local policies to regulate the phenomenon. The project has 4 objectives: 1. Develop a horizontal partnership to conduct health system research in Mozambique, South Africa and the UK. 2. Conduct a mixed-methods assessment of the prevailing forms of dual practice, doctors’ time allocation between public and private service provision, the factors driving these, perceptions of their impacts and perceptions of the implementation of dual practice policies in selected hospitals in South Africa and Mozambique. 3. Clarify doctors’ preferences and estimating trade-offs between job attributes including opportunities for dual practice through a discrete choice experiment. 4. Apply Agent-Based Modelling to develop an understanding of how interactions between hospital managers and doctors under different dual practice regulatory policies determine service availability to public patients, using the findings from previous phases. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Queen Mary University of London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 88139.32 271465.7 278442 230426.66 45709.14 914182.82 GB-GOV-10-HPSR_Project_1_158137 COMMITMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 88139.32 GB-GOV-10-HPSR_Project_1_158137 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 23878.39 GB-GOV-10-HPSR_Project_1_158137 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 35790.34 GB-GOV-10-HPSR_Project_1_158137 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 80081.56 GB-GOV-10-HPSR_Project_1_158137 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 60626 GB-GOV-10-HPSR_Project_1_158137 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London GB-GOV-10-HPSR_Project_1_158215 UK - Department of Health and Social Care (DHSC) This initiative aims to refine, test, and implement a redesigned primary care model to improve healthcare outcomes for individuals with Type 2 Diabetes in Mendoza, Argentina. The model will strengthen primary care to enhance disease control, improve care quality, and increase patient confidence in the healthcare system. The results will help shape healthcare policy in Mendoza Province. They could serve as a model for effective and efficient chronic disease care in other parts of Argentina and across Latin America. The Institute for Clinical Effectiveness and Health Policy (IECS) leads the effort in collaboration with the Quality Evidence for Health System Transformation (QuEST) initiative, which seeks to transform health systems in low- and middle-income countries (LMICs). Cayetano Heredia University - Peru and University of California San Francisco (UCSF), will be collaborators on the project as well. Local stakeholders, including the provincial Ministry of Health, healthcare professionals, and policymakers, are involved in developing practical, scalable solutions. The work will span from November 2024 to October 2027 and will be carried out in three phases. During phase I, the team will work with people involved in healthcare to fine-tune the plan based on the current list of recommendations and conduct a pilot test in 2 facilities. In phase II, the improved plan in 24 primary healthcare centres will be tested, with 12 using the new plan for 15 months. The team will look at patient records and follow patients over time to see how well the interventions work to improve disease control, enhance quality of care, and strengthen confidence in the government health system. Phase III will focus on analysing results, collaborating with policymakers to share findings, and suggesting policy changes. Managing the growing population of individuals living with chronic conditions like diabetes is a global challenge. In Argentina, a middle-income country, the increasing number of people with chronic conditions depends on a government healthcare system that is poorly equipped for long-term care. Although access to health services is high, the quality of care and system competence are inadequate for effectively detecting and managing diseases like diabetes. The proposed redesigned primary care model will better support long-term disease management and create a more resilient, efficient, and equitable healthcare system for people with diabetes, particularly in underserved areas like Mendoza. Additionally, the model has the potential to be replicated in other LMIC regions. The project has 4 objectives: 1. To assess the feasibility and acceptability of the redesigned primary care model to improve healthcare outcomes for individuals with Type 2 Diabetes in Mendoza, Argentina. 2. To test the model’s impacts on service use patterns, system competence, user confidence and cost per visit. 3. To analyse the impact of the model on potential inequalities by sociodemographic factors. 4. To work with local policymakers to share findings and suggest evidence-based policy changes that can improve chronic disease management within the public healthcare system. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Institute for Clinical Effectiveness and Health Policy UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 105003.38 267172.02 293355.73 228135.09 47035.06 940701.28 GB-GOV-10-HPSR_Project_1_158215 COMMITMENT UK - Department of Health and Social Care (DHSC) Institute for Clinical Effectiveness and Health Policy 42001.35 GB-GOV-10-HPSR_Project_1_158215 2024/25 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Institute for Clinical Effectiveness and Health Policy 63002.03 GB-GOV-10-HPSR_Project_1_158215 2024/25 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Institute for Clinical Effectiveness and Health Policy 66818 GB-GOV-10-HPSR_Project_1_158215 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Institute for Clinical Effectiveness and Health Policy 69470 GB-GOV-10-HPSR_Project_1_158215 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Institute for Clinical Effectiveness and Health Policy 89296 GB-GOV-10-HPSR_Project_1_158215 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Institute for Clinical Effectiveness and Health Policy 58310.99 GB-GOV-10-HPSR_Project_1_158215 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Institute for Clinical Effectiveness and Health Policy GB-GOV-10-HPSR_Project_1_158314 UK - Department of Health and Social Care (DHSC) Somaliland has a high burden of mental health conditions (MHCs), exacerbated by conflict trauma, poverty and substance abuse. The mental health system in Somaliland does not meet the needs of people with MHC. Co-design of interventions to improve the experience of people with MHC when they seek care has a proven track record of success, including in similar contexts such as Ethiopia, as illustrated by work conducted by members of our research team. Our plan incorporates various approaches and methods. We will adapt existing approaches from Ethiopia and Somaliland to empower people with MHC, their caregivers and health workers and create an enabling environment so they can actively participate in the project. We will use interviews, observation and existing service data to understand and analyse behaviour, experiences and perspectives on care seeking and provision. Following this process, we will conduct Theory of Change workshops with community members, health and social care organisation representatives, practitioners and people with MHCs and their carers. The goal will be to identify what outcomes people value that need to be achieved by mental health services. Lastly, we will co-produce and pilot an intervention package to improve person-centred care in both public and private-religious sectors. The intervention package will be evaluated using process evaluation. The project will work with key stakeholders in Somaliland, particularly the Ministry of Health Development (MoHD), people with mental health conditions (MHC), their caregivers and health workers to co-design and pilot interventions to improve the quality of mental health care. The work will span from February 2024 to January 2028. Our research group is a multidisciplinary team comprising of members from Addis Ababa University, Amoud University, Dalarna University, Jigjiga University, Ministry of Health Development Somaliland, University of Hargeisa, The University of Edinburgh and King's College London. The project has 3 objectives: 1. To empower people with mental health conditions (MHCs) and their caregivers so they have the skills and knowledge to proactively shape the direction of future mental health research in Somaliland. 2. To improve understanding of and respect for MHCs among health workers to increase respectful, rights-based care. 3. To identify the major issues people with MHCs and their caregivers experience in accessing and using mental healthcare and intervene to address these issues. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) King's College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 56715.46 326652.78 265291.03 299657.57 49911.41 998228.25 GB-GOV-10-HPSR_Project_1_158314 COMMITMENT UK - Department of Health and Social Care (DHSC) King's College London 56715.46 GB-GOV-10-HPSR_Project_1_158314 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 85073.2 GB-GOV-10-HPSR_Project_1_158314 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 64841 GB-GOV-10-HPSR_Project_1_158314 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 20247 GB-GOV-10-HPSR_Project_1_158314 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 78856 GB-GOV-10-HPSR_Project_1_158314 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 132302.59 GB-GOV-10-HPSR_Project_1_158314 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London GB-GOV-10-HPSR_Project_1_158320 UK - Department of Health and Social Care (DHSC) Adivasi communities (indigenous communities in India) are known to have poor access to healthcare and poor health status, often due to social and historical reasons. Healthcare services in Adivasi settings often do not provide care in a way that is acceptable and respectful of their culture and history. The study will apply state-of-the-art health policy & systems research methods to co-produce knowledge on improving the health system's responsiveness to Adivasi communities in Southern India. Guided by the tenets of indigenous standpoint theory, the study will take a multi-method participatory action research approach to reimagine and co-produce transformative solutions for strengthening health systems' responsiveness in two Adivasi community settings in Southern India. This project will build upon existing, long-term, trust-based collaborative relationships between the research team, Adivasi leaders, community-based organisations, and government decision-makers in two remote, forested Adivasi settings in two states in Southern India. The study team aims to improve the responsiveness of the health system to the needs and expectations of Adivasi communities in these two settings and use the knowledge to build a model of practice that can achieve this in other settings. The study will be undertaken by Deva Soliga Cultural and Development Trust (India), Institute of Public Health Bangalore (India), the M S Swaminathan Research Foundation (India) and the University of Melbourne (Australia) between September 2025 and August 2028. The project has 3 objectives: 1. To characterise how Adivasi communities perceive, interact, and relate to the health system in their specific social and historical context in two Adivasi settings in Southern India. 2. To describe other health systems actors' understandings and perspectives about what constrains health systems actors ability to, and what will enable them to, deliver culturally responsive care to the Adivasi communities they serve. 3. To co-produce a health system responsiveness practice model with the Adivasi communities, healthcare providers and decision-makers to enhance health system responsiveness for Adivasi communities. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU India Medical research Research and Innovation 180578.46 303259.77 302417.86 227096.88 1013352.97 GB-GOV-10-HPSR_Project_1_158320 COMMITMENT UK - Department of Health and Social Care (DHSC) University College London 103187.69 GB-GOV-10-HPSR_Project_1_158320 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 77390.77 GB-GOV-10-HPSR_Project_1_158320 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 110725.71 GB-GOV-10-HPSR_Project_1_158320 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London GB-GOV-10-HPSR_Project_1_158330 UK - Department of Health and Social Care (DHSC) This project will produce evidence on different health system factors and policies that exacerbate or reduce racial health inequalities in Brazil. It specifically aims to comprehensively measure racial health inequalities across Brazil, including changes over time and between geographical areas. It will strengthen the capacity of researchers working on racial health inequalities in Brazil and promote their institutions and networks to increase the prominence of their work and deliver change. The research will use multiple methods. The project team will carefully quantify the differences in health outcomes between racial groups and identify the impact of policies. In addition, interviews will be conducted with stakeholders to understand the roles of different policies and health system factors. The project team will also conduct experiments with health professionals to explore implicit bias and treatment decisions. This work will be carried out in Brazil by the Institute of Health Policy Studies (IEPS) in Sao Paulo in collaboration with Imperial College London in the UK. It will be carried out between May 2025 and April 2028. Racial and/or ethnic health inequalities are large, unjust, preventable, and remediable. Health systems can exacerbate these inequalities by reflecting discrimination in wider society or by actively addressing these inequalities. Specific actions are needed to strengthen policies, financing, and clinical services to reduce racial health inequalities. Brazil is a key setting for this research as it has significant health inequalities across racial groups and high-quality healthcare datasets. There are also important policies related to the health of the Black population that need to be evaluated, as well as effective civil society movements and engaged policymakers requesting evidence to inform their agendas. The project has 7 objectives: 1. Co-produce indicators to document the magnitude and evolution of racial inequalities in healthcare access, quality, and health outcomes in Brazil. 2. Identify the contributory role of health system factors in explaining racial inequalities including political, civil society, managerial, economic, and health-system factors (for example financing arrangements and differential treatment by health professionals). 3. Evaluate race-related policies like the National Health Policy for Black People, affirmative action policies (educational quotas) and welfare policies (Bolsa Familia), understanding health system and health inequalities impacts. 4. Engage stakeholders in the research project and dissemination and or advocacy activities and produce policy briefs and online training courses/seminars to raise awareness. 5. Strengthen research capacity, especially for Black researchers to investigate racial inequalities in health. 6. Build capacity among key stakeholders to use research results and influence policy development related to race and health equity. 7. Build research capacity in mixed-methods approaches and apply these to integrate qualitative and quantitative research for a more robust and comprehensive understanding of race, health systems, and health in Brazil. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Brazil Medical research Research and Innovation 282049.53 307408.72 260633.12 121365.25 971456.62 GB-GOV-10-HPSR_Project_1_158330 COMMITMENT UK - Department of Health and Social Care (DHSC) Imperial College London 112936 GB-GOV-10-HPSR_Project_1_158330 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 77826 GB-GOV-10-HPSR_Project_1_158330 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 4732 GB-GOV-10-HPSR_Project_1_158330 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London GB-GOV-10-HPSR_Project_1_158384 UK - Department of Health and Social Care (DHSC) Rising rates of mental illness are an urgent global health problem. As mental health problems often start in youth, intervening early is crucial in mitigating long-term personal and economic costs. In countries such as Vietnam and Cambodia, there is appetite for delivering early mental health interventions but there are also system-level limitations, especially outside major cities. The question is, how can we build capacity in mental health care systems in Vietnam and Cambodia to co-develop and implement a feasible, acceptable, beneficial and sustainable youth-targeted mental health intervention? This three year project (Nov 2024-Oct 2027) builds on previous work of the interdisciplinary team members (from Queen Mary University of London, the Royal University of Phnom Penh, and Vietnam National University), and includes a multi-level framework for conceptualising systems strengthening, and has 4 overlapping phases. Phase 1 will identify and map youth-targeted interventions and services in Vietnam and Cambodia. In Phase 2, we will use this knowledge to identify 40 people in each country who work with young people and train them on youth mental health, increasing their mental health literacy. This capacity building will end with the co-design of the youth targeted intervention. In Phase 3, the intervention will be implemented by the trainees in schools and community centres in Kampong Chhnang and Siem Reap in Cambodia and Khanh Hoa and Thai Binh in Vietnam. We will deliver this intervention to 175 young people in each country, with another 175 being allocated to a wait-list control condition. Data will be collected on the mental health literacy of trainees (in Phase 2) as well as the observation of their delivery in Phase 3. Using mixed methods, we will evaluate the feasibility, acceptability, and potential range of effects on reductions in anxiety and depression symptoms and other relevant secondary outcomes e.g., well-being among youth. Finally, in Phase 4, we will co-develop mechanisms for embedding, scaling up and strengthening youth mental health systems including considering intersectoral communication and referral pathways. Our project will lead to an increased ability to address youth mental health in Cambodia and Vietnam through an increased number of youth mental health services providers and through a strengthened and integrated system of provision. The project has 3 objectives: 1. Train potential service providers across different sectors (health, education, social) on mental health literacy and then co-design and co-adapt with them and youth an intervention for youth (aged ~14-19) that we developed and pilot-tested in previous projects. 2. Measure the feasibility, acceptability and potential effects of these interventions in promoting good mental health. 3. Co-design referral pathways for the scale-up of these interventions. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Queen Mary University of London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 109952.29 311894.82 331384.86 254334.05 1007566.02 GB-GOV-10-HPSR_Project_1_158384 COMMITMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 43980.92 GB-GOV-10-HPSR_Project_1_158384 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 65971.37 GB-GOV-10-HPSR_Project_1_158384 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 81081 GB-GOV-10-HPSR_Project_1_158384 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 7180.84 GB-GOV-10-HPSR_Project_1_158384 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 84237 GB-GOV-10-HPSR_Project_1_158384 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 61501.01 GB-GOV-10-HPSR_Project_1_158384 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 112976.92 GB-GOV-10-HPSR_Project_1_158384 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London GB-GOV-10-HPSR_Project_1_158451 UK - Department of Health and Social Care (DHSC) The Primary Care Assessment Tool (PCAT) has the potential to measure all the core functions of primary care in the manner suggested by the World Health Organization (WHO) and to enable improvement in the quality of care. The question is how best to create a PCAT for general use in sub-Saharan Africa (SSA), a region with a critical need for improved healthcare, so that countries can measure and monitor the core primary care functions and drive improvement in the quality of care. The vital role of a comprehensive primary care system within any healthcare infrastructure cannot be overstated. It functions as the initial point of contact for individuals within the healthcare system, providing an enduring continuum of care and a broad range of services. This need is acutely felt in SSA, a region grappling with many health-related challenges. The WHO has delineated fundamental primary care functions, including first-contact accessibility, continuity, comprehensiveness, coordination, and a people-centric approach. However, evaluating these core functions presents a formidable challenge, particularly in low to middle-income nations with restricted access to data and health information systems. To rectify this, the PCAT has been developed and implemented in various countries, demonstrating its potential to measure all core functions of primary care. This study aims to adapt a PCAT for widespread use in 11 countries in SSA. This would allow countries to track and monitor their primary care functions and improve the quality of care provided. The proposed PCAT will be multilingual and available in digital and paper formats, ensuring its accessibility and usability throughout the region. Local and regional stakeholders will engage with the PCAT findings and plan interventions to improve the quality of primary care. The findings are expected to inform improvements in the core functions of primary care in African healthcare systems. The PCAT is anticipated to become a widely used tool for primary care researchers and health information systems to gauge primary care performance. The evidence generated could inform WHO recommendations on measuring core primary care functions. The proposed timeline for this study spans three years from 2024-2027. The project team comprises a central project leadership team, ten additional country-level research leads, and their respective teams. An external advisory board will guide the team in meeting the project aims. The project has 1 objective: 1. This project aims to create a version of the Primary Care Assessment Tool (PCAT) for general use in the sub-Saharan region, enabling these countries to measure their primary health cares core functions as intended by the World Health Organization (WHO). This region already has a robust academic family medicine network, the Primary Care and Family Medicine (PRIMAFAMED) network, which spans 40 departments across 25 countries. Family medicine is the clinical discipline which trains family physicians and doctors to provide comprehensive care in primary care teams. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Cape Town UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 90648.88 319198.99 366683.19 236466.99 1012998.05 GB-GOV-10-HPSR_Project_1_158451 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 36259.55 GB-GOV-10-HPSR_Project_1_158451 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 54389.33 GB-GOV-10-HPSR_Project_1_158451 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 17049 GB-GOV-10-HPSR_Project_1_158451 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 62521 GB-GOV-10-HPSR_Project_1_158451 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 92874 GB-GOV-10-HPSR_Project_1_158451 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 153891.79 GB-GOV-10-HPSR_Project_1_158451 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town GB-GOV-10-HPSR_Project_1_158474 UK - Department of Health and Social Care (DHSC) We are developing models to integrate eye screening and treatment services for people with diabetes into Malawi's health system. The research focuses on Malawi, but our goal is to create an approach that can be applied in other African countries. Our project team includes researchers from the Eye Health Research Group (EHRG) and Health Economics and Policy Unit (HEPU) at KUHeS, the International Centre for Eye Health (ICEH) at the London School of Hygiene & Tropical Medicine, the Diabetes Association of Malawi, and the Malawi Ministry of Health. The project will run for 3 years, starting in October 2024. Eye disease caused by diabetes is a growing problem in Africa and across the world. Currently, 24 million adults in Africa have diabetes, and this number is expected to more than double in the next 20 years. Eye disease caused by diabetes (diabetic retinopathy) is one of the most common causes of blindness in working-age people. In Africa, one in three people with diabetes have this condition, and one in six need urgent treatment to save their sight. In Malawi, nearly half a million people with diabetes need regular eye check-ups. These check-ups help identify those who need treatment to prevent sight loss. Currently, health services for this are limited. Blindness leads to significant loss of productivity and also increases the risk of early death. The World Health Organization considers screening and treatment for diabetic eye disease to be highly cost-effective. However, these services are not yet available in most of Africa. We will gather data on diabetic eye disease in Malawi. Using this data, we'll create a mathematical model to show how eye care services could be integrated into the health system and calculate the health benefits of these services. We'll use an existing model for long term health conditions in Malawi as a starting point. We aim to provide Malawian policy makers with evidence to support the integration of diabetic retinopathy services into the health system. Our findings will help policy makers decide which health services to prioritise. Our results will be shared through a network of 12 African countries working on diabetic eye disease, publications in scientific journals, and presentations at international scientific meetings. The project has 5 objectives: 1. To explore different ways to provide eye care services for people with diabetes in Malawi. We will analyse how cost-effective these methods are and assess how well they could work within Malawi's existing healthcare system. This will help us identify the most suitable and efficient approaches for the country. 2. To determine how many people in Malawi are affected by diabetes-related eye problems. We will also investigate what factors make people more likely to develop these eye issues. This information will help us understand the scale of the problem and who is most at risk. 3. To review Malawi's current health policies related to diabetes care and eye health services. We will check if these policies work well together and support each other. This analysis will highlight any gaps or inconsistencies in the current approach to managing diabetes and its eye-related complications. 4. To examine how eye care services for people with diabetes are currently provided in Malawi's healthcare system. We will look at what services are available, where they are offered, and how effectively they're meeting people's needs. This assessment will give us a clear picture of the current situation and areas for improvement. 5. To create a plan for including eye care services within diabetes care programs and the broader healthcare system in Malawi. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Malawi Research for prevention and control of NCDs Research and Innovation 148682.02 294688.62 289988.26 243981.62 977340.52 GB-GOV-10-HPSR_Project_1_158474 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 74341.01 GB-GOV-10-HPSR_Project_1_158474 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 74341.01 GB-GOV-10-HPSR_Project_1_158474 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 63242.12 GB-GOV-10-HPSR_Project_1_158474 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 56802.58 GB-GOV-10-HPSR_Project_1_158474 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 97015.55 GB-GOV-10-HPSR_Project_1_158474 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 99711.55 GB-GOV-10-HPSR_Project_1_158474 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 58235.73 GB-GOV-10-HPSR_Project_1_158474 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-HPSR_Project_1_158619 UK - Department of Health and Social Care (DHSC) Responding to the lack of systemic protections, public services or policies to provide people with marginalised sexual orientations, gender identities and expressions, and sex characteristics (SOGIESC minorities) with access to inclusive and high quality mental health services in this geographic context, the project takes a micro-systems approach, to enhance capacity for mental health services that are inclusive, affirming and culturally safe for key populations in Malaysia. Specifically, this is for individuals with marginalised sexual orientations, gender identities and expressions, and sex characteristics (SOGIESC minorities). This community faces high mental health risks compounded by a lack of accessibility to inclusive mental health services largely due to the local environment where SOGIESC minorities lack legal, social or political protection. Led by a team comprising researchers from Universiti Malaya, community advocate groups, People Like Us Hang Out and Justice for Sisters, and researchers from Cardiff University and University of Waikato, this project will enhance community-based capacity building in the form of training for mental health practitioners in providing affirming services for people with marginalised sexual orientations, gender identities and expressions, and sex characteristics (SOGIESC minorities). We will utilise a discursive approach to enhance, implement and validate a community-based training tools for SOGIESC-affirming mental health practitioners in Malaysia. This three-year-project will run from 1 November 2024 to 30 October 2027 and is expected to impact the provision of inclusive health care in Malaysia by increasing the availability of mental health professionals able to deliver SOGIESC affirming mental health care to this stigmatised and minoritised group. This could have the long-term impact of improving mental health outcomes for SOGIESC minorities. In addition, by providing two graduate training posts and research skills training for junior members of the team, the project will also contribute to capacity building in Malaysia, both in the community-organisation community and in academic and research capacity. The project will be co-developed and implemented by an alliance of social science and clinical researchers, community advocacy organisations and SOGIESC affirming mental health professionals, from Malaysia, UK and New Zealand, with project activities carried out in Malaysia. The project has 4 objectives: 1. To collate and analyse data on social context, discursive practices and stakeholder perspectives in relation to mental health(care) and people with marginalised sexual orientations, gender identities and expressions, and sex characteristics (SOGIESC minorities) in Malaysia. 2. To enhance training tools for SOGIESC affirming mental health practitioners. 3. To Implement, evaluate, and validate the enhanced training tools for SOGIESC affirming mental health practitioners. 4. To consolidate and disseminate findings and advocacy to engage with stakeholders. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Universiti Malaya UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Malaysia Medical research Research and Innovation 62004.34 157121.04 164614.96 163824.62 28819 576383.96 GB-GOV-10-HPSR_Project_1_158619 COMMITMENT UK - Department of Health and Social Care (DHSC) Universiti Malaya 24801.74 GB-GOV-10-HPSR_Project_1_158619 2024/25 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Universiti Malaya 37202.6 GB-GOV-10-HPSR_Project_1_158619 2024/25 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Universiti Malaya 3352 GB-GOV-10-HPSR_Project_1_158619 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Universiti Malaya 55031 GB-GOV-10-HPSR_Project_1_158619 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Universiti Malaya 28682 GB-GOV-10-HPSR_Project_1_158619 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Universiti Malaya GB-GOV-10-HPSR_Project_1_158782 UK - Department of Health and Social Care (DHSC) This research aims to investigate the structure and functioning of evidence advisory systems (also called evidence ecosystems) serving to provide policy-relevant scientific evidence and advice to national government to inform health policy responses in Africa. The research will be undertaken by Health Research Operations Kenya Limited, Makerere University School of Public Health Uganda, University of Global Health Equity Rwanda, The Malawi Liverpool Wellcome Trust Clinical Research Programme, London School of Economics & Political Science and Liverpool School of Tropical Medicine UK. The research will take place in Kenya, Malawi, Rwanda and Uganda from March 2025 to February 2028. For almost all aspects of health policy and planning, there is a need to inform policy decision with robust and policy appropriate evidence. It is therefore critically important for countries to build effective systems of evidence provision which can serve these needs. This is a particular challenge however for lower income settings, which may have limited capacity but which could benefit greatly from robust uses of scientific research, evidence, and innovation. The team aims to work directly with local government stakeholders to co-produce research questions, establish locally-relevant normative conceptual frameworks of analysis, and ultimately coordinate activities which may lead to institutional improvements in evidence systems in Africa. The project has 4 objectives: 1. Mapping national evidence advisory systems, institutional arrangements, and cultures of evidence in four case study countries: Kenya, Malawi, Rwanda, and Uganda. 2. Developing a framework on which to judge and evaluate the structure and function of national evidence advisory systems, co-produced with key stakeholders. 3. Comparing national evidence advisory systems in relation to two contrasting health policy challenges (Universal Health Care and COVID-19). 4. Development and monitoring of action plans for national stakeholders working to improve evidence systems for health. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Economics and Political Science UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 316532.15 299314.87 330952.45 49831.55 996631.02 GB-GOV-10-HPSR_Project_1_158782 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Economics and Political Science 24303.52 GB-GOV-10-HPSR_Project_1_158782 2025/26 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) London School of Economics and Political Science 39441 GB-GOV-10-HPSR_Project_1_158782 2025/26 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) London School of Economics and Political Science 176974 GB-GOV-10-HPSR_Project_1_158782 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Economics and Political Science 39962 GB-GOV-10-HPSR_Project_1_158782 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Economics and Political Science 108869.47 GB-GOV-10-HPSR_Project_1_158782 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Economics and Political Science GB-GOV-10-HPSR_Project_1_158806 UK - Department of Health and Social Care (DHSC) Corruption in the health system allows people who work in healthcare to use their power in a way that benefits themselves instead of doing what is best for patients. This makes healthcare less efficient and trustworthy and also negatively impacts health system goals including ensuring access to high quality care for all patients, irrespective of their ability to pay. When people in charge are corrupt, it also makes it harder for a country's health system to handle complex health crises. In the Middle East and North Africa (MENA) region, corruption is particularly pervasive, with many countries scoring poorly on Transparency International’s Corruption Perceptions Index. Despite evidence of the negative impacts of corruption on health systems, there is a lack of attention to this issue in the region. This research aims to address this gap by examining the nature, drivers, consequences and potential solutions to health system vulnerabilities and corruption risks in two lower-and middle-income countries (LMICs) in the MENA region: Lebanon and Jordan. Both countries are dealing with multiple problems, such as the huge influx of refugees that have affected their economy, politics and health systems. In both countries, the health sector is also heavily affected by corruption. The research will be undertaken by American University of Beirut, Jordan International Academy for Public Health (IAPH) and London School of Hygiene & Tropical Medicine (UK). The findings of the research will be used to inform national policies and strategies to curb corruption in health systems and can be adapted for use in other settings in the MENA region and beyond. We will engage with policymakers, stakeholders, and communities from both countries to inform anti-corruption policy formulation, strategies and programs in the health sector, which will ultimately help the health system to achieve its objectives, including the goal of Universal Health Coverage. Our research will also produce an interactive monitoring and assessment tool that can help prevent, detect and respond to corruption risks in the health system during both ordinary times and in health crises. A final key benefit of our research will be to strengthen research capacity in partner countries to demand, generate, and utilise high quality policy-relevant research. The project will be implemented from 2024 to 2027. The project has 4 objectives: 1. To understand and define the specific meanings and manifestations of corruption in the health systems of Lebanon and Jordan. 2. To identify the most important corruption risks and vulnerabilities in the health systems in Lebanon and Jordan by conducting a comprehensive assessment using a range of methods. 3. To examine the key political factors which drive anti-corruption efforts and how these can be addressed. 4. To co-develop actionable strategies and corresponding action plans with stakeholders from healthcare, policy, and civil society sectors in Lebanon and Jordan to mitigate identified corruption risks. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) American University of Beirut UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 105063.87 261614.86 260594.61 196980.78 43381.8 867635.92 GB-GOV-10-HPSR_Project_1_158806 COMMITMENT UK - Department of Health and Social Care (DHSC) American University of Beirut 42025.55 GB-GOV-10-HPSR_Project_1_158806 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) American University of Beirut 63038.32 GB-GOV-10-HPSR_Project_1_158806 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) American University of Beirut 61324 GB-GOV-10-HPSR_Project_1_158806 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) American University of Beirut 118614 GB-GOV-10-HPSR_Project_1_158806 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) American University of Beirut GB-GOV-10-HPSR_Project_1_158924 UK - Department of Health and Social Care (DHSC) Palliative care is a fundamental human right, yet accessibility of palliative care in Lao People's Democratic Republic (PDR) remains extremely limited, with only a small fraction of those in need receiving appropriate care. This project aims to improve palliative care services in Lao PDR by estimating the current and future need for palliative care, analysing the structure and performance of the health and social systems, and developing a simulation model to support better policymaking. The research study is led by the Lao Tropical and Public Health Institute (Lao TPHI) in collaboration with the Ministry of Health, Laos Cancer Center, Karunruk Palliative Care Center of Khon Kaen University, and Swiss Tropical and Public Health Institute, and the research will be conducted in Vientiane Capital, Luang Prabang, and Champasack Provinces for a 36-month period from 2025 to 2028. The project will measure serious health-related suffering (SHS) among people living with advanced and irreversible diseases, assess how the healthcare system currently supports palliative care, and engage stakeholders to design a system dynamics model. This model will help policymakers test different strategies virtually before implementing them in the real world. The final goal will be a decision-support tool to guide the design of cost-effective strategies to reduce suffering and improve the quality of life for patients and families. The research project is essential to inform national health strategies and to address the growing burden of serious health-related suffering in Lao People's Democratic Republic. The project has 3 objectives: 1. To estimate the burden of serious health-related suffering for deceased and non-deceased living with an advanced and irreversible disease in Lao People's Democratic Republic and to project the future burden. 2. To conceptualise the structure, dynamics, governance, and value chain of the social and healthcare system to provide continuum of care for patients with advanced and irreversible diseases. 3. To create a comprehensive system dynamics model that analyses the impact of different intervention strategies to improve the quality of life and wellbeing for patients at the end of life, as well as their families and caregivers. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Lao Tropical and Public Health Institute UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Lao People’s Democratic Republic (the) Medical research Research and Innovation 208268.43 347605.82 304871.2 149012.66 1009758.11 GB-GOV-10-HPSR_Project_1_158924 COMMITMENT UK - Department of Health and Social Care (DHSC) Lao Tropical and Public Health Institute 20826.84 GB-GOV-10-HPSR_Project_1_158924 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Lao Tropical and Public Health Institute 62480.53 GB-GOV-10-HPSR_Project_1_158924 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Lao Tropical and Public Health Institute 7385 GB-GOV-10-HPSR_Project_1_158924 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Lao Tropical and Public Health Institute 89902 GB-GOV-10-HPSR_Project_1_158924 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Lao Tropical and Public Health Institute 101814.35 GB-GOV-10-HPSR_Project_1_158924 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Lao Tropical and Public Health Institute GB-GOV-10-HPSR_Project_2 UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR Global Health Policy and Systems Research (Global HPSR) programme funds health policy and systems research that is directly and primarily of benefit to people in low- and middle-income countries (LMICs), to improve access to appropriate and affordable health services aligned with the aims of Universal Health Coverage and Sustainable Development Goal 3. Global HPSR Projects Call 2 supports applied health policy and systems research projects. UK and LMIC universities and research institutes were invited to submit applications including either a sole LMIC Lead Applicant, or two Joint Lead Applicants from either a LMIC or the UK, at least one of whom must be employed by a LMIC institution. To support applied Health Policy and Systems Research Projects which: 1) Will support new entrants to global health policy and systems research through smaller scale awards. 2) Have clearly defined questions which specifically target an identified health policy and/or system(s) challenge or evidence gap and set out how the outcome of the research will benefit vulnerable populations in LMICs. 3) Address priorities identified by and relevant to local stakeholders and policymakers, and deliver evidence and outcomes that will inform policy or change practice, for example informing local, regional or national strategies. 4) Have plans to involve relevant communities and stakeholders to ensure that research objectives address their needs. 5) Include research capacity development plans for LMIC partners that are proportionate and relevant to delivery of the proposed activities and include appropriate project management and financial/administrative support. 6) Support career development for research leaders of the future, e.g. through supporting less experienced researchers in LMICs to lead/jointly lead on the research proposal with effective mentoring and support from appropriate Co-Applicants. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health Makerere University School of Public Health UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-HPSR_Project_2_168786 UK - Department of Health and Social Care (DHSC) The project will develop, implement and evaluate the National Integrated Anti-Microbial Resistance (NIAMR) Digital Platform which will be designed to integrate and share data generated in health facilities across Uganda to support rapid detection and monitoring of AMR, and inform scaling of the platform across other One Health sectors (i.e. animal health, environment, water and wildlife). This initiative bridges the gap between raw laboratory data and actionable public health intelligence. By creating a unified national picture of resistance patterns and quickly identifying resistance hotspots, the platform aims to support better patient care, guide treatment policies and target interventions more effectively. Beyond the technology, the project implements comprehensive training and protocols to empower a wide range of stakeholders (frontline health workers, communities, researchers and policy makers) to use digital data to improve health outcomes and national antimicrobial stewardship. This work involves assessing current data systems, co-designing the platform with stakeholders, piloting it in selected regions, and evaluating its impact on surveillance and clinical decision-making. The goal is to establish a sustainable, scalable tool that enables data-driven action to reduce the burden of AMR in Uganda with future potential to include animal, water and environmental health AMR data. The NIAMR Project is a collaborative project between Makerere University, the Ministry of Health, Mbarara University of Science and Technology and the Baylor College of Medicine, Uganda. The project will be undertaken in Uganda from February 2026 to January 2029 (3 years). The project addresses the critical problem of AMR in Uganda where it is a leading public health security problem. The major challenge is that valuable AMR data generated in health facilities remains siloed and unavailable for decision-making. This project has 5 objectives: 1. To analyse the current landscape, challenges and opportunities of anti-microbial resistance (AMR) data management in Uganda. 2. To co-develop and implement a National Integrated AMR Digital Platform for capturing, processing and sharing of AMR data. 3. To evaluate the platform’s impact on improving AMR surveillance, clinical decision-making and identification of resistance hotspots. 4. To assess the platform’s feasibility, acceptability, and usability among healthcare workers, policy makers and other stakeholders. 5. To plan for the platform’s sustainable scale-up nationally and its future expansion to other One Health sectors. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Uganda Medical research Research and Innovation 37228.6 224337.21 233420.64 271886.11 40361.71 807234.27 GB-GOV-10-HPSR_Project_2_168786 COMMITMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health 37228.6 GB-GOV-10-HPSR_Project_2_168786 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health 55842.9 GB-GOV-10-HPSR_Project_2_168786 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health GB-GOV-10-HPSR_Project_2_169017 UK - Department of Health and Social Care (DHSC) This project is a three year, mixed-methods research programme that aims to strengthen community health systems and epidemic preparedness in Uganda by integrated governance analysis, knowledge mobilisation, and participatory modelling. Organised into three interlinked workstreams, the study examines how different configurations of community health systems and community health workers perform during routine service delivery and during epidemic response, and how these can be optimised for efficiency, equity, and resilience. The work is led by a multidisciplinary team of Ugandan and UK researchers, with expertise in health systems research, epidemiology, economics, and modelling, working at Makere University, Uganda and University of York, UK. Working in close collaboration with the Ministry of Health, district health teams, community health supervisors, community health workers, civil society organisations, and development partners. Stakeholders are engaged not only as respondents but as active contributors through participatory dialogue, capacity-building, and co-production of evidence. The research is conducted in Uganda at national, district, and community levels. Selected districts provide focal sites for qualitative research, stakeholder dialogues, simulation exercises, and participatory modelling, reflecting variation in health system capacity and epidemic risk. National-level engagement ensures alignment with policy priorities and relevance to planning and epidemic preparedness. The project will be implemented from August 2025 to July 2028, with workstreams running in parallel and iteratively. The study is being conducted because most outbreaks in Uganda are geographically constrained in their early phases and require targeted, community-level responses in which community health workers play a central role. Yet policy decisions on community health systems and community health workers' deployment are often made without integrated evidence on system performance, trade-offs, and resilience. By embedding participatory epidemic modelling within real-world governance and planning processes, the project generates actionable evidence to support better decision-making, strengthen epidemic preparedness, and safeguard routine primary health care delivery. This project has 2 objectives: 1. To establish how Uganda's community health system can be strengthened to optimise resource allocation, improve outbreak preparedness, and enhance delivery of routine and emergency services. 2. To establish how stakeholder engagement, supported by participatory modelling, can facilitate evidence-informed decision-making and strengthen policy coalitions for community health systems in Uganda. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Uganda Medical research Research and Innovation 33859.82 207325.05 227220.7 247760.89 37692.97 753859.43 GB-GOV-10-HPSR_Project_2_169017 COMMITMENT UK - Department of Health and Social Care (DHSC) Imperial College London 33859.82 GB-GOV-10-HPSR_Project_2_169017 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 50789.72 GB-GOV-10-HPSR_Project_2_169017 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London GB-GOV-10-CENTRES_1 UK - Department of Health and Social Care (DHSC) The Global Health Research Centres programme funds research-driven partnerships between institutions in low and middle income countries (LMICs) and in the UK. The Centres undertake high quality research and strengthen LMIC institutional capacity to undertake, manage and disseminate high-quality applied health research. The Global Health Research Centres programme funds high quality applied health research in LMICs and supports the development of a critical mass of sustainable, competitive research capacity. By delivering high quality research evidence and strengthening research capacity at all levels, our Global Health Research Centres will improve health outcomes for people in LMICs and support sustainable growth of the LMIC research ecosystem. The Global Health Research Centres programme funds ambitious, transformative, innovative and collaborative consortia of research institutions in the UK and in LMICs that are eligible for Official Development Assistance (ODA). High quality research and research capacity strengthening in LMICs are equally essential components of the programme. Each funding call addresses an area where there is a need for coordinated, high quality research in LMICs to increase the global evidence base. The first funding call will fund and designate NIHR Global Health Research Centres in non-communicable diseases. Centres also have a focus on capacity building and training in partner LMIC institutions, through: -strengthening career pathways for researchers, from masters students to senior academics -developing and retaining a trained and networked global cohort of experts and future research leaders -supporting the training and development of research managers and other non-academic staff. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine Imperial College London University of York University of Leicester Queen Mary University of London Athena Infonomics Ltd Ecorys UK Limited UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation GB-GOV-10-CENTRES_1_203246 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) partnership that aims to contribute to improved health of populations in West Africa by strengthening capacity for high-quality research and developing and implementing contextually adapted packages of interventions for prevention, diagnosis and management of non-communicable diseases (NCDs) at community and primary care levels The partnership involves two joint lead organisations - Ghana College of Physicians and Surgeons and the London School of Hygiene & Tropical Medicine and three partners namely Ashesi University, Laboratoire d'Etudes et de Recherche sur les Dynamiques Sociales et le Développement Local (LASDEL) and Université Catholique de l'Afrique de l'Ouest - Unité Universitaire at Bobo-Dioulasso (UCAOUUB) Between October 2022 and September 2027, we will work in three West African countries namely Ghana, Burkina Faso and Niger with varying ethnic-socio-cultural-economic environments to develop, implement and evaluate ways of improving control of hypertension, diabetes and mental health conditions related to chronic illness such as stress, anxiety and depression. We will start by analysing the roles of key stakeholders (patients and communities, health workers, managers, policymakers) in the development, provision, and use of NCD policies, programmes and services in each country, using appropriate methods such as analysis of available data, observations and interviews. Working closely with those stakeholders, we will co-produce packages of interventions for improving NCD control. This package will include adapting international guidelines to local contexts and supporting healthcare workers in implementing these, and establishing a community-based prevention, early-detection and management of NCDs. We will implement and rigorously evaluate the interventions packages for their costs and effectiveness, assess their potential for wide-scale application, and will identify transferable lessons for improving NCD control beyond these three countries Throughout our work, we will: (a) firstly strengthen individual skills and expertise, organisational systems and processes and system-wide networking capabilities and leadership of researchers to conduct high-quality research, secondly local communities to engage with, and understand, how to enable healthy lifestyles and thirdly, policymakers and practitioners to use evidence-informed interventions. (b) engage with key stakeholders i.e. patients, health workers, managers for consulting on their views, preferences and expectations, sharing results as they emerge and facilitating uptake of research results into their decisions and practices; and (c) maintain equitable national and international partnerships, through shared leadership involving both senior and earlier-career staff, and equally distributed management responsibilities. We will share research results with different audiences, through easyto-understand leaflets, briefs, audio-visual materials, adapted guidelines, policy dialogues, academic publications and conference presentations. The Centre’s goal is to contribute to improved health of West African populations through comprehensive and sustainable capacity strengthening for high-quality applied research and through developing and implementing contextually adapted packages of interventions for prevention, diagnosis and management of hypertension, diabetes and related common mental disorders such as anxiety, stress and depression. Our ambition is to leave a legacy of person-centred, integrated (not disease-specific) and system-wide (combining staff, structures, resources at multiple levels) responses to inter-connected NCDs at community and primary care levels, through African-led research by high-calibre scholars embedded within supportive institutions, networks and policy environments. This will all ultimately contribute to the reduction in premature mortality from NCDs, to improved health, wellbeing and socio-economic gains. Specific objectives are to: 1. Deepen understanding of contextual influences and effective pathways to prevention, diagnosis and management of NCDs in West Africa. 2. Co-produce with key stakeholders, contextually adapted packages of interventions for prevention, diagnosis and management of NCDs at community and primary care levels; and conduct formative process evaluation. 3. Implement the intervention package through existing health systems in each country, and evaluate its feasibility, acceptability, clinical effects, equitable reach and cost-effectiveness. 4. Comprehensively and sustainably strengthen capacities of researchers, communities and decision-makers, for high-quality applied NCD research and its uptake. 5. Ensure effective research communication and uptake into policies and practices of patients, communities, service providers, and national/West African decision-makers. 6. Continuously engage with key stakeholders at community, subnational, national levels within each country and within West Africa. 7. Establish and maintain equitable partnerships across West African and UK applicants, through shared leadership and governance arrangements. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 909168 1810476 1933092 1946484 2037728 1140574 454584 GB-GOV-10-CENTRES_1_203246 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 9777522 GB-GOV-10-CENTRES_1_203246 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 319881 GB-GOV-10-CENTRES_1_203246 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 133881 GB-GOV-10-CENTRES_1_203246 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 183881 GB-GOV-10-CENTRES_1_203246 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 874158 GB-GOV-10-CENTRES_1_203246 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 397982 GB-GOV-10-CENTRES_1_203246 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 427325 GB-GOV-10-CENTRES_1_203246 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 366169 GB-GOV-10-CENTRES_1_203246 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 255351 GB-GOV-10-CENTRES_1_203246 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 620777 GB-GOV-10-CENTRES_1_203246 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 528260 GB-GOV-10-CENTRES_1_203246 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 489538 GB-GOV-10-CENTRES_1_203246 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 572872 GB-GOV-10-CENTRES_1_203246 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 511190 GB-GOV-10-CENTRES_1_203246 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-CENTRES_1_203247 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) partnership to create a centre of excellence on non-communicable diseases (NCDs) and global environmental change in Bangladesh, India and Indonesia offering world-leading research, training and policy advice for health equity. LMICs face dual, intertwined challenges of a rapidly growing burden of NCDs and the existential threat of global environmental change. In addition, health systems in LMICs face specific challenges in delivering high-quality, equitable services for NCDs prevention and care, especially for marginalised populations most impacted by environmental change. Despite an increasingly recognised imperative for action, there is a paucity of evidence on cost-effective interventions to address major challenges emerging at the nexus of NCDs and environmental change. Our Centre will focus on three countries highly impacted by the dual challenges of NCDs and environmental change. Partner institutions are the George Institute in New Delhi, India, Imperial College London, International Centre for Diarrhoeal Disease Research, Bangladesh in Dhaka, Sri Ramachandra Institute of Higher Education & Research in Chennai and University of Brawijaya in Malang. This project will start in October 2022 and runs for five years ending in September 2027. We will address crucial knowledge gaps through three integrated research themes: 1. Strengthening primary health care and essential public health services for NCD prevention and management in communities affected by rapid environmental change; 2. Developing and evaluating multi-sectoral interventions that have dual benefits in reducing the burden of NCDs and hazardous environmental exposures at the population level; 3. Strengthening engagement of communities in the generation and use of evidence and advocacy for health and environment policy change. All interventions will have a focus on reducing inequities in addition to cost-effectively improving health outcomes. An example of the integrated research program relates to the burning of plastic wastes in Indonesia. In the same communities, dual benefit interventions (e.g. reduced burning within the context of improved waste management strategies) and an innovative technology-based primary health care model will focus on the prevention of exposure to environmental hazards, while also promoting screening for and management of airpollution related NCDs, such as chronic obstructive pulmonary disease. Common systems to collect data for both implementation and evaluation of such complementary interventions will be deployed. Throughout the research lifecycle, our Centre will emphasise systematic and meaningful engagement of community members and policymakers – including through co-design and evaluation of interventions. In addition to delivering high-quality impactful research, we will focus also on research capacity strengthening and will deliver several training and development opportunities targeting three critical career periods: pre-doctoral, early post-doctoral and transitioning to senior leadership. Recruitment into these training opportunities and posts will be based on gender parity and we will monitor and report diversity in career progression for all staff and students across academic career levels. We will strengthen research capability at institution, network and ecosystems levels to enable LMIC-led production and use of highquality evidence at the nexus of NCDs and environmental change. Our aim is to be a recognised centre of excellence on NCDs and global environmental change in LMICs, co-producing world leading implementation research with local communities, strengthening research capability, advocacy, and policy for health equity. Objectives To establish a common data platform across all three countries that can comprehensively capture community environmental risks, behavioural risk factors and disease management To expand existing PHC strengthening strategies (COBRA-BPS in Bangladesh, SMARThealth in India and Indonesia;) to incorporate environmental risks and a broader range of disease conditions using a community co-design approach To develop, implement and evaluate multi-sectoral interventions in each country which address key dual threats to NCDs and the environment (water salinity, air pollution, poor dietary diversity) To understand the nature of Community Engagement and Involvement (CEI) in the evidence to policy process in each of our focus countries and identify opportunities for enhancement To evaluate the process for CEI in co-production and collaborative engagement activities undertaken within our Research Programme and to understand how and how well the CEI activities have been implemented under these themes To strengthen Research Capability in four domains identified in our framework, covering individuals, institutions, networks and ecosystems UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 890088 2196260 2419404 2116920 1682092 690320 445044 GB-GOV-10-CENTRES_1_203247 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 9995084 GB-GOV-10-CENTRES_1_203247 COMMITMENT UK - Department of Health and Social Care (DHSC) Imperial College London 30044 GB-GOV-10-CENTRES_1_203247 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 497065 GB-GOV-10-CENTRES_1_203247 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 100065 GB-GOV-10-CENTRES_1_203247 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 560647 GB-GOV-10-CENTRES_1_203247 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 753503 GB-GOV-10-CENTRES_1_203247 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 380057 GB-GOV-10-CENTRES_1_203247 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 270857 GB-GOV-10-CENTRES_1_203247 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 770161 GB-GOV-10-CENTRES_1_203247 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 746723 GB-GOV-10-CENTRES_1_203247 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 440261 GB-GOV-10-CENTRES_1_203247 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 552195 GB-GOV-10-CENTRES_1_203247 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 629897 GB-GOV-10-CENTRES_1_203247 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London GB-GOV-10-CENTRES_1_203248 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership aiming to improve the lives of those experiencing noncommunicable diseases (NCDs) such as heart disease, depression and diabetes in Pakistan and Afghanistan, and the relevant systems available to those populations. The project will also develop the research capacity of related organisations working in these countries. NCDs are rapidly increasing and are now responsible for most deaths and disabilities globally. In Afghanistan and Pakistan, countries with limited resources and affected by recent conflicts, NCDs risk crippling fragile health systems and economies. In response, health systems and policies are evolving and diversifying, e.g. non-specialist healthcare workers share tasks usually delivered by specialists; and private sector organisations are increasingly providing health coverage. There is a knowledge gap, however, on effective, scalable interventions in low-resource, conflict-affected settings. This provides timely opportunities to develop, test and embed evidence-based approaches to address NCDs. In preparing this project, we held consultations with practitioners, affected communities and policymakers in both countries, who identified a time-critical need to strengthen capacity in discovering and implementing affordable effective solutions to address NCDs. We also referred to a recent research prioritisation process undertaken by the Higher Education Commission in Pakistan. The long-term aim is to promote mental and physical health in Afghanistan and Pakistan by reducing premature deaths and disabilities caused by NCDs. In this proposal, we focus on three of the four key NCDs: common mental disorders (depression and anxiety), heart conditions, and diabetes. We will evaluate approaches to prevent and treat these, targeting those most at risk, and giving mental health parity alongside physical health. Firstly, we will identify the most practical, affordable solutions. A group of academics, practitioners and policymakers will prioritise a shortlist of solutions, including those offered to individuals and communities as well as those implemented at population level. Using various research methods, we will assess the health and economic impact of these solutions. Secondly, we will train researchers, particularly women scholars, to become tomorrow’s research leaders. The trainees will include 8 Masters, 16 Doctoral, 6 Post-doctoral scholars (at least 60% women) and 70 research and support staff (short-term courses). Participating institutions will create competitive faculty positions to retain these scholars beyond the funding period. We will enhance health research standards in our institutions whilst promoting an environment in the two countries that demands, understands and utilises research to inform policy and practice. We will use Community Advisory Panels to engage with patients and families. Following training, Panels will help design, conduct, and disseminate research, bringing practitioners and policymakers together to inform the research and share findings. Multiple channels–journal articles, policy briefs, print and social media– will be used to make findings accessible to academic and lay audiences. Over time, we will develop strong, diverse academic leadership bringing wider health, societal, and economic benefits to the region. Jointly led by Aga Khan University, and the University of York, this global project network brings together experts in diabetes, cardiovascular disease, mental health and global public health research from Pakistan (Aga Khan University; Khyber Medical University; The Institute of Psychiatry; Baqai Institute of Diabetology & Endocrinology at the Baqai Medical University; The Initiative), Afghanistan (HealthNet TPO; Kabul University of Medical Sciences) and the UK (University of York; University of Liverpool; University of Edinburgh). The project will start in October 2022 and run until September 2027. The research plan has ten objectives which are related to research and capacity strengthening activities. All objectives are in line with the overall Centre aims to i) develop and evaluate innovative and sustainable models to deliver individual and population-level interventions, in order to strengthen health systems and support policies for equitable roll-out of strategies for the prevention and treatment of non-communicable diseases (NCDs) and; ii) to strengthen capacity in applied health research and research governance, prioritising gender equality. The Centre objectives are as follows: • By the end of Year 1 of the project, we will complete a valueof-information analysis and stakeholder prioritisation exercise with policy makers, practitioners and community advisory panels. This will help us identify the most suitable interventions we could trial and to assess their feasibility in local contexts in Pakistan and Afghanistan. • By the end of Year 1 we will identify suitable data sources, refine/expand existing population cohorts, digitise data collection and prepare study sites. This will ensure the Centre is ready to carry out identified interventions from Year 2 onwards. • By the end of Year 1 we will assess the existing capacity within the project partner organisations and health, policy and community systems in Pakistan and Afghanistan, in order to develop a tailored action plan with a special emphasis on gender equity. • By the end of Year 1 we will develop a research training and mentorship programme for researchers, practitioners and policymakers. • By the end of Year 1 we will establish research governance functions, Community Engagement and Involvement and Policy Fora. This is in order to share best research governance practice, to receive advice from key stakeholders and to ensure communication between the project and stakeholders is effective. • By the end of Year 4 we will evaluate the (cost-)effectiveness, equity and implementation of selected interventions (Objective 1) for modifying NCD risk factors and/or improving NCD outcomes through randomised controlled trials and health economic approaches. • By the end of Year4 we will deliver a training programme to project members and key stakeholders, strengthen institutional capacity in data and financial management within partner organisations and strengthen applied health research courses/degrees in partner organisations. • By the end of Year 3 we will conduct a mid-term review of all training and capacity strengthening plans and activities. • By the end of Year 5 we will work with key stakeholder fora to translate our project findings into policy and practice and enact plans to sustain research and its impact. We will use our links to extend the Centre's impact across the World Health Organization Eastern Mediterranean Region. • By the end of Year 5 we will support project trainees to secure follow-on fellowships or extramural funding and conduct an end of project impact- assessment. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of York UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 328158 890347 1356987 2060501 1909844 1075812 289079 GB-GOV-10-CENTRES_1_203248 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 7621649 GB-GOV-10-CENTRES_1_203248 COMMITMENT UK - Department of Health and Social Care (DHSC) University of York 39079 GB-GOV-10-CENTRES_1_203248 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 339164 GB-GOV-10-CENTRES_1_203248 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 203164 GB-GOV-10-CENTRES_1_203248 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 296195 GB-GOV-10-CENTRES_1_203248 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 51824 GB-GOV-10-CENTRES_1_203248 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 261560 GB-GOV-10-CENTRES_1_203248 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 317349 GB-GOV-10-CENTRES_1_203248 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 298903 GB-GOV-10-CENTRES_1_203248 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 479175 GB-GOV-10-CENTRES_1_203248 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 503194 GB-GOV-10-CENTRES_1_203248 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 466871 GB-GOV-10-CENTRES_1_203248 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 297290 GB-GOV-10-CENTRES_1_203248 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 461138 GB-GOV-10-CENTRES_1_203248 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 455108 GB-GOV-10-CENTRES_1_203248 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York GB-GOV-10-CENTRES_1_203257 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) partnership that aims to improve the care for people with multiple long-term conditions (MLTC) through innovative health system level interventions in India and Nepal. The proposed project will be co-led by investigators from the Public Health Foundation of India and University of Leicester in partnership with co-applicant institutions - All India Institute of Medical Sciences, Jodhpur (India), Health Related Information Dissemination Amongst Youth (India) and Kathmandu Medical College (Nepal). Patients with MLTCs in India and Nepal typically display worsened health and increased adverse outcome risk. Additionally, healthcare access is often limited in marginalized communities, and MLTC healthcare service delivery can be fragmented and inefficient. To address this, we will implement health system level interventions in Visakhapatnam (India), Jodhpur (India) and Bhaktapur and Kavrepalanchowk (Nepal). The interventions will meaningfully engage patients, their communities, and other relevant stakeholders. We will use their views to co-design a person or patient-centred care model that works for them. In addition, we will build the capacity of patients, providers, researchers, and research supporting staff to ensure that the proposed activities under the project are implemented and sustained beyond the project end date. The project activities will begin from October 2022 and end in September 2027. In the short term, we will analyse existing and new data to understand the patterns of multiple long-term conditions in both countries, how the health systems provide care and identify the best method to deliver patient-centred and responsive care for people living with these conditions. We will conduct community conversations and interviews among people living with these conditions and their caregivers, healthcare providers and the wider community to identify their experiences, needs, beliefs and living environment. We will identify “Community Champions”, who will represent people living with multiple long-term conditions, to work with us to help develop a responsive care model. In the medium term, we will propose interventions or a treatment package that respect people’s culture, beliefs, and environment and work in close partnership with the Community Champions to create a network of patients. We will test the interventions to understand if they are appropriate and adequately adapted to the context and if they could be integrated into the pre-existing health system. The interventions will use digital technology (an electronic decision support system, telemedicine) to provide care. Simultaneously, we will build the capacity of young researchers through varied educational programmes to address multiple long-term conditions and bolster institutional capacity to advance research. In the long term, we will work with the governments of India and Nepal to address multiple long-term conditions (MLTC) and embed the care model in the respective health systems to improve population health outcomes. Findings and materials developed by this collaboration will be widely disseminated and shared to improve the quality of lives of people with multiple long-term conditions, strengthen the health systems, and benefit societies and national economies. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Leicester UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 511040 450652 705185 1507544 3999488 1663759 377571 413020 GB-GOV-10-CENTRES_1_203257 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 9657158 GB-GOV-10-CENTRES_1_203257 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Leicester 98020 GB-GOV-10-CENTRES_1_203257 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 233511 GB-GOV-10-CENTRES_1_203257 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 217141 GB-GOV-10-CENTRES_1_203257 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 135465 GB-GOV-10-CENTRES_1_203257 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 425338 GB-GOV-10-CENTRES_1_203257 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 144382 GB-GOV-10-CENTRES_1_203257 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 767520 GB-GOV-10-CENTRES_1_203257 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 541016 GB-GOV-10-CENTRES_1_203257 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 101232 GB-GOV-10-CENTRES_1_203257 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 97776 GB-GOV-10-CENTRES_1_203257 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester -441919 GB-GOV-10-CENTRES_1_203257 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Leicester 707323 GB-GOV-10-CENTRES_1_203257 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester GB-GOV-10-CENTRES_1_203266 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) partnership that aims to strengthen community-based care for people with diabetes, cardiovascular disease, respiratory conditions and mental health problems in Latin America. The partnership will develop a world-class research centre with a regional focus in three Latin American countries – Bolivia, Colombia and Guatemala, to strengthen research and service capacity, conduct high quality research and ultimately improve quality of life and disease specific outcomes for individuals with longterm NCDs, including those from often neglected indigenous communities. Supported by Queen Mary University of London (UK), the Centre will link a leading university in Colombia, Universidad Javeriana, as a regional hub with two universities namely in Bolivia (Universidad Franz Tamayo) and Guatemala (Universidad Rafael Landívar). Studies will investigate the best way to manage long-term conditions within the community. The approach involves using resource-oriented interventions that help people use their strengths and resources to reduce lifestyle factors and behaviours linked to developing long-term conditions. This research will adapt and test these interventions to see whether they have a beneficial effect and to investigate the best way to deliver them in health care services. The research will be implemented from 2022 to 2027. The project will develop the skills of local researchers and clinicians to help sustain the Centre and increase impact. A PhD and Masters programme will run in Colombia to provide formal training to students from all three countries and will help us develop a network of researchers, linking them with others in the region and internationally. The research will be developed and discussed in collaboration with advisory groups. These groups will involve people with long-term conditions, clinicians in community services, community organisations and representatives of local governments. There will be a particular focus on people from indigenous communities as active participants and collaborators, as the impact of long-term conditions is greatest for indigenous people. The project activities will begin from October 2022 and end in September 2027. The overall objective of this project is to build a world-class research centre with a regional focus in Latin America to strengthen research and service capacity, conduct high quality research and ultimately improve quality of life and disease specific outcomes for individuals with long-term Non-Communicable Diseases (NCDs), including those from often neglected indigenous communities. Short-term aims: build relationships between partners to establish a shared vision, link with local stakeholders, initiate the postgraduate training programme, and identify future research leaders. Medium-term: consolidate capacity strengthening activities through cross cutting, high quality and priority driven research studies testing effectiveness and implementation of appropriate interventions for patients with long-term NCDs. Long-term: sustain and grow the Centre through a critical mass of researchers with regional and international collaborations, complementary skill sets and top-level expertise to lead research groups and generate further funding; the Centre will provide relevant research evidence and influence policies to improve health and social outcomes for patients with NCDs. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Queen Mary University of London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 690344 1535576 1545756 1386188 1254808 579371 345172 GB-GOV-10-CENTRES_1_203266 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 6992043 GB-GOV-10-CENTRES_1_203266 COMMITMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 95172 GB-GOV-10-CENTRES_1_203266 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 373757 GB-GOV-10-CENTRES_1_203266 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 66224 GB-GOV-10-CENTRES_1_203266 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 187224 GB-GOV-10-CENTRES_1_203266 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 179981 GB-GOV-10-CENTRES_1_203266 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 209595 GB-GOV-10-CENTRES_1_203266 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 397165 GB-GOV-10-CENTRES_1_203266 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 152117 GB-GOV-10-CENTRES_1_203266 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 127158 GB-GOV-10-CENTRES_1_203266 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 436249 GB-GOV-10-CENTRES_1_203266 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 431572 GB-GOV-10-CENTRES_1_203266 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 399690 GB-GOV-10-CENTRES_1_203266 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 408286 GB-GOV-10-CENTRES_1_203266 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 786279 GB-GOV-10-CENTRES_1_203266 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London GB-GOV-10-CENTRES_1_LP_205661 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) partnership that aims to support, embed and advance best-in-class methodological approaches - spanning MEL, research on research, and continuous improvement - across the lifetime of the Centres programme. The Learning Research Partner (LRP) will support all five (5) GHR Centres and stakeholders to develop and implement equitable and participatory MEL approaches including facilitating training and learning opportunities. This project has four objectives: a. Exemplify the value of equitable and participatory monitoring, evaluation and learning approaches through supporting the Centres, providing insights of good practice and facilitating the design and delivery of training activities. b. Work with Centres award-holders and NIHR programme teams to design and set up sustainable routes to enable shared learning and engagement in research capacity strengthening (RCS), community engagement and involvement (CEI), knowledge management etc. through e.g. learning, training platforms, networking events, workshops, seminars and/or other events. c. Facilitate the development of an overarching programme-level Centres monitoring, evaluation and learning framework and strategy which is contextually-relevant and which both incorporates and supports Centres’ own development of participatory monitoring, evaluation and learning strategies and approaches at local level. d. Work collaboratively with Centres award-holders and wider partners to consider which topics are suitable for formal ‘research on research’ studies across the programme, and consider potential for research training of individuals (e.g. via LMIC-based PhD studentships). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Athena Infonomics Ltd UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research/scientific institutions Research and Innovation 152132 178980 116332 44744 GB-GOV-10-CENTRES_1_LP_205661 2023/24 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Athena Infonomics Ltd 17900 GB-GOV-10-CENTRES_1_LP_205661 2023/24 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Athena Infonomics Ltd 447444 GB-GOV-10-CENTRES_1_LP_205661 COMMITMENT UK - Department of Health and Social Care (DHSC) Athena Infonomics Ltd 44744 GB-GOV-10-CENTRES_1_LP_205661 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Athena Infonomics Ltd 44090 GB-GOV-10-CENTRES_1_LP_205661 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Athena Infonomics Ltd 119665 GB-GOV-10-CENTRES_1_LP_205661 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Athena Infonomics Ltd 33945 GB-GOV-10-CENTRES_1_LP_205661 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Athena Infonomics Ltd 34532 GB-GOV-10-CENTRES_1_LP_205661 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Athena Infonomics Ltd 23837 GB-GOV-10-CENTRES_1_LP_205661 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Athena Infonomics Ltd 16765 GB-GOV-10-CENTRES_1_LP_205661 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Athena Infonomics Ltd 28476 GB-GOV-10-CENTRES_1_LP_205661 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Athena Infonomics Ltd 18707 GB-GOV-10-CENTRES_1_LP_205661 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Athena Infonomics Ltd GB-GOV-10-CENTRES_1_MEL_502855 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership that is developing a Value for Money (VfM) framework to assess the NIHR Global Health Research (GHR) portfolio. The work is being undertaken by Ecorys in partnership with Access Health – India and an international Public Health consultant. Commencing in October 2025, this six-month award is based in the UK with expected fieldwork in select LMICs where NIHR-funded research is delivered. The primary objectives are to provide evidence of the value created through global health research, improve accountability for Official Development Assistance (ODA) spending, and strengthen future decision-making. Key activities include: • Development and refinement of a framework via stakeholder consultations, document review and benchmarking. • Development of a draft VfM framework inclusive of indicators, feasibility assessment, and refinement of programme‑level and portfolio‑level assessment tools. • VfM framework testing through case studies (via further interviews and fieldwork), applying it across programmes and the selected awards. • Gathering and synthesising of evidence, before producing recommendations to support long-term assessment and learning across the GHR portfolio. The award has 5 objectives: 1. Develop a clear and practical Value for Money (VfM) framework. To design a VfM framework for the NIHR Global Health Research (GHR) portfolio that explains how value is created across programmes and awards, including economy, efficiency, effectiveness, cost-effectiveness, equity, and sustainability, using evidence from interviews, document review and benchmarking. This will support DHSC and NIHR to assess the value of investments in global health research. 2. Define indicators and a set of instructions that can be used consistently. To identify and describe indicators for assessing value across the GHR Portfolio and produce a set of instructions that explain different levels of progress. This includes specifying the data needed for each indicator and ensuring that indicators can be used with available programme and award evidence. 3. Test and refine the framework through case studies. To apply the draft VfM framework to case studies drawing on selected programmes and awards, test indicator feasibility, refine the instructions, and identify strengths and challenges in the assessment process. 4. Gather evidence across the portfolio to assess value. To collect evidence from programme and award documents, interviews, focus groups, and site visits to understand how value is created through NIHR‑funded research, including effects on research capacity, partnerships, community engagement, policy influence and health systems. 5. Produce VfM assessments with confidence ratings. To synthesise available evidence and apply the VfM set of instructions to generate assessments of progress for each programme, including a confidence rating for each indicator and clear explanations of evidence quality, gaps and assumptions. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Ecorys UK Limited UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Health policy and administrative management Research and Innovation 268807 29867 89602 GB-GOV-10-CENTRES_1_MEL_502855 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ecorys UK Limited 298674 GB-GOV-10-CENTRES_1_MEL_502855 COMMITMENT UK - Department of Health and Social Care (DHSC) Ecorys UK Limited 89602 GB-GOV-10-CENTRES_1_MEL_502855 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ecorys UK Limited 89603 GB-GOV-10-CENTRES_1_MEL_502855 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ecorys UK Limited GB-GOV-10-RIGHT_1 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)’s first Research and Innovation for Global Health Transformation (RIGHT) call. RIGHT funds cutting-edge interdisciplinary applied health research in key areas in in low- and middle-income countries (LMICs) where a strategic and targeted investment can result in a transformative impact. RIGHT Call 1 addresses research in three key areas: epilepsy, infection-related cancers and severe stigmatising skin diseases. UK universities and research institutes were invited to submit applications including a co-applicant or joint lead applicant from an LMIC relevant to the research proposal. Research must be focused on improving the health and welfare of people in LMICs. 1. Deliver research for the primary benefit to the health and welfare of the poorest individuals living in LMICs, typically through research for the prevention of ill health and optimal disease management, in three research areas: (1) Epilepsy (2) Infection-related cancers (3) Severe stigmatising skin diseases. 2. Strengthen capacity for research and knowledge exchange through equitable partnerships between researchers in the UK and LMICs. 3. Promote interdisciplinary approaches to working (including, but not limited to: clinical, health economics, statistics, qualitative and social sciences), to ensure that research objectives can be delivered. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine Liverpool School of Tropical Medicine University of Warwick University of Oxford University of Oxford Keele University University of Sussex Imperial College London Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-RIGHT_1_200125 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership that aims to improve outcomes for individuals with leprosy, yaws, Buruli ulcer and cutaneous leishmaniasis. The Skin Health Africa Research Programme (SHARP) is a an interdiscplinary partnership of clinicians, social scientists, epidemiologists, statisticians and laboratory scientists working with communities affected by severe stigmatising skin diseases. To improve outcomes for people with severe stigmatising skin diseases by strengthening the care cascade through scalable strategies for earlier detection, improving management to reduce disability and counteracting stigma: 1. to evaluate integrated community-based strategies for early diagnosis, adherence support and stigma reduction 2. to undertake facility-based trials of dressings for Buruli ulcer 3. to develop clinical and patient reported outcome measures for cutaneous leishmaniasis 4. to promote collaboration and build research capacity in Ghana and Ethiopia. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 522452 944664 1327324 1368672 836070 4999182 GB-GOV-10-RIGHT_1_200125 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 180888 GB-GOV-10-RIGHT_1_200125 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 341564 GB-GOV-10-RIGHT_1_200125 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 35370 GB-GOV-10-RIGHT_1_200125 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 393526 GB-GOV-10-RIGHT_1_200125 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 393525 GB-GOV-10-RIGHT_1_200125 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 393524 GB-GOV-10-RIGHT_1_200125 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 391821 GB-GOV-10-RIGHT_1_200125 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 136103 GB-GOV-10-RIGHT_1_200125 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 381219 GB-GOV-10-RIGHT_1_200125 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 225151 GB-GOV-10-RIGHT_1_200125 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 173317 GB-GOV-10-RIGHT_1_200125 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 329612 GB-GOV-10-RIGHT_1_200125 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 297567 GB-GOV-10-RIGHT_1_200125 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 326378 GB-GOV-10-RIGHT_1_200125 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 314067 GB-GOV-10-RIGHT_1_200125 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 308592 GB-GOV-10-RIGHT_1_200125 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-RIGHT_1_200129 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership that aims to reduce illness, stigma, mental distress, social exclusion and poverty caused by severe stigmatising skin diseases in Liberia. Using a person-centred approach, evaluate, develop and adapt health systems interventions for the management of severe stigmatising skin diseases (SSSDs) in Liberia to generate learning for other settings in sub-Saharan Africa by: 1. Identifying effective strategies to detect, refer, treat and support people living with SSSDs that are acceptable, affordable and sustainable especially amongst the most vulnerable 2. Designing and testing innovative health systems interventions that are responsive to biomedical, psychological and social support needs by assessing persons living with SSSDs, family, and provider perspectives and priorities at different levels 3. Enhancing quality and equity of approaches that will see all persons living with SSSDs receiving essential, effective and affordable treatment, care and support at the individual, family, community and facility level. Additionally, the project will also work toward developing a strong and sustainable research infrastructure for multi-disciplinary applied health research which focuses on severe stigmatising skin diseases and associated interventions in Liberia. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Liberia Medical research Research and Innovation 373989 730962 426602 756032 716467 192726 3047239 GB-GOV-10-RIGHT_1_200129 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 120017 GB-GOV-10-RIGHT_1_200129 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 253972 GB-GOV-10-RIGHT_1_200129 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 68082 GB-GOV-10-RIGHT_1_200129 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 220960 GB-GOV-10-RIGHT_1_200129 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 220960 GB-GOV-10-RIGHT_1_200129 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 220960 GB-GOV-10-RIGHT_1_200129 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 213301 GB-GOV-10-RIGHT_1_200129 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 213301 GB-GOV-10-RIGHT_1_200129 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 223715 GB-GOV-10-RIGHT_1_200129 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 89367 GB-GOV-10-RIGHT_1_200129 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 240520 GB-GOV-10-RIGHT_1_200129 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 202430 GB-GOV-10-RIGHT_1_200129 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 277430 GB-GOV-10-RIGHT_1_200129 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 202430 GB-GOV-10-RIGHT_1_200129 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 236607 GB-GOV-10-RIGHT_1_200129 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 149539 GB-GOV-10-RIGHT_1_200129 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 32887 GB-GOV-10-RIGHT_1_200129 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-RIGHT_1_200132 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership that aims to improve care and reduce stigma and social isolation for leprosy and Buruli ulcer in Nepal, India and Nigeria. 1. To improve self-care in the community for patients who are at risk of recurring leprosy ulcers. 2. To better understand the needs of patients with Buruli ulcer and the barriers to meeting those needs. 3. To develop new and improved methods of clinical care for both leprosy and Buruli ulcer patients. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Warwick UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 406436 1196837 1188292 1301822 905512 4998899 GB-GOV-10-RIGHT_1_200132 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Warwick 406436 GB-GOV-10-RIGHT_1_200132 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 92755 GB-GOV-10-RIGHT_1_200132 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 341845 GB-GOV-10-RIGHT_1_200132 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 341845 GB-GOV-10-RIGHT_1_200132 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 341845 GB-GOV-10-RIGHT_1_200132 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 301820 GB-GOV-10-RIGHT_1_200132 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 97504 GB-GOV-10-RIGHT_1_200132 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 356799 GB-GOV-10-RIGHT_1_200132 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Warwick 341801 GB-GOV-10-RIGHT_1_200132 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Warwick 204097 GB-GOV-10-RIGHT_1_200132 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 249136 GB-GOV-10-RIGHT_1_200132 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 324138 GB-GOV-10-RIGHT_1_200132 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 249661 GB-GOV-10-RIGHT_1_200132 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 392321 GB-GOV-10-RIGHT_1_200132 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 146877 GB-GOV-10-RIGHT_1_200132 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 241978 GB-GOV-10-RIGHT_1_200132 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 311656 GB-GOV-10-RIGHT_1_200132 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick GB-GOV-10-RIGHT_1_200133 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership that aims to test two new diagnostic technologies that can help provide fast and reliable diagnosis for Epstein-Barr virus (EBV) in sub-Saharan Africa. 1. To test two new technologies which, by leapfrogging conventional diagnostic approaches, could bring fast and precise diagnosis of Epstein Barr Virus Lymphoma to sub-Sahara Africa; 2. To generate viral and tumour sequence information to inform the design of future screening programmes and vaccine development; 3. To perform a clinical validation of our diagnostic tools and then a controlled before-after study to test whether these speed up diagnosis, increase the number of children diagnosed and treated, and ultimately improve survival compared to gold-standard pathology. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Oxford UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 370177 1441423 1081109 1075734 340366 4308809 GB-GOV-10-RIGHT_1_200133 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Oxford 195800 GB-GOV-10-RIGHT_1_200133 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 174377 GB-GOV-10-RIGHT_1_200133 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 411704 GB-GOV-10-RIGHT_1_200133 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 442157 GB-GOV-10-RIGHT_1_200133 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 442157 GB-GOV-10-RIGHT_1_200133 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 442157 GB-GOV-10-RIGHT_1_200133 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 280381 GB-GOV-10-RIGHT_1_200133 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Oxford 280381 GB-GOV-10-RIGHT_1_200133 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Oxford 74655 GB-GOV-10-RIGHT_1_200133 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) University of Oxford 213499 GB-GOV-10-RIGHT_1_200133 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) University of Oxford 178392 GB-GOV-10-RIGHT_1_200133 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 219225 GB-GOV-10-RIGHT_1_200133 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 164225 GB-GOV-10-RIGHT_1_200133 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 119225 GB-GOV-10-RIGHT_1_200133 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 455031 GB-GOV-10-RIGHT_1_200133 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford GB-GOV-10-RIGHT_1_200134 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership that aims to address the diagnosis, treatment and understanding of epilepsy in Ghana, Kenya and Tanzania. PREVENT: reduce the incidence of infection and peri-natal injury in an endemic region in Tanzania and the subsequent risk of epilepsy. DIAGNOSE: improve the rate of accurate diagnosis of epilepsy by developing app-based technologies. TREATMENT: increase the adherence to medication using text messaging. SOCIETAL CHANGE: ensure an enduring, positive change by improving public awareness and reducing the stigma experienced by people with epilepsy in Sub Saharan Africa. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Oxford UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 1385660 363454 0 563001 1492302 613864 808029 4990809 GB-GOV-10-RIGHT_1_200134 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Oxford 375677 GB-GOV-10-RIGHT_1_200134 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 375677 GB-GOV-10-RIGHT_1_200134 2019/20 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Oxford 634306 GB-GOV-10-RIGHT_1_200134 2019/20 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Oxford 363454 GB-GOV-10-RIGHT_1_200134 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 292094 GB-GOV-10-RIGHT_1_200134 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Oxford 270907 GB-GOV-10-RIGHT_1_200134 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 260632 GB-GOV-10-RIGHT_1_200134 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 495632 GB-GOV-10-RIGHT_1_200134 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 316105 GB-GOV-10-RIGHT_1_200134 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 419933 GB-GOV-10-RIGHT_1_200134 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 298919 GB-GOV-10-RIGHT_1_200134 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 314945 GB-GOV-10-RIGHT_1_200134 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 249001 GB-GOV-10-RIGHT_1_200134 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Oxford 559539 GB-GOV-10-RIGHT_1_200134 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford -13500 GB-GOV-10-RIGHT_1_200134 COMMITMENT (3) UK - Department of Health and Social Care (DHSC) University of Oxford GB-GOV-10-RIGHT_1_200135 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership, Empowering people with Cutaneous Leishmaniasis: Intervention Programme to improve patient journey and reduce Stigma via community Education (ECLIPSE) is a four-year healthcare programme which aims to improve the cutaneous leishmaniasis patient journey and reduce stigma in the most marginalised and underserved communities in Brazil, Ethiopia and Sri Lanka. 1. IMPROVE PATIENT OUTCOMES AND EMPOWER COMMUNITIES - To co-develop, implement and evaluate two interventions (community education campaigns and training packages for healthcare workers) in each Low and Middle Income Country (LMIC). 2. FOSTER CROSS-CULTURAL LEARNING THROUGH ECLIPSE PARTNERSHIP - To establish the transcontinental ECLIPSE consortium and carry out the 4-year applied health programme, which will enhance rapid international knowledge mobilisation. 3. INFLUENCE HEALTH POLICY - To recommend policy changes that address gaps in public health provision related to cutaneous leishmaniasis identified through the ECLIPSE research and influence implementation of these recommendations through the ECLIPSE Policy Network. 4. ACQUIRE NEW KNOWLEDGE ON cutaneous leishmaniasis - To produce a comprehensive biopsychosocial model of cutaneous leishmaniasis embedded in the syndemics theoretical framework in three LMICs and to widely disseminate results and policy recommendations. 5. DEVELOP SUSTAINABLE HEALTHCARE INTERVENTIONS - To ensure sustainability of interventions through collaboration with a wide range of cutaneous leishmaniasis constituents (including patients, community stakeholders, healthcare practitioners and policy makers) who have the ability and motivation to advocate for the routine implementation of ECLIPSE interventions and recommend new strategies in cutaneous leishmaniasis-endemic regions at national and international level. 6. APPLIED HEALTH AND CL RESEARCH CAPACITY BUILDING - To establish a cohort of 18 early career researchers and ensure their onward employability and retention through a robust interdisciplinary training and mentorship programme, in addition to enhancing leadership skills of senior ECLIPSE researchers to sustain the newly formed research groups. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Keele University UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 494407 1144932 1105396 1150540 681544 4576819 GB-GOV-10-RIGHT_1_200135 COMMITMENT UK - Department of Health and Social Care (DHSC) Keele University 197763 GB-GOV-10-RIGHT_1_200135 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 296644 GB-GOV-10-RIGHT_1_200135 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 251749 GB-GOV-10-RIGHT_1_200135 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 304983 GB-GOV-10-RIGHT_1_200135 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 304983 GB-GOV-10-RIGHT_1_200135 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 270597 GB-GOV-10-RIGHT_1_200135 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 66948 GB-GOV-10-RIGHT_1_200135 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 373365 GB-GOV-10-RIGHT_1_200135 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Keele University 352491 GB-GOV-10-RIGHT_1_200135 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Keele University 259520 GB-GOV-10-RIGHT_1_200135 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 194215 GB-GOV-10-RIGHT_1_200135 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 403341 GB-GOV-10-RIGHT_1_200135 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 315078 GB-GOV-10-RIGHT_1_200135 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 47133 GB-GOV-10-RIGHT_1_200135 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 363779 GB-GOV-10-RIGHT_1_200135 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 147493 GB-GOV-10-RIGHT_1_200135 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 167850 GB-GOV-10-RIGHT_1_200135 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University GB-GOV-10-RIGHT_1_200140 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership, Social Sciences for Severe Stigmatising Skin Diseases (5S) Foundation aims to fill gaps between knowledge, treatment and practice around three diseases, podoconiosis, mycetoma and scabies, working in Ethiopia, Sudan and Rwanda. 1. To examine the cultural logics and social and economic contexts of podoconiosis, mycetoma and scabies; 2. To understand the dynamics and dimensions of stigma; 3. To investigate how all three diseases have been conceptualised at national and international policy levels; 4. To evaluate existing interventions using social science perspectives; 5. To refine the conceptual framework developed to guide the Foundation’s research; 6. To develop a comprehensive intervention strategy for each disease; 7. To support endemic-country training posts (PhD and postdoctoral) in a manner that will leave enduring capacity or social science research; 8. To facilitate South-South and North-South sharing of best practice in research and advocacy applicable to a wide range of stigmatising conditions in low-resource settings. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Sussex UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 241610 745068 973000 979816 580441 3519935 GB-GOV-10-RIGHT_1_200140 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Sussex 106378 GB-GOV-10-RIGHT_1_200140 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 135232 GB-GOV-10-RIGHT_1_200140 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 128212 GB-GOV-10-RIGHT_1_200140 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 244732 GB-GOV-10-RIGHT_1_200140 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 244732 GB-GOV-10-RIGHT_1_200140 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 244734 GB-GOV-10-RIGHT_1_200140 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 244483 GB-GOV-10-RIGHT_1_200140 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 21548 GB-GOV-10-RIGHT_1_200140 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 382081 GB-GOV-10-RIGHT_1_200140 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 227602 GB-GOV-10-RIGHT_1_200140 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Sussex 170829 GB-GOV-10-RIGHT_1_200140 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Sussex 170829 GB-GOV-10-RIGHT_1_200140 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 217520 GB-GOV-10-RIGHT_1_200140 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 145520 GB-GOV-10-RIGHT_1_200140 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 124093 GB-GOV-10-RIGHT_1_200140 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 157577 GB-GOV-10-RIGHT_1_200140 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 151677 GB-GOV-10-RIGHT_1_200140 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 213863 GB-GOV-10-RIGHT_1_200140 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex GB-GOV-10-RIGHT_1_200144 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) partnership that aims to examine if a simple, pragmatic, and evidenced-based intrapartum care bundle for labour involving birth companions and empowering mothers will reduce perinatal brain injury and thus prevent epilepsy in India. 1. To examine if a pragmatic and evidenced-based intrapartum care bundle involving birth companions and empowering mothers will reduce birth injury related epilepsy at 18 months of age in India. 2. If effective, incorporate care bundle into the Labour Room Quality Improvement (LaQshya) programme, for national implementation, thus averting approximately 50,000 epilepsy cases every year in India. 3. Provide opportunities for academic and clinical capacity building in India in midwifery, neonatal/paediatric neurology and epilepsy, and public health. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU India Medical research Research and Innovation 389385 812408 709373 780578 349834 268661 174763 3318702 GB-GOV-10-RIGHT_1_200144 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Imperial College London 155754 GB-GOV-10-RIGHT_1_200144 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 233631 GB-GOV-10-RIGHT_1_200144 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 184793 GB-GOV-10-RIGHT_1_200144 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 209205 GB-GOV-10-RIGHT_1_200144 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 209205 GB-GOV-10-RIGHT_1_200144 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 209205 GB-GOV-10-RIGHT_1_200144 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 223906 GB-GOV-10-RIGHT_1_200144 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 223906 GB-GOV-10-RIGHT_1_200144 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 261561 GB-GOV-10-RIGHT_1_200144 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 121078 GB-GOV-10-RIGHT_1_200144 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Imperial College London 121078 GB-GOV-10-RIGHT_1_200144 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Imperial College London 112105 GB-GOV-10-RIGHT_1_200144 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) Imperial College London 307075 GB-GOV-10-RIGHT_1_200144 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) Imperial College London 119242 GB-GOV-10-RIGHT_1_200144 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 71439 GB-GOV-10-RIGHT_1_200144 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 158439 GB-GOV-10-RIGHT_1_200144 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 74648 GB-GOV-10-RIGHT_1_200144 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 45308 GB-GOV-10-RIGHT_1_200144 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 70728 GB-GOV-10-RIGHT_1_200144 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 197933 GB-GOV-10-RIGHT_1_200144 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 166300 GB-GOV-10-RIGHT_1_200144 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Imperial College London GB-GOV-10-RIGHT_1_PPDA UK - Department of Health and Social Care (DHSC) The purpose of Proposal and Partnership Development Awards (PPDA) funding is to improve the quality and likelihood of success of the projects funded through the NIHR Research and Innovation for Global Health Transformation (RIGHT) programme. Applicants that are successful at RIGHT Stage 1 and invited to submit a Stage 2 application are eligible for a PPDA, subject to satisfactory submission of a PPDA application. Not all Stage 2 applicants awarded a PPDA go on to secure RIGHT programme funding, therefore the details of PPDA recipients are not published. For RIGHT Call 1, PPDA were extended to 13 applicant organisations to support partnership development and the preparation of a RIGHT Stage 2 application. Proposal and Partnership Development Awards (PPDA) provide funding of up to £10,000 for organisations applying to NIHR Research and Innovation for Global Health Transformation (RIGHT) programme funding to: 1. Support applicants to work collaboratively with all study partners to develop the stage 2 application 2. Enhance partnerships across the proposed research collaboration 3. Initiate preparation of study governance documentation (i.e. due diligence and finance assurance policies) PPDA funds must be spent between the notification of RIGHT stage 1 outcome and the submission of the RIGHT stage 2 application. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 109553.62 109553.62 GB-GOV-10-RIGHT_1_PPDA 2019/20 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 109553.62 GB-GOV-10-RIGHT_1_PPDA COMMITMENT UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified Recipients of NIHR Proposal and Partnership Development (PPDA) Awards are funded subject to the following conditions being met: a) The Award may only be used in accordance with the plans outlined in the application submitted to the PPD fund in order to pay for: (i) reasonable travel and subsistence expenses; and/or (ii) reasonable partnership formation and development costs to support the production of related memorandum(s) of understanding and/or draft governance policies between the relevant oversea partner(s), collaborator(s) and/or service provider(s); both for the purposes of supporting the funding application to the National Institute for Health and Care Research (NIHR) Research on Interventions for Global Health Transformation (RIGHT)programme. b) No variation to the plans outlined in the application to the PPD fund is permitted without the prior written consent of the NIHR; c) In the event that VAT or any other tax or duty is payable in respect of the Award or the use of the Award, such VAT, tax or duty shall be payable by the Award holder; d) In using the Award and before making any payment to a local partner, collaborator or service provider, the Award holder must complete appropriate due diligence and take all steps reasonably necessary to ensure that both Award holder and their local partners, collaborators and/or service providers comply with all directly applicable legislation including (but not limited to), anti-bribery and corruption, the “NIHR Policy on Preventing Harm in Research” and “NIHR Safeguarding Guidance”; e) The Award holder must provide updates on how you have spent and/or plan to spend the Award as required by DHSC; f) In the event that any part of the award is not applied as outlined in your application, you will repay the relevant amount to the Department of Health and Social Care (DHSC) at the DHSC’s request; and g) The Award holder will provide verbal or written reports as required by DHSC on any aspect of the use of the Award. GB-GOV-10-RIGHT_2 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)'s second Research and Innovation for Global Health Transformation (RIGHT) call. RIGHT funds cutting-edge interdisciplinary applied health research in key areas in low- and middle-income countries (LMICs) where a strategic and targeted investment can result in a transformative impact. RIGHT Call 2 is funding mental health research in LMICs through supporting applied research on the development and evaluation of interventions to improve outcomes for people affected by mental health issues. UK universities and research institutes were invited to submit applications including a co-applicant or joint lead applicant from an LMIC relevant to the research proposal. Research must be focused on improving the health and welfare of people in LMICs. 1. Deliver research for the primary benefit to the health and welfare of the poorest individuals living in in low- and middle-income countries (LMICs), through research for the development and evaluation of interventions to improve outcomes for those affected by mental health issues. 2. Strengthen capacity for research and knowledge exchange through equitable partnerships between researchers in the UK and LMICs. 3. Promote interdisciplinary approaches to working (including, but not limited to: clinical, health economics, statistics, qualitative and social sciences), to ensure that research objectives can be delivered. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of York University of Liverpool Queen Mary University of London King's College London University of Warwick University College London Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation GB-GOV-10-RIGHT_2_200806 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership that aims to develop and evaluate a culturally adapted behavioural activation intervention for people with depression and diabetes in Bangladesh and Pakistan. The project aims to develop and test a culturally appropriate treatment for depression in people with diabetes in Bangladesh and Pakistan. This will be based on a relatively simple psychological talking treatment called Behavioural Activation (BA). The projects objectives are: 1. Develop and evaluate a culturally relevant, scalable behavioural activation intervention that can be delivered by non-specialists, and integrated within diabetes care. 2. Evaluate the clinical cost effectiveness of the new intervention in comparison to optimised usual care practices. 3. Evaluate the economic impacts of diabetes and depression multimorbidities. The work will generate knowledge that can improve mental and physical health, reduce inequalities and stigma for vulnerable groups, and provide economic benefit. Research collaboration is also expected to lead to further enhanced capacity in applied mental-physical multimorbidity research and policymaking in Bangladesh and Pakistan. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of York UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 407262 457565 696025 680600 497839 512136 58180 GB-GOV-10-RIGHT_2_200806 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 3005541 GB-GOV-10-RIGHT_2_200806 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of York 174541 GB-GOV-10-RIGHT_2_200806 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 174541 GB-GOV-10-RIGHT_2_200806 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 41213 GB-GOV-10-RIGHT_2_200806 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 185559 GB-GOV-10-RIGHT_2_200806 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 185559 GB-GOV-10-RIGHT_2_200806 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 45234 GB-GOV-10-RIGHT_2_200806 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 213373 GB-GOV-10-RIGHT_2_200806 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of York 152674 GB-GOV-10-RIGHT_2_200806 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) University of York 197820 GB-GOV-10-RIGHT_2_200806 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) University of York 132158 GB-GOV-10-RIGHT_2_200806 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 162703 GB-GOV-10-RIGHT_2_200806 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 162703 GB-GOV-10-RIGHT_2_200806 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 186585 GB-GOV-10-RIGHT_2_200806 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 168609 GB-GOV-10-RIGHT_2_200806 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 92648 GB-GOV-10-RIGHT_2_200806 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of York 146820 GB-GOV-10-RIGHT_2_200806 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 144944 GB-GOV-10-RIGHT_2_200806 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 128381 GB-GOV-10-RIGHT_2_200806 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 77694 GB-GOV-10-RIGHT_2_200806 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 153238 GB-GOV-10-RIGHT_2_200806 COMMITMENT (3) UK - Department of Health and Social Care (DHSC) University of York 203989 GB-GOV-10-RIGHT_2_200806 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 132491 GB-GOV-10-RIGHT_2_200806 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 13085 GB-GOV-10-RIGHT_2_200806 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York GB-GOV-10-RIGHT_2_200817 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership that aims to scale-up care for Perinatal Depression in Pakistan, Nepal, Bangladesh and Sri Lanka, through development of technology to support lay-therapists to deliver a World Health Organization (WHO)-approved Cognitive Therapy based intervention. The project aims to develop knowledge and tools to improve management of perinatal depression in women in four South Asian countries (Pakistan, Nepal, Bangladesh and Sri Lanka). Perinatal depression affects about one in four women in South Asia and has huge human and economic costs. It can be treated effectively with talking therapies. However, the vast majority of women in low-income countries remain untreated because of overburdened health systems and lack of mental-health specialists. The project focuses on use of technology to enable local lay-therapists to deliver an established talking therapy. If successful the technology would facilitate task-shifting the delivery of the therapy from a few specialists in overburdened health systems to appropriately trained lay-persons, thereby increasing the number of care providers and improving opportunities for women to access treatment. The objectives of the work are: 1. Develop and evaluate a digital Application (App) to facilitate delivery of a WHO-approved talking therapy, the “Thinking Healthy Programme”, by lay-women in Pakistan. 2. Improve implementation research capacity in four South Asian countries, Pakistan, Nepal, Bangladesh and Sri Lanka, to facilitate scale-up of the intervention in their settings. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 564360 860144 860164 647188 324622 225744 GB-GOV-10-RIGHT_2_200817 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 3256478 GB-GOV-10-RIGHT_2_200817 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 169308 GB-GOV-10-RIGHT_2_200817 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 169308 GB-GOV-10-RIGHT_2_200817 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 256777 GB-GOV-10-RIGHT_2_200817 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 215036 GB-GOV-10-RIGHT_2_200817 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 215036 GB-GOV-10-RIGHT_2_200817 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 215036 GB-GOV-10-RIGHT_2_200817 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 208158 GB-GOV-10-RIGHT_2_200817 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 151934 GB-GOV-10-RIGHT_2_200817 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) University of Liverpool 245606 GB-GOV-10-RIGHT_2_200817 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) University of Liverpool 246872 GB-GOV-10-RIGHT_2_200817 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 190824 GB-GOV-10-RIGHT_2_200817 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 200824 GB-GOV-10-RIGHT_2_200817 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 121570 GB-GOV-10-RIGHT_2_200817 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 230031 GB-GOV-10-RIGHT_2_200817 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 156366 GB-GOV-10-RIGHT_2_200817 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool GB-GOV-10-RIGHT_2_200824 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership to improve the quality of community-based care for people with psychosis in Pakistan and India by adapting and testing a low-cost approach called DIALOG+, and to raise awareness through arts projects involving people with psychosis and community members. Psychosis is a serious mental illness and can be very distressing for individuals and their families. People with psychosis often have a poor quality of life, and many do not receive the treatment they need. This is called the treatment gap. This project seeks to address the treatment gap in India and Pakistan through adapting a low cost treatment called “DIALOG+” so that it can be delivered in the community. DIALOG+ is known to help reduce symptoms and support people to have improved quality of life. The projects objectives are as follows: 1. Work with the communities in Pakistan and India to adapt DIALOG+ for their needs, thereby making this treatment more widely available and accessible. 2. Test the effectiveness of the adapted DIALOG+ in the selected communities to see if people with psychosis receiving DIALOG+ show improvements. 3. Develop the skills of local researchers and services through a programme of capacity-building and knowledge exchange. 4. Use arts based methods to educate and raise awareness about psychosis in the selected communities, so as to tackle discrimination against people with psychosis. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Queen Mary University of London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 364082 630140 600184 624184 275321 52012 GB-GOV-10-RIGHT_2_200824 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 2493911 GB-GOV-10-RIGHT_2_200824 COMMITMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 156035 GB-GOV-10-RIGHT_2_200824 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 156035 GB-GOV-10-RIGHT_2_200824 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 141039 GB-GOV-10-RIGHT_2_200824 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 157535 GB-GOV-10-RIGHT_2_200824 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 79725 GB-GOV-10-RIGHT_2_200824 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 196084 GB-GOV-10-RIGHT_2_200824 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 152210 GB-GOV-10-RIGHT_2_200824 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) Queen Mary University of London 234142 GB-GOV-10-RIGHT_2_200824 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) Queen Mary University of London 73226 GB-GOV-10-RIGHT_2_200824 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 114252 GB-GOV-10-RIGHT_2_200824 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 145252 GB-GOV-10-RIGHT_2_200824 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 154646 GB-GOV-10-RIGHT_2_200824 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 95948 GB-GOV-10-RIGHT_2_200824 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 49257 GB-GOV-10-RIGHT_2_200824 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 164724 GB-GOV-10-RIGHT_2_200824 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 118768 GB-GOV-10-RIGHT_2_200824 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London GB-GOV-10-RIGHT_2_200842 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership to improve the wellbeing and mental health of children with developmental disorders and their caregivers, by developing and evaluating a model of care with and for local Kenyan and Ethiopian communities. Many African children with developmental disorders (including intellectual disability and autism) and their caregivers experience severe challenges. Due to community stigma and parental blame, children with developmental disorders are often locked in their home. Many of these children do not attend school and receive no formal support. Affected families often live in poverty as care responsibilities mean caregivers are unable to work. Caregivers also report severe stress and social isolation, and associated mental health problems, including suicidal thoughts. This project seeks to improve the mental health of Kenyan and Ethiopian children and their caregivers through developing care-giver training packages, raising awareness and promoting community based support and inclusion. The objectives and intended impacts are as follows: 1. Working directly with communities to understand and break down barriers to accessing health and education services. 2. Awareness raising and education activities to promote community based support and inclusion. 3. Training local caregivers to identify children with development disorders and facilitate referrals to a new “Caregivers Skills Training” (CST) package developed by the World Health Organization. The package teaches parents / caregivers strategies to support child development, and since it is a group delivered activity it also helps alleviate the social isolation experienced by the caregiver. 4. Evaluate how well the CST package works in improving the mental health and wellbeing of children with developmental disorders and their caregivers, and whether the package offers value for money. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) King's College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 686100 388919 674943 804185 928876 807524 252693 98014 GB-GOV-10-RIGHT_2_200842 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 4385539 GB-GOV-10-RIGHT_2_200842 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) King's College London 294043 GB-GOV-10-RIGHT_2_200842 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 294043 GB-GOV-10-RIGHT_2_200842 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 82718 GB-GOV-10-RIGHT_2_200842 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 306201 GB-GOV-10-RIGHT_2_200842 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 143070 GB-GOV-10-RIGHT_2_200842 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) King's College London 376531 GB-GOV-10-RIGHT_2_200842 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) King's College London 155342 GB-GOV-10-RIGHT_2_200842 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 70487 GB-GOV-10-RIGHT_2_200842 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 226987 GB-GOV-10-RIGHT_2_200842 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 258770 GB-GOV-10-RIGHT_2_200842 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 247941 GB-GOV-10-RIGHT_2_200842 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 315891 GB-GOV-10-RIGHT_2_200842 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 264283 GB-GOV-10-RIGHT_2_200842 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 253381 GB-GOV-10-RIGHT_2_200842 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 95321 GB-GOV-10-RIGHT_2_200842 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 356028 GB-GOV-10-RIGHT_2_200842 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 140128 GB-GOV-10-RIGHT_2_200842 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 187083 GB-GOV-10-RIGHT_2_200842 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 157701 GB-GOV-10-RIGHT_2_200842 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) King's College London 124285 GB-GOV-10-RIGHT_2_200842 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 11555 GB-GOV-10-RIGHT_2_200842 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London GB-GOV-10-RIGHT_2_200846 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership to increase access to care and improve outcomes of serious mental disorders (SMDs) in slums in India and Nigeria, through development of an innovative collaborative care model involving traditional/faith healers, mental health professionals, primary care practitioners and community health workers (CHWs). Slum populations in low- and middle-income countries (LMICs) have high rates of serious and enduring mental disorders (SMDs) and very poor access to professional medical mental health care. Sufferers and their families often choose traditional and faith-based practices since these are more accessible, considered affordable, and are in tune with their cultural beliefs and traditions. Faith-based and traditional healing can play an important part in delivering care in LMICs, but those with SMDs require additional biomedical treatment and follow-up. This projects’ primary objective is to improve access to care and improve the outcomes for people with SMDs, through fostering cooperation between traditional/faith-based healers and professional medical services. The work focuses on two specifically identified slum populations, in New Dehli (India) and in Ibadan (Nigeria). The researchers will: 1. investigate each communities’ awareness and understanding of SMDs, including working with CHWs and traditional/faith-based healers to understand who seeks and receives care from these healers and how those processes could be linked to medical care. 2. Develop training packages to support CHWs and traditional/faith-based healers to identify SMDs that require referral to medical care, and create a mechanism for referral to medical care and other support services. 3. Develop street theatre performances and documentaries to reach and engage the relevant communities to raise awareness and reduce stigma, and share information on how to access care for SMDs. 4. The overall output from the work is an innovative collaborative care model involving traditional/faith healers, mental health professionals, primary care practitioners and CHWs in Nigeria and India. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Warwick UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 510897 901804 925000 902228 368698.3 72985 GB-GOV-10-RIGHT_2_200846 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 3608627.3 GB-GOV-10-RIGHT_2_200846 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Warwick 218956 GB-GOV-10-RIGHT_2_200846 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 71257 GB-GOV-10-RIGHT_2_200846 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 146662 GB-GOV-10-RIGHT_2_200846 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 127344 GB-GOV-10-RIGHT_2_200846 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 136369 GB-GOV-10-RIGHT_2_200846 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 249952 GB-GOV-10-RIGHT_2_200846 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Warwick 88632 GB-GOV-10-RIGHT_2_200846 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) University of Warwick 320193 GB-GOV-10-RIGHT_2_200846 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) University of Warwick 145879 GB-GOV-10-RIGHT_2_200846 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 56215 GB-GOV-10-RIGHT_2_200846 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 148715 GB-GOV-10-RIGHT_2_200846 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 259164 GB-GOV-10-RIGHT_2_200846 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 174141 GB-GOV-10-RIGHT_2_200846 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 190389 GB-GOV-10-RIGHT_2_200846 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 321144 GB-GOV-10-RIGHT_2_200846 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 181647 GB-GOV-10-RIGHT_2_200846 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 173131 GB-GOV-10-RIGHT_2_200846 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 56449 GB-GOV-10-RIGHT_2_200846 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick 288972 GB-GOV-10-RIGHT_2_200846 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Warwick GB-GOV-10-RIGHT_2_200851 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership to evaluate the impact of Group Interpersonal Psychotherapy (g-IPT+) for treatment of postnatal depression in Lebanon and Kenya. The research will adapt the therapy for use in these two countries and evaluate its potential impact on child developmental outcomes, maternal depression and the mother-child relationship. Depression is the most common mental health issue affecting women of childbearing age. 20%-25% of women in low- and middle-income countries (LMICs) experience depression during pregnancy or shortly after childbirth, which can have long term consequences for both the mother and child. However, treatment for postnatal depression is rarely available in primary care in many LMICs. This project seeks to improve understanding of postnatal depression and increase access to treatment for communities in Lebanon and Kenya by developing and evaluating a Group Interpersonal Psychotherapy (g-IPT+) treatment. Overall the study will determine whether a culturally-adapted g-IPT+ delivered in community settings in Lebanon and Kenya could have a greater impact on child developmental outcomes, maternal depression and the mother-child relationship than high quality standard care for postnatal depression. The projects objectives are: 1. To develop a systematic understanding of how the local communities perceive postnatal depression, and use this learning to work with experienced local practitioners to develop a culturally appropriate and optimised g-IPT+. 2. Improve access to treatment by training local workers to identify postnatal depression and to deliver adapted g-IPT+. 3. Assess the potential of the g-IPT+ approach to promote child development and treat maternal depressive symptoms, and estimate the cost effectiveness. 4. Embed sustainable care pathways for postnatal depression. 5. Leverage partnerships with local communities to build research capacity in Lebanon and Kenya. 6. Develop a toolkit to support training and implementation in other countries around the globe. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 229966 653812 634507 1013182 1094080 296081 3833778 GB-GOV-10-RIGHT_2_200851 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University College London 229966 GB-GOV-10-RIGHT_2_200851 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 158649 GB-GOV-10-RIGHT_2_200851 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 235402 GB-GOV-10-RIGHT_2_200851 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 235402 GB-GOV-10-RIGHT_2_200851 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 24359 GB-GOV-10-RIGHT_2_200851 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 284069 GB-GOV-10-RIGHT_2_200851 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University College London 101588 GB-GOV-10-RIGHT_2_200851 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University College London 248850 GB-GOV-10-RIGHT_2_200851 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 343966 GB-GOV-10-RIGHT_2_200851 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 224966 GB-GOV-10-RIGHT_2_200851 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 200723 GB-GOV-10-RIGHT_2_200851 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 243527 GB-GOV-10-RIGHT_2_200851 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 221720 GB-GOV-10-RIGHT_2_200851 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 327119 GB-GOV-10-RIGHT_2_200851 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 244907 GB-GOV-10-RIGHT_2_200851 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 300334 GB-GOV-10-RIGHT_2_200851 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 87850 GB-GOV-10-RIGHT_2_200851 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University College London 100000 GB-GOV-10-RIGHT_2_200851 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London GB-GOV-10-RIGHT_2_PPDA UK - Department of Health and Social Care (DHSC) The purpose of Proposal and Partnership Development Awards (PPDA) funding is to improve the quality and likelihood of success of the projects funded through the NIHR Research and Innovation for Global Health Transformation (RIGHT) programme. Applicants that are successful at RIGHT Stage 1 and invited to submit a Stage 2 application are eligible for a PPDA, subject to satisfactory submission of a PPDA application. Not all Stage 2 applicants awarded a PPDA go on to secure RIGHT programme funding, therefore the details of PPDA recipients are not published. For RIGHT Call 2, PPDA were extended to 13 applicant organisations to support partnership development and the preparation of a RIGHT Stage 2 application. Proposal and Partnership Development Awards (PPDA) provide funding of up to £10,000 for organisations applying to NIHR Research and Innovation for Global Health Transformation (RIGHT) programme funding to: 1. Support applicants to work collaboratively with all study partners to develop the stage 2 application 2. Enhance partnerships across the proposed research collaboration 3. Initiate preparation of study governance documentation (i.e. due diligence and finance assurance policies) PPDA funds must be spent between the notification of RIGHT stage 1 outcome and the submission of the RIGHT stage 2 application. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 120571.34 103204 GB-GOV-10-RIGHT_2_PPDA 2019/20 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 10000 GB-GOV-10-RIGHT_2_PPDA 2020/21 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 120571.34 GB-GOV-10-RIGHT_2_PPDA COMMITMENT UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 7367.34 GB-GOV-10-RIGHT_2_PPDA 2021/22 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified Recipients of NIHR Proposal and Partnership Development (PPDA) Awards are funded subject to the following conditions being met: a) The Award may only be used in accordance with the plans outlined in the application submitted to the PPD fund in order to pay for: (i) reasonable travel and subsistence expenses; and/or (ii) reasonable partnership formation and development costs to support the production of related memorandum(s) of understanding and/or draft governance policies between the relevant oversea partner(s), collaborator(s) and/or service provider(s); both for the purposes of supporting the funding application to the National Institute for Health and Care Research (NIHR) Research on Interventions for Global Health Transformation (RIGHT)programme. b) No variation to the plans outlined in the application to the PPD fund is permitted without the prior written consent of the NIHR; c) In the event that VAT or any other tax or duty is payable in respect of the Award or the use of the Award, such VAT, tax or duty shall be payable by the Award holder; d) In using the Award and before making any payment to a local partner, collaborator or service provider, the Award holder must complete appropriate due diligence and take all steps reasonably necessary to ensure that both Award holder and their local partners, collaborators and/or service providers comply with all directly applicable legislation including (but not limited to), anti-bribery and corruption, the “NIHR Policy on Preventing Harm in Research” and “NIHR Safeguarding Guidance”; e) The Award holder must provide updates on how you have spent and/or plan to spend the Award as required by DHSC; f) In the event that any part of the award is not applied as outlined in your application, you will repay the relevant amount to the Department of Health and Social Care (DHSC) at the DHSC’s request; and g) The Award holder will provide verbal or written reports as required by DHSC on any aspect of the use of the Award. GB-GOV-10-RIGHT_3 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)'s third Research and Innovation for Global Health Transformation (RIGHT) call. RIGHT funds cutting-edge interdisciplinary applied health research in key areas in low- and middle-income countries (LMICs) where a strategic and targeted investment can result in a transformative impact. RIGHT Call 3 supports equitable partnerships between LMIC and UK researchers to generate new research knowledge and evidence on interventions to improve outcomes for those affected by multimorbidity in ODA-eligible countries. UK universities and research institutes were invited to submit applications including a co-applicant or joint lead applicant from an LMIC relevant to the research proposal. Research must be focused on improving the health and welfare of people in LMICs. The aims of NIHR RIGHT Call 3 are to: 1. Deliver applied health research for the direct and primary benefit to the health and wealth of people living in ODA-eligible countries affected by multimorbidity 2. Ensure that the research funded through this call strengthens capacity for research and knowledge exchange through development of equitable partnerships between researchers in the ODA-eligible countries and the UK 3. Promote interdisciplinary approaches to working, by specifically encouraging applications necessitating expertise and activities associated with a broad range of health-science disciplines, including but not limited to: clinical, health economics, statistics, qualitative and social sciences. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine Keele University Queen Mary University of London King's College London Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-RIGHT_3_201708 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) research partnership that aims to design and test a system which identifies patients suffering from multiple diseases (multimorbidity) when they seek emergency care in hospitals in Malawi and Tanzania. This could improve early disease treatment (reducing death), and ensure better follow-up (preventing complications, disability, and hospital readmission). The research project is being implemented by Malawi Liverpool Wellcome Trust (Malawi), Kilimanjaro Christian Medical Centre (Tanzania) and Muhimbili University (Tanzania), in collaboration with Liverpool School of Tropical Medicine (UK), between 01-09-2021 and 31-12-2025. 1. To confirm the prevalence of multimorbidity in patients attending acute hospital services in Malawi and Tanzania. 2. To create a strategy to recognise and treat multimorbidity using point-of-care tests incorporated into the emergency care pathways in Malawi and Tanzania, maximising acceptability to patients and healthcare workers, and optimising the impact of available resources. 3. To test the optimised emergency care pathway intervention with a primary outcome of hospital admission-free survival three months after hospital admission UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 505587.81 270305 1656268 1620748 946756.19 298040 GB-GOV-10-RIGHT_3_201708 2021/22 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 207547.81 GB-GOV-10-RIGHT_3_201708 2021/22 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 4999665 GB-GOV-10-RIGHT_3_201708 COMMITMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 96708 GB-GOV-10-RIGHT_3_201708 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 62691 GB-GOV-10-RIGHT_3_201708 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 110906 GB-GOV-10-RIGHT_3_201708 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 310000 GB-GOV-10-RIGHT_3_201708 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 144317 GB-GOV-10-RIGHT_3_201708 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 158293 GB-GOV-10-RIGHT_3_201708 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 252646 GB-GOV-10-RIGHT_3_201708 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 328518 GB-GOV-10-RIGHT_3_201708 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 303442 GB-GOV-10-RIGHT_3_201708 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 243695 GB-GOV-10-RIGHT_3_201708 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 462745 GB-GOV-10-RIGHT_3_201708 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 558459 GB-GOV-10-RIGHT_3_201708 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine -16685.81 GB-GOV-10-RIGHT_3_201708 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-RIGHT_3_201773 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) research partnership that aims to improve outcomes for depression and tuberculosis (TB) in Pakistan, Afghanistan, and the Afghan refugee population in Pakistan. Tuberculosis (TB) is the 10th leading cause of death in the world. Pakistan ranks fifth and fourth in the world for having a high-burden of TB and MultiDrug Resistant Tuberculosis (MDR-TB), respectively. Afghanistan has an even worse TB situation due to ongoing conflict. It is estimated that almost 49% of people receiving TB treatment may also have depression. Depression may be caused as a result of TB related stigma or the side effects of TB treatments. When these conditions co-exist they may raise the risk of TB reactivation, contribute to poor adherence to TB treatment and disease progression. Inadequate treatment adherence often results in drug resistant TB (MDR-TB), potentially leading to a public health crisis and health security threat. Through four linked work packages the project team aims to develop, test and implement a brief intervention: CONTROL (Cognitive therapy for depression in tuberculosis treatment) to improve the mental health and adherence to TB treatment in people who have TB and MDR-TB in Pakistan and Afghanistan, and the refugee Afghan population in Pakistan. The cognitive therapy for depression in tuberculosis treatment (CONTROL) programme of research has five objectives: 1. To develop, and pilot test the CONTROL intervention with patient and public involvement and engagement (PPIE). 2. To evaluate the effectiveness and cost-effectiveness of CONTROL versus Enhanced Treatment As Usual (ETAU) in improving depressive symptoms in people with TB and depression (TBD) and also enhance adherence with anti TB treatment (ATT). 3. To examine the effects of implementing CONTROL on the TB control programme and the wider health system. 4. To complete a process evaluation, refine the intervention, to identify barriers and facilitators for implementation and examine how the intervention can be scaled up in the health system. 5. To enhance capacity for implementation research in multimorbidity associated with chronic infections in the region. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Keele University UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 453944 198503 1619916 1466680 1105664 207264 RIGHT Call 3 - NIHR201773-Professor Saeed Farooq UK - Department of Health and Social Care (DHSC) Keele University 246680 GB-GOV-10-RIGHT_3_201773 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 4844707 GB-GOV-10-RIGHT_3_201773 COMMITMENT UK - Department of Health and Social Care (DHSC) Keele University 166324 GB-GOV-10-RIGHT_3_201773 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Keele University 32179 GB-GOV-10-RIGHT_3_201773 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 144979 GB-GOV-10-RIGHT_3_201773 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 31479 GB-GOV-10-RIGHT_3_201773 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 208620 GB-GOV-10-RIGHT_3_201773 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 307218 GB-GOV-10-RIGHT_3_201773 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 232611 GB-GOV-10-RIGHT_3_201773 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 213057 GB-GOV-10-RIGHT_3_201773 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 258981 GB-GOV-10-RIGHT_3_201773 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 427451 GB-GOV-10-RIGHT_3_201773 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 357985 GB-GOV-10-RIGHT_3_201773 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 338625 GB-GOV-10-RIGHT_3_201773 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 442926 GB-GOV-10-RIGHT_3_201773 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 269324 GB-GOV-10-RIGHT_3_201773 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 216812 GB-GOV-10-RIGHT_3_201773 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University GB-GOV-10-RIGHT_3_201813 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) partnership that aims to improve the recovery of children with human immunodeficiency virus (HIV) infection and severe acute malnutrition (SAM) after they leave hospital by tackling underlying medical and social causes of ill-health. Two networks of researchers with expertise in child health, mental health, laboratory science, social science and health economics, based in southern Africa (Zimbabwe and Zambia) and east Africa (Kenya), together with partner institutions in the UK, USA and Netherlands, will come together to undertake this project between 01-09-2021 and 31-08-2025. The goal is to better understand why children with HIV and SAM have a higher risk of dying and a lower chance of long-term recovery compared to children with SAM alone. The partnership plans to develop packages of interventions to ensure that children with HIV and SAM can survive and thrive. 1: To understand the ‘multimorbidity’ of with human immunodeficiency virus (HIV) and severe acute malnutrition (SAM). 2: To develop packages of interventions that will help children with HIV and SAM to recover more effectively when they leave hospital. 3: To conduct a clinical trial which compares the new treatments (singly or in combination) against the best current treatment which is therapeutic food, anti-HIV drugs and an antibiotic called cotrimoxazole. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Queen Mary University of London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 750234 344313 1678869 1273740 932263 107176 GB-GOV-10-RIGHT_3_201813 2021/22 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Queen Mary University of London 321529 GB-GOV-10-RIGHT_3_201813 2021/22 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Queen Mary University of London 321529 GB-GOV-10-RIGHT_3_201813 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 4979419 GB-GOV-10-RIGHT_3_201813 COMMITMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 9955 GB-GOV-10-RIGHT_3_201813 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) Queen Mary University of London 324288 GB-GOV-10-RIGHT_3_201813 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) Queen Mary University of London 10070 GB-GOV-10-RIGHT_3_201813 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 67517 GB-GOV-10-RIGHT_3_201813 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 135284 GB-GOV-10-RIGHT_3_201813 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 88341 GB-GOV-10-RIGHT_3_201813 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 307614 GB-GOV-10-RIGHT_3_201813 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 238294 GB-GOV-10-RIGHT_3_201813 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 340008 GB-GOV-10-RIGHT_3_201813 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 179520 GB-GOV-10-RIGHT_3_201813 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 659505 GB-GOV-10-RIGHT_3_201813 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 1006258 GB-GOV-10-RIGHT_3_201813 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 348695 GB-GOV-10-RIGHT_3_201813 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London 132597 GB-GOV-10-RIGHT_3_201813 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Queen Mary University of London GB-GOV-10-RIGHT_3_201816 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership will identify the commonest patterns of multiple long-term conditions (MLTC-M) in South Africa where high burdens of communicable diseases (HIV, TB, COVID-19), non-communicable diseases and mental health problems are colliding and disproportionately affecting people of working age. This information will inform improvements to an existing primary care clinical guidance and training package called PACK (Practical Approach to Care Kit). ‘PACK Multiple Long-Term Conditions’ will include enhanced clinical guidance and patient/ household information for the care of people living with MLTC-M. Implementation strategies will be co-developed that address barriers to system change and patient/ household priorities and will be tested in two provinces of South Africa (KwaZulu-Natal and Western Cape). We will model the cost and impact of the programme if it were to be scaled country wide. This four-year project commencing in September 2021 is being led by Principal Investigators from King’s College London and the University of Cape Town and brings together an interdisciplinary team with extensive experience of working in South African healthcare and in over 20 other LMICs. New models of care for people living with multiple long-term conditions are urgently needed worldwide, as health systems look to reform to realise Universal Health Coverage in the time of a pandemic. This project aims to deliver streamlined care that allows contacts with health services to be optimised and capacitates people and those living in their households to assume greater agency for their long-term health and wellbeing. The project’s overall aim is to produce evidence-based, scalable solutions for care, treatment and support systems for people living with multiple long-term conditions – multimorbidity (MLTC-M) in low- and middle-income countries (LMICs) to enhance their health and well-being. The project objectives are to: 1. Generate evidence on the prevalence and commonest configurations of MLTC-M, its determinants, associated healthcare utilisation and outcomes. 2. Systematically - and throughout the project - engage with people living with MLTC-M, communities and civil society partners to address their priorities for care. 3. With the health system, patient and community stakeholders, co-produce clinical tools (guidance + support materials) to enable providers to deliver streamlined, evidence-informed care to people living with MLTC-M. 4. With health system, patient and community stakeholders, co-produce optimised implementation strategies for people-centred health systems strengthening to support the successful integration of quality MLTC-M care into routine practice. 5. Evaluate the effectiveness of a co-produced intervention comprising these tools and implementation strategies on detection, treatment and control of MLTC-M; patient wellbeing; provider competence to deliver effective person-centred care; and costs, in two provinces in South Africa. 6. Estimate the health gain and cost-effectiveness that would result from implementation of this intervention country wide. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) King's College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU South Africa Research for prevention and control of NCDs Research and Innovation 479367 647326 922803 1203634 1423538 138926 GB-GOV-10-RIGHT_3_201816 2021/22 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) King's College London 208390 GB-GOV-10-RIGHT_3_201816 2021/22 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) King's College London 132051 GB-GOV-10-RIGHT_3_201816 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 4486021 GB-GOV-10-RIGHT_3_201816 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) King's College London 90450 GB-GOV-10-RIGHT_3_201816 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) King's College London 234103 GB-GOV-10-RIGHT_3_201816 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) King's College London 192831 GB-GOV-10-RIGHT_3_201816 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) King's College London 129942 GB-GOV-10-RIGHT_3_201816 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 172990 GB-GOV-10-RIGHT_3_201816 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 116627 GB-GOV-10-RIGHT_3_201816 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 397666 GB-GOV-10-RIGHT_3_201816 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 235520 GB-GOV-10-RIGHT_3_201816 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 274224 GB-GOV-10-RIGHT_3_201816 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 412273 GB-GOV-10-RIGHT_3_201816 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 228849 GB-GOV-10-RIGHT_3_201816 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 288288 GB-GOV-10-RIGHT_3_201816 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 190647 GB-GOV-10-RIGHT_3_201816 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) King's College London 257746 GB-GOV-10-RIGHT_3_201816 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 183884 GB-GOV-10-RIGHT_3_201816 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 291189 GB-GOV-10-RIGHT_3_201816 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 272309 GB-GOV-10-RIGHT_3_201816 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 184577 GB-GOV-10-RIGHT_3_201816 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London GB-GOV-10-RIGHT_3_PPDA UK - Department of Health and Social Care (DHSC) The purpose of Proposal and Partnership Development Awards (PPDA) funding is to improve the quality and likelihood of success of the projects funded through the NIHR Research and Innovation for Global Health Transformation (RIGHT) programme. Applicants that are successful at RIGHT Stage 1 and invited to submit a Stage 2 application are eligible for a PPDA, subject to satisfactory submission of a PPDA application. Not all Stage 2 applicants awarded a PPDA go on to secure RIGHT programme funding, therefore the details of PPDA recipients are not published. For RIGHT Call 3, PPDA were extended to 12 applicant organisations to support partnership development and the preparation of a RIGHT Stage 2 application. Proposal and Partnership Development Awards (PPDA) provide funding of up to £10,000 for organisations applying to NIHR Research and Innovation for Global Health Transformation (RIGHT) programme funding to: 1. Support applicants to work collaboratively with all study partners to develop the stage 2 application 2. Enhance partnerships across the proposed research collaboration 3. Initiate preparation of study governance documentation (i.e. due diligence and finance assurance policies) PPDA funds must be spent between the notification of RIGHT stage 1 outcome and the submission of the RIGHT stage 2 application. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 65713.69 7716.67 GB-GOV-10-RIGHT_3_PPDA 2020/21 Q4 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 36256.66 GB-GOV-10-RIGHT_3_PPDA 2021/22 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 65713.69 GB-GOV-10-RIGHT_3_PPDA COMMITMENT UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 7453.94 GB-GOV-10-RIGHT_3_PPDA 2022/23 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 9996.93 GB-GOV-10-RIGHT_3_PPDA 2022/23 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 4289.49 GB-GOV-10-RIGHT_3_PPDA 2022/23 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified Recipients of NIHR Proposal and Partnership Development (PPDA) Awards are funded subject to the following conditions being met: a) The Award may only be used in accordance with the plans outlined in the application submitted to the PPD fund in order to pay for: (i) reasonable travel and subsistence expenses; and/or (ii) reasonable partnership formation and development costs to support the production of related memorandum(s) of understanding and/or draft governance policies between the relevant oversea partner(s), collaborator(s) and/or service provider(s); both for the purposes of supporting the funding application to the National Institute for Health and Care Research (NIHR) Research on Interventions for Global Health Transformation (RIGHT)programme. b) No variation to the plans outlined in the application to the PPD fund is permitted without the prior written consent of the NIHR; c) In the event that VAT or any other tax or duty is payable in respect of the Award or the use of the Award, such VAT, tax or duty shall be payable by the Award holder; d) In using the Award and before making any payment to a local partner, collaborator or service provider, the Award holder must complete appropriate due diligence and take all steps reasonably necessary to ensure that both Award holder and their local partners, collaborators and/or service providers comply with all directly applicable legislation including (but not limited to), anti-bribery and corruption, the “NIHR Policy on Preventing Harm in Research” and “NIHR Safeguarding Guidance”; e) The Award holder must provide updates on how you have spent and/or plan to spend the Award as required by DHSC; f) In the event that any part of the award is not applied as outlined in your application, you will repay the relevant amount to the Department of Health and Social Care (DHSC) at the DHSC’s request; and g) The Award holder will provide verbal or written reports as required by DHSC on any aspect of the use of the Award. GB-GOV-10-RIGHT_4 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)'s fourth Research and Innovation for Global Health Transformation (RIGHT) call. RIGHT funds cutting-edge interdisciplinary applied health research in key areas in low- and middle-income countries (LMICs) where a strategic and targeted investment can result in a transformative impact. RIGHT Call 4 supports equitable partnerships between LMIC and UK researchers to generate new research knowledge and evidence to address the global burden of unintentional injuries (including but not limited to road traffic accidents, falls, burns and drowning, and urgent and emergency care). UK and LMIC-based universities and research institutes were invited to submit applications. Research must be focused on improving the health and welfare of people in LMICs. The aims of NIHR RIGHT Call 4 are to: 1. Deliver applied health research for the direct and primary benefit to the health and wealth of people living in ODA-eligible countries, with a focus on addressing the global burden of unintentional injuries and urgent and emergency care 2. Ensure that the research funded through this call strengthens capacity for research and knowledge exchange through development of equitable partnerships between researchers in the ODA-eligible countries and the UK 3. Promote interdisciplinary approaches to working, by specifically encouraging applications necessitating expertise and activities associated with a broad range of health-science disciplines, including but not limited to: clinical, health economics, statistics, qualitative and social sciences. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Birmingham Ishrat Husain Pakistan Institute Of Living and Learning (PILL) The University of Edinburgh University of Oxford Bournemouth University Higher Education Corporation Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-RIGHT_4_203062 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) partnership that aims to improve the management of pre-hospital transport for injured people in Rwanda. In Rwanda, injury causes 9% of deaths; 47% of these deaths happen before the patient has reached hospital. Similar to many LMICs, Rwanda experiences long delays in getting patients to a hospital which is suitable to treat their injuries, with all communication between patients, ambulances, and hospitals done using multiple phone-calls. In this project, we will develop and test Rwanda912, a novel electronic communication tool for use in ambulances in low resource settings. Rwanda912 uses an ambulance Destination Decision Support Algorithm (DDSA) which matches injured patients with the nearest hospital that can treat their injuries. It does this based on information from hospitals on availability of staff and equipment, and from the ambulance crew on patient status. In collaboration with the Rwandan Ministry of Health, Rwandan ambulance services, and local and international academics, this project will test whether Rwanda912 reduces time from injury to arrival at hospital and improves clinical outcomes such as death, length of stay in hospital, and need for an intensive care unit. Our study will be done in one urban and one rural setting. The aim of the study is to improve the management of pre-hospital transport for injured people in Rwanda. The objectives of the study are as follows; 1. Finalise development of Rwanda912’s Ambulance Destination Decision Support Algorithm (DDSA) and user interfaces. The Rwanda912 concept has been designed and the initial version approved for rapid development to give a testable prototype. The basic software foundations for this prototype has been developed in another grant, funded by the US National Institute of Health. In this NIHR grant, the prototype will be iteratively improved by repeated user testing until a final Rwanda912 product, that accurately matches patients with facilities, is ready for implementation. 2. Develop training materials and train staff to use the Rwanda912 app. This will occur in 2 stages. The first stage is the rapid development of training materials. The second stage is the delivery of training and user testing. 3. Do mock field-trials and roll out the intervention to ensure the app will work well under “real world” conditions, Rwanda912 will be tested under controlled conditions in the field during mock trauma scenarios using dummy patients (actors who will act out different injury scenarios) at different locations in the study sites. The complete pathway from calling for an ambulance to arriving at a facility will be tested. 4. Testing the application in the real world. We will collect baseline data on time that injured patients take to get to hospital and other study outcomes (like death, length of stay in hospital, and admission to the intensive care unit) for a period of over one1 year, whilst objectives 1-3 are being completed. This data collection will be done in both the rural and urban site. We will compare outcomes from after deployment of Rwanda912 to those collected before deployment of Rwanda912. This comparison will show us whether Rwanda912 has improved outcomes. 5. In addition to the outcomes mentioned above, we will also collect information which will help us to find out why Rwanda912 worked or didn’t work. These “implementation outcomes” will include costs, acceptability, and use of the Rwanda912 app. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Birmingham UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Rwanda Medical research Research and Innovation 270141 679544 704720 684516 681984 415490 108056 GB-GOV-10-RIGHT_4_203062 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 3436395 GB-GOV-10-RIGHT_4_203062 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 162085 GB-GOV-10-RIGHT_4_203062 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 106886 GB-GOV-10-RIGHT_4_203062 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 184069 GB-GOV-10-RIGHT_4_203062 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 229832 GB-GOV-10-RIGHT_4_203062 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 186087 GB-GOV-10-RIGHT_4_203062 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 142814 GB-GOV-10-RIGHT_4_203062 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 173246 GB-GOV-10-RIGHT_4_203062 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 149941 GB-GOV-10-RIGHT_4_203062 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 120055 GB-GOV-10-RIGHT_4_203062 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham GB-GOV-10-RIGHT_4_203082 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) partnership to address burn management, treatment and prevention in low-resource settings in Pakistan.  Globally, burns are responsible for around 11 million injuries and 180 000 burn-related deaths yearly. Unfortunately, 9 of 10 burn injuries and deaths happen in low-and-middle-income countries (LMICs) such as Pakistan. One in three people admitted to hospitals with burn injuries die within three weeks, and survivors face serious lifelong physical, emotional and social problems.  Current preventive practice and treatment services in Pakistan are lacking for burns-related problems. Therefore, there is an urgent need to improve the quality of health services for burn victims and reduce the rate of burns in Pakistan. The project will be carried out in burn centres and community across Pakistan.  The project’s overall aim is to evaluate culturally adapted prevention and multidisciplinary care quality and rehabilitation programmes for burns that can be implemented across LMICs. The projects objectives are; 1. To understand lived experiences of burn survivors, families, and other stakeholders including the experience of care and impact of burns 2. To work together with key stakeholders (such as burn survivors, family members) to adapt a culturally appropriate affordable burn rehabilitation programme 3. To develop a national burn registry that will help to collect information on burn injuries and after-effects 4. To carry out a small-scale study to assess whether the co-adapted burn rehabilitation programme is feasible and acceptable in Pakistan. This will help the research team to prepare themselves for a larger study particularly on the aspects around how best to recruit and retain burn survivors in the study. 5. To determine clinical effectiveness of the burn rehabilitation programme. This will be evident from changes in number of deaths caused by burn injuries, number of burn survivors readmitted to hospitals and impact on burn survivors’ health-related of quality life 6. To determine whether the proposed burn rehabilitation programme is effective/valuable in relation to its cost. 7. To undertake social media campaigns to promote burn prevention and risk assessment in communities, workplaces, industries, and households, improve first aid and address burn related stigma 8. To work with policy makers and parliamentarians to develop national guidelines for burns care and prevention in Pakistan 9. To build the capacity and capability of researchers and health professionals both in research and clinical practice. These activities are crucial to improve prevention and burn rehabilitation across the country after the end of the project. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Pakistan Medical research Research and Innovation 384587 205241 1269888 879627 631056 153835 GB-GOV-10-RIGHT_4_203082 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 3347670 GB-GOV-10-RIGHT_4_203082 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 230752 GB-GOV-10-RIGHT_4_203082 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 125241 GB-GOV-10-RIGHT_4_203082 2023/24 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 80000 GB-GOV-10-RIGHT_4_203082 2023/24 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 74234 GB-GOV-10-RIGHT_4_203082 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 200735 GB-GOV-10-RIGHT_4_203082 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 662077 GB-GOV-10-RIGHT_4_203082 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 332842 GB-GOV-10-RIGHT_4_203082 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 233162 GB-GOV-10-RIGHT_4_203082 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 316668 GB-GOV-10-RIGHT_4_203082 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 215826 GB-GOV-10-RIGHT_4_203082 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 113971 GB-GOV-10-RIGHT_4_203082 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 22729 GB-GOV-10-RIGHT_4_203082 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 154804 GB-GOV-10-RIGHT_4_203082 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) GB-GOV-10-RIGHT_4_203140 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) research partnership that aims to prevent deaths from acute poisoning. The project team will work closely with the World Health Organization (WHO) to strengthen Poison Information Centres (PIC), develop global guidelines, and provide clinical/public health research training. Primary research will address two major global problems: methanol and occupational pesticide poisoning. Clinical research on novel methanol diagnostics will be performed in major hospitals in India and Bangladesh, while an anthropological study of pre-hospital treatment of pesticide poisoning will take place in Sri Lankan villages. This work is a collaboration between 17 professionals located in partner institutions in Bangladesh, Sri Lanka, India, Iran, South Africa, China, Australia, Denmark, Norway, and the UK. Capacity building for research and PIC development will be done in partnership with the Asia-Pacific Association of Medical Toxicology (APAMT) and the Middle-East and North Africa Clinical Toxicology Association (MENATOX). The work of this NIHR RIGHT4 award is essential because poisoning is a neglected problem that kills more than 300,000 people each year, many of them in LMICs. The WHO recognises the urgent need for better knowledge on how/where poisoning occurs, tools to diagnose or treat patients, and national standards/guidance. The Centre will directly address these issues. To improve the clinical care of patients with acute poisoning in low-and-middle-income countries (LMICs) by: 1) Testing the use and cost-effectiveness of a novel bed-side diagnostic method for methanol poisoning in two controlled clinical trials in India and Bangladeshi hospitals 2)Addressing community acceptance of antidotes for pesticide poisoning that could be given after poisoning but before the patient reaches hospital To expand LMIC research on acute poisoning and global Poison Information Centre (PIC) capacity, through providing training at annual international clinical toxicology congresses in the Asia-Pacific and Middle-East/North African regions. To create a global network of LMIC research centres of excellence on acute poisoning by increasing research capacity at sites in India, Bangladesh, and Sri Lanka. Develop international guidance for management of pesticide poisoning and methanol poisoning, in collaboration with the World Health Organization. Our overarching question is whether the individual research work programs, generation of international guidelines, and increase in research and PIC capacity, will result in substantially more patients receiving evidence-based treatment for poisoning across the world, especially in LMICs. For the two poisons we have highlighted (methanol, pesticides) primary research will develop new diagnostic and treatment options and deepen our understanding. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Edinburgh UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 170050 566256 1146620 1152392 951152 998020 4984490 GB-GOV-10-RIGHT_4_203140 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 170050 GB-GOV-10-RIGHT_4_203140 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 90564 GB-GOV-10-RIGHT_4_203140 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 185135 GB-GOV-10-RIGHT_4_203140 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 75900 GB-GOV-10-RIGHT_4_203140 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 289131 GB-GOV-10-RIGHT_4_203140 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 294371 GB-GOV-10-RIGHT_4_203140 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 108628 GB-GOV-10-RIGHT_4_203140 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 277035 GB-GOV-10-RIGHT_4_203140 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 100260 GB-GOV-10-RIGHT_4_203140 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 300809 GB-GOV-10-RIGHT_4_203140 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 416520 GB-GOV-10-RIGHT_4_203140 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh GB-GOV-10-RIGHT_4_203194 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) partnership that aims to improve quality-of-life for hip fracture patients and to reduce healthcare costs in India, the Philippines, Sri Lanka, Thailand and Vietnam. Older patients are particularly likely to break a bone (fracture) because of a fall from a standing height, as their bones are weakened by osteoporosis. These ‘fragility’ fractures have serious consequences; in the UK 25% of hip fracture patients die within a year and survivors have a reduction in their quality-of-life similar to having a stroke. Outcomes may be even worse in LMIC without the same level of healthcare resource. Asia is particularly affected by rapidly ageing populations. The number of hip fractures is expected to increase from 1,124,060 now to 2,563,488 in 2050. Associated healthcare cost may rise to US$15 billion. Improving care for patients with hip fracture is therefore a priority in this region. Looking after patients following a hip fracture requires healthcare workers from many different backgrounds to work together. These include surgeons, doctors specialising in looking after older patients, nurses and therapists, each with defined roles and responsibilities. In the UK, this team approach has reduced the number of patients dying and improved quality-of-life after hip fracture. It also reduced time spent in hospital and associated healthcare costs. This study is about testing the benefits of such ‘multidisciplinary’ care in 5 LMIC in South Asia. To optimise the care, hospitals will receive a training package called HIPCARE. After refining the training materials to make HIPCARE specific to each country, we will do a large study to compare HIPCARE with usual care in 40 hospitals in LMIC in South Asia. The main aim is to improve the quality of life of patients after they have broken their hip and to reduce healthcare costs in low-and-middle-income-countries (LMIC). The project will have two principal objectives: 1. To prepare the HIPCARE training package for each different country taking into account their specific healthcare system. 2. To run a study to compare the quality of life of hip fracture patients who have been treated in a hospital where the HIPCARE training package has been introduced with patients who have been treated in a hospital that follows its standard care. Within the study, the following seven outcomes will be compared between patients treated in HIPCARE hospitals and patients treated in Standard Care hospitals. The outcomes will be measured up to 4 months after hip fracture surgery: 1) Quality of Life 2) Mortality rate 3) Mobility Status 4) The need of residential care 5) Complication rate 6) Healthcare and resource needs 7) Cost effectiveness of the trial treatments These comparisons will be made for each country individually as well as for all countries together. In addition, this study will create a long-lasting research collaboration and sustainable infrastructure that can be used to facilitate future service improvements in each LMIC. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Oxford UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 322717 945668 1207680 1030380 414373 129087 GB-GOV-10-RIGHT_4_203194 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 3920818 GB-GOV-10-RIGHT_4_203194 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Oxford 108528 GB-GOV-10-RIGHT_4_203194 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 157875 GB-GOV-10-RIGHT_4_203194 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 179601 GB-GOV-10-RIGHT_4_203194 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 406582 GB-GOV-10-RIGHT_4_203194 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 150000 GB-GOV-10-RIGHT_4_203194 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 200594 GB-GOV-10-RIGHT_4_203194 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 277075 GB-GOV-10-RIGHT_4_203194 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 205789 GB-GOV-10-RIGHT_4_203194 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford GB-GOV-10-RIGHT_4_203216 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership to prevent drowning young children aged 1-2 in Bangladesh. The project is a collaboration between Bournemouth University, the Royal National Lifeboat Institute (RNLI), the University of the West of England, the University of Southampton (all in the UK), and the Center for Injury Prevention & Research Bangladesh. Using an inclusive, humancentred design approach to identify the solutions that are most acceptable to local communities, whose input will be central to the whole process. Our interdisciplinary project aims to reduce the incidence of drowning in young children in the north and south of Bangladesh. The objectives of the project are; 1. Build skills needed by communities and our research partners in rural Bangladesh, focusing on research capacity building around both public involvement in research and Human-Centred Design. 2. Explore existing supervision practice for newly mobile children and the social, cultural and environmental circumstances in which drowning occurs. Using social science research methods will help understand the failures of existing interventions (if any) and challenges of keeping young children safe from drowning; 3. Identify possible solutions to the prevention of drowning from literature and our explorative social science study. Engage stakeholders (including local community, government officials, designers, social scientists, drowning prevention experts, our international advisory group) to help prioritise a range of possible solutions; 4. Develop and create new solutions, using Human-Centred-Design principles and processes, co-designed with people in the local community; 5. Test the best solutions from the Human-Centred Design process in communities and evaluate them on use and maintenance, effectiveness, and ability to roll out the interventions across Bangladesh; 6. Share the findings and lessons learnt both locally with the communities involved in the research, nationally in Bangladesh with policy-makers and relevant civil servants, and internationally through academic papers and at conferences. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Bournemouth University Higher Education Corporation UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Bangladesh Medical research Research and Innovation 149707 372072 407784 457648 293051 59883 GB-GOV-10-RIGHT_4_203216 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bournemouth University Higher Education Corporation 1680262 GB-GOV-10-RIGHT_4_203216 COMMITMENT UK - Department of Health and Social Care (DHSC) Bournemouth University Higher Education Corporation 59824 GB-GOV-10-RIGHT_4_203216 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bournemouth University Higher Education Corporation 64831 GB-GOV-10-RIGHT_4_203216 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bournemouth University Higher Education Corporation 16052 GB-GOV-10-RIGHT_4_203216 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bournemouth University Higher Education Corporation 182257 GB-GOV-10-RIGHT_4_203216 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bournemouth University Higher Education Corporation 58683 GB-GOV-10-RIGHT_4_203216 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bournemouth University Higher Education Corporation 72822 GB-GOV-10-RIGHT_4_203216 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bournemouth University Higher Education Corporation 61295 GB-GOV-10-RIGHT_4_203216 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bournemouth University Higher Education Corporation 125987 GB-GOV-10-RIGHT_4_203216 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bournemouth University Higher Education Corporation 34050 GB-GOV-10-RIGHT_4_203216 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bournemouth University Higher Education Corporation 37279 GB-GOV-10-RIGHT_4_203216 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bournemouth University Higher Education Corporation 22928 GB-GOV-10-RIGHT_4_203216 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bournemouth University Higher Education Corporation 100000 GB-GOV-10-RIGHT_4_203216 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Bournemouth University Higher Education Corporation GB-GOV-10-RIGHT_4_PPDA UK - Department of Health and Social Care (DHSC) The purpose of Proposal and Partnership Development Awards (PPDA) funding is to improve the quality and likelihood of success of the projects funded through the NIHR Research and Innovation for Global Health Transformation (RIGHT) programme. Applicants that are successful at RIGHT Stage 1 and invited to submit a Stage 2 application are eligible for a PPDA, subject to satisfactory submission of a PPDA application. Not all Stage 2 applicants awarded a PPDA go on to secure RIGHT programme funding, therefore the details of PPDA recipients are not published. For RIGHT Call 4, PPDA were extended to 7 applicant organisations to support partnership development and the preparation of a RIGHT Stage 2 application. Proposal and Partnership Development Awards (PPDA) provide funding of up to £10,000 for organisations applying to NIHR Research and Innovation for Global Health Transformation (RIGHT) programme funding to: 1. Support applicants to work collaboratively with all study partners to develop the stage 2 application 2. Enhance partnerships across the proposed research collaboration 3. Initiate preparation of study governance documentation (i.e. due diligence and finance assurance policies) PPDA funds must be spent between the notification of RIGHT stage 1 outcome and the submission of the RIGHT stage 2 application. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 45756.21 43717.41 GB-GOV-10-RIGHT_4_PPDA 2022/23 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 45756.21 GB-GOV-10-RIGHT_4_PPDA COMMITMENT UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 2038.8 GB-GOV-10-RIGHT_4_PPDA 2023/24 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 2501 GB-GOV-10-RIGHT_4_PPDA 2024/25 Q4 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified Recipients of NIHR Proposal and Partnership Development (PPDA) Awards are funded subject to the following conditions being met: a) The Award may only be used in accordance with the plans outlined in the application submitted to the PPD fund in order to pay for: (i) reasonable travel and subsistence expenses; and/or (ii) reasonable partnership formation and development costs to support the production of related memorandum(s) of understanding and/or draft governance policies between the relevant oversea partner(s), collaborator(s) and/or service provider(s); both for the purposes of supporting the funding application to the National Institute for Health and Care Research (NIHR) Research on Interventions for Global Health Transformation (RIGHT)programme. b) No variation to the plans outlined in the application to the PPD fund is permitted without the prior written consent of the NIHR; c) In the event that VAT or any other tax or duty is payable in respect of the Award or the use of the Award, such VAT, tax or duty shall be payable by the Award holder; d) In using the Award and before making any payment to a local partner, collaborator or service provider, the Award holder must complete appropriate due diligence and take all steps reasonably necessary to ensure that both Award holder and their local partners, collaborators and/or service providers comply with all directly applicable legislation including (but not limited to), anti-bribery and corruption, the “NIHR Policy on Preventing Harm in Research” and “NIHR Safeguarding Guidance”; e) The Award holder must provide updates on how you have spent and/or plan to spend the Award as required by DHSC; f) In the event that any part of the award is not applied as outlined in your application, you will repay the relevant amount to the Department of Health and Social Care (DHSC) at the DHSC’s request; and g) The Award holder will provide verbal or written reports as required by DHSC on any aspect of the use of the Award. GB-GOV-10-RIGHT_5 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)'s fifth Research and Innovation for Global Health Transformation (RIGHT) call. RIGHT funds cutting-edge interdisciplinary applied health research in key areas in low- and middle-income countries (LMICs) where a strategic and targeted investment can result in a transformative impact. RIGHT Call 5 supports equitable partnerships between researchers to generate new research knowledge and evidence on interventions aimed to strengthen health service delivery and resilience for extreme weather events in ODA-eligible countries. UK and LMIC-based universities and research institutes were invited to submit applications. Research must be focused on improving the health and welfare of people in LMICs. The aims of NIHR RIGHT Call 5 are to: 1. Deliver applied health research for the direct and primary benefit to the health and wealth of people living in ODA-eligible countries, with a focus on strengthening health service delivery and resilience for extreme weather events. 2. Strengthen capacity for research and knowledge exchange through equitable partnerships between researchers and institutions involved in the research. 3. Promote interdisciplinary approaches to working (including, but not limited to: clinical medicine, health economics, statistics, qualitative and social sciences), to ensure that research objectives can be delivered. 4. Generate new research knowledge and evidence on interventions to improve health outcomes of people in LMICs. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of East Anglia University of the West of Scotland University of Sussex Instituto Nacional de Saude University of Oxford Liverpool School of Tropical Medicine Malaria Consortium University of Birmingham Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-RIGHT_5_204820 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) partnership jointly led by the University of East Anglia and the Kamuzu University of Health Sciences, Malawi. Beginning in January 2024, the four-year project builds on key recommendations derived from the 2012 Intergovernmental Panel on Climate Change Special Report. These include a portfolio of actions to reduce risk; a multi hazard risk management approach; and the importance of integration of local and scientific knowledge. The award consists of a four-phase research plan. Phase one involves the collation, synthesis and improved knowledge of the effects of extreme weather events on healthcare systems globally, and of factors affecting healthcare system resilience. Phase two involves an in-depth investigation using several different approaches and four case-study areas within Malawi, Vietnam, Tanzania and Uganda. Phase three will build on the baseline analysis to deploy a novel integration of business continuity planning, resilience engineering and participatory research methods to develop and deliver a set of tools for extreme weather event mitigation preparedness, response, and recovery. Phase four focuses on the evaluation of co-designed tools in other district level health services to enhance healthcare resilience. The research will include work with national governments, non-governmental organisations and international agencies (World Health Organization and International Organization for Standardization to help drive improvements in health care system resilience globally. To help enhance research capacity in the global south, as the project progresses, the co-creation of research activities and project leadership will increasingly transfer to southern partners. The project has four objectives: 1. Improve knowledge of the impact that extreme weather events have on healthcare systems globally and what factors affect systems’ resilience in the face of such events (Work Package 1). 2. Describe the healthcare systems in the case study areas, their served communities and how both have been affected by, and responded to, extreme weather events to provide a foundation for locally relevant insights into processes and adaptations, and their influence on health outcomes (Work Package 2). 3. Develop protocols for extreme weather event preparedness, response and recovery, and guidance on good practices, knowledge exchange, and interventions development with local partners as a process for enhancing resilient healthcare delivery (Work Package 3). 4. Apply and evaluate the interventions, targeting specific levels of healthcare systems, and embed resources and processes to sustain and enhance broader healthcare system resilience, with feedback into global frameworks (Work Package 4). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of East Anglia UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 60172 445880 863175 982923 643553 24769 60172 GB-GOV-10-RIGHT_5_204820 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of East Anglia 3020472 GB-GOV-10-RIGHT_5_204820 COMMITMENT UK - Department of Health and Social Care (DHSC) University of East Anglia 111470 GB-GOV-10-RIGHT_5_204820 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of East Anglia 196311 GB-GOV-10-RIGHT_5_204820 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of East Anglia 29779 GB-GOV-10-RIGHT_5_204820 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of East Anglia 169393 GB-GOV-10-RIGHT_5_204820 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of East Anglia 217556 GB-GOV-10-RIGHT_5_204820 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of East Anglia 84771 GB-GOV-10-RIGHT_5_204820 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of East Anglia 173744 GB-GOV-10-RIGHT_5_204820 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of East Anglia 232052 GB-GOV-10-RIGHT_5_204820 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of East Anglia 225988 GB-GOV-10-RIGHT_5_204820 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of East Anglia GB-GOV-10-RIGHT_5_204825 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) collaborative research partnership between the University of the West of Scotland and the University of KwaZulu-Natal that aims to develop an early warning system for extreme weather such as flooding in two vulnerable districts; eThekwini and Ugu districts of KwaZulu-Natal province, South Africa. Due to commence in January 2024, this four-year award consists of four work packages which work together to assess the relationship between extreme weather and health risk due to water contamination and associated disease outbreaks. The research will investigate predictive disease modelling and develop an early warning system to improve communication between affected communities and central healthcare providers from existing mobile phone platforms in conjunction with predictive technology. This includes the design, development, pilot adaptation, and testing of a pathogen and contamination management tool to inform the development of the early warning system and for identification and management of resources during flooding. The disease burden, health needs, and community experiences during flooding and health system resilience to respond to flooding will be assessed through a mixed methods approach. The early warning system will enhance communication, resource allocation, predict disease outbreaks and improve healthcare service delivery during flooding. The project has seven objectives: 1. To develop a community engagement and co-creation strategy informing Objectives 2-7. 2. To assess the relationship between the health risk agents and reported disease outbreaks of extreme weather events. 3. To map and review healthcare delivery organisations to establish pre-existing capacity/ resilience and training needs. 4. To develop an early warning system, pathogen and contamination management tool to be used by healthcare providers. 5. To support and deliver disaster management and intervention implementation training to health professionals. 6. To evaluate the impact of the early warning system on extreme weather event preparedness, system resilience and establish cost-effectiveness. 7. To build local research capability, strengthen knowledge transfer with other lower- and middle-income countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of the West of Scotland UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU South Africa Medical research Research and Innovation 39559 199328 518788 1005396 506902 19543 2289516 GB-GOV-10-RIGHT_5_204825 COMMITMENT UK - Department of Health and Social Care (DHSC) University of the West of Scotland 39559 GB-GOV-10-RIGHT_5_204825 2024/25 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of the West of Scotland 49832 GB-GOV-10-RIGHT_5_204825 2024/25 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of the West of Scotland 112460 GB-GOV-10-RIGHT_5_204825 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the West of Scotland 181830 GB-GOV-10-RIGHT_5_204825 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the West of Scotland 243704 GB-GOV-10-RIGHT_5_204825 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the West of Scotland 2554 GB-GOV-10-RIGHT_5_204825 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the West of Scotland 219766 GB-GOV-10-RIGHT_5_204825 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the West of Scotland 20951 GB-GOV-10-RIGHT_5_204825 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the West of Scotland 134511 GB-GOV-10-RIGHT_5_204825 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the West of Scotland GB-GOV-10-RIGHT_5_204828 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) partnership jointly led by the University of Sussex and The Aurum Institute, South Africa. Starting in January, 2024, the four-year project aims to evaluate interventions to strengthen community and health system resilience to extreme weather events on vulnerable populations living with human immunodeficiency virus (HIV) and/or tuberculosis in Mozambique, South Africa and Zambia. These three countries are exposed to recurrent extreme weather events resulting in injuries, loss of lives, damage to infrastructure, including of healthcare facilities, often resulting in their inability to provide care during these extreme events. The research findings will be analysed with stakeholders to develop interventions and policies that will be evaluated for their effectiveness in increasing the resilience of healthcare facilities during extreme weather events. The project has nine objectives: 1. Systematically engage communities, health service implementers, and policymakers from health determining sectors to prioritise needs and design interventions/adaptations to strengthen health service delivery in the context of extreme weather events. 2. Undertake community and health service delivery vulnerability and adaptive capacity assessments to establish health-related extreme weather events vulnerability baseline in study countries. 3. Develop system dynamics models to evaluate the impact of co-created interventions for improving health system resilience. 4. Quantify the value for money of identified interventions. 5. Strengthen existing partnership between the University of Sussex, Africa Health Research Institute, South Africa, Zambart, Zambia and the London School of Hygiene and Tropical Medicine and extend the partnership to include the two Aurum institutes, civil society (Groundwork) and industry (Black box and Pista). 6. Develop a sustainable network of researchers with expertise in climate and health research. 7. Train the next generation of researchers and foster research leadership on climate change and health. 8. Educate the health workforce about climate change and impact on human health to better prepare the health system to respond during extreme weather events. 9. Facilitate South-South and North-South sharing of best practice in research and advocacy in climate change and health. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Sussex UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 44847 247564 501865 988497 1216170 24792 44847 GB-GOV-10-RIGHT_5_204828 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 3023735 GB-GOV-10-RIGHT_5_204828 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Sussex 60876 GB-GOV-10-RIGHT_5_204828 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 231165 GB-GOV-10-RIGHT_5_204828 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 219211 GB-GOV-10-RIGHT_5_204828 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 49195 GB-GOV-10-RIGHT_5_204828 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 166455 GB-GOV-10-RIGHT_5_204828 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 153771 GB-GOV-10-RIGHT_5_204828 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex 307199 GB-GOV-10-RIGHT_5_204828 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Sussex GB-GOV-10-RIGHT_5_204845 UK - Department of Health and Social Care (DHSC) A low-and-middle-income-country (LMIC) award led by the National Institute of Health, Mozambique which aims to develop an intervention that can reduce health service delivery disruption at the community-level , service-level, and district-level in the most vulnerable communities of two provincial districts in Mozambique. Commencing in January 2024, the three-year award will involve the engagement of community members and stakeholders in participatory systems; dynamic modelling to map out causes and consequences of health service delivery disruption in disaster-affected settings; and the design of a multi-component intervention to address the challenge of extreme weather events in Mozambique. This multicomponent intervention will involve building a robust data surveillance system to provide the data needed to inform adequate preparedness and response, the implementation and development of the intervention, as well as capacity-building of public health sector staff that can progress the preparedness and response of health facilities and services during extreme weather events. The project has five objectives: 1. To outline the causes and consequences of disrupted access to equitable health care services by using two modelling approaches. Two groups of identified stakeholders will work together to identify variables considered to be causal factors, and those that are consequences of disrupted access to health services during extreme weather events in Mozambique. 2. To design interventions aimed at improving disaster resilience across health services through robust preparedness, response, and recovery strategies. The proposed intervention/strategy will be multi-component using a modified intervention mapping approach that will address critical weak points in disaster preparedness that lead to high morbidity and mortality. 3. To develop a robust and integrated data surveillance system, and methods to monitor and assess the impact of disasters on population health. A rapid assessment of data collection for non-communicable diseases will take place, followed by in-depth interviews with front-line data collectors, information technology staff and epidemiologists. With the information produced in this assessment, the current data surveillance system will be reprogrammed followed by a quick assessment of the feasibility of the system on a small scale. 4. To implement and evaluate an integrated disaster preparedness response and recovery strategy to build climate-induced disaster resilience. Based on outcomes from objectives two and three, interventions will involve community, healthcare, and government-level individuals to implement the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) Framework to evaluate the multilevel intervention/strategy. Quantitative and qualitative data will be integrated using a narrative approach to provide a comprehensive understanding of the effectiveness and implementation of interventions to improve disaster resilience at multiple levels in the most vulnerable communities of Mozambique. 5. To strengthen capacity for integrated community-engaged research using systems science and implementation science methodologies among faculty members in Mozambique with interest and enough skills to continue working in climate and health. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Instituto Nacional de Saude UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Mozambique Medical research Research and Innovation 49619 207672 825064 583711 15195 1681261 GB-GOV-10-RIGHT_5_204845 COMMITMENT UK - Department of Health and Social Care (DHSC) Instituto Nacional de Saude 49619 GB-GOV-10-RIGHT_5_204845 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Instituto Nacional de Saude 37970 GB-GOV-10-RIGHT_5_204845 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Instituto Nacional de Saude 255657 GB-GOV-10-RIGHT_5_204845 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Instituto Nacional de Saude 114415 GB-GOV-10-RIGHT_5_204845 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Instituto Nacional de Saude 112679 GB-GOV-10-RIGHT_5_204845 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Instituto Nacional de Saude 220862 GB-GOV-10-RIGHT_5_204845 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Instituto Nacional de Saude 137560 GB-GOV-10-RIGHT_5_204845 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Instituto Nacional de Saude GB-GOV-10-RIGHT_5_204850 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) partnership which aims to investigate the best ways to protect Kenya’s health system from the effects of extreme weather. Currently, lower middle income countries like Kenya face significant health impacts from extreme weather, but do not have plans in place to protect their vulnerable populations. Beginning in January 2024, Oxford University will work with Kenyan partners over four years to address this issue by developing high resolution climate models that show how anticipated changes to Kenya’s climate and impacts on the country’s health facilities. The team will map vulnerable populations and survey health facilities in order to determine how extreme weather will impact access to healthcare and the effects that this will have on people living in different areas. The award will involve work with communities, local and national governments, and with other stakeholders to devise plans designed to encourage adaptation and preparedness. The research will work to determine the feasibility of climate risk insurance in assisting identified populations’ access to health services to address extreme weather-related health problems. Targeted financial support to facilities and staff will be provided. The project has five objectives: 1) To create a comprehensive overview of hazards posed by extreme weather events in a changing climate at the level of individual health facilities in Kenya and create methods to replicate this approach elsewhere. 2) To explore the scale and impact of effects related to closure or limitations of health services due to extreme weather on vulnerable populations in Kenya and methods to replicate this approach elsewhere. 3) To determine the physical, operational, and workforce risks posed to health facilities by extreme weather and design new tools for analysing these risks. 4) To explore how climate risks and their effect on health and health services can be conveyed to community members in Kenya and how their priorities can inform practical adaptive action to ensure local resilience of health facilities. 5) To examine the economic impact of extreme weather events on the Kenyan population and on healthcare facilities and what climate risk strategies, including climate risk insurance, can be used to manage risks. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Oxford UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Kenya Medical research Research and Innovation 48524 248300 689766 1297031 714834 24788 48524 GB-GOV-10-RIGHT_5_204850 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 3023243 GB-GOV-10-RIGHT_5_204850 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Oxford 56752 GB-GOV-10-RIGHT_5_204850 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 265817 GB-GOV-10-RIGHT_5_204850 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 128591 GB-GOV-10-RIGHT_5_204850 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 201837 GB-GOV-10-RIGHT_5_204850 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 35465 GB-GOV-10-RIGHT_5_204850 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 149057 GB-GOV-10-RIGHT_5_204850 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 190429 GB-GOV-10-RIGHT_5_204850 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 211832 GB-GOV-10-RIGHT_5_204850 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford GB-GOV-10-RIGHT_5_204854 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) partnership between the Liverpool School of Tropical Medicine and the George Institute for Global Health in India which aims to collaboratively design, implement and evaluate context sensitive interventions to improve the preparedness and responsiveness of health service delivery in the context of extreme weather events for urban marginalised people. Commencing in January 2024, this three-year research will be undertaken through equitable partnerships with urban marginalised people, and identified health system and governance actors in ten urban informal settlements across seven cities between India, Kenya and Sierra Leone. The research consists of five phases, with capacity strengthening of all actors including the research team built into phases two through five. Phase one will bring together all stakeholders to collaboratively finalise the research design and plans for capacity strengthening, ethics, and safeguarding. Phase two will involve assessments aimed at bridging existing data gaps regarding health impacts, community vulnerabilities and capacities, as well as health service preparedness in each setting. Phase three will use these assessments to focus on collaboratively designing packages of interventions to improve health service provision in extreme weather events. Phase four will implement and evaluate the intervention packages, which are likely to include utilisation of existing technologies such as mobile phone applications and two-way information systems. Learning within and across settings will be monitored and evaluated throughout the project. Phase five focuses on knowledge uptake at local, national and global levels. This phase will create and communicate evidence-based models to improve the responsiveness of health systems and service delivery to extreme weather events. The project has six objectives: 1. To retrospectively assess the health and social vulnerabilities and health service impacts of specific recent extreme weather events for urban marginalised people. 2. To assess the preparedness and capacities of health systems for health service delivery during and following extreme weather events based on existing frameworks, policies, tools and mechanisms. 3. To work with communities, health system and governance actors to co-produce and implement a package of research-informed interventions to strengthen health service preparedness and delivery for urban marginalised people during and following extreme weather events. 4. To assess and strengthen the capacities of researchers, community groups, health system and governance actors, their relationships and processes for working together equitably to improve responsiveness of health services to the health consequences of extreme weather events. 5. To collaboratively monitor and evaluate implementation of the intervention package within and across city and country contexts for feasibility, fidelity, costs and enabling/constraining factors across diverse contexts. 6. To promote uptake of project learning by health system actors, communities, other stakeholders and global health researchers by integrating communication within all phases to ensure timely sharing of actionable information. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 82464 370092 1066769 1480637 24799 82464 GB-GOV-10-RIGHT_5_204854 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 3024761 GB-GOV-10-RIGHT_5_204854 COMMITMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 34978 GB-GOV-10-RIGHT_5_204854 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 305950 GB-GOV-10-RIGHT_5_204854 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 284964 GB-GOV-10-RIGHT_5_204854 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 230883 GB-GOV-10-RIGHT_5_204854 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 360950 GB-GOV-10-RIGHT_5_204854 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 147246 GB-GOV-10-RIGHT_5_204854 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 319888 GB-GOV-10-RIGHT_5_204854 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-RIGHT_5_204869 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) partnership between the Malaria Consortium and Uganda Virus Research Institute that aims to improve the health system in Uganda to develop a capacity to forecast impending outbreaks of mosquito-borne diseases associated with extreme weather events. Commencing in January 2024, the four-year research will be implemented in three phases: Phase one involves the analysis of data on past outbreaks to determine associations with extreme weather events and other factors. Past data on disease incidence, weather variables, and other risk indicators will be used to develop forecasting models. Phase two, involves the development of an interactive risk mapping platform based on the forecasting models and data inputs for routine use. The mapping approach will be based on a dashboard portal developed within the research partnership. Phase three consists of developing a national outbreak preparedness and response plan which will be based on existing plans in close collaboration with all relevant partners. The plan will be aligned with outputs of the online portal to provide specific guidance on interventions. Affected communities, local health services, and village health workers will be engaged to identify important risk factors and gaps in outbreak preparedness. The researchers will be working closely with government and other partners for adoption and routine use of the system and the associated plan for prevention of outbreaks and effective mitigation of their impacts. The project has six objectives: 1. To document past mosquito-borne disease outbreaks in Uganda and analyse their association with extreme weather. 2. To develop and validate a risk index and early warning models to forecast the outbreaks. 3. To develop a platform that maps risks and generates predictions continuously, with real-time surveillance data feeding into it, for routine use by disease control programmes. 4. To develop an outbreak preparedness and response plan for various risk scenarios. 5. To facilitate adoption and use of the outbreak risk mapping system. 6. To engage communities across the research activities. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Malaria Consortium UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Uganda Medical research Research and Innovation 46220 234812 637151 1193680 615222 22835 2749920 GB-GOV-10-RIGHT_5_204869 COMMITMENT UK - Department of Health and Social Care (DHSC) Malaria Consortium 26864 GB-GOV-10-RIGHT_5_204869 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Malaria Consortium 13674 GB-GOV-10-RIGHT_5_204869 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Malaria Consortium 155287 GB-GOV-10-RIGHT_5_204869 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Malaria Consortium 83828 GB-GOV-10-RIGHT_5_204869 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Malaria Consortium 55229 GB-GOV-10-RIGHT_5_204869 2025/26 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Malaria Consortium 150290 GB-GOV-10-RIGHT_5_204869 2025/26 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Malaria Consortium 114036 GB-GOV-10-RIGHT_5_204869 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Malaria Consortium 134011 GB-GOV-10-RIGHT_5_204869 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Malaria Consortium 187093 GB-GOV-10-RIGHT_5_204869 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Malaria Consortium GB-GOV-10-RIGHT_5_204871 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income-country (LMIC) research partnership between University of Birmingham and Sree Chitra Tirunal Institute for Medical Sciences and Technology, India that aims to co-develop primary care interventions with communities and stakeholders, to improve preparedness and response for non-communicable diseases (NCDs) during flood-disasters in India. India has the second highest rates of diabetes and heart disease globally. During flood-emergencies, patients may not receive their usual medicines or care from their doctor or hospital, interrupting the on-going care that is needed. Lack of medicines and stress or other illnesses due to floods cause conditions to get worse. The health system prepares for infectious diseases or injuries caused by disasters but has limited plans in place for dealing with these common diseases. This results in worsening health and increased complications, hospital admissions, and death. Floods have become more frequent, unpredictable, and severe, and current warning systems are inadequate to prepare the population or services adequately. The research will involve surveys, discussions, and interviews with patients and health-workers, and observe how services work in Kerala districts during annual monsoon floods. Key stakeholders will be consulted to develop and test a practical, community-focused intervention to ensure that community members and primary healthcare services are better prepared for and can respond to the needs of patients with common long-term conditions during floods. The ‘prepare-and-response’ intervention system will adapt existing, and develop new processes with communities and health-workers. Climate specialists will provide methods for future advanced flood forecasting. The development of the intervention will be tested across 20 flood-prone Kerala communities over two years. How well the community and health system are using the new ‘prepare-and-response’ system will be measured before comparing results with data gathered in the same district before the intervention, and with another district without the intervention. An assessment of the economic costs and benefits to patients and health systems with and without the system will be undertaken. Subsequent investigation involving Bihar state will take place to understand the context and prospective adaptation of the Kerala-based intervention. Community members and stakeholders will be involved in the decision-making process in a culturally appropriate and inclusive way in all aspects of research and intervention development. Additionally, the project aims to influence policy-makers in other Indian states and share findings with other flood-risk countries through a targeted communication plan and engagement with expert partners, the United Nations, and other global agencies. The project has ten objectives: 1. To conduct a situation analysis in Kerala to investigate the major flood-related non-communicable disease management challenges, including mapping healthcare service and patient needs. 2. Co-develop health system and community preparedness intervention components to manage non-communicable diseases during floods. 3. Implement and evaluate the complex intervention model in Kerala. 4. Investigate co-adaptation of the complex-intervention model in Bihar through situation analysis, and community and stakeholder engagement activities. 5. Co-develop an integrated meteorological-hydrological modelling system to provide timely flood forecasts, integrated with the needs of the health system. 6. Estimate the potential costs and benefits of the complex intervention with the health system, community, and meteorological-hydrological forecasting, including a societal perspective and the effect of flood-forecasting on this estimate. 7. Engage stakeholders, patients, and communities in two-way exchanges of experiences and information that support their meaningful involvement. 8. Ensure capacity building across the range of research disciplines in our consortium. 9. Ensure comprehensive dissemination of the findings to key stakeholders and academics across states, national and global levels. 10. Ensure equitable partnership in governance and project management. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Birmingham UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU India Research for prevention and control of NCDs Research and Innovation 28605 179084 647490 1093084 680131 368523 24777 3021694 GB-GOV-10-RIGHT_5_204871 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 28605 GB-GOV-10-RIGHT_5_204871 2024/25 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Birmingham 44771 GB-GOV-10-RIGHT_5_204871 2024/25 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Birmingham 44771 GB-GOV-10-RIGHT_5_204871 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 13213 GB-GOV-10-RIGHT_5_204871 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 512266 GB-GOV-10-RIGHT_5_204871 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 15524 GB-GOV-10-RIGHT_5_204871 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 162195 GB-GOV-10-RIGHT_5_204871 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham GB-GOV-10-RIGHT_5_PPDA UK - Department of Health and Social Care (DHSC) The purpose of Proposal and Partnership Development Awards (PPDA) funding is to improve the quality and likelihood of success of the projects funded through the NIHR Research and Innovation for Global Health Transformation (RIGHT) programme. Applicants that are successful at RIGHT Stage 1 and invited to submit a Stage 2 application are eligible for a PPDA, subject to satisfactory submission of a PPDA application. Not all Stage 2 applicants awarded a PPDA go on to secure RIGHT programme funding, therefore the details of PPDA recipients are not published. For RIGHT Call 5, PPDA were extended to 12 applicant organisations to support partnership development and the preparation of a RIGHT Stage 2 application. Proposal and Partnership Development Awards (PPDA) provide funding of up to £10,000 for organisations applying to NIHR Research and Innovation for Global Health Transformation (RIGHT) programme funding to: 1. Support applicants to work collaboratively with all study partners to develop the stage 2 application 2. Enhance partnerships across the proposed research collaboration 3. Initiate preparation of study governance documentation (i.e. due diligence and finance assurance policies) PPDA funds must be spent between the notification of RIGHT stage 1 outcome and the submission of the RIGHT stage 2 application. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 119407 24859.9 GB-GOV-10-RIGHT_5_PPDA 2023/24 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 50722.61 GB-GOV-10-RIGHT_5_PPDA 2023/24 Q4 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 119407 GB-GOV-10-RIGHT_5_PPDA COMMITMENT UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 16340.89 GB-GOV-10-RIGHT_5_PPDA 2024/25 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified Recipients of NIHR Proposal and Partnership Development (PPDA) Awards are funded subject to the following conditions being met: a) The Award may only be used in accordance with the plans outlined in the application submitted to the PPD fund in order to pay for: (i) reasonable travel and subsistence expenses; and/or (ii) reasonable partnership formation and development costs to support the production of related memorandum(s) of understanding and/or draft governance policies between the relevant oversea partner(s), collaborator(s) and/or service provider(s); both for the purposes of supporting the funding application to the National Institute for Health and Care Research (NIHR) Research on Interventions for Global Health Transformation (RIGHT)programme. b) No variation to the plans outlined in the application to the PPD fund is permitted without the prior written consent of the NIHR; c) In the event that VAT or any other tax or duty is payable in respect of the Award or the use of the Award, such VAT, tax or duty shall be payable by the Award holder; d) In using the Award and before making any payment to a local partner, collaborator or service provider, the Award holder must complete appropriate due diligence and take all steps reasonably necessary to ensure that both Award holder and their local partners, collaborators and/or service providers comply with all directly applicable legislation including (but not limited to), anti-bribery and corruption, the “NIHR Policy on Preventing Harm in Research” and “NIHR Safeguarding Guidance”; e) The Award holder must provide updates on how you have spent and/or plan to spend the Award as required by DHSC; f) In the event that any part of the award is not applied as outlined in your application, you will repay the relevant amount to the Department of Health and Social Care (DHSC) at the DHSC’s request; and g) The Award holder will provide verbal or written reports as required by DHSC on any aspect of the use of the Award. GB-GOV-10-RIGHT_6 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)'s sixth Research and Innovation for Global Health Transformation (RIGHT) call. RIGHT funds cutting-edge interdisciplinary applied health research in key areas in low- and middle-income countries (LMICs) where a strategic and targeted investment can result in a transformative impact. RIGHT Call 6 supports equitable partnerships between researchers to generate new research knowledge and evidence on interventions to improve prevention, treatment, and management of multiple long-term conditions in ODA-eligible countries. UK and LMIC-based universities and research institutes were invited to submit applications. Research must be focused on improving the health and welfare of people in LMICs. The aims of NIHR RIGHT Call 6 are to: 1. Deliver applied health research for the direct and primary benefit to the health and wealth of people living in ODA-eligible countries, with a focus on preventing, treating, and managing multiple long-term conditions. 2. Strengthen capacity for research and knowledge exchange through equitable partnerships between researchers and institutions involved in the research. 3. Promote interdisciplinary approaches to working (including, but not limited to: clinical medicine, health economics, statistics, qualitative and social sciences), to ensure that research objectives can be delivered. 4. Generate new research knowledge and evidence on interventions to improve health outcomes of people in LMICs. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Glasgow University of Birmingham King's College London Ishrat Husain Pakistan Institute Of Living and Learning (PILL) University of York Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-RIGHT_6_205540 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership between the University of Glasgow and Ishrat Husain Pakistan Institute of Living and Learning that aims to develop an affordable home-based rehabilitation programme for people with long term conditions including heart disease and mental health conditions in Bangladesh, Pakistan and India. Beginning in July 2025, the five-year project intends to build on existing research collaborations in South Asia to address the unmet needs of heart disease and mental health multimorbidity in South Asia. Home-based programmes provide an affordable model of delivery that can leverage a scalable increase in rehabilitation access in LMICs, a key strategic global goal of the World Health Organisation. The project aims to do this through the evaluation and implementation of a sustainable, cultural, and contextually appropriate model of home-based rehabilitation for people with multimorbidity that includes heart disease and a mental health disorder that is both affordable and scalable. The award has five objectives: 1. To co-design with key stakeholders a culturally and contextually adapted, affordable home-based rehabilitation (‘ACROSS’) programme with low intensity inventions for depression and anxiety (Work Package 1). 2. To co-design ACROSS delivery training for health professionals to include a train-the-trainer programme to enable the cascade of training (Work Package 1). 3. To assess the feasibility and acceptability of the implementation of ACROSS programme as well as trial design and examine the parameters and processes of a full-scale trial, including recruitment, randomisation, and retention (Work Package 2). 4. To determine clinical effectiveness (hierarchical primary outcome of mortality, hospital admission, and health-related of quality life) of the ACROSS programme (Work Package 3). 5. To determine cost-effectiveness of ACROSS programme in terms of an incremental cost per quality adjusted life year (Work Package 3). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Glasgow UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 244556 1041951 878390 883080 742413 251755 39170 5035106 GB-GOV-10-RIGHT_6_205540 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Glasgow 201292 GB-GOV-10-RIGHT_6_205540 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 43264 GB-GOV-10-RIGHT_6_205540 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow -953791 GB-GOV-10-RIGHT_6_205540 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Glasgow 390030 GB-GOV-10-RIGHT_6_205540 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow GB-GOV-10-RIGHT_6_205554 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income country (LMIC) research partnership between the University of Birmingham and the University of Jaffna, Sri Lanka which aims to improve the management of multiple long-term conditions (MLTC) in primary care in Sri Lanka. In Sri Lanka, many people suffer from diabetes, high blood pressure, heart disease, kidney disease, and mental health conditions. When someone has several long-term conditions, it becomes more difficult to manage their care, leading to poor health outcomes. Commencing in July 2024, the five-year project intends to use the team's previous trial experience and evaluation of complex digital healthcare implementations in the region to develop, implement and evaluate a digitally integrated care pathway within electronic health records. This will be done to manage primary care patients with MLTC in Sri Lanka. The electronic patient record systems in primary care centres will be used to create an improved care plan for those with MLTC in order to standardise care and improve the patient experience using digital technologies. The project has six objectives: 1. To establish a stakeholder consultation group (SCG) consisting of people living with Multiple Long-Term-Conditions (MLTC), healthcare professionals, clinical informaticians, policy makers and researchers to provide expertise throughout the research lifecycle. 2. To evaluate existing care pathways and clinical guidelines and identify stakeholder priorities for improvement. 3. To develop and implement a stakeholder designed Digitally Integrated Care Pathway (DICP). 4. To evaluate the DICP through a cluster randomised controlled trial. 5. To evaluate the contextual and organisational factors that may influence scalability and transferability of the DICP across Sri Lanka and countries with similar population and health systems. 6. To carry out an economic evaluation of the DICP. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Birmingham UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Sri Lanka Research for prevention and control of NCDs Research and Innovation 546252 728336 728336 728336 728336 384396 30876 3874868 GB-GOV-10-RIGHT_6_205554 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 182084 GB-GOV-10-RIGHT_6_205554 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 48802 GB-GOV-10-RIGHT_6_205554 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 100887 GB-GOV-10-RIGHT_6_205554 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 121577 GB-GOV-10-RIGHT_6_205554 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 74340 GB-GOV-10-RIGHT_6_205554 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 145185 GB-GOV-10-RIGHT_6_205554 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham 70766 GB-GOV-10-RIGHT_6_205554 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Birmingham GB-GOV-10-RIGHT_6_205556 UK - Department of Health and Social Care (DHSC) A UK and low-and-middle-income countries (LMICs) research partnership between King’s College London and Scientific University of the South (Universidad Científica del Sur), Peru. Depression, hypertension, and diabetes are the three biggest health problems in Peru, Argentina, and across Latin American countries (LACs). These long-term conditions often present together, posing a challenge and an opportunity to integrate an effective and common treatment in LACs and elsewhere. Health care for people with chronic problems is often limited, disjointed, and of low quality, among other things because there is a dearth of medical doctors and psychologists. Commencing in July 2024, the five-year project intends to use the team’s previous research, on technology and community resources to support the treatment of depression, hypertension, and diabetes, to develop more powerful and integrated effective components to manage comorbidity. Planned research activities aim to improve the health and quality of life of low-income people with comorbid depression, hypertension and/or diabetes in Peru and Argentina. The project has five objectives: 1. Develop and evaluate the effectiveness, cost-effectiveness, and implementation of a technology-supported intervention for people with comorbid depression, hypertension, and/or diabetes attending primary care clinics in low-income communities in Argentina and Peru. 2. Better understand the settings and needs of those with and those involved in the management of chronic comorbid conditions and identify appropriate strategies to effectively implement the intervention to increase its chances of successful adoption. 3. Adapt previously tried treatments or develop new treatments, when unavailable, in close collaboration with local stakeholders. 4. Evaluate clinical gains and costs of successfully implementing this intervention among people with comorbid depression, hypertension, and/or diabetes in Peru and Argentina. 5. Deliver a robust training programme for researchers and community members in Argentina and Peru and an extended network in Latin American countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) King's College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 849595 900832 1021391 1023763 388014 444902 36525 4665022 GB-GOV-10-RIGHT_6_205556 COMMITMENT UK - Department of Health and Social Care (DHSC) King's College London 283198 GB-GOV-10-RIGHT_6_205556 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 253344 GB-GOV-10-RIGHT_6_205556 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 54547 GB-GOV-10-RIGHT_6_205556 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 181897 GB-GOV-10-RIGHT_6_205556 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 195245 GB-GOV-10-RIGHT_6_205556 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London 214961 GB-GOV-10-RIGHT_6_205556 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) King's College London GB-GOV-10-RIGHT_6_205561 UK - Department of Health and Social Care (DHSC) A partnership led by the Pakistan Institute of Living and Learning, and the University of Sheffield aims to develop, implement, and evaluate a culturally adapted prevention and integrated psychosocial care plan for depressed breast cancer survivors that can be implemented across low-resource settings. Breast cancer is one of the main causes of death in women across the world every year. Pakistan has the highest rate of breast cancer in women in South Asia. The unavailability of and costly self-paid breast cancer treatment adds to increasing significant distress among women, with women who do survive having higher levels of depression and anxiety. This impacts their treatment outcomes and increases chances of the cancer returning. Beginning in July 2024, the five-year project aims to improve the well-being of breast cancer survivors as well as promote awareness to assist with increasing chances of early detection. This award is built on earlier work: Moving on After Breast Cancer Plus (Moving on ABC Plus) in Pakistan, and intends to assess different methods of offering support through mental health care plans or a combination of treatments in survivors of breast cancer with depression in Pakistan. Research activities include the development and application of a suitable mental health care plan for women survivors of breast cancer in Pakistan. The project has six objectives: 1. Develop and apply a suitable mental health care plan for women survivors of breast cancer in Pakistan (Workstream One). 2. Work with policy makers, patients, families, and other professionals to understand their views on how to make the mental health care plan available for all survivors (Workstream Two). 3. To understand the cost of breast cancer and depression in Pakistan and assess the cost-effectiveness of the proposed intervention (Workstream Three). 4. Develop a social media campaign to increase public awareness to help reduce the rate of breast cancer and bolster the identification of early symptoms (Workstream Four). 5. Train researchers and healthcare professionals in breast cancer research and ways of providing mental health support (Workstream Five). 6. Set up a system to collect information about people with breast cancer in Sindh Province, Pakistan (Workstream Six). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Pakistan Research for prevention and control of NCDs Research and Innovation 710355 947140 947140 947140 947140 499871 39191 5037977 GB-GOV-10-RIGHT_6_205561 COMMITMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 118392 GB-GOV-10-RIGHT_6_205561 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 118393 GB-GOV-10-RIGHT_6_205561 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 365428 GB-GOV-10-RIGHT_6_205561 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 118498 GB-GOV-10-RIGHT_6_205561 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 375062 GB-GOV-10-RIGHT_6_205561 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 750000 GB-GOV-10-RIGHT_6_205561 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) 356221 GB-GOV-10-RIGHT_6_205561 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Ishrat Husain Pakistan Institute Of Living and Learning (PILL) GB-GOV-10-RIGHT_6_205601 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMICs) research partnership, between The University of York and the National Institute of Mental Health and Neurosciences, India. People with severe mental illness constitute one of the most vulnerable populations, with a life expectancy that is reduced by approximately 20 years. Much of this reduced life expectancy is driven by the development of multiple long-term conditions (MLTCs) in these populations. The greatest contributor to this inequality is the use of tobacco, and addressing this problem can result in the greatest health gains for people with severe mental illness. Beginning in July 2024, the four year programme will adapt and refine a treatment for tobacco use by people with severe mental illness in Bangladesh, India and Pakistan. The award will use valid and reliable tests to assess the success of the intervention before assessing the economic benefits of the treatment and identifying strategies which are most useful in delivering the treatment in mental health facilities. The project has six objectives: 1. Develop and apply a suitable mental health care plan for women survivors of breast cancer in Pakistan (Workstream One). 2. Work with policy makers, patients, families, and other professionals to understand their views on how to make the mental health care plan available for all survivors (Workstream Two). 3. To understand the cost of breast cancer and depression in Pakistan and assess the cost-effectiveness of the proposed intervention (Workstream Three). 4. Develop a social media campaign to increase public awareness to help reduce the rate of breast cancer and bolster the identification of early symptoms (Workstream Four). 5. Train researchers and healthcare professionals in breast cancer research and ways of providing mental health support (Workstream Five). 6. Set up a system to collect information about people with breast cancer in Sindh Province, Pakistan (Workstream Six). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of York UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 628203 837604 837604 837604 348996 28328 3518339 GB-GOV-10-RIGHT_6_205601 COMMITMENT UK - Department of Health and Social Care (DHSC) University of York 209401 GB-GOV-10-RIGHT_6_205601 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 116937 GB-GOV-10-RIGHT_6_205601 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 162859 GB-GOV-10-RIGHT_6_205601 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 129954 GB-GOV-10-RIGHT_6_205601 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 183962 GB-GOV-10-RIGHT_6_205601 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 169406 GB-GOV-10-RIGHT_6_205601 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 250004 GB-GOV-10-RIGHT_6_205601 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York GB-GOV-10-RIGHT_6_PPDA UK - Department of Health and Social Care (DHSC) The purpose of Proposal and Partnership Development Awards (PPDA) funding is to improve the quality and likelihood of success of the projects funded through the NIHR Research and Innovation for Global Health Transformation (RIGHT) programme. Applicants that are successful at RIGHT Stage 1 and invited to submit a Stage 2 application are eligible for a PPDA, subject to satisfactory submission of a PPDA application. Not all Stage 2 applicants awarded a PPDA go on to secure RIGHT programme funding, therefore the details of PPDA recipients are not published. For RIGHT Call 6, PPDA were extended to 12 applicant organisations to support partnership development and the preparation of a RIGHT Stage 2 application. Proposal and Partnership Development Awards (PPDA) provide funding of up to £10,000 for organisations applying to NIHR Research and Innovation for Global Health Transformation (RIGHT) programme funding to: 1. Support applicants to work collaboratively with all study partners to develop the stage 2 application 2. Enhance partnerships across the proposed research collaboration 3. Initiate preparation of study governance documentation (i.e. due diligence and finance assurance policies) PPDA funds must be spent between the notification of RIGHT stage 1 outcome and the submission of the RIGHT stage 2 application. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 118645 17014 GB-GOV-10-RIGHT_6_PPDA 2023/24 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 25818.940000000002 GB-GOV-10-RIGHT_6_PPDA 2023/24 Q4 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 118645 GB-GOV-10-RIGHT_6_PPDA COMMITMENT UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 19997.77 GB-GOV-10-RIGHT_6_PPDA 2024/25 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 9900 GB-GOV-10-RIGHT_6_PPDA 2024/25 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 15130.939999999999 GB-GOV-10-RIGHT_6_PPDA 2025/26 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 850 GB-GOV-10-RIGHT_6_PPDA 2025/26 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified Recipients of NIHR Proposal and Partnership Development (PPDA) Awards are funded subject to the following conditions being met: a) The Award may only be used in accordance with the plans outlined in the application submitted to the PPD fund in order to pay for: (i) reasonable travel and subsistence expenses; and/or (ii) reasonable partnership formation and development costs to support the production of related memorandum(s) of understanding and/or draft governance policies between the relevant oversea partner(s), collaborator(s) and/or service provider(s); both for the purposes of supporting the funding application to the National Institute for Health and Care Research (NIHR) Research on Interventions for Global Health Transformation (RIGHT)programme. b) No variation to the plans outlined in the application to the PPD fund is permitted without the prior written consent of the NIHR; c) In the event that VAT or any other tax or duty is payable in respect of the Award or the use of the Award, such VAT, tax or duty shall be payable by the Award holder; d) In using the Award and before making any payment to a local partner, collaborator or service provider, the Award holder must complete appropriate due diligence and take all steps reasonably necessary to ensure that both Award holder and their local partners, collaborators and/or service providers comply with all directly applicable legislation including (but not limited to), anti-bribery and corruption, the “NIHR Policy on Preventing Harm in Research” and “NIHR Safeguarding Guidance”; e) The Award holder must provide updates on how you have spent and/or plan to spend the Award as required by DHSC; f) In the event that any part of the award is not applied as outlined in your application, you will repay the relevant amount to the Department of Health and Social Care (DHSC) at the DHSC’s request; and g) The Award holder will provide verbal or written reports as required by DHSC on any aspect of the use of the Award. GB-GOV-10-RIGHT_7 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)'s seventh Research on Interventions for Global Health Transformation (RIGHT) call. RIGHT funds cutting-edge interdisciplinary applied health research in key areas in low- and middle-income countries (LMICs) where a strategic and targeted investment can result in a transformative impact. RIGHT Call 7 supports equitable partnerships between researchers to generate new research knowledge and evidence on supporting research to develop and evaluate interventions for the early detection and management of metabolic risk factors for cardiovascular disease and stroke in ODA-eligible countries. UK and LMIC-based universities and research institutes were invited to submit applications. Research must be focused on improving the health and welfare of people in LMICs. The aims of NIHR RIGHT Call 7 are to: 1. Deliver applied health research for the direct and primary benefit to the health and wealth of people living in ODA-eligible countries, with a focus on research to develop and evaluate interventions for the early detection and management of metabolic risk factors for cardiovascular disease and stroke. 2. Strengthen capacity for research and knowledge exchange through equitable partnerships between researchers and institutions involved in the research. 3. Promote interdisciplinary approaches to working (including, but not limited to: clinical medicine, health economics, statistics, qualitative and social sciences), to ensure that research objectives can be delivered. 4. Generate new research knowledge and evidence on interventions to improve health outcomes of people in LMICs. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine University of York University of the West Indies University of Leicester Imperial College London London School of Hygiene and Tropical Medicine King's College London Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-RIGHT_7_206968 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership between the London School of Hygiene & Tropical Medicine and the Wellcome Trust Kenya Research Programme that aims to develop and evaluate a community-centred intervention for cardiovascular disease (CVD) risk reduction is proposed. This partnership, involving experts from the UK, Kenya, and The Gambia, focuses on addressing high CVD risks in sub-Saharan Africa (SSA), especially in regions where CVD management is challenging due to limited resources and complex health system barriers. CVD rates are high in SSA, with younger populations at risk due to untreated hypertension, high blood pressure and other risk factors. The research will take place in Kilifi County, Kenya, and Kiang West, The Gambia. These regions are selected due to their high CVD burden and existing research infrastructure support that facilitates effective data collection and carrying out the intervention implementation. Commencing in March 2025, this award aims to address significant gaps in CVD risk management by implementing cost-effective, affordable, evidence-based solutions that are sustainable within the local health systems. The long-term goal is to improve CVD outcomes and make it easier to expand and use the approach in other areas with similar facilitated scalability and adoption across similar high-burden regions in SSA. The award involves the designing and testing of a tailored intervention that includes several components, such as task-sharing with community health workers, using digital health tools, providing combination therapy, and forming peer support groups to manage overall CVD risk in high-burden SSA areas. The award has five objectives: 1. Co-design a community-centered intervention for cardiovascular disease (CVD) risk reduction in sub-Saharan Africa. 2. Evaluate the feasibility of implementing the co-designed intervention in real-world community and primary care settings. 3. Conduct a cluster randomised trial to assess the effectiveness of the intervention on CVD risk factors and health outcomes. 4. Evaluate the economic viability and sustainability of the community-centred intervention for cardiovascular disease risk reduction. 5. Conduct a process evaluation to understand the factors influencing the success and scalability of the intervention. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 848322 1328696 1098565 675085 667270 36449 4654387 GB-GOV-10-RIGHT_7_206968 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 38625 GB-GOV-10-RIGHT_7_206968 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 18062 GB-GOV-10-RIGHT_7_206968 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 87489 GB-GOV-10-RIGHT_7_206968 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 180784 GB-GOV-10-RIGHT_7_206968 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-RIGHT_7_206976 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership that aims to develop and evaluate a community pharmacy-based intervention to improve hypertension management among low-income urban residents in Bangladesh and Pakistan. By delivering hypertension care through community pharmacies, the team seeks to enhance access to care and reduce the risk of cardiovascular diseases (CVDs). CVDs are the leading cause of death globally, and hypertension is the most significant modifiable risk factor for CVDs. In Bangladesh and Pakistan, a high percentage of individuals with hypertension remain undiagnosed, untreated, or have uncontrolled blood pressure, particularly among low-income urban residents who face significant barriers to accessing healthcare. Community pharmacies are widely accessible and frequently used by these populations but are not fully integrated into formal healthcare systems. The long-term aim of the award is to reduce premature deaths and disabilities caused by hypertension and associated CVDs in Bangladesh and Pakistan. This intervention will enable community pharmacists to provide hypertension care, including blood pressure monitoring, medication adherence support, health education, and referrals to primary care physicians. Commencing in March 2025, the award will map existing community pharmacies and engage with key stakeholders to understand the current practices and identify barriers and facilitators regarding the implementation of the intervention. The intervention will be tested via a feasibility study before undertaking a randomised control trial to assess the effectiveness and cost effectiveness of the intervention in reducing systolic blood pressure. The award has nine objectives: 1. Develop a context-specific intervention aimed at managing hypertension among low-income urban residents in Bangladesh and Pakistan through community pharmacies. 2. Explore the feasibility of delivering the intervention and refine methods and procedures for a large-scale trial. 3. Assess the effectiveness of the intervention in reducing systolic blood pressure among low-income urban residents aged 30 years and older with hypertension in Bangladesh and Pakistan. 4. Conduct a comprehensive process evaluation to understand the implementation process of the intervention and how the health system and urban context in each site influence its effectiveness and sustainability. 5. Develop a cost-effectiveness model for hypertension care and assess the long-term cost-effectiveness of the intervention, including the costs of scaling up and the value of investing in strategies to improve uptake. 6. Enhance capacity in applied research, leadership, and community-based hypertension management among researchers, pharmacists, and healthcare professionals in Bangladesh and Pakistan. 7. Establish Community Advisory Panels in each country to engage patients, families, and community members in the research process. 8. Work with key stakeholders to translate our project findings into policy and practice and enact plans to sustain research and its impact. 9. Disseminate the intervention findings through academic publications, policy briefs, workshops, print and social media, and community events. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of York UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 481308 807292 1086808 1164656 1278693 0 37895 4856652 GB-GOV-10-RIGHT_7_206976 COMMITMENT UK - Department of Health and Social Care (DHSC) University of York 40000 GB-GOV-10-RIGHT_7_206976 2025/26 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of York 110327 GB-GOV-10-RIGHT_7_206976 2025/26 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of York 256695 GB-GOV-10-RIGHT_7_206976 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 201994 GB-GOV-10-RIGHT_7_206976 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 188786 GB-GOV-10-RIGHT_7_206976 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York 345821 GB-GOV-10-RIGHT_7_206976 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of York GB-GOV-10-RIGHT_7_206987 UK - Department of Health and Social Care (DHSC) A low- and middle-income country (LMIC) award led by The University of the West Indies which aims to develop a community-led digital support system for the primary prevention of cardiovascular disease in four Caribbean countries: Commonwealth of Dominica, Guyana, Jamaica and St Vincent and the Grenadines. Due to commence in March 2025, the five-year project intends to work with research partners in India (the George Insitute for Global Health), the UK (Imperial College London and the University of Glasgow) and Canada (McMaster University) to reduce the risk of developing future diabetes, high blood pressure, heart disease and stroke. This has the potential to benefit women, their families/households, and communities and to strengthen regional health systems. This will be done via the delivery of the SMARThealth platform intervention for screening and managing cardiovascular disease risk factors in mothers who develop gestational diabetes (diabetes during pregnancy) or hypertensive disorders of pregnancy (high blood pressure during pregnancy), and their families. The project has four objectives: 1. To improve women’s cardiometabolic health in the first twelve months after gestational diabetes (diabetes during pregnancy) or hypertensive disorders of pregnancy (high blood pressure during pregnancy). 2. To diagnose and reduce risk for diabetes, high blood pressure, heart disease and stroke in other adult household members. 3. To implement a community-based screening and prevention program leading to health systems strengthening for women and families after the six-week postnatal care period. 4. To build community awareness and develop clinical and research capacity around improving cardiometabolic health in the Caribbean. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of the West Indies UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 499312 837488 1127456 1208220 1326524 0 48991 5047991 GB-GOV-10-RIGHT_7_206987 COMMITMENT UK - Department of Health and Social Care (DHSC) University of the West Indies 40000 GB-GOV-10-RIGHT_7_206987 2025/26 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of the West Indies 114828 GB-GOV-10-RIGHT_7_206987 2025/26 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of the West Indies 41083 GB-GOV-10-RIGHT_7_206987 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the West Indies GB-GOV-10-RIGHT_7_206988 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership led by University of Leicester (UoL) and the Centre for Chronic Disease Control (CCDC) in India which aims to co-create, implement, and evaluate a community and health system-based intervention to improve the early detection, treatment, and management of metabolic risk factors for cardiovascular diseases among older people in India. Heart disease and stroke cause the greatest number of deaths in India and are not always identified early enough. Older people are more at risk of these two conditions because they might not get enough physical activity, be overweight, or have high blood pressure or high cholesterol or diabetes. As such, they often face challenges in getting continued care and complying with treatment advice. The project team will work with older people, their caregivers and frontline health workers to design a contextually relevant innovative care package. Commencing in July 2025, the award will deliver four interlinked work packages which will be guided by the community engagement and involvement activities. The intervention package will consist of a decision support system to aid doctors in providing guideline recommended care, an assisted telemedicine platform to seek specialist consultation where necessary, and a patient-facing mobile application to promote self-management. The award has four objectives: 1. To conduct formative research to understand key challenges in the detection, treatment, and management of metabolic risk factors for cardiovascular diseases and co-create an intervention, engaging all relevant stakeholders (Work Package 1). 2. To implement the intervention and evaluate its effectiveness and cost-effectiveness in improving patient-related clinical outcomes in comparison to current care pathways (Work Package 2). 3. To understand the acceptability, barriers, facilitators to implementing the intervention for different stakeholders and at different health system levels (Work Package 3). 4. If the intervention is found to be effective, a toolkit will be developed to facilitate it's adoption across India and other low- and middle-income countries (LMICs) (Work Package 4). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Leicester UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU India Research for prevention and control of NCDs Research and Innovation 332211 810044 1090508 1168624 1190136 242231 38003 4871757 GB-GOV-10-RIGHT_7_206988 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Leicester 221474 GB-GOV-10-RIGHT_7_206988 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester 36992 GB-GOV-10-RIGHT_7_206988 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Leicester GB-GOV-10-RIGHT_7_207002 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership that aims to improve hypertension control in Nigeria and Sri Lanka. Hypertension, or high blood pressure, is a major global challenge, especially in regions such as Africa and Asia. The conventional treatment approach involves starting with one medication, subsequently increasing the dose, or adding another medication, but this is considered an ineffective and inefficient approach. Commencing in March 2025, the proposed research aims to evaluate a new treatment strategy for managing hypertension, focusing on its effectiveness, safety, and cost-effectiveness compared to usual care. This includes assessing hypertension control rates, budget impact, and implementation feasibility in primary care settings. In turn, this works to improve healthcare providers' skills and confidence, increase access to quality care among vulnerable populations, and reduce health inequities. Additionally, the award outputs seek to influence policy, potentially integrating the strategy into national health policies and ensuring sustainable hypertension control practices within primary care settings in Nigeria and Sri Lanka. The award has four objectives: 1. Formative research: understand the context and refine and adapt the new treatment strategy. 2. Evaluate the effectiveness and safety of the new treatment strategy. 3. Evaluate the implementation of the new treatment strategy. 4. Evaluate the budget impact and cost-effectiveness of the new treatment strategy. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Imperial College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 344553 999987 1999974 1405425 249997 39199 5039135 GB-GOV-10-RIGHT_7_207002 COMMITMENT UK - Department of Health and Social Care (DHSC) Imperial College London 304148 GB-GOV-10-RIGHT_7_207002 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 263468 GB-GOV-10-RIGHT_7_207002 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London 381224 GB-GOV-10-RIGHT_7_207002 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Imperial College London GB-GOV-10-RIGHT_7_207031 UK - Department of Health and Social Care (DHSC) A UK and low- and middle-income country (LMIC) research partnership which aims to improve weight management in Thailand. Heart disease is the number one cause of death in Thailand and obesity is one of the main causes of heart disease. Technology has the potential to improve the quality of weight management services at a low cost. However, research is needed to ensure that these features would be equally accessible and effective for various disadvantaged groups in Thailand. This award aims to understand whether weight management programs that use technology can be an economical way for Thailand’s government to help people to lose weight and lower their risk of heart disease. Specifically, this research will work to reduce the risk of heart disease for 250,000 people in Thailand each year, with the potential for other countries facing similar challenges to also benefit. Commencing in March 2025, this award will assess the current situation in Thailand to understand what issues are important for the weight management program to be effective before working with healthcare providers and overweight people to develop two weight management programs. These will involve technology at two different price points, making sure that they are appealing for the elderly, poor and those living in rural or remote areas. Both interventions will be tested via a large study involving 4,500 overweight people across 60 health centres in Thailand, comparing those who use the two programs with people who are only given some advice, before the cost-effectiveness of the programme and whether it offers Thai taxpayers value for money will be assessed. The award has four objectives: 1. Undertake context (behavioural, technological, and organisational) analysis to inform intervention development. 2. Co-create technology-enabled interventions for two price points being considered by the Thai policy makers, and assess their acceptability to diverse socio-demographic groups. 3. Evaluate the effectiveness of intervention using a cluster randomised trial. 4. Conduct economic evaluation and develop service standards for the interventions. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Thailand Research for prevention and control of NCDs Research and Innovation 355632 596496 803024 860544 951569 28884 3596149 GB-GOV-10-RIGHT_7_207031 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 118908 GB-GOV-10-RIGHT_7_207031 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 140245 GB-GOV-10-RIGHT_7_207031 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 107683 GB-GOV-10-RIGHT_7_207031 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 117809 GB-GOV-10-RIGHT_7_207031 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-RIGHT_7_207046 UK - Department of Health and Social Care (DHSC) A UK and low-and middle-income country (LMIC) research partnership between King’s College London and University of Zambia bringing together experts in maternal medicine, hypertensive disorders of pregnancy, nephrology, cardiology, midwifery, nursing, community engagement, public health, and nutrition, across Sierra Leone, South Africa and Zambia to support women with high blood pressure early after delivery. Women who have high blood pressure during pregnancy are at higher risk of heart disease, kidney disease or stroke as they get older. Across the world, more women die from these diseases than from any other cause. Over three quarters of these deaths take place in sub-Saharan Africa. Our early research shows that the risks of developing high blood pressure after childbirth may be much higher in LMICs like Sierra Leone, Zambia and South Africa. Women have limited knowledge about the risks of ongoing raised blood pressure after pregnancy, and damage it can cause. They also struggle to access and trust care that is available. Commencing in March 2025, the award aims to provide accessible, trusted, acceptable and affordable quality care to lower blood pressure and prevent long-term harm which will work to improve women’s current and future health, including later pregnancies. The award will work together with women, families, communities, healthcare providers and policy makers in three countries to understand day-to-day barriers and facilitators for accessing and providing quality postnatal care before using findings to design a new monitoring pathway of women with high blood pressure. Point-of-care tests will be used to check for kidney and heart damage, which will bolster understanding of how to best collect information, and the extent to which this disease is affecting target communities (teenage girls, women who have lost their babies and those with disabilities) to plan future care. The award has four objectives: 1. To work together with women, families, communities, healthcare providers and policy makers in Sierra Leone, South Africa and Zambia to understand day-to-day barriers and facilitators to access and provision of quality postnatal care, and to establish community partnerships. 2. To undertake a study of women with raised blood pressure in a previous or current pregnancy to understand what proportion of women develop longer-term or ‘chronic’ raised blood pressure and related damage to their body organs, using bedside testing for heart and kidney function. 3. To work together to develop and evaluate a new ‘community champion-led’ intervention in order to: improve women’s knowledge about high blood pressure care and long-term health risks; improve access to local care, for example, testing blood pressure during the first year after birth; improve trust in care through tailored community champion support for monitoring, healthy-living and taking blood pressure medicines and improve blood pressure and risk of damage to other organs. 4. To support training and development of local future research leaders including in research methods, management and governance. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) King's College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 1016359 979846 989449 987182 942378 38590 4953804 GB-GOV-10-RIGHT_7_207046 COMMITMENT UK - Department of Health and Social Care (DHSC) King's College London 218484 GB-GOV-10-RIGHT_7_207046 2025/26 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) King's College London 159724 GB-GOV-10-RIGHT_7_207046 2025/26 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) King's College London GB-GOV-10-RIGHT_7_PPDA UK - Department of Health and Social Care (DHSC) The purpose of Proposal and Partnership Development Awards (PPDA) funding is to improve the quality and likelihood of success of the projects funded through the NIHR Research on Interventions for Global Health Transformation (RIGHT) programme. Applicants that are successful at RIGHT Stage 1 and invited to submit a Stage 2 application are eligible for a PPDA, subject to satisfactory submission of a PPDA application. Not all Stage 2 applicants awarded a PPDA go on to secure RIGHT programme funding, therefore the details of PPDA recipients are not published. For RIGHT Call 7, PPDA were extended to 13 applicant organisations to support partnership development and the preparation of a RIGHT Stage 2 application. Proposal and Partnership Development Awards (PPDA) provide funding of up to £10,000 for organisations applying to NIHR Research on Interventions for Global Health Transformation (RIGHT) programme funding to: 1. Support applicants to work collaboratively with all study partners to develop the stage 2 application 2. Enhance partnerships across the proposed research collaboration 3. Initiate preparation of study governance documentation (i.e. due diligence and finance assurance policies) PPDA funds must be spent between the notification of RIGHT stage 1 outcome and the submission of the RIGHT stage 2 application. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 129007 129007 GB-GOV-10-RIGHT_7_PPDA COMMITMENT UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 12462.470000000001 GB-GOV-10-RIGHT_7_PPDA 2024/25 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 29504.730000000003 GB-GOV-10-RIGHT_7_PPDA 2024/25 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 25741.31 GB-GOV-10-RIGHT_7_PPDA 2024/25 Q4 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 6712.53 GB-GOV-10-RIGHT_7_PPDA 2025/26 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified Recipients of NIHR Proposal and Partnership Development (PPDA) Awards are funded subject to the following conditions being met: a) The Award may only be used in accordance with the plans outlined in the application submitted to the PPD fund in order to pay for: (i) reasonable travel and subsistence expenses; and/or (ii) reasonable partnership formation and development costs to support the production of related memorandum(s) of understanding and/or draft governance policies between the relevant oversea partner(s), collaborator(s) and/or service provider(s); both for the purposes of supporting the funding application to the National Institute for Health and Care Research (NIHR) Research on Interventions for Global Health Transformation (RIGHT)programme. b) No variation to the plans outlined in the application to the PPD fund is permitted without the prior written consent of the NIHR; c) In the event that VAT or any other tax or duty is payable in respect of the Award or the use of the Award, such VAT, tax or duty shall be payable by the Award holder; d) In using the Award and before making any payment to a local partner, collaborator or service provider, the Award holder must complete appropriate due diligence and take all steps reasonably necessary to ensure that both Award holder and their local partners, collaborators and/or service providers comply with all directly applicable legislation including (but not limited to), anti-bribery and corruption, the “NIHR Policy on Preventing Harm in Research” and “NIHR Safeguarding Guidance”; e) The Award holder must provide updates on how you have spent and/or plan to spend the Award as required by DHSC; f) In the event that any part of the award is not applied as outlined in your application, you will repay the relevant amount to the Department of Health and Social Care (DHSC) at the DHSC’s request; and g) The Award holder will provide verbal or written reports as required by DHSC on any aspect of the use of the Award. GB-GOV-10-RIGHT_8_PPDA UK - Department of Health and Social Care (DHSC) The purpose of Proposal and Partnership Development Awards (PPDA) funding is to improve the quality and likelihood of success of the projects funded through the NIHR Research on Interventions for Global Health Transformation (RIGHT) programme. Applicants that are successful at RIGHT Stage 1 and invited to submit a Stage 2 application are eligible for a PPDA, subject to satisfactory submission of a PPDA application. Not all Stage 2 applicants awarded a PPDA go on to secure RIGHT programme funding, therefore the details of PPDA recipients are not published. RIGHT Call 8 was cancelled in 2025 due to spending pressures and no RIGHT programme funding was awarded. The details of the 6 RIGHT 8 PPDA recipients are therefore not published. Proposal and Partnership Development Awards (PPDA) provide funding of up to £10,000 for organisations applying to NIHR Research on Interventions for Global Health Transformation (RIGHT) programme funding to: 1. Support applicants to work collaboratively with all study partners to develop the stage 2 application 2. Enhance partnerships across the proposed research collaboration 3. Initiate preparation of study governance documentation (i.e. due diligence and finance assurance policies) PPDA funds must be spent between the notification of RIGHT stage 1 outcome and the submission of the RIGHT stage 2 application. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 57023 57023 GB-GOV-10-RIGHT_8_PPDA COMMITMENT UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 5014.01 GB-GOV-10-RIGHT_8_PPDA 2025/26 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 43532.59 GB-GOV-10-RIGHT_8_PPDA 2025/26 Q4 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified Recipients of NIHR Proposal and Partnership Development (PPDA) Awards are funded subject to the following conditions being met: a) The Award may only be used in accordance with the plans outlined in the application submitted to the PPD fund in order to pay for: (i) reasonable travel and subsistence expenses; and/or (ii) reasonable partnership formation and development costs to support the production of related memorandum(s) of understanding and/or draft governance policies between the relevant oversea partner(s), collaborator(s) and/or service provider(s); both for the purposes of supporting the funding application to the National Institute for Health and Care Research (NIHR) Research on Interventions for Global Health Transformation (RIGHT)programme. b) No variation to the plans outlined in the application to the PPD fund is permitted without the prior written consent of the NIHR; c) In the event that VAT or any other tax or duty is payable in respect of the Award or the use of the Award, such VAT, tax or duty shall be payable by the Award holder; d) In using the Award and before making any payment to a local partner, collaborator or service provider, the Award holder must complete appropriate due diligence and take all steps reasonably necessary to ensure that both Award holder and their local partners, collaborators and/or service providers comply with all directly applicable legislation including (but not limited to), anti-bribery and corruption, the “NIHR Policy on Preventing Harm in Research” and “NIHR Safeguarding Guidance”; e) The Award holder must provide updates on how you have spent and/or plan to spend the Award as required by DHSC; f) In the event that any part of the award is not applied as outlined in your application, you will repay the relevant amount to the Department of Health and Social Care (DHSC) at the DHSC’s request; and g) The Award holder will provide verbal or written reports as required by DHSC on any aspect of the use of the Award. GB-GOV-10-DevAwards_1 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)’s first Global Health Research (GHR) Development Awards call. The GHR Development Awards provides funding to increase the competitiveness of global health research applications led by researchers based in countries eligible for Official Development Assistance (ODA). Funding awards can be led by a principal investigator employed by a higher education institution or a research institute based in an ODA-eligible country. Through the programme, NIHR aims to support researchers to progress to larger awards and be better positioned to generate a high-quality internationally competitive proposal for research funding addressing needs identified in ODA-eligible countries. Funding is awarded for a 12 month period to support the underpinning work to develop high-quality research proposals. 1. Support the development of high-quality research proposals led by researchers in low and middle-income countries (LMICs) which directly target local needs and priorities. 2. Build global health research capacity and capability by supporting underpinning work to develop high-quality research proposals that will help award holders and their organisations secure further research funding from the NIHR and other funders. 3. Promote the development of equitable and sustainable research partnerships among collaborators, including communities and community organisations based in LMICs. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Universidad Autónoma de Querétaro - Mexico Sitaram Bhartia Institute of Science and Research - India Makerere University School of Public Health American University of Beirut International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) University of Cape Town The Child Health Research Foundation (CHRF) - Bangladesh University of the Philippines Makerere University School of Public Health University of the Witwatersrand Universidade Eduardo Mondlane University of Colombo UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-DevAwards_1_208255 UK - Department of Health and Social Care (DHSC) A low- and middle-income country (LMIC) award led by the Universidad Autónoma de Querétaro, Mexico that aims to tackle childhood obesity in Bangladesh, Mexico, and Pakistan. In Bangladesh, Mexico, and Pakistan, overweight and obesity is common among children, posing serious risks to their health. Childhood obesity persists into adulthood and increases the likelihood of chronic diseases, including heart disease, diabetes, cancer, and mental health problems. The impact extends beyond individual health, straining healthcare resources and hindering economic growth. Previous attempts to address childhood obesity have had limited success, underscoring the need for innovative and culturally sensitive approaches. These should address both individual and environmental factors and should be tailored to the specific contexts of these countries. Commencing in January 2025, the twelve-month award involves the assembly of researchers, community representatives, and policymakers from the three countries to develop a research proposal aimed at tackling the epidemic of childhood obesity. Planned activities include a review of the latest research on the topic, training individuals in developing high-quality research proposals, consulting stakeholders, and defining important outcomes. Activities will be conducted through a combination of in-person and online engagements to maximise efficiency and inclusivity. The primary output of this award is the development of a research funding proposal to tackle the issue of childhood obesity. The proposed research will fill critical knowledge gaps regarding prevention and management of childhood obesity. By involving children, parents, and teachers in the design process, the award will work to develop interventions that address various contributing factors, including diet, physical activity, sleep, and environmental influences. The award has four objectives: 1. To strengthen the applicant team by identifying and inviting additional experts, policymakers, and representatives of relevant community organisations to participate in our research. 2. To build capacity to develop, submit and manage global health research awards and to engage communities in research. 3. To develop the future research programme by searching for the most important information gaps, refining research questions, identifying outcomes that are important to stakeholders, and writing the research funding application. 4. To establish equitable South-South and North-South partnership by agreeing shared values, equitable distribution of responsibilities, determining a transparent decision-making process, and achieving gender equity. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Universidad Autónoma de Querétaro - Mexico UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 49758 49759 0 2500 102017 GB-GOV-10-DevAwards_1_208255 COMMITMENT UK - Department of Health and Social Care (DHSC) Universidad Autónoma de Querétaro - Mexico 49758 GB-GOV-10-DevAwards_1_208255 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Universidad Autónoma de Querétaro - Mexico 24511 GB-GOV-10-DevAwards_1_208255 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Universidad Autónoma de Querétaro - Mexico 11536 GB-GOV-10-DevAwards_1_208255 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Universidad Autónoma de Querétaro - Mexico GB-GOV-10-DevAwards_1_208259 UK - Department of Health and Social Care (DHSC) A low- and middle-income country (LMIC) award led by the Sitaram Bhartia Institute of Science and Research in India working in collaboration with partners based in Bangladesh, Nepal, Bhutan and Sri Lanka and key stakeholders across the health, policy and non-governmental organisation sector to understand how a lack of vitamins and minerals (micronutrients) in mothers and babies affects children's brain development and how it can be prevented and/or treated. Vitamins and minerals are critical for maintaining health at all stages of life. Despite recent efforts to support children's growth, the problem of inadequate micronutrient intake among mothers and infants remains prevalent and under emphasised in low- and middle-income countries (LMICs), particularly within the most impoverished communities. Data indicates that deficiencies in certain micronutrients, such as Vitamin B-12, Vitamin D, or iron, can adversely affect a child's brain development. However, there is insufficient research on effective strategies to address these within LMICs. Addressing these gaps in knowledge is critical to preventing children in poorer communities from being left behind, perpetuating a cycle of inequality. The award explores key research questions aimed at addressing how the needed micronutrients can best be provided, whether the focus should be on single nutrients or multiple nutrients at once, and increasing the understanding of how restrictive diets during pregnancy affect micronutrient levels. Additional consideration will be given to whether to supplement mothers, babies, or both, determining the most appropriate doses and duration for identified supplements, and identifying and screening risk factors during pregnancy. The award will involve a detailed review of existing research on the impact of micronutrient deficiencies on children's brain development, coupled with interviews, home environment assessments, and blood tests of a few mother-infant pairs from four countries. Current policies will form the basis of activities focused on the identification of potential enhancements, the arrangement of workshops to assess the efficiency, cost-effectiveness, and sustainability of proposed interventions which will be used to develop and refine a multicentric intervention plan along with identification and assessment of potential study sites. At the same time, the training and development of skills in South Asian partner countries will take place to build local capacity. The research team will work with government health administrations across South Asia to develop an evidence-based public health intervention plan, based on the tested interventions. The award has four objectives: 1. To develop a multi-disciplinary partnership involving nutrition, maternal and child health and public health expertise in India, Nepal, Bhutan, Bangladesh and Sri Lanka. 2. To develop an understanding of key maternal micronutrient deficiencies and their impact on infant neurodevelopment. 3. To evaluate the national health policy framework of identified South Asian countries and propose a mitigation plan for addressing maternal micronutrient deficiencies. 4. To identify key research areas and to understand the feasibility of such work in the field including potential study sites and the ethics/data governance frameworks. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Sitaram Bhartia Institute of Science and Research - India UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 49966 49967 2500 102433 GB-GOV-10-DevAwards_1_208259 COMMITMENT UK - Department of Health and Social Care (DHSC) Sitaram Bhartia Institute of Science and Research - India 49966 GB-GOV-10-DevAwards_1_208259 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Sitaram Bhartia Institute of Science and Research - India 32194 GB-GOV-10-DevAwards_1_208259 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Sitaram Bhartia Institute of Science and Research - India 7780 GB-GOV-10-DevAwards_1_208259 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Sitaram Bhartia Institute of Science and Research - India 6191 GB-GOV-10-DevAwards_1_208259 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Sitaram Bhartia Institute of Science and Research - India GB-GOV-10-DevAwards_1_208263 UK - Department of Health and Social Care (DHSC) A low- and middle-income country (LMIC) award led by Makerere University, Uganda in partnership with Ugandan institutions: Mbarara University and Kabale University as well as Southampton University in the UK. Research activity is focused on conducting a pilot study which aims to provide an evidence base for a larger research proposal. The Ugandan sub-region and location of the research is plagued with high levels of alcohol abuse that has affected health and productivity, and is associated notably with increasing poverty and domestic violence. Commencing in January 2025, the focus of the 12-month award is on the development, piloting and evaluation of a community-based peer support intervention to reduce the problem of alcohol use in Uganda. The study involves a systematic review of literature on intervention studies against alcohol abuse in rural settings, a survey on alcohol consumption patterns and a qualitative study of perceptions towards alcohol consumption. The award has three objectives: 1. To review existing evidence on community-based interventions for reducing harmful alcohol use in rural areas of low- and middle-income countries (LMICs), their effectiveness in different contexts, and potential mechanisms. 2. To conduct a survey to establish the level of harmful use of alcohol and factors associated with the behaviour. 3. To explore reasons for harmful use of alcohol, and perceptions on effective and acceptable ways of reducing the alcohol abuse. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Uganda Medical research Research and Innovation 50000 49999 2500 102499 GB-GOV-10-DevAwards_1_208263 COMMITMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health 50000 GB-GOV-10-DevAwards_1_208263 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health 35457 GB-GOV-10-DevAwards_1_208263 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health 4543 GB-GOV-10-DevAwards_1_208263 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health 9999 GB-GOV-10-DevAwards_1_208263 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health GB-GOV-10-DevAwards_1_208266 UK - Department of Health and Social Care (DHSC) A low- and middle-income country (LMIC) award led by the American University of Beirut, Lebanon in partnership with Imperial College London, UK. Refugees in the Middle East and North Africa (MENA) region have insecure living conditions. This makes them a vulnerable population to the increasing impacts of climate change through extreme weather events such as heatwaves, droughts, floods and sandstorms. There is a demonstrated need for climate-related vulnerabilities to be considered for refugees and the development of partnerships with academic, policy, community and humanitarian actors are important to co-produce solutions and policies that will reduce the health impact of climate change on refugee populations. Commencing in January 2025, this one-year award aims to generate a research agenda about climate change and refugee health via the development of a conceptual framework and defining and refining research questions based on existing knowledge and the needs of the community and relevant actors. This award will establish a stakeholder advisory group to understand their key priorities and needs through interactive workshops, and work to identify the needs and priorities of refugees through refugee community group workshops and regular meetings. The main output from this award is the development of a proposal, which is based on established equitable partnerships, for a research programme that addresses the needs and priorities of refugees, decision-makers and humanitarian partners on climate change and refugee health. The award has four objectives: 1. To establish new partnerships between the American University of Beirut, Imperial College London, and other Middle East and North Africa (MENA) regional partners on climate change and health. 2. To develop a conceptual framework for climate change and refugee health, and to define and refine research questions on climate change and refugee health based on existing knowledge and the needs of the community and actors. 3. To train and strengthen the team in writing research proposals and identified capacity building needs. 4. To design and develop a future research programme on climate change and refugee health that can be submitted for a relevant funding call. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) American University of Beirut UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Lebanon Medical research Research and Innovation 49805 49806 2500 102111 GB-GOV-10-DevAwards_1_208266 COMMITMENT UK - Department of Health and Social Care (DHSC) American University of Beirut 49805 GB-GOV-10-DevAwards_1_208266 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) American University of Beirut 22672 GB-GOV-10-DevAwards_1_208266 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) American University of Beirut 17172 GB-GOV-10-DevAwards_1_208266 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) American University of Beirut 4609 GB-GOV-10-DevAwards_1_208266 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) American University of Beirut GB-GOV-10-DevAwards_1_208267 UK - Department of Health and Social Care (DHSC) A low- and middle-income country (LMIC) award, led by the International Centre for Diarrheal Disease Research, Bangladesh (ICDDR,B) which aims to address the issue of unnecessary caesarean sections (C-sections) in Bangladesh. In recent years, Bangladesh has seen an alarming rise in C-sections in contrast to normal vaginal delivery. While C-sections can be lifesaving in certain circumstances, unnecessary C-sections carry significant risks and costs, making it a priority for the government and stakeholders in Bangladesh to reduce these procedures where appropriate. Although some progress has been made in policies and guidelines, along with increasing midwives and improving public maternity services for normal delivery, many women still opt for private facilities where vaginal births are significantly less common. Understanding of the factors driving high C-section rates in Bangladesh remains incomplete. While profit incentives play a role, the issue is more complex. Further work is needed to identify these drivers and potential actions. The ultimate goal of the project is to collaboratively design a research programme aimed at developing and testing novel solutions for reducing unnecessary C-sections. Commencing in January 2025, the twelve-month award will involve the review and compilation of existing research, before holding workshops with key stakeholder groups, including urban and rural women, midwives, nurses, obstetricians, women's health organisations, and policymakers. The award team will facilitate dialogues with diverse stakeholders in order to develop a shared understanding of the current situation and potential strategies for improvement. Individuals interested in joining a multi-stakeholder research team to develop a detailed follow-on research plan will be identified. Additionally, the award focuses on strengthening the research capacity and confidence of Bangladeshi researchers to lead large-scale research programmes. The award has five objectives: 1. Summarise existing research on recent C-section patterns and drivers in Bangladesh, and interventions to reduce unnecessary C-sections. 2. Integrate stakeholder perspectives with research evidence to develop a shared understanding of the scale, drivers, and possible actions for unnecessary C-sections. 3. Build a consortium of individuals equipped to design and implement a new applied research programme. 4. Design a follow-on research programme to develop, pilot, and evaluate novel approaches to reducing unnecessary C-sections. 5. Strengthen health research capacity in Bangladesh. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Bangladesh Medical research Research and Innovation 48491 48492 2500 99483 GB-GOV-10-DevAwards_1_208267 COMMITMENT UK - Department of Health and Social Care (DHSC) International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) 48491 GB-GOV-10-DevAwards_1_208267 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) 25253 GB-GOV-10-DevAwards_1_208267 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) 2549 GB-GOV-10-DevAwards_1_208267 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Centre for Diarrhoeal Disease Research, Bangladesh (icddr,b) GB-GOV-10-DevAwards_1_208268 UK - Department of Health and Social Care (DHSC) A low- and middle-income country (LMIC) award led by the Knowledge Translation Unit (KTU) of the University of Cape Town, South Africa, which aims to develop a research collaboration with key government, academic and community stakeholders and a proposal to conduct a comparative study evaluating the implementation of a primary care health system strengthening programme in South Africa, Brazil, Indonesia and Ethiopia. The programme is called PACK, the Practical Approach to Care Kit. PACK is a system-strengthening programme that comprises a comprehensive clinical decision support tool for primary care and an implementation strategy that addresses health system barriers to its uptake. It has been introduced to all four countries to support primary care reforms and has shown some success in improving health outcomes and quality of care. However, there is limited evidence around how best to localise and implement the programme. Due to commence in January 2025, the one-year award intends to evaluate how best to ensure that patient care is relevant to local diseases, health worker skills and available resources via the implementation of PACK within health systems in South Africa, Brazil, Indonesia and Ethiopia. While the award focuses on the development of a proposal centred on a cross-country comparative study of PACK implementation, activities also aim to foster research collaboration between KTU and key government, academic and community stakeholders. Increased collaboration between KTU and implementing partners works to bolster research skills, capacity and literacy, as well as efforts to ensure the most appropriate approach to measure successes and challenges of the programme are established. The award has five objectives: 1. To convene a group focused on the cultivation of a research collaboration between implementing partners across four countries. 2. To identify and address the research collaboration’s capacity-strengthening needs. 3. To determine the research methodology required to conduct a cross-country comparison of the Practical Approach to Care Kit (PACK) implementation experiences. 4. To create a Community Engagement and Involvement methodology. 5. To generate a research proposal focused on the evaluation of cross-country PACK implementation experiences. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Cape Town UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 49898 49899 2500 102297 GB-GOV-10-DevAwards_1_208268 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 49898 GB-GOV-10-DevAwards_1_208268 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 36007 GB-GOV-10-DevAwards_1_208268 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 3912 GB-GOV-10-DevAwards_1_208268 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 7355 GB-GOV-10-DevAwards_1_208268 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town GB-GOV-10-DevAwards_1_208273 UK - Department of Health and Social Care (DHSC) A low- and middle-income country (LMIC) led award led by the Child Health Research Foundation in Bangladesh which aims to establish a research partnership with the UK-based Centre for Antimicrobial Optimisation Network (CAMO-Net). Neonatal deaths remain a major challenge to Bangladesh in its pursuit of achieving the Sustainable Development Goals (SDGs) by 2030. Specifically, infections are a significant cause of neonatal deaths in Bangladesh, and the rise of antimicrobial-resistant infections continues to exacerbate this issue and threaten progress made. Commencing in January 2025 this partnership, known as the Bangladesh Initiative for Advancing Research on Neonatal Infections (BARN), aims to build clinical research capacity in Bangladesh to better monitor and manage neonatal infections. The BARN initiative will lay the foundation for the transfer of knowledge and skills related to cutting-edge biomonitoring and surveillance technologies from the Global North to the Global South, enabling their critical evaluation and use in LMIC settings. This will be done through the co-development of two pilot studies aimed at examining the use of continuing monitoring systems for non-invasive tracking of antibiotics and biomarkers in neonates to optimise antimicrobial usage, as well as to use molecular epidemiological methods to track and reduce healthcare-associated infections in neonates. The award has five objectives: 1. To strengthen the ongoing partnership between the Child Health Research Foundation in Bangladesh and UK-based Centre for Antimicrobial Optimisation Network (CAMO-Net) through stakeholder engagement meetings. 2. To examine the use of continuous monitoring systems for non-invasive tracking of antibiotics and biomarkers in neonates to optimise antimicrobial usage. 3. To use molecular epidemiological methods to track and reduce healthcare-associated infections in neonates. 4. To conduct retrospective analysis of clinical and epidemiological data on neonatal infections available from four hospitals in Bangladesh. 5. To develop training workshops for early career researchers in Bangladesh, focusing on research methods, ethics, and project management. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The Child Health Research Foundation (CHRF) - Bangladesh UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Bangladesh Medical research Research and Innovation 49985 49985 2500 102470 GB-GOV-10-DevAwards_1_208273 COMMITMENT UK - Department of Health and Social Care (DHSC) The Child Health Research Foundation (CHRF) - Bangladesh 49985 GB-GOV-10-DevAwards_1_208273 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Child Health Research Foundation (CHRF) - Bangladesh 35797 GB-GOV-10-DevAwards_1_208273 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Child Health Research Foundation (CHRF) - Bangladesh 4191 GB-GOV-10-DevAwards_1_208273 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Child Health Research Foundation (CHRF) - Bangladesh 9997 GB-GOV-10-DevAwards_1_208273 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Child Health Research Foundation (CHRF) - Bangladesh GB-GOV-10-DevAwards_1_208280 UK - Department of Health and Social Care (DHSC) A low- and-middle-income country (LMIC) award led by the University of the Philippines Manila, Philippines in partnership with the University of Oxford, United Kingdom which aims to convene a community engagement group to explore and understand patient, carer, and healthcare provider experiences and priorities, map existing care pathways, and develop strategies to enhance recovery from fragility fractures. Commencing in January 2025, this twelve-month award will undertake patient and carer interviews and hospital surveys to identify the facilities currently available for treating these patients in the Philippines. This work will inform a subsequent research proposal to improve patient outcomes, reduce healthcare costs, and influence national healthcare policy in the Philippines and other LMICs in Southeast Asia. The number of people with fragility fractures is increasing in many LMICs. Asia is particularly affected by rapidly aging populations; a study in nine countries predicts a two-fold increase in the number of hip fractures alone, from just over a million in 2018 to more than two and a half million by 2050. Data from the Orthogeriatric and Fracture Liaison Service registry of the Philippine General Hospital show significant healthcare costs, with an estimated economic burden of PhP 1 billion per year (approximately USD 17 million). This may underrate the real situation, as the majority of hip fractures are still underreported due to economic and logistical reasons, and osteoporosis and fragility fracture treatment is not a priority of the Philippine healthcare system at present. No cost-effective treatment pathway of care for patients with fragility fractures is in place in the Philippines. Unlike hip fractures, most patients with a shoulder, wrist, or ankle fracture are not admitted to hospital but are treated as outpatients via the hospital fracture clinic; these patients’ disabilities compromise independence, quality of life, and productivity as well. This award has three objectives: 1. To expand the existing Philippines Community Engagement and Involvement Group to include patients with shoulder, wrist, and ankle fractures and conduct in-depth interviews with patients aged 50 and above, and carers or family members. By exploring their experiences, challenges, and priorities during their recovery this will help identify key points in the care pathway where targeted interventions can improve outcomes. 2. To map capabilities in managing fragility fractures, particularly those involving the shoulder, wrist, and ankle through a comprehensive survey assessing service availability and service-specific readiness using the World Health Organisation Service Availability and Readiness Assessment (SARA) tool. 3. To create bespoke country-specific data to influence and change policy at a national and regional level to improve care for all patients with fragility fractures. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of the Philippines UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Philippines (the) Medical research Research and Innovation 98944 2500 101444 GB-GOV-10-DevAwards_1_208280 COMMITMENT UK - Department of Health and Social Care (DHSC) University of the Philippines 29683 GB-GOV-10-DevAwards_1_208280 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the Philippines 50000 GB-GOV-10-DevAwards_1_208280 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the Philippines GB-GOV-10-DevAwards_1_208283 UK - Department of Health and Social Care (DHSC) A low- and middle-income country (LMIC) award led by Makerere University School of Public Health (MakSPH), Uganda in partnership with the University of Rwanda and Kamuzu University of Health Sciences, Malawi, University of Antwerp, Belgium and Canterbury Christ Church University, UK. Together this partnership aims to understand the political and governance dynamics of cities in order to inform mobility planning and contextually adapted strategies in Uganda, Rwanda and Malawi. In the context of rapid urbanisation, African countries are grappling with how to manage emerging issues such as unplanned transport systems, accessibility challenges, traffic congestion and vehicle accidents. Sustainable Development Goal (SDG) 11 focuses on making cities and human settlements inclusive, safe, resilient and sustainable with its achievement largely influenced by governance, politics and interests that shape how policy decisions are made and implemented. However, such broad health objectives, coupled with complex governance arrangements have received inadequate attention in the area of mobility and road safety within the African region. Commencing in January 2025, the twelve-month award will draw on diverse methodologies, theoretical frameworks and empirical analyses to generate evidence which will inform a broader research proposal. Capacity enhancement efforts will be cross-cutting and pursued at individual, organisational and partnership levels. Core activities include knowledge generation via analysis of policies and a scoping review on the political factors and dynamics shaping mobility in African cities, coupled with stakeholder and partnership engagement, evidence needs assessments and capacity development. This award will provide opportunities for mutual learning across the partnership, research community and practitioners through a comparative approach, learning by doing, exchanges and embedded capacity-building activities. These insights will inform the development of broader research projects and wider partnerships which are the ultimate outcomes of this award’s activity. The award has five objectives: 1. To map and characterise the mobility-related policies across relevant sectors and organisations in cities of Kampala (Uganda), Kigali (Rwanda), and Lilongwe (Malawi). 2. To conduct a scoping review on how contextual factors, actor relationships, and power dynamics shape the development and implementation of mobility-related policies in different urban contexts in the wider global context. 3. To engage decision-makers in the identification and understanding of context-specific evidence needs required for policy changes and implementation challenges related to advancing mobility. 4. To develop a partnership to foster capacity enhancement for interdisciplinary social science research on public health policy in select African university settings. 5. To widen partnerships and produce a proposal for a longer-term grant that develops a consortium approach to enhance expertise, knowledge and resources for political analyses, policy advice and influence at partner institutions to support mobility in African cities. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 49999 49999 2500 102498 GB-GOV-10-DevAwards_1_208283 COMMITMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health 49999 GB-GOV-10-DevAwards_1_208283 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health 25000 GB-GOV-10-DevAwards_1_208283 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health 15000 GB-GOV-10-DevAwards_1_208283 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health 9999 GB-GOV-10-DevAwards_1_208283 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Makerere University School of Public Health GB-GOV-10-DevAwards_1_208287 UK - Department of Health and Social Care (DHSC) A low- and-middle-income country (LMIC) award led by the University of Witwatersrand, South Africa, which aims to develop a research proposal for the co-design, implementation, and evaluation of a community health worker-based service for screening for serious mental illness and supporting people living with serious mental illness (PLSMI) in a peri-urban community in Gauteng province, South Africa, that is integrated with primary health care services. The government-implemented community health worker (CHW) programme expects CHWs to identify and refer cases of common mental disorders, gender-based violence, and drug, alcohol and child abuse. However, little training is provided on the skills necessary to fulfil these roles nor on the skills needed to support PLSMI. Due to commence in January 2025, the twelve-month award intends to develop a research proposal for future research on a community health worker-based model for PLSMI through community engagement and involvement. Award activity initially focuses on understanding community health workers’ (CHWs) perceptions of serious mental illness and how they perceive their role in relation to PLSMI. It will involve engagement with community representatives and key stakeholders including decision-makers in order to better understand the experiences of PLSMI, and the existing and prospective role of CHWs and service providers in supporting CHWs to provide care for PLSMI. The focus on community engagement within this award will work to establish a core group of community representatives to ensure the integration of community representation, provide capacity-strengthening activities for community members and facilitate the co-development of a research proposal. The project has four objectives: 1. To understand community health workers’ perceptions of serious mental illness, the role of traditional and biomedical treatments, and how they currently perceive their role concerning people living with serious mental illness. 2. To explore with community members the potential role of community health workers can play in supporting people living with serious mental illnesses. 3. To engage with healthcare providers and decision-makers on whether and how the publicly funded primary care system might integrate and support community health workers working with people living with serious mental illness. 4. To map the evidence for components of a community health worker-based service for people living with serious mental illness via an evidence map. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of the Witwatersrand UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU South Africa Medical research Research and Innovation 50000 50000 2500 102500 GB-GOV-10-DevAwards_1_208287 COMMITMENT UK - Department of Health and Social Care (DHSC) University of the Witwatersrand 50000 GB-GOV-10-DevAwards_1_208287 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the Witwatersrand 37516 GB-GOV-10-DevAwards_1_208287 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the Witwatersrand 10977 GB-GOV-10-DevAwards_1_208287 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of the Witwatersrand GB-GOV-10-DevAwards_1_208289 UK - Department of Health and Social Care (DHSC) A low-and-middle-income country (LMIC) award led by Universidade Eduardo Mondlane, Mozambique in partnership with the University of Glasgow, United Kingdom which aims to generate preliminary data on causes of heart failure in the Mozambican population, and demonstrate approaches to population-based studies within low-resourced African settings. Pre-existing data suggests that heart failure in Africa varies from the rest of the world due to a prevalence within a younger age demographic. Additionally, there are different causes and risk factors for heart failure in the African context, which is limited to data collected from hospital patients and not inclusive of cases not managed in hospitals. To implement measures that can be effective in preventing and controlling heart failure, it is important to know exactly how it presents at the population level. As such, data generated via award activity will guide the design and implementation aimed at bridging the knowledge gap of data more representative of the country’s population. Commencing in January 2025, the twelve-month award will engage with community leaders and local authorities before undertaking data collection across a rural and urban setting within Mozambique. As a result, the design and implementation process of this study will employ community engagement and involvement to ensure integration of community perspectives and experiences, and increased collaboration between teams at the University of Glasgow in the United Kingdom and Maputo Central Hospital in Mozambique will bolster capacity strengthening initiatives. The award has eight objectives: 1. To demonstrate the feasibility of conducting a population-based study in a low resourced African setting and obtain preliminary data on the prevalence, aetiology and risk factors of heart failure in Mozambique. 2. To design and apply questionnaires to estimate the proportion of eligible people who are willing to participate, the proportion of participants who drop out and the standard deviation that will be used for the sample size calculation in the follow-up study on a representative urban and rural population sample of Mozambique. 3. To pilot-test study tools/questionnaires and measurement procedures for assessment of prevalence, risk factors and the diagnosis of heart failure. To describe the process for conducting population-based heart failure research in a low resourced African setting, including the challenges found and actions taken to overcome them. 4. To describe the process for conducting a population-based heart failure research in a low resourced African setting, including the challenges found and actions taken to overcome them during planning, patient recruitment and collection of epidemiological, clinical and biospecimen data. 5. To determine and compare the age and sex-specific prevalence of heart failure via questionnaire in a sample of both the urban and rural population of Mozambique. 6. To describe the antecedents (risk factors and aetiologies) and specific phenotypes of heart failure found in a sample of the population of Mozambique, according to residence in urban or rural area and socio-economic status. 7. To measure household expenditure, according to residence in urban or rural areas. 8. To evaluate the quality of life of participants, including heart failure patients, according to residence in urban or rural areas. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Universidade Eduardo Mondlane UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Mozambique Medical research Research and Innovation 32497 32497 0 2500 67494 GB-GOV-10-DevAwards_1_208289 COMMITMENT UK - Department of Health and Social Care (DHSC) Universidade Eduardo Mondlane 32497 GB-GOV-10-DevAwards_1_208289 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Universidade Eduardo Mondlane 25998 GB-GOV-10-DevAwards_1_208289 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Universidade Eduardo Mondlane 8559 GB-GOV-10-DevAwards_1_208289 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Universidade Eduardo Mondlane GB-GOV-10-DevAwards_1_208290 UK - Department of Health and Social Care (DHSC) A low- and middle-income country (LMIC) award led by the University of Colombo, Sri Lanka, with mentorship from the University of Birmingham, UK, which aims to reduce long-term complications and improve clinical outcomes and quality of life for pregnant women in Sri Lanka. Due to commence in January 2025, the one-year award intends to manage hypertensive disorders in pregnancy, improve Sri Lanka’s maternal care information system for future research and assist health professionals in decision-making. Sri Lanka is a low-middle-income country. Despite vast improvements in reducing the number of women dying during or soon after delivery in the country, quality of care and reducing complications and the development of pregnancy-related conditions is still an ongoing issue. Specifically, the award aims to form a diverse stakeholder group to provide comprehensive expertise throughout the project’s lifecycle and beyond, as well as co-creating a prototype of a digital Clinical Decision Support System (CDSS) embedded within Sri Lanka’s Electronic Health Records (EHR) system with an initial focus on hypertensive disorders during pregnancy. Plans to generate a co-developed research proposal for funding to test and evaluate the EHR and CDSS system are also highlighted. These research activities provide an opportunity to improve in-country information systems in maternal care for future research, health system strengthening and eventually in establishing a learning health system. This award has three objectives: 1. To establish an inclusive and representative stakeholder consultation group to provide comprehensive expertise throughout the project's lifecycle and beyond. 2. To co-develop a comprehensive maternity Electronic Health Record and clinical decision support system prototype for managing hypertensive disorders during antenatal care. 3. To co-develop an applied global health research proposal to improve antenatal care during pregnancy in Sri Lanka, and test and evaluate the prototype in antenatal hospital clinics. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Colombo UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Sri Lanka Medical research Research and Innovation 98886 2500 101386 GB-GOV-10-DevAwards_1_208290 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Colombo 49443 GB-GOV-10-DevAwards_1_208290 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Colombo 37472 GB-GOV-10-DevAwards_1_208290 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Colombo 2083 GB-GOV-10-DevAwards_1_208290 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Colombo 9888 GB-GOV-10-DevAwards_1_208290 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Colombo GB-GOV-10-RP_01 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)’s first Global Research Professorship call. The Global Research Professorships programme funds research leaders, with a track-record of applied health research in low- and middle-income countries (LMICs), to promote effective translation of research and to strengthen research leadership at the highest academic levels. Funding of up to £2m over up to 5 years is awarded to Professors working in close partnership with a research institution in an LMIC. By the end of the award, NIHR Global Research Professors will be expected to: 1) Have demonstrated research leadership at a national and/or international level. 2) Have been developed and protected by their institutions, including being relieved of administrative tasks. 3) Enhance existing and establish new research collaborations in low- and middle-income countries (LMICs). 4) Have supported training and capacity strengthening/mentorship within LMIC and UK (if applicable) institutions that enhances research capacity for future global health and care research. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Southampton London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-RP_2017_08_ST2_008 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship scheme is open to all professions and all Higher Education Institutions (HEI), based in England and the Devolved Administrations, to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Health Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. The aim of this Global Research Professorship is to evaluate couple-focused interventions to reduce the burden of diseases in sub-Saharan Africa, in particular Human Immunodeficiency Virus (HIV) and diabetes. The majority of adults are in a partnership and to varying degrees live shared lives. Couples-focused interventions can be more effective than individual interventions in facilitating long-term behavioral change by one or both members of a couple. To contribute to the design and evaluation of interventions for couples affected by Human Immunodeficiency Virus (HIV), other Sexually Transmitted Infections (STIs) and, diabetes in South Africa; support other research sites in sub-Saharan Africa (SSA) to prepare for couples-focused research and evaluation; and develop capacity in the design of complex interventions, models and theory of behavioural change, and quantitative dyadic analyses. The research has three strands: 1) adapting an existing intervention to substantially enhance promotion of couples HIV testing and counselling among couples who have never tested together for HIV or mutually disclosed their status; 2) developing a couples-focused intervention for couples where one partner has diabetes; and, 3) establishing a research agenda in couples-focused health research in SSA UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Southampton UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 155439 464466 505980 154872 332768 341871.06000000006 155439 GB-GOV-10-RP_2017_08_ST2_008 2018/19 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Southampton 1955396.06 GB-GOV-10-RP_2017_08_ST2_008 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Southampton 93675 GB-GOV-10-RP_2017_08_ST2_008 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 94702 GB-GOV-10-RP_2017_08_ST2_008 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 29344 GB-GOV-10-RP_2017_08_ST2_008 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 28708 GB-GOV-10-RP_2017_08_ST2_008 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 126383 GB-GOV-10-RP_2017_08_ST2_008 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 127772 GB-GOV-10-RP_2017_08_ST2_008 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 127772 GB-GOV-10-RP_2017_08_ST2_008 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 124995 GB-GOV-10-RP_2017_08_ST2_008 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 95141 GB-GOV-10-RP_2017_08_ST2_008 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 15771 GB-GOV-10-RP_2017_08_ST2_008 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 67420 GB-GOV-10-RP_2017_08_ST2_008 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 127314 GB-GOV-10-RP_2017_08_ST2_008 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Southampton 128712 GB-GOV-10-RP_2017_08_ST2_008 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Southampton 128712 GB-GOV-10-RP_2017_08_ST2_008 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Southampton 59306 GB-GOV-10-RP_2017_08_ST2_008 2023/24 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Southampton 210143 GB-GOV-10-RP_2017_08_ST2_008 2023/24 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Southampton 88183 GB-GOV-10-RP_2017_08_ST2_008 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton 54732 GB-GOV-10-RP_2017_08_ST2_008 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Southampton GB-GOV-10-RP_2017_08_ST2_012 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship scheme is open to all professions and all Higher Education Institutions (HEI), based in England and the Devolved Administrations, to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. Infections of the central nervous system (CNS) are major causes of mortality in low- and middle-income countries. This research aims to generate a detailed understanding of the aetiology of adult meningitis in this setting to inform diagnostic pathways and treatment strategies. The research group will evaluate affordable point-of-care diagnostic tests for meningitis, which are urgently needed to facilitate diagnosis, screening and prevention strategies, and trial novel effective treatments required to improve patient outcomes. The project is based in Botswana and the majority of the research will be conducted in this region. To improve management of adult meningitis in African settings with high levels of Human Immunodeficiency Virus (HIV). Key goals are (1) to collect information on all patients being tested for meningitis at an African hospital, and run very detailed testing to determine the causes; (2) to evaluate new tests for meningitis capable of testing for many different infections at once and diagnosing infection at the bedside; (3) to test a new treatment for cryptococcal meningitis (CM), the commonest cause of meningitis in this setting, based on a single very high dose of an existing drug called liposomal amphotericin; and (4) to perform a detailed examination of the patients’ immune responses and genetic make up to try to find out why some patients develop CM while some do not, and what factors are associated with death from CM. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 92855 226629 396404 377937 300984 367922 245959 23789 GB-GOV-10-RP_2017_08_ST2_012 2018/19 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 69066 GB-GOV-10-RP_2017_08_ST2_012 2018/19 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 2008690 GB-GOV-10-RP_2017_08_ST2_012 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 69833 GB-GOV-10-RP_2017_08_ST2_012 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 70601 GB-GOV-10-RP_2017_08_ST2_012 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 43571 GB-GOV-10-RP_2017_08_ST2_012 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 42624 GB-GOV-10-RP_2017_08_ST2_012 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 114933 GB-GOV-10-RP_2017_08_ST2_012 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 83812 GB-GOV-10-RP_2017_08_ST2_012 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 99916 GB-GOV-10-RP_2017_08_ST2_012 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 97743 GB-GOV-10-RP_2017_08_ST2_012 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 127674 GB-GOV-10-RP_2017_08_ST2_012 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 19242 GB-GOV-10-RP_2017_08_ST2_012 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 110698 GB-GOV-10-RP_2017_08_ST2_012 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 120323 GB-GOV-10-RP_2017_08_ST2_012 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 99598 GB-GOV-10-RP_2017_08_ST2_012 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 100693 GB-GOV-10-RP_2017_08_ST2_012 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 100693 GB-GOV-10-RP_2017_08_ST2_012 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 91728 GB-GOV-10-RP_2017_08_ST2_012 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 92737 GB-GOV-10-RP_2017_08_ST2_012 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 92737 GB-GOV-10-RP_2017_08_ST2_012 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 90720 GB-GOV-10-RP_2017_08_ST2_012 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 91730 GB-GOV-10-RP_2017_08_ST2_012 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 92738 GB-GOV-10-RP_2017_08_ST2_012 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-RP_02 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)’s second Global Research Professorship call. The Global Research Professorships programme funds research leaders, with a track-record of applied health research in low- and middle-income countries (LMICs), to promote effective translation of research and to strengthen research leadership at the highest academic levels. Funding of up to £2m over up to 5 years is awarded to Professors working in close partnership with a research institution in an LMIC. By the end of the award, NIHR Global Research Professors will be expected to: 1) Have demonstrated research leadership at a national and/or international level. 2) Have been developed and protected by their institutions, including being relieved of administrative tasks. 3) Enhance existing and establish new research collaborations in low- and middle-income countries (LMICs). 4) Have supported training and capacity strengthening/mentorship within LMIC and UK (if applicable) institutions that enhances research capacity for future global health and care research. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-RP_2018_300039 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship scheme is open to all professions and all Higher Education Institutions (HEI), based in England and the Devolved Administrations, to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. Typhoid fever and Invasive Non-Typhoidal Salmonella (iNTS) disease are two invasive blood-stream infections caused by bacteria called Salmonella responsible for serious illness and death particularly in young children in sub-Saharan Africa. This research aims to drive translational impact in the prevention of invasive Salmonella disease in Africa, with the major focus on accelerating and advancing the national and regional introduction of vaccination for Typhoid and for iNTS disease. The project is based in Malawi and the majority of the research will be conducted in this region. To accelerate the vaccine prevention of Typhoid fever and Invasive Non-Typhoidal Salmonella disease. The research has 3 workstreams: 1.) Epidemiology: how much typhoid and iNTS disease are happening, and how do they spread in urban and rural communities? 2.) Protection: How do people’s bodies make protective immune responses against Salmonella infection, and how can we design better vaccines? 3.) Vaccines: How well do the vaccines actually work in healthy and immunosuppressed children? In addition Professor Gordon will support these workstreams with activities to discuss and explain Salmonella disease and research among the communities she works with, use research findings to engage with stakeholders and accelerated introduction of vaccines, and train the next generation of doctors and scientists in Malawi to be the researchers of the future. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 129404 390146 326092 206229 302224 38000 380440 129404 GB-GOV-10-RP_2018_300039 2020/21 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Liverpool 96523 GB-GOV-10-RP_2018_300039 2020/21 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Liverpool 1772535 GB-GOV-10-RP_2018_300039 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 97583 GB-GOV-10-RP_2018_300039 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 98351 GB-GOV-10-RP_2018_300039 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 97689 GB-GOV-10-RP_2018_300039 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 98775 GB-GOV-10-RP_2018_300039 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 40566 GB-GOV-10-RP_2018_300039 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 89682 GB-GOV-10-RP_2018_300039 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 97069 GB-GOV-10-RP_2018_300039 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 98148 GB-GOV-10-RP_2018_300039 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 53081 GB-GOV-10-RP_2018_300039 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 55000 GB-GOV-10-RP_2018_300039 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 99254 GB-GOV-10-RP_2018_300039 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 101070 GB-GOV-10-RP_2018_300039 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 101900 GB-GOV-10-RP_2018_300039 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 100000 GB-GOV-10-RP_2018_300039 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 80173 GB-GOV-10-RP_2018_300039 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 143735 GB-GOV-10-RP_2018_300039 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool GB-GOV-10-RP_03 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)’s third Global Research Professorship call. The Global Research Professorships programme funds research leaders, with a track-record of applied health research in low- and middle-income countries (LMICs), to promote effective translation of research and to strengthen research leadership at the highest academic levels. Funding of up to £2m over up to 5 years is awarded to Professors working in close partnership with a research institution in an LMIC. By the end of the award, NIHR Global Research Professors will be expected to: 1) Have demonstrated research leadership at a national and/or international level. 2) Have been developed and protected by their institutions, including being relieved of administrative tasks. 3) Enhance existing and establish new research collaborations in low- and middle-income countries (LMICs). 4) Have supported training and capacity strengthening/mentorship within LMIC and UK (if applicable) institutions that enhances research capacity for future global health and care research. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Oxford University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-RP_2019_300791 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship scheme is open to all professions and all Higher Education Institutions (HEI), based in England and the Devolved Administrations, to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners.Melioidosis is a grossly under-recognised tropical disease, caused by bacterium in the soil. Most people with melioidosis are poor and live in rural regions, typically working in rice farming. Ubon in Northeast Thailand is a world hotspot for melioidosis. More than half of melioidosis patients have diabetes, which is rising rapidly in low- and middle-income countries. This research will conduct the world’s first clinical trial of a new vaccine to prevent melioidosis, targeted for people with diabetes in Thailand and other tropical regions. The laboratory research carried out will identify which biomarkers to use to monitor how the vaccine works in Thailand, and study why people with diabetes are at a greater risk of infections compared to other people. The aims of the research are: 1. To evaluate the safety and immunogenicity of a vaccine for melioidosis in people with diabetes in Oxford, UK, and compare immunogenicity with healthy non-diabetic subjects. 2. Characterisation of the impact of diabetes and ageing on infection and vaccination. 3. To define the key biomarkers (immune correlates of protection) for future monitoring of efficacy of the vaccine for melioidosis using an existing melioidosis patient cohort study. 4. To undertake a community consultation activity to explore perceptions, understanding and key sensitivities amongst people living with diabetes in Ubon Ratchathani, Thailand towards participation in future efficacy trials of a melioidosis vaccine. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Oxford UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 58881 378308 448780 427850 368761 273741 241511 GB-GOV-10-RP_2019_300791 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 91814 GB-GOV-10-RP_2019_300791 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 103864 GB-GOV-10-RP_2019_300791 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 1956321 GB-GOV-10-RP_2019_300791 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Oxford 112481 GB-GOV-10-RP_2019_300791 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Oxford 72997 GB-GOV-10-RP_2019_300791 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Oxford 72997 GB-GOV-10-RP_2019_300791 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Oxford 69028 GB-GOV-10-RP_2019_300791 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 108811 GB-GOV-10-RP_2019_300791 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 120007 GB-GOV-10-RP_2019_300791 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 120007 GB-GOV-10-RP_2019_300791 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 109025 GB-GOV-10-RP_2019_300791 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 104620 GB-GOV-10-RP_2019_300791 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 105771 GB-GOV-10-RP_2019_300791 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 105771 GB-GOV-10-RP_2019_300791 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 14497 GB-GOV-10-RP_2019_300791 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 92059 GB-GOV-10-RP_2019_300791 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 93071 GB-GOV-10-RP_2019_300791 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford GB-GOV-10-RP_2019_300808 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship scheme is open to all professions and all Higher Education Institutions (HEI), based in England and the Devolved Administrations, to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. Maternal sepsis is one of the most important causes of death and harm to mothers and their babies during or after pregnancy. It disproportionately impacts women and their families in low income countries. This research will improve our understanding of the epidemiology of maternal infection, optimise approaches to better prevent and diagnose maternal sepsis, and rigorously test at scale a facility level intervention aiming to improve maternal sepsis outcomes. The research will be focused in Malawi, and an important part of this programme will be working collaboratively with Malawian researchers to build maternal health research capacity. This research aims to make major advances in the understanding of maternal infection in Malawi, and how to better prevent and manage these infections in order to reduce mortality and morbidity from maternal sepsis in Africa. The research programme workstreams are 1.) Understanding maternal infection in Malawi; 2.) Preventing infections; focussing on caesarean section and miscarriage surgery and 3.) Improving the management of maternal sepsis. Additionally, the research programme has two cross-cutting themes – 1) training and capacity building and 2) Communication with the public, practitioners, and policy makers. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 57540 357109 371206 407531 370289 312452 57540 GB-GOV-10-RP_2019_300808 2021/22 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Liverpool 88748 GB-GOV-10-RP_2019_300808 2021/22 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Liverpool 89723 GB-GOV-10-RP_2019_300808 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 89723 GB-GOV-10-RP_2019_300808 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 88915 GB-GOV-10-RP_2019_300808 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 1876127 GB-GOV-10-RP_2019_300808 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 90510 GB-GOV-10-RP_2019_300808 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 91504 GB-GOV-10-RP_2019_300808 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 91504 GB-GOV-10-RP_2019_300808 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 97688 GB-GOV-10-RP_2019_300808 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 103115 GB-GOV-10-RP_2019_300808 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 104248 GB-GOV-10-RP_2019_300808 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 104248 GB-GOV-10-RP_2019_300808 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 95920 GB-GOV-10-RP_2019_300808 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 92203 GB-GOV-10-RP_2019_300808 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 93216 GB-GOV-10-RP_2019_300808 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 93216 GB-GOV-10-RP_2019_300808 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 91654 GB-GOV-10-RP_2019_300808 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 92918 GB-GOV-10-RP_2019_300808 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 93940 GB-GOV-10-RP_2019_300808 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool GB-GOV-10-RP_04 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)’s fourth Global Research Professorship call. The Global Research Professorships programme funds research leaders, with a track-record of applied health research in low- and middle-income countries (LMICs), to promote effective translation of research and to strengthen research leadership at the highest academic levels. Funding of up to £2m over up to 5 years is awarded to Professors working in close partnership with a research institution in an LMIC. By the end of the award, NIHR Global Research Professors will be expected to: 1) Have demonstrated research leadership at a national and/or international level. 2) Have been developed and protected by their institutions, including being relieved of administrative tasks. 3) Enhance existing and establish new research collaborations in low- and middle-income countries (LMICs). 4) Have supported training and capacity strengthening/mentorship within LMIC and UK (if applicable) institutions that enhances research capacity for future global health and care research. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine Liverpool School of Tropical Medicine University College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-RP_04_301621 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship scheme is open to all professions and Higher Education Institutions in England and the Devolved Administrations, to nominate health researchers and methodologists with an outstanding clinical and applied health research record and its effective translation for improved health. Global Research Professors are required to have existing strong links with partners in institutions in countries on the OECD DAC list and the award should plan to support training and capacity development in these partners. There are one billion disabled people globally. Disabled people, on average, have higher healthcare needs than others, yet they face barriers in accessing it. As a result, they have worse health outcomes, including 2-3 times higher mortality rates across all ages. Policies and laws supporting the right to healthcare for disabled people are often not put into practice. Evidence is growing that interventions to improve healthcare led by communities are particularly effective. They are low-cost, scalable and address locally relevant concerns. One example is the Participatory Learning and Action (PLA) approach developed to prevent maternal and newborn deaths. In PLA, women’s community groups are established and meet monthly to: 1) identify problems, 2) identify solutions, 3) plan and implement solutions, and 4) evaluate their efforts. PLA significantly reduces maternal and newborn deaths, usually by at least 20%, and is endorsed by WHO. The aim of this study is to assess whether the PLA for Disability (PLA-D) approach can reduce mortality and improve health of disabled people in Uganda. Research will be undertaken by a consortium of UK and Uganda based partners. We will identify the problems facing disabled people in accessing healthcare in Uganda, through: 1) In-depth interviews with key informants (e.g. disabled people, health workers), 2) Analysis of existing numerical data, 3) Updating reviews on access to healthcare for disabled people. We will then collaborate with disabled people and health professionals to use this information to adapt the PLA approach for disabled people. We will decide who should facilitate the groups, where they should meet, and how to adapt PLA delivery and materials. Five PLA-D groups will be established, each including about 20 disabled people. We will assess whether they are feasible to run or need further adaptations. We will then undertake a trial to assess whether PLA-D is effective. We will identify 128 clusters (villages or city blocks) in Luuka district, and randomly assign them to be in the intervention or control group. In the control group, we will help to strengthen the health system, by undertaking an accessibility audit of health facilities and providing training on disability to healthcare workers. In the intervention group we will establish one PLA-D group per cluster, as well as the health system strengthening activities. We will interview all disabled people in the study about health and healthcare access at baseline and follow-up (1 year and 2 years), and record if any participants had died. The intervention and control groups will be compared to assess whether mortality rates were lower and health/healthcare access better in the intervention groups than among controls, and what the cost was for the outcomes achieved. Community engagement is at the heart of PLA as well as the Disability Movement with its ethos “Nothing about us, without us”. We will include disabled people as advisors at every stage, and as researchers wherever possible. We will hold community meetings and with disabled people’s organisations. We will engage with policy and programme implementers, both in Uganda and internationally, by producing short documents of key findings and holding meetings. We will reach academics through publishing articles in journals and presenting at meetings and conferences. Objectives: To use an evidenced-based approach to co-create PLA-D. To assess the feasibility of PLA-D implementation. To undertake a cluster-based Randomised Controlled Trial (RCT) to assess the effectiveness/cost-effectiveness of PLA-D in reducing mortality. To undertake a process evaluation of PLA-D to understand mechanisms for impact and scale-up. To strengthen capacity for informing disability policy and practice through the conduct of high-quality research. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Uganda Medical research Research and Innovation 138654 318330 422794 395064 292809 283531 133078 138654 GB-GOV-10-RP_04_301621 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 104277 GB-GOV-10-RP_04_301621 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 1984260 GB-GOV-10-RP_04_301621 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 71872 GB-GOV-10-RP_04_301621 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 71872 GB-GOV-10-RP_04_301621 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 70309 GB-GOV-10-RP_04_301621 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 115705 GB-GOV-10-RP_04_301621 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 116976 GB-GOV-10-RP_04_301621 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 117323 GB-GOV-10-RP_04_301621 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 116722 GB-GOV-10-RP_04_301621 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 64480 GB-GOV-10-RP_04_301621 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 109604 GB-GOV-10-RP_04_301621 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 80161 GB-GOV-10-RP_04_301621 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 90251 GB-GOV-10-RP_04_301621 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 91244 GB-GOV-10-RP_04_301621 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 85817 GB-GOV-10-RP_04_301621 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 73503 GB-GOV-10-RP_04_301621 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 79182 GB-GOV-10-RP_04_301621 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-RP_04_301627 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship scheme is open to all professions and Higher Education Institutions in England and the Devolved Administrations, to nominate health researchers and methodologists with an outstanding clinical and applied health research record and its effective translation for improved health. Global Research Professors are required to have existing strong links with partners in institutions in countries on the OECD DAC list and the award should plan to support training and capacity development in these partners. To address Healthcare Associated Infection (HAI) in Africa, I will use cutting edge molecular microbiology and mathematical modelling to investigate the implementation of the WHO framework for Infection Prevention and Control (IPC) in Malawi. Key to this will be the development of equitable partnerships with the Ministry of Health and College of Medicine. I will use the data to develop effective, acceptable and scalable interventions to reduce HAI in Africa. Hospitals are perceived as places of safety, however the concentration of vulnerable people, staff and visitors makes maintaining safety a major challenge that requires the involvement of multiple professional groups and patients, staff and visitors. Infections contracted because of admission to hospital, or exposure to other healthcare facilities are the most common adverse outcome associated with healthcare settings globally. Further, the germs, specifically bacteria, associated with HAI are increasingly resistant to antibiotics, making the treatment of HAI an increasing challenge. It is therefore best to prevent HAI. IPC is the term used to describe strategies to prevent HAI and the WHO has published a substantial body of work to support the implementation of IPC in low- and middle-income countries (LMIC). However, HAI and IPC are often not prioritised in LMIC due to lack of resources and multiple competing priorities. I will work in three government hospitals in Malawi. The project will be based at the Malawi Liverpool Wellcome Programme and will run in partnership with the College of Medicine, Ministry of Health and African Institute of Development Policy (AFIDEP). I will implement my project in 4 workstrands: 1) Implementing IPC strategy: The priority will be to convene a national steering group to build an equitable partnership and reinvigorate existing ministry of health IPC teams. We will assess previous IPC strategies. I will conduct clinical and laboratory surveillance of HAI before implementing an IPC programme co-created with partners. Assessment of effectiveness of the implementation will be made and shared with policy makers. 2) Using mathematical modelling to understand the intervention: I will recruit cohorts of patients with different types of HAI and study them in-depth by capturing comprehensive patient and bacterial data before and after implementation for key HAI syndromes. I will use cutting edge microbiological tools and mathematical methods to analyse these data and iteratively improve the IPC programme. 3) Health economics: We will estimate the cost of HAI, and then evaluate cost effectiveness of interventions to enable policy makers to make recommendations about targeting efforts. 4) Policy: We will actively involve MoH and CoM throughout the project, co-creating nationally scalable IPC interventions. We will involve patents and the public in co-producing IPC strategy and interventions and in doing so raise the profile of HAI, IPC and AMR in Malawi, in partnership with MLW’s community advisory group. Our findings will be shared with the WHO Infection Prevention team and more broadly to the academic community through presentation and peer-reviewed publication. We will engage with the public through MLW’s communications team, using radio, print and social media, and share information with hospitals through peer education meetings, and with the Ministry of Health through relevant technical advisory groups. Objectives In equitable partnership with a national-level IPC steering group, to reinvigorate local IPC teams in three hospitals in Southern Malawi; Establish clinical and microbiological HAI surveillance, then implement, test and improve the WHO guidelines on IPC, investigating their effectiveness within an implementation science framework; Assess the efficacy of IPC implementation using descriptive epidemiology, high resolution molecular surveillance and causal inference; To estimate the economic burden associated with HAI, and cost-effectiveness of IPC Co-create acceptable, sustainable, and nationally generalisable guidelines, policy and protocols to mitigate HAI in Malawi in partnership with College of Medicine and Public Health Institute of Malawi. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 355307 402187 405694 406978 344565 117787 GB-GOV-10-RP_04_301627 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 88583 GB-GOV-10-RP_04_301627 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 1914731 GB-GOV-10-RP_04_301627 COMMITMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 89557 GB-GOV-10-RP_04_301627 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 93538 GB-GOV-10-RP_04_301627 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 99169 GB-GOV-10-RP_04_301627 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 100271 GB-GOV-10-RP_04_301627 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 101373 GB-GOV-10-RP_04_301627 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 101577 GB-GOV-10-RP_04_301627 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 100869 GB-GOV-10-RP_04_301627 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 33100 GB-GOV-10-RP_04_301627 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 35346 GB-GOV-10-RP_04_301627 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 134591 GB-GOV-10-RP_04_301627 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 135961 GB-GOV-10-RP_04_301627 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 130660 GB-GOV-10-RP_04_301627 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 127832 GB-GOV-10-RP_04_301627 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 133664 GB-GOV-10-RP_04_301627 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-RP_04_301634 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship scheme is open to all professions and Higher Education Institutions in England and the Devolved Administrations, to nominate health researchers and methodologists with an outstanding clinical and applied health research record and its effective translation for improved health. Global Research Professors are required to have existing strong links with partners in institutions in countries on the OECD DAC list and the award should plan to support training and capacity development in these partners. My goal is to bring the benefits of recent advances in HIV prevention to stem the HIV epidemic and its negative impact on young people in South Africa. I will do this through a peer-led community-based package of biomedical HIV prevention and psychosocial support that is tailored to young persons’ need. Despite huge advances in HIV treatment and prevention, HIV related ill-health and death remains a huge problem in South Africa. 7.7 million people are living with HIV and young people bear the brunt of both the health and socioeconomic impact of the HIV pandemic. The anticipated doubling in number of young people over the next twenty years underscores the urgency of developing scalable models of delivering HIV prevention alongside treatment. The study will be conducted amongst men and women aged 16-30 living in a poor, rural area of KwaZulu-Natal: In the first 18 months we will use participatory research to optimise Thetha Nami (a peer-navigator delivered HIV prevention intervention for young people). We will: a) optimise the peer navigator needs assessment tool so that vulnerable and at risk individuals receive more support b) refine the social support and peer mentorship components of the intervention c) establish safe clinical pathways for delivery of sexual health self-care to young people d) identify ways to use routine service use data to identify groups that need increased support In the second 30 months we will test this intervention in a randomised controlled trial. 3000 men and women aged 16-30 will be selected at random from the study area, ensuring gender and age balance. If they agree to participate they will be randomly offered one of four intervention combinations: a) usual care: clinic based HIV testing and treatment if positive and biomedical prevention if negative; b) the peer-led biosocial intervention c) the sexual health self-care kit and d) combination of the peer-led intervention and sexual health self-care kits. The participants will then be followed up after 24 months for an interviewer administered survey and a finger prick test for HIV. The main outcome is the effect of the interventions on reducing sexually transmissible HIV. This is defined as participants remaining HIV negative, or, if living with HIV, starting antiretroviral therapy and having an undetectable HIV viral load. We will also measure the effect of the intervention/s on sexual and mental health and quality of life. We involved patients and the public to iteratively co-create the peer-led intervention. We will engage young people throughout the study. This will include strengthening the youth advisory component of our community advisory board, delivery of interventions through peer-navigators, and involvement of youth on the project steering committee. I will use participatory dissemination workshops to understand enablers and ensure that these interventions are equitable in their reach. The final output will be a well-defined and scalable implementation strategy to reduce the negative impact of HIV on youth in South Africa. It will comprise a feasible approach to identify those at risk, and then deliver an intervention to improve uptake and effective use of HIV prevention and care. By engaging our technical advisory group, which includes service users and providers and health policy makers, we are confident that we will generate the evidence needed to scale-up the interventions. Aims and objectives: The goal of my fellowship is to stem the HIV epidemic and it’s negative impact on young people in SA through effective implementation of advances in HIV prevention. Specific aim one: I will use community based participatory research to optimise risk-differentiated and tailored biosocial HIV prevention for young people in rural KZN Optimise the risk-differentiation (where more vulnerable and at risk individuals receive more support), and the psychosocial components of the intervention delivered by the peer navigators Establish safe clinical pathways to support decentralised PrEP, ART, and sexual health selfcare Use routine service use data to identify groups that need increased support Specific aims two: I will use a 4X2 factorial randomised controlled trial and process evaluation to evaluate the effectiveness and scalability of risk-differentiated and tailored biosocial HIV prevention delivered by peers to reduce the prevalence of sexually transmissible HIV among 16-30-year-old men and women Evaluate the effectiveness and cost effectiveness of the risk-differentiated and tailored biosocial HIV prevention delivered by peers to reduce the prevalence of transmissible HIV Conduct a process evaluation of the acceptability, feasibility, and equitable reach of each component of the intervention UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU South Africa Medical research Research and Innovation 408580 469609 476770 348237 244986 1948182 GB-GOV-10-RP_04_301634 COMMITMENT UK - Department of Health and Social Care (DHSC) University College London 171268 GB-GOV-10-RP_04_301634 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) University College London 102985 GB-GOV-10-RP_04_301634 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) University College London 100746 GB-GOV-10-RP_04_301634 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 111850 GB-GOV-10-RP_04_301634 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 118044 GB-GOV-10-RP_04_301634 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 118044 GB-GOV-10-RP_04_301634 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 116761 GB-GOV-10-RP_04_301634 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 118172 GB-GOV-10-RP_04_301634 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 120172 GB-GOV-10-RP_04_301634 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 120172 GB-GOV-10-RP_04_301634 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 117560 GB-GOV-10-RP_04_301634 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 97385 GB-GOV-10-RP_04_301634 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 87775 GB-GOV-10-RP_04_301634 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 87775 GB-GOV-10-RP_04_301634 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 85867 GB-GOV-10-RP_04_301634 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 69565 GB-GOV-10-RP_04_301634 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London GB-GOV-10-RP_05 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)’s fifth Global Research Professorship call. The Global Research Professorships programme funds research leaders, with a track-record of applied health research in low- and middle-income countries (LMICs), to promote effective translation of research and to strengthen research leadership at the highest academic levels. Funding of up to £2m over up to 5 years is awarded to Professors working in close partnership with a research institution in an LMIC. By the end of the award, NIHR Global Research Professors will be expected to: 1) Have demonstrated research leadership at a national and/or international level. 2) Have been developed and protected by their institutions, including being relieved of administrative tasks. 3) Enhance existing and establish new research collaborations in low- and middle-income countries (LMICs). 4) Have supported training and capacity strengthening/mentorship within LMIC and UK (if applicable) institutions that enhances research capacity for future global health and care research. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Bristol University of KwaZulu-Natal London School of Hygiene and Tropical Medicine University College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-RP_05_302394 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship (GRP) scheme is open to all professions and all Higher Education Institutions (HEI), based in UK and low-and-middle-income-country (LMIC), to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. Thanks to advances in health and sanitation, around the world people are living longer than ever before, with the greatest changes happening in Africa. In these added years of life, older people understandably want health and wellbeing, that is ‘healthy ageing’. However, currently many African countries, with challenged healthcare services and limited resources, are struggling to provide for their rapidly ageing populations, meaning older people are more likely to be living with disability and dependence. The World Health Organization (WHO) describes healthy ageing as an older person’s ability to walk, see and hear, and function mentally within the place they live. As countries develop health services to meet the growing needs of ageing populations, there is an opportunity now to proactively plan innovative ways of providing healthcare to help people age well. I have an established research network across The Gambia, South Africa and Zimbabwe on which to build this research programme. I want to understand why some people age healthily and some ‘unhealthily’ in these three very different countries, and then develop a ‘Healthy Ageing Check-up’, run by nurses and therapists in local communities, where older people can be assessed and offered practical management to maintain health as they age. Initially my team and I will analyse information collected from 5030 older adults across the three countries, to understand how commonly people are ageing healthily (and unhealthily), and how this influences quality of life. We will then look at what diseases particularly pre-dispose someone to unhealthy ageing, which we should address in our healthy ageing check-ups. State-of-the-art blood tests for molecules reflecting how our bodies work, will help us understand the underlying processes behind how these diseases affect the way we age. We will then work with a range of stakeholders, healthcare experts and older people themselves, to develop a health check-up for people aged 65 years and older, that we will test in Zimbabwe. The check-up will assess for example, walking, balance, nutrition, memory, mood, eyesight, and hearing. We expect most older people will have problems in several areas. When we identify a problem we will offer advice, practical solutions and if needed arrange specialist referral. We will test how well the roll-out of this system of health checks works, for example how often we identify a health problem, how often we can offer a solution and, when we follow them up again after 4 months, how frequently the older person has taken up the recommendations. In theory access to public healthcare is free to older people in Zimbabwe. As well as calculating how much it costs to provide the health check-ups and care, we will see if people experience extra ‘out-of-pocket’ costs because of the health checks, and if so, the reasons for this. Finally, working with the WHO, we will develop a ‘Healthy Ageing Intervention Toolkit’ to guide the structured, comprehensive, person-centred assessment and management of older people, ready for scale-up across sub-Saharan Africa. Over the 5 years, I will grow a highly-skilled and experienced Global Health and Ageing Research team to ensure positive impacts on older people’s health for many years to come. 1. To evaluate ‘healthy ageing’ in three diverse settings in sub-Saharan Africa (The Gambia, Zimbabwe, South Africa): a. Quantifying healthy ageing and generating T-Scores to enable rural-urban and inter-country comparisons. b. Understanding associations between healthy ageing and key outcomes including health-related quality of life (HRQoL), food insecurity and household wealth c. Determining drivers of ‘unhealthy ageing’, particularly multimorbidity clusters that associate with adverse ageing profiles d. Describing the metabolomic ‘signatures’ of healthy and unhealthy ageing in these three diverse populations. 2. To develop a healthy ageing screening and intervention programme for community-dwelling older adults which addresses challenges to functional ability. 3. To determine the feasibility, acceptability, effectiveness and costs of introducing community-based health checks of functional ability for older people in Zimbabwe. 4. Through community engagement and involvement (CEI), co-design and implement community-based healthy ageing peer-to-peer support groups, to promote and maintain functional ability by facilitating self-management. 5. To develop a ‘Healthy Ageing’ Intervention Toolkit guiding a structured, comprehensive, person-centred approach for non-specialist assessment and management of functional ability in older people living in sub Saharan Africa. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Bristol UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 307524 441271 547374 444879 247912 1988960 GB-GOV-10-RP_05_302394 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Bristol 76461 GB-GOV-10-RP_05_302394 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 77301 GB-GOV-10-RP_05_302394 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 77301 GB-GOV-10-RP_05_302394 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 76461 GB-GOV-10-RP_05_302394 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 110016 GB-GOV-10-RP_05_302394 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 111224 GB-GOV-10-RP_05_302394 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 111224 GB-GOV-10-RP_05_302394 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 136469 GB-GOV-10-RP_05_302394 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 137968 GB-GOV-10-RP_05_302394 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 137968 GB-GOV-10-RP_05_302394 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 134969 GB-GOV-10-RP_05_302394 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol 110915 GB-GOV-10-RP_05_302394 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Bristol GB-GOV-10-RP_05_302418 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship (GRP) scheme is open to all professions and all Higher Education Institutions (HEI), based in UK and low-and-middle-income-country (LMIC), to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. Vision: All children and adolescents with asthma in Africa having equitable access to affordable and effective care. Aims: My overall aim is to improve access to effective and affordable care for children and adolescents with asthma in Africa. Around 1 in 10 children and adolescents have asthma and mortality from asthma in some African countries is 100 times that in the UK. Medications to reduce suffering and death have been available for over half a century, but these have largely been unavailable in Africa. Quality data on prevalence and cost of care are largely unavailable resulting in low prioritisation by policymakers. These inequities warrant urgent intervention. A recent change in asthma management recommends against use of asthma relievers (reliefs airways obstruction) inhaler therapy alone based on disproportionately high deaths associated with their excessive use. Combination inhalers which include both a controller (treatment to prevent airway swelling) medication usually corticosteroids and fast-acting relievers (β2-agonist) are now widely accepted and endorsed as the first step in the treatment ladder, but are inaccessible in Africa. Design and methods: Individually randomised controlled trial of the clinical-and cost-effectiveness of a pragmatic single inhaler-based approach to asthma management in poor rural South African setting. Population: Children and adolescents 6-18 years, who have had ≥1 asthma attack in the last 12 months. A total of 2028 will be included with equal numbers in the intervention and the control group. Intervention: An easy to use strategy of an inhaled corticosteroid/ fast-onset β2-agonist (ICS/LABA) inhaler for symptom relief (reliever) as well as for maintenance (controller) therapy. Control: Local standard asthma care Primary outcome: Severe asthma attack defined as any asthma attack that requires medication with oral or intravenous corticosteroids. Time: 12 months’ follow-up. I will conduct a multi-country cross-sectional study to determine the prevalence and risk factors for asthma in children and adolescents in three African countries, with a view to create an African Asthma Observatory. I will collect data with standardised tools Global Asthma Network (GAN) methodology with a self-administered written and video questionnaire on symptoms of asthma, allergic rhinitis, eczema and environmental questions. In addition, a list of questions on risk factors tailored for the African setting will be included. Patient Public Involvement: Pilot work from focus groups with patients and carers of the NIHR Global Group Achieving Control of Asthma in Children in Africa (ACACIA) informed the research. Half of the asthmatics experienced severe symptoms which affected participation in sport, school and leisure activities. Asthmatics also expressed a need for effective, easy to use inhalers. A pilot on the prevalence of asthma in the uMkhanyakude community with the Vukuzazi health camp by Africa Health Research Institute where I propose to perform the clinical trial found than only 55% of adolescents with asthma symptoms had a diagnosis. I will adapt the NIHR INVOLVE information for participation in clinical trials to isiZulu to ensure equitable participation. Community stakeholders and service-users will be engaged throughout the project. 1. To determine the clinical and cost effectiveness of ICS/LABA compared to standard asthma care 2. The determine the prevalence and risk factors for asthma in adolescents in Africa 3. To create an observatory for asthma for Africa 4. To establish opportunities for early career researcher in Africa to strengthen research capacity 5. To advocate for access and effective medications for asthma for African children and adolescents. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of KwaZulu-Natal UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 19878 203375 612648 612119 467680 84024 1999724 GB-GOV-10-RP_05_302418 COMMITMENT UK - Department of Health and Social Care (DHSC) University of KwaZulu-Natal 81535 GB-GOV-10-RP_05_302418 2023/24 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of KwaZulu-Natal 30997 GB-GOV-10-RP_05_302418 2023/24 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of KwaZulu-Natal 110721 GB-GOV-10-RP_05_302418 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of KwaZulu-Natal 152086 GB-GOV-10-RP_05_302418 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of KwaZulu-Natal 153757 GB-GOV-10-RP_05_302418 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of KwaZulu-Natal 153757 GB-GOV-10-RP_05_302418 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of KwaZulu-Natal 59826 GB-GOV-10-RP_05_302418 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of KwaZulu-Natal 156148 GB-GOV-10-RP_05_302418 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of KwaZulu-Natal 157864 GB-GOV-10-RP_05_302418 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of KwaZulu-Natal 157864 GB-GOV-10-RP_05_302418 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of KwaZulu-Natal 140243 GB-GOV-10-RP_05_302418 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of KwaZulu-Natal 134263 GB-GOV-10-RP_05_302418 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of KwaZulu-Natal GB-GOV-10-RP_05_302421 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship (GRP) scheme is open to all professions and all Higher Education Institutions (HEI), based in UK and low-and-middle-income-country (LMIC), to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. Problem drinking affects large numbers of individuals and their families across the world. It also leads to social harm through violence, loss of work, and increased direct law enforcement and healthcare costs. As India and other similar countries become more affluent, drinking is becoming more common. Furthermore, the harms related to drinking are disproportionately affecting the poorest in society. Despite this burden of problem drinking, only one out of ten such drinkers has any access to appropriate care in India. This is due to the inability of our health systems to successfully integrate and scale-up effective treatments in a sustainable manner. Through my programme I aim to bridge this gap between 'what works' and 'how to make it work at the population level' by developing contextually-relevant strategies to guide the translation of such research evidence in low resource settings. I will do this by using the lessons learnt in a series of research studies conducted in India. In one study I will first develop and then test a contextually relevant and scalable intervention that caters to the various levels of severity of problem drinking and also engages the families of those with drinking problems to enhance entry into and adherence to the treatment. In the other study I will test how engaging communities in care allows greater engagement in care and consequently better outcomes in those with depression. While investigating if these interventions work in real-world settings, I will also examine the various strategies required to prepare the health-systems for efficiently and sustainably integrating these interventions into routine healthcare delivery. All these studies will include a systematic engagement with a range of community stakeholders including service users, their families, clinicians, community leaders, and policy makers. All these stakeholders will be equal partners in the research and will actively contribute to the design and implementation of the studies. The studies will be designed so that they are responsive to inputs of the stakeholders and felt needs of the communities in which they will be implemented. In parallel with all these studies, I will coordinate a systematic process, involving various stakeholders, through which I will consolidate the lessons learnt from the individual studies to develop a guidance document to aid the efficient scaling-up of psychosocial interventions in low resource settings. The short-term impact of the programme will be the benefits accrued by the study participants receiving the psychosocial interventions, and contextually relevant knowledge generated about ‘what works’ i.e. psychosocial interventions for problem drinking. The long-term benefits beyond the duration of the programme, and also beyond India, will be through the knowledge generated on how to sustainably scale up effective programmes so that they are easily accessible to those who need them. Study 1 (Development of Alcohol Problems Treatment Plus (APT+)): Using systematic and evidence-based intervention development processes I will integrate interventions developed in the study setting into a single integrated intervention (APT+). The process will include consultations with various stakeholders such as expert clinicians, individuals with drinking problems, and family members; followed by evaluation of acceptability and feasibility through treatment cohorts using process evaluation and in-depth interviews with the various stakeholders. Study 2 (Integrated Care for Alcohol Problems): hybrid effectiveness-implementation RCT with two arms comparing treatment as usual (TAU) with APT+. Study 3 (IMPRESS): hybrid implementation cluster RCT which will compare two task-sharing models for delivering a psychological intervention by non-specialist health workers, i.e. as a stand-alone intervention in public-sector primary care clinics versus being integrated with an evidence-based community intervention delivered by community based agents aimed at increasing demand for care and improving treatment adherence and effectiveness. Study 4 (Bench to Bedside-B2B): I will systematically review lessons learnt from ICAP and IMPRESS and consolidate them into strategies using a systematic process which includes triangulation of data from nested qualitative studies and process data from the two studies, Delphi process with implementation science experts, and semi-structured interviews with key stakeholders, including policymakers. Community engagement/Dissemination A range of community stakeholders will actively contribute to the intervention development and/or implementation and testing as equal partners. Through rapid feedback loops integrated into the study design; and involving participatory research and dissemination through various channels, we will ensure that the study outputs are responsive to inputs and felt needs of the communities in which they will be implemented. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU India Research for prevention and control of NCDs Research and Innovation 352940 429439 420662 299661 296853 1799555 GB-GOV-10-RP_05_302421 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 87753 GB-GOV-10-RP_05_302421 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 88717 GB-GOV-10-RP_05_302421 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 88717 GB-GOV-10-RP_05_302421 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 87753 GB-GOV-10-RP_05_302421 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 107066 GB-GOV-10-RP_05_302421 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 108242 GB-GOV-10-RP_05_302421 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 108242 GB-GOV-10-RP_05_302421 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 104877 GB-GOV-10-RP_05_302421 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 106030 GB-GOV-10-RP_05_302421 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 106030 GB-GOV-10-RP_05_302421 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 103725 GB-GOV-10-RP_05_302421 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 74710 GB-GOV-10-RP_05_302421 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-RP_05_302422 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship (GRP) scheme is open to all professions and all Higher Education Institutions (HEI), based in UK and low-and-middle-income-country (LMIC), to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. Vision: to improve the health of newborns and children by building equitable institutional partnerships through which global learning and innovation can flourish. The scientific gap I will address is how to improve newborn care in health facilities in low-resource settings. Every year, around two thirds of the 2.4 million deaths occurring within the first month of life and half of the 2 million stillbirths are likely avoidable by ensuring that the most generalisable (already-well-described) clinical pathways are delivered. Over the last 7 years I have been working with: families, healthcare providers, software developers, data scientists and the Ministries of Health in Zimbabwe, Malawi and the UK, to co-develop a data driven quality improvement system for hospital-based newborn care. Neotree is a tablet-based application developed with and for nurses and doctors to give better care to newborns, especially in low-resource settings where most newborn health care is delivered by those with little or no training in newborn health. The app guides the healthcare provider through clinical history taking and examination for sick and small babies, providing educational messaging and prompts. This straightforward combination of the key data, education and guidelines is incredibly powerful: not just because it can improve the result for each individual baby, but also because the data can be sent onward to local and national data stores allowing doctors and nurses to look at data for their own population and then improve the guidelines. Neotree is open source, and all data captured by the system are owned locally. As of 19/11/2021 the Neotree has been used in two countries to assist the care of ~16,000 newborns by more than 350 healthcare professionals and has been shown to improve quality of care (e.g. more targeted and evidenced based prescription antibiotics). Plans and funding applications for larger scale testing to assess impact on mortality are underway (out of scope for this application). Through this Professorship I will extend Neotree to the care of the mother and baby during birth and the care of babies born in rural primary care clinics in Zimbabwe. In addition, I will substantially improve two existing areas: how to use data from the Neotree to improve guidelines, and how we work with families and parents to create partnerships in care - in particular we will find out how best to involve parents in feeding babies and keeping them warm. I will increase the number of African researchers who are able to conduct research in digital innovation, newborn care and community engagement through (i) supervision and mentorship of African PhD and Masters students and clinicians; (ii) ensuring the Neotree data are curated, easily accessible and reusable and (iii) delivering a 2-year programme in engaging families and communities in newborn research and care. The latter will build on work we have conducted over the last 6 months with families and ArtGlo Africa, a Malawian based participatory arts group, to empower families as active participants in healthcare and research and to strengthen community engagement in newborn care in Malawi and Zimbabwe. I will also mentor a junior researcher in UK-focused community child health. 1. Extend Neotree to new outcomes (quality of perinatal care) and populations (rural health clinics) to help with the care of over a million babies and mothers annually in Zimbabwe and Malawi. 2. Substantially improve neonatal outcomes in communities already using Neotree by optimising clinical care pathways for thermoregulation, convulsions, low birth weight, prematurity, hypoglycaemia, HIV, respiratory distress, neonatal encephalopathy, sepsis, syphilis, jaundice and congenital abnormalities. 3. Actively and explicitly involve families in newborn care research and also in the co-creation of family centred clinical pathways. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 103301 435411 473760 457458 428329 233413 2000730 GB-GOV-10-RP_05_302422 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University College London 207750 GB-GOV-10-RP_05_302422 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 105597 GB-GOV-10-RP_05_302422 2023/24 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 105597 GB-GOV-10-RP_05_302422 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 119768 GB-GOV-10-RP_05_302422 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 119768 GB-GOV-10-RP_05_302422 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 121084 GB-GOV-10-RP_05_302422 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 121084 GB-GOV-10-RP_05_302422 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 111824 GB-GOV-10-RP_05_302422 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 113066 GB-GOV-10-RP_05_302422 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 114309 GB-GOV-10-RP_05_302422 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 114309 GB-GOV-10-RP_05_302422 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 130942 GB-GOV-10-RP_05_302422 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University College London 83039 GB-GOV-10-RP_05_302422 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 83962 GB-GOV-10-RP_05_302422 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London GB-GOV-10-RP_06 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)’s sixth Global Research Professorship call. The Global Research Professorships programme funds research leaders, with a track-record of applied health research in low- and middle-income countries (LMICs), to promote effective translation of research and to strengthen research leadership at the highest academic levels. Funding of up to £2m over up to 5 years is awarded to Professors working in close partnership with a research institution in an LMIC. By the end of the award, NIHR Global Research Professors will be expected to: 1) Have demonstrated research leadership at a national and/or international level. 2) Have been developed and protected by their institutions, including being relieved of administrative tasks. 3) Enhance existing and establish new research collaborations in low- and middle-income countries (LMICs). 4) Have supported training and capacity strengthening/mentorship within LMIC and UK (if applicable) institutions that enhances research capacity for future global health and care research. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University College London Wits Health Consortium (Pty) Limited The University of Edinburgh Africa Health Research Institute Keele University Liverpool School of Tropical Medicine University of Oxford UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-RP_06_303125 UK - Department of Health and Social Care (DHSC) AIM: The scientific challenge I will address is how to better identify people living with chronic respiratory diseases (CRDs) in low- and middle-income countries (LMICs). Specifically, I will demonstrate the ability to reliably identify previously un-diagnosed CRDs in people attending clinics for other conditions such as high-blood pressure and diabetes in San Carlos, Brazil. I will also demonstrate that identifying chronic obstructive pulmonary disease (COPD) and asthma in this way benefits those affected and society. This project has 5 aims: AIM-1: Determine the patterns and time-sequence of acquiring other medical conditions in people with chronic respiratory diseases (CRDs). This will be achieved by applying a novel mathematical approach to our existing, large random population dataset of 10,664 people. AIM-2: Assess the accuracy of simple chronic obstructive pulmonary disease (COPD) case-finding questionnaires to find people with un-diagnosed CRDs in community-based high-blood pressure and/or diabetes clinics in Brazil. We will enrol 859 people from such clinics, use casefinding questionnaires to measure CRD risk, and compare this against a gold-standard diagnosis using spirometry. AIM-3: Assess if CRD case-finding questionnaires can be successfully used by clinicians in community high-blood pressure and/or diabetes clinics in Brazil. We will ask four clinicians at each of five clinics to use the questionnaire in 50 patients each (1,000 people in total). We will test how well they use the questionnaire and ask about ease of use. AIM-4: Investigate whether people identified using case-finding questionnaires as being at high-risk for CRDs in high-blood pressure and/or diabetes clinics are able to access health-care. We will re-contact people identified in AIMS 2 and 3 as being at high-risk for CRDs to see if they were able to access a confirmatory diagnosis and treatment six months later. AIM-5: Determine whether optimisation of care in people found to have COPD and asthma through case-finding is associated with improvement in their health and benefit to society. For people confirmed as having COPD and asthma in AIMS 3 and 4, we will recommend optimal care and measure health-status before and after six months. We will collect information on costs to tell us whether such an approach could be cost effective at scale. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University College London UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Brazil Research for prevention and control of NCDs Research and Innovation 29101 344610 365886 367445 372542 320142 1799726 GB-GOV-10-RP_06_303125 COMMITMENT UK - Department of Health and Social Care (DHSC) University College London 114527 GB-GOV-10-RP_06_303125 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University College London 86365 GB-GOV-10-RP_06_303125 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University College London 86365 GB-GOV-10-RP_06_303125 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 86454 GB-GOV-10-RP_06_303125 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 91198 GB-GOV-10-RP_06_303125 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 92200 GB-GOV-10-RP_06_303125 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 92200 GB-GOV-10-RP_06_303125 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 90288 GB-GOV-10-RP_06_303125 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London 91469 GB-GOV-10-RP_06_303125 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University College London GB-GOV-10-RP_06_303140 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship (GRP) scheme is open to all professions and all Higher Education Institutions (HEI), based in UK and low-and-middle-income-countries (LMICs), to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. This Global Research Professorship aims to reduce deaths caused by serious bacterial and fungal infections amongst adults living with Advanced HIV Disease (AHD) in Africa. The work is being done predominantly in South Africa, taking place between March 2024 and February 2029. In 2021, approximately 650,000 people died of AIDS-related causes, two-thirds in African countries. Serious bacterial and fungal infections cause a third of AIDS-related deaths at least on par with tuberculosis. The World Health Organization (WHO) recommends ways to reduce infection-related deaths in people with advanced HIV disease, their preferred term for AIDS. This includes taking a daily tablet antibiotic (cotrimoxazole) to prevent bacterial/ fungal infections, and a blood test plus a course of antifungal medicines for a fungal infection called cryptococcosis. The main work packages in this professorship are firstly to collect information using laboratory records on the number and causes of bacterial blood infections and meningitis among South African adults with advanced HIV disease, and at some hospitals, collect detailed information from patients and run additional tests directly on their blood samples plus any bacteria cultured from these samples. Secondly to test fluconazole and flucytosine treatment for cryptococcosis in a clinical trial, while meaningfully involving patients and the public in a study design to answer questions about acceptability and feasibility. And finally to evaluate new laboratory tests, which measure the amount of fungal genetic material in blood, to work out if such tests can: (a) identify patients with cryptococcosis at higher risk of meningitis, and (b) diagnose histoplasmosis/ emergomycosis. This project has three specific objectives: 1. Determine the burden, aetiological causes of, and risk factors for bacterial bloodstream infections/ meningitis, relative to cryptococcosis and tuberculosis, in a South African inpatient cohort with Advanced HIV Disease (AHD). 2. Evaluate fluconazole and flucytosine treatment for cryptococcal antigenaemia in a randomised-controlled trial (EFFECT), with added-value qualitative-methods research studies guided by patient and public involvement and engagement. 3. Evaluate novel quantitative molecular assays for risk stratification of subclinical cryptococcosis and early diagnosis of histoplasmosis/ emergomycosis. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Wits Health Consortium (Pty) Limited UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU South Africa Medical research Research and Innovation 23077 286317 444974 464559 513887 285818 2018632 GB-GOV-10-RP_06_303140 COMMITMENT UK - Department of Health and Social Care (DHSC) Wits Health Consortium (Pty) Limited 90818 GB-GOV-10-RP_06_303140 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Wits Health Consortium (Pty) Limited 68485 GB-GOV-10-RP_06_303140 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Wits Health Consortium (Pty) Limited 68485 GB-GOV-10-RP_06_303140 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Wits Health Consortium (Pty) Limited 81606 GB-GOV-10-RP_06_303140 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Wits Health Consortium (Pty) Limited 110628 GB-GOV-10-RP_06_303140 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Wits Health Consortium (Pty) Limited 111844 GB-GOV-10-RP_06_303140 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Wits Health Consortium (Pty) Limited 111844 GB-GOV-10-RP_06_303140 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Wits Health Consortium (Pty) Limited 110658 GB-GOV-10-RP_06_303140 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Wits Health Consortium (Pty) Limited 114284 GB-GOV-10-RP_06_303140 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Wits Health Consortium (Pty) Limited GB-GOV-10-RP_06_303157 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship (GRP) scheme is open to all professions and all Higher Education Institutions (HEI), based in UK and low-and-middle-income-country (LMIC), to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. Sexually transmitted infections (STIs), including HIV, cause a high morbidity and mortality burden in Southern and Eastern Africa. During pregnancy and post-partum, STIs have additional serious consequences. This is also a period when women are engaging with health services, presenting a window of opportunity for intervention, both to prevent immediate adverse consequences and to educate and empower for the future. Generating evidence-based guidance on sexual healthcare in pregnancy is a priority for the World Health Organization (WHO). To generate the evidence needed to inform sexual healthcare in pregnancy and post-partum, this Professorship will build on my well-established programme of research at the Botswana Sexual and Reproductive Health Initiative and a newer collaboration with the Malawi-Liverpool-Wellcome Trust Programme. We will conduct many different types of research to learn how to improve these services using better STI diagnostic tests. We will also design and evaluate an intervention for STI testing and treatment in pregnancy to improve care for women, their babies and their partners. Pregnancy and breastfeeding are a time of high risk for women getting HIV infection and passing HIV onto their babies. Treatments to prevent HIV in people at high HIV risk, called HIV PrEP, are already available and many more are being developed. We need to learn more about how to best deliver these treatments to pregnant and breastfeeding women. We will conduct research to understand women’s knowledge, needs, and preferences for HIV prevention in pregnancy. Using that information, we will design and test an intervention for HIV prevention in pregnancy to improve care for women, their babies and their partners. This work is being done between March 2024 and February 2030. At the end of this project, together with women, their partners, young people and healthcare providers, we will develop a ‘Better Sexual Health in Pregnancy’ intervention that is people-centred and based on scientific evidence. We will also set up a research site within public health services in Botswana to test the intervention, and to study the impact of other interventions in the future. This project has five specific objectives: 1. Public-patient involvement and engagement. A Community Engagement and Involvement Group and Community and Youth Advisory Boards will be appointed to map out the overall project priorities, goals, processes, review progress, and co-produce/co-design specific project activities and interventions. 2. Diagnostic-driven sexually transmitted infections (STI) management. STI services are often unavailable, inaccessible or inappropriate to populations in Africa; rely on ‘syndromic management’ which has been shown to be ineffective in controlling STIs; are not routinely informed by surveillance data; and often do not include care for sexual partners. We will conduct a series of mixed-method studies to address these challenges, developing and evaluating a patient-centred, diagnostic STI intervention, with cost-effectiveness assessments and antimicrobial resistance surveillance. 3. Preventing HIV-infection. HIV incidence is high during pregnancy and post-partum. Pre-exposure prophylaxis for HIV (PrEP) is critical, yet implementation models remain undefined. We will assess preferences for PrEP and HIV self-testing among HIV-uninfected pregnant and post-partum women and their partners using discrete choice experiments and qualitative methodologies. We will then co-design and test an intervention to improve PrEP and HIV self-testing using integrated delivery models. 4. Intervention and cohort. From Aim 1-3 outputs, we will co-create a people-centred, evidence-based ‘Better Sexual Health in Pregnancy’ intervention and a cohort infrastructure embedded within routine services in Botswana to test it, and ultimately to determine programmatic outcomes when delivered at scale. 5. Policy and practice. To maximise sustainable impact, we will engage key stakeholders and develop relationships and resources to influence regional and international policy and build a well-equipped advocacy network to drive progress beyond this Professorship. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The University of Edinburgh UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 16089 160396 416945 501003 483313 310092 119750 2007588 GB-GOV-10-RP_06_303157 COMMITMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 95916 GB-GOV-10-RP_06_303157 2024/25 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The University of Edinburgh 41235 GB-GOV-10-RP_06_303157 2024/25 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The University of Edinburgh 39334 GB-GOV-10-RP_06_303157 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 96547 GB-GOV-10-RP_06_303157 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 97607 GB-GOV-10-RP_06_303157 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 97607 GB-GOV-10-RP_06_303157 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 125184 GB-GOV-10-RP_06_303157 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh 125015 GB-GOV-10-RP_06_303157 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The University of Edinburgh GB-GOV-10-RP_06_303161 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship (GRP) scheme is open to all professions and all Higher Education Institutions (HEI), based in UK and low-and-middle-income-country (LMIC), to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. Despite advances in HIV treatment, HIV-related ill-health and death remains a huge problem in South Africa. The goal of HIV treatment is to keep the virus count/load (VL) in the blood very low or suppressed to ensure that HIV does not result in sickness, death or impact the growth and development of children during this critical stage in their lives. Despite advances in HIV treatment, children lag behind adults, with only 40% of children virally suppressed compared to 70% of adults. There is an urgent need to develop scalable models of delivering HIV treatment to optimise the number of virally suppressed children retained in care. The study will be conducted amongst people living with HIV in a poor, rural area (uMkhadyakude district) and an urban area (eThekwini district) of KwaZulu-Natal. The work is being done between March 2024 and February 2029. The aim of this work is to improve the outcomes of children and adolescents living with HIV in South Africa. I will do this through improved HIV treatments (biomedical) and develop a peer-led intervention with psychosocial support (biosocial intervention) tailored to this population. First, we will evaluate a peer-support intervention conducted either in-person or via mobile phone (mHealth) to support adolescents (15-19years) living with HIV transition to adult care where they need to be responsible for their own health. Second, we will develop and conduct a study to evaluate a peer-support intervention to support families of children (0-15years) living with HIV. During the first 12 months, we will use participatory research with patients and public involvement (PPI) to optimise a peer-navigator-delivered intervention for families. Thirdly, we will use a mixture of interviews with children, families and caregivers, service providers and peer navigators, and programme data to evaluate the implementation of the peer-support intervention at the clinic to understand the barriers and enabling factors. And finally, we will explore the perspectives of children, adolescents, caregivers, healthcare workers and policymakers on potential new long-acting HIV treatments to be developed in the future and establish a platform to evaluate them in primary healthcare settings. These will be used to inform the development of new generations of simplified treatment options. The study will consist of four work packages linked to the four main study aims: Aim 1: Using a stepped-wedge cluster randomised controlled trial, determine the effectiveness of in-person or mHealth-based adolescent-friendly transition interventions compared to standard care on retention in care and viral suppression among adolescents (aged 15-19) living with HIV who have low transition readiness. The study is funded by the National Institutes of Health (NIH) (InTSHA VIP Grant: R01MH131434). Aim 2: Using a stepped-wedge cluster randomised controlled trial to determine the effectiveness of the peer-led interventions with or without financial incentives with families and carers compared to standard care on retention in care and viral suppression among children (1month-14 years) living with HIV. The study will be conducted in the same sites as an NIH-funded adolescent study (InTSHA-VIP). It will leverage the clinic staff and study set-up but will adapt the intervention to be family-based with a younger cohort of participants. Aim 3: Using the Reach, Effectiveness, Adoption, Implementation, and Maintenance (RE-AIM) framework, determine the implementation factors involved in the provision of the interventions (aims 1 and 2). Aim 4: Conduct a nested acceptability and feasibility study to evaluate children, adolescents, caregivers, health care workers (HCWs), and policymakers' perceptions of novel antiretroviral treatment (ART) formulations in urban and rural settings in South Africa, including long-acting injectables and micro-array patches (MAP). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Africa Health Research Institute UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU South Africa Medical research Research and Innovation 99441 293202 453594 445311 361178 244066 1896792 GB-GOV-10-RP_06_303161 COMMITMENT UK - Department of Health and Social Care (DHSC) Africa Health Research Institute 131980 GB-GOV-10-RP_06_303161 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Africa Health Research Institute 99526 GB-GOV-10-RP_06_303161 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Africa Health Research Institute 99526 GB-GOV-10-RP_06_303161 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Africa Health Research Institute 61611 GB-GOV-10-RP_06_303161 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Africa Health Research Institute 110622 GB-GOV-10-RP_06_303161 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Africa Health Research Institute 111838 GB-GOV-10-RP_06_303161 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Africa Health Research Institute 231134 GB-GOV-10-RP_06_303161 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Africa Health Research Institute 110296 GB-GOV-10-RP_06_303161 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Africa Health Research Institute GB-GOV-10-RP_06_303164 UK - Department of Health and Social Care (DHSC) Aims: We aim to develop and establish early intervention for psychosis services in Pakistan and Sri Lanka and assess whether the service can help improve the health outcomes among people with first episodes of psychosis. We also aim to understand the factors that are associated with treatment resistant schizophrenia (TRS) and whether based on these factors we can develop a tool that can predict the likelihood of a patient developing treatment resistant schizophrenia. This project has 6 objectives: 1. To implement a culturally sensitive early intervention psychosis (EIP) service in Pakistan and Sri Lanka based on recent guidelines for managing first episode psychosis (FEP) adopted for low-and-middle-income (LMIC) settings. 2. Evaluate the implementation of EIP in maintaining engagement with the services, achieving remission in FEP, and other relevant implementation outcomes. 3. To assemble a cohort of FEP within the EIP service and identify potential predicting factors of treatment resistant schizophrenia at one-year follow-up. 4. To develop a prognostic model for estimating an individual's risk of treatment resistance at one year and to undertake the validation of the model's predictive performance. 5. To identify barriers and facilitators for the scale-up of the EIP at regional and international level. 6. To build capacity for implementation research and service development for youth mental health in LMICs. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Keele University UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 44074 304577 490794 476401 446963 229590 1992399 GB-GOV-10-RP_06_303164 COMMITMENT UK - Department of Health and Social Care (DHSC) Keele University 110919 GB-GOV-10-RP_06_303164 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Keele University 67580 GB-GOV-10-RP_06_303164 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Keele University 67580 GB-GOV-10-RP_06_303164 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 102572 GB-GOV-10-RP_06_303164 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 123082 GB-GOV-10-RP_06_303164 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 124435 GB-GOV-10-RP_06_303164 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 124435 GB-GOV-10-RP_06_303164 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 118842 GB-GOV-10-RP_06_303164 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University 118628 GB-GOV-10-RP_06_303164 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Keele University GB-GOV-10-RP_06_303165 UK - Department of Health and Social Care (DHSC) To work together with students to develop a self-care strategy that combines mHealth and decision aids and enables students to optimally use HIV and contraception services. The study is divided into five stages and builds on another study where a self-care strategy supported by an mHealth tool (without decision aids) was developed. In the first stage, we will conduct research to find out what students prefer a self-care strategy that is combined with decision aids to look like. In the second stage, we will use findings from the first stage to develop blueprints for two decision aids: one for contraception and the other for HIV prevention. In the next stage we will integrate the decision aids with the existing mHealth tool through a group activity that includes students and experts in health and mHealth. In the fourth stage we will test whether the whole self-care strategy, supported by the mHealth tool with decision aids, works well. Finally, in the fifth stage we will compare colleges/universities that use the self-care strategy with those that do not, to see whether promoting self-care results in more students taking up HIV and contraception services. We will also make recommendations on how the strategy can be provided outside colleges/universities. This project has 6 specific objectives: 1. Explore preferences for decision aids and how they can be incorporated into the existing self-care intervention. 2. Develop/adapt blueprints for human immunodeficiency virus (HIV) prevention and contraception decision aids according to student values/preferences. 3. Integrate the existing mHealth tool with decision aids for HIV prevention and contraception. 4. Determine feasibility and acceptability of MASCOT (mobile health (mHealth) supported self-care among tertiary education students in Zimbabwe) in two colleges/universities. 5. Determine the effectiveness of MASCOT in improving uptake of HIV and contraception services and its societal costs in a cluster randomised trial in 16 colleges/universities. 6. Explore how to adapt MASCOT for other settings. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Zimbabwe Medical research Research and Innovation 162930 429099 397909 383724 359802 247592 1981056 GB-GOV-10-RP_06_303165 COMMITMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 278944 GB-GOV-10-RP_06_303165 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 117289 GB-GOV-10-RP_06_303165 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 98974 GB-GOV-10-RP_06_303165 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 28172 GB-GOV-10-RP_06_303165 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 97898 GB-GOV-10-RP_06_303165 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 98974 GB-GOV-10-RP_06_303165 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 101623 GB-GOV-10-RP_06_303165 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 109414 GB-GOV-10-RP_06_303165 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 100518 GB-GOV-10-RP_06_303165 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-RP_06_303168 UK - Department of Health and Social Care (DHSC) The NIHR Global Research Professorship (GRP) scheme is open to all professions and all Higher Education Institutions (HEI), based in UK and low-and-middle-income-countries (LMIC), to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. This programme of work is being carried out in Kenya but will also include staff working in other African and Asian countries. The work is being done between March 2024 and February 2029. The programme of research will examine an essential but neglected ethics and social justice concern in global health research: How international research programmes can ensure fairer research processes that protect frontline staff from moral distress. The goal is to advance policy, practice and understanding of this neglected area and contribute to fairer research conduct, a more inclusive and creative research culture, and strengthened health and research systems. This project has four specific objectives: 1. Understand the nature and systemic drivers of moral distress experienced by frontline research staff and the health system staff who host them, and the functioning of support processes. 2. Co-design & evaluate strategies that promote fairness and that address moral distress among frontline research staff. 3. Explore the potential to extend support processes for research staff to health system colleagues experiencing similar distress and how promising interventions might be transferred and embedded into wider health systems. 4. Develop practical ethics and social justice guidance and toolkits targeting researchers and funders that take into account a) the expectations, rights and obligations of different stakeholders (frontline health and research staff, research managers) and b) ideas from promising interventions. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Oxford UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Kenya Medical research Research and Innovation 59579 148847 539306 501634 485587 346818 1999599 GB-GOV-10-RP_06_303168 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) University of Oxford 82172 GB-GOV-10-RP_06_303168 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) University of Oxford 21115 GB-GOV-10-RP_06_303168 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Oxford 61983 GB-GOV-10-RP_06_303168 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Oxford 62664 GB-GOV-10-RP_06_303168 2024/25 Q2 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) University of Oxford 62664 GB-GOV-10-RP_06_303168 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 135335 GB-GOV-10-RP_06_303168 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 136822 GB-GOV-10-RP_06_303168 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 136822 GB-GOV-10-RP_06_303168 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 130327 GB-GOV-10-RP_06_303168 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 124999 GB-GOV-10-RP_06_303168 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford GB-GOV-10-RP_07 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)’s seventh Global Research Professorship call. The Global Research Professorships programme funds research leaders, with a track-record of applied health research in low- and middle-income countries (LMICs), to promote effective translation of research and to strengthen research leadership at the highest academic levels. Funding of up to £2m over up to 5 years is awarded to Professors working in close partnership with a research institution in an LMIC. By the end of the award, NIHR Global Research Professors will be expected to: 1) Have demonstrated research leadership at a national and/or international level. 2) Have been developed and protected by their institutions, including being relieved of administrative tasks. 3) Enhance existing and establish new research collaborations in low- and middle-income countries (LMICs). 4) Have supported training and capacity strengthening/mentorship within LMIC and UK (if applicable) institutions that enhances research capacity for future global health and care research. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine University of Liverpool University of Cape Town University of Glasgow University of Oxford University of Glasgow UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-RP_07_304257 UK - Department of Health and Social Care (DHSC) The NIHR Global Health Research Professorship (GRP) scheme is open to all professions and all Higher Education Institutions (HEI), based in UK and low- and middle-income countries (LMICs), to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. Improving access to diagnosis has the potential to improve lives, particularly in settings where people are exposed to multiple chronic conditions and outbreaks of disease with high numbers of deaths and where health systems are under-resourced and over-burdened. Self-testing was effective in contributing to disease control during the COVID-19 pandemic and there have been global calls for action to improve access to diagnostics. Opportunities for self-care have increased with advances in technology and the private direct to consumer self-testing market is predicted to expand to 13.6 billion USD by 2033. This has potential to lead to unregulated and uncontrolled access through both public and private sources. However, self-testing can lead to equitable transformations in disease management and outcomes if used appropriately, presuming it is aligned to the wider social context and that it reaches marginalised and vulnerable populations who are appropriately informed. Self-testing has the potential to contribute to self-management of chronic conditions such as Human Immunodeficiency Virus (HIV) and non-communicable diseases such as diabetes and has been shown to aid in responsiveness to emergency disease outbreaks such as Ebola. Self-testing is an important element in country-level strategies to increase access to diagnostics but there remains a gap in evidence on how to do this. This project will contribute evidence from user perspectives to address this gap. I will focus on three examples of self-testing and self monitoring for infectious and non-communicable disease under different social conditions across two countries: Malawi and Uganda. I will establish a team of qualitative researchers across Malawi, Uganda and the UK in collaboration with two in-country institutions: Malawi-Liverpool-Wellcome Trust (Malawi) and the University of Makerere (Uganda). We will use in-depth qualitative methods (social mapping, ethnography, interviews and group discussions) and work directly with communities of users to understand the drivers of use of self-testing and self-monitoring under external conditions of stigma, emergency disease outbreaks and lifestyle and risk management. We will work together to explore how use of self-testing and self monitoring for HIV, diabetes and Ebola impacts on people’s lives and how they engage with care and treatment. We will develop community approaches that can be adopted to communicate appropriate use aligned to the needs of target populations and establish a pathway to advocate for user perspectives as countries develop national strategies for diagnostics. We will work to inform international guidance aimed at inclusive and equitable access to diagnostics that reflects actual use. The project aims to focus on understanding the potential and actual, intended and unintended harms and benefits and ‘rational use’ of self-testing for Human Immunodeficiency Virus (HIV), Ebola and Type 1 and Type 2 diabetes. I will situate this through the lived experiences of individuals, families, communities and frontline health workers and the impact on management of health and well-being at home and through interactions with the primary health system. The aims of this work are to: 1. Define and document social and structural drivers of ‘rational use’ under conditions of stigma, emergency disease outbreaks and lifestyle and risk management. unpack the dynamic between empowerment through self-testing and engagement with public and private health services. 2. Explore uncertainty, trust and risk influencing decisions, embedded within complex socio ecological environments and impact on intended and unintended, beneficial and potentially harmful health and social consequences. 3. Co-produce toolkits for ‘rational use’ of frontline diagnostics. 4. Promote health equity across mainstream and marginalised groups through ‘rational use’ of self-testing and monitoring that reflects direct to consumer markets. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 18526 233182 393687 381806 425182 261758 1714141 GB-GOV-10-RP_07_304257 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 72909 GB-GOV-10-RP_07_304257 2025/26 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 54980 GB-GOV-10-RP_07_304257 2025/26 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 54980 GB-GOV-10-RP_07_304257 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 68839 GB-GOV-10-RP_07_304257 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 98574 GB-GOV-10-RP_07_304257 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-RP_07_304266 UK - Department of Health and Social Care (DHSC) The NIHR Global Health Research Professorship (GRP) scheme is open to all professions and all Higher Education Institutions (HEI), based in UK and low- and middle-income countries (LMICs), to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. Exclusive breastfeeding is recommended by the World Health Organisation (WHO) for the first six months of life, because of benefits to the mother and child. However, globally around half of all women require treatment with some form of medication during breastfeeding. For all mothers, their first concern will be about potential consequences to the infant. A woman may stop breastfeeding before she wishes, or not take medication because of these concerns. This risks harm to both the mother and child. For decades, there has been recognition that everybody deserves access to the information they need to make an informed choice about their healthcare. But frequently, when a breastfeeding mother requires treatment with a medicine, that evidence simply does not exist. Studying drug safety and effectiveness in breastfeeding, so-called ‘lactation pharmacology’, is complicated. It requires breastfeeding mothers to trust the research team, and for the research team to have the skills and equipment to perform research that keeps the number of participants and biological sampling points to a minimum whilst maximising the information gained. Once the research is complete, the research team must also engage with policy makers to make sure that the results change healthcare practice. We aim to meet the critical need for better understanding of which drugs are safe for mother and infant during breastfeeding by establishing a centre of excellence for lactation pharmacology at the Infectious Diseases Institute in Uganda. This work builds on community priorities established in Uganda. Peer mothers and a public engagement officer will ensure community participation in research, including Citizens Juries, using street theatre to create messages and other approaches established during my previous work. Strategic partnership with the Oxford Centre for Research Equity will enable knowledge exchange, mentorship and training in equity in engagement. Through strategic partnership with the WHO and the South African Healthcare Products Regulatory Agency, my group will ensure rapid sharing of findings at policy level. We will also share results through presentations and publications, community-facing events, social media channels, stakeholder newsletters and posting on the webpages of the Uganda Chapter of Pharmacometrics Africa. This project will create a special research centre in Uganda focused on understanding which medications are safe for mothers and babies during breastfeeding. There are 5 key objectives: 1. To work with communities and decision-makers to understand which drugs we should study first. 2. Develop ethical and safe ways to include breastfeeding mothers in our studies, especially those who might be in more vulnerable situations, such as young mothers (14-17), those with mental health challenges, or mothers breastfeeding during an infectious disease outbreak. 3. Measure the transfer of specific medications, like antidepressants and antibiotics, into breast milk and, consequently, to the infant. 4. Create computer models that predict how likely certain drugs transfer into breast milk. 5. Be prepared to quickly study the safety and breast milk transfer of new drugs during a virus outbreak. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Uganda Medical research Research and Innovation 111121 407539 435742 416617 360161 249194 1980374 GB-GOV-10-RP_07_304266 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 99398 GB-GOV-10-RP_07_304266 2025/26 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Liverpool 209439 GB-GOV-10-RP_07_304266 2025/26 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Liverpool 102777 GB-GOV-10-RP_07_304266 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 107046 GB-GOV-10-RP_07_304266 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 108235 GB-GOV-10-RP_07_304266 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool GB-GOV-10-RP_07_304286 UK - Department of Health and Social Care (DHSC) The NIHR Global Health Research Professorship (GHRP) scheme is open to all professions and all Higher Education Institutions (HEI), based in UK and low- and-middle-income-countries (LMICs), to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Health Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. The main goal of this research is to understand, prevent and manage angioedema more effectively in sub-Saharan Africa (SSA). Angioedema is sudden swelling, often around the face and throat, which can be life-threatening if not treated quickly and correctly. In many African countries, while everyone is aware of diseases like HIV and malaria, not many know about angioedema. This condition, although less common, is becoming more frequent. Angioedemas have different causes with specific treatments, and most doctors are not equipped to diagnose and manage angioedemas. Angiotensin-converting enzyme inhibitors (ACEI) used to treat blood pressure are the commonest cause, and this side effect may be more common in African populations. There are no tools to predict or diagnosis ACEI-angioedema. Hereditary angioedemas, requiring targeted treatments, are under-diagnosed in SSA. The role of food-additives in damaging the gut barrier and causing angioedemas in an African context is unknown. This research aims to address these important gaps. Our research design and method is divided into three parts: 1. Developing a simple test for ACEI-angioedema - We are working on a test that could be used in clinics to identify people at risk of getting angioedema from their blood pressure medication. This test looks for specific proteins in urine samples. In this project we will validate the accuracy of these urinary proteins in diverse groups across SSA. We will also develop a prototype, low-cost lateral flow test that could be scaled for use in resource poor settings. 2. Improving how angioedema is managed and finding hereditary angioedema cases - Through engagement with healthcare workers, patients and communities we will form a strategy of targeted healthcare worker trainings, telemedicine allergy-specialist support and community-level advocacy with awareness campaigns that improve the management of acute angioedemas and diagnose new hereditary angioedema families across underserved SSA. 3. Studying the role of food additives in damaging the gut barrier and causing recurrent angioedema - Food additives may make angioedema worse by damaging the gut barrier. We will conduct a detailed study of patients with recurrent angioedema to understand the contributions of food additives and gut infections in causing angioedema. Patient engagement work will examine knowledge and barriers to low food-additive diets, and using this we will design a randomised controlled trial to see if a low-food-additive diet can heal the gut barrier and resolve angioedema. This research is important because angioedema can be life-threatening if not treated correctly, and currently ACEI-angioedema is the key safety issue that limits use of this life-saving medication across diverse African countries. We can save lives and valuable resources by improving angioedema diagnosis and management, and developing a low-cost predictive tool for ACEI-angieodema. Understanding food additives in gut barrier damage and angioedema, and the healing benefits of low additive diets would mean affordable, effective treatment, and data for advocacy around improve food additives regulations in SSA. This research has the potential to change lives, not just in Africa but in other parts of the world too. The overall focus of this research professorship is angioedemas in Africa. This project has 3 distinct, but interconnected objectives: 1. Develop an early prototype low-cost lateral flow urine test to identify patients at high-risk for Angiotensin-Converting Enzyme Inhibitors - AngioEdema (ACEI-AE). 2. Enhance the management of angioedema in sub-Saharan Africa (SSA), and diagnoses of hereditary angioedemas through a comprehensive, integrated approach combining community engagement, healthcare provider education, telemedicine-specialist support, and strategic partnerships with local and international organisations. 3. Determine the role and synergy between food additives, chronic gastrointestinal tract infections and altered gastrointestinal permeability in recurrent angioedemas and the impact and barriers to low-food-additive diets. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Cape Town UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 107937 390334 402721 387207 353027 242603 1883829 GB-GOV-10-RP_07_304286 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 203438 GB-GOV-10-RP_07_304286 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 96551 GB-GOV-10-RP_07_304286 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 98416 GB-GOV-10-RP_07_304286 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 99866 GB-GOV-10-RP_07_304286 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 100976 GB-GOV-10-RP_07_304286 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town GB-GOV-10-RP_07_304295 UK - Department of Health and Social Care (DHSC) The NIHR Global Health Research Professorship (GHRP) scheme is open to all professions and all Higher Education Institutions (HEI), based in UK and low-and-middle-income-countries (LMICs), to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. East Africa, known for its many different types of plants and animals (biodiversity), is a key place for studying viruses that can pass from animals to humans (zoonoses). Uganda is a leader in finding new viruses but has been hit hard by diseases that come from animals, including more than 50 serious outbreaks in the last ten years of some of the most dangerous viruses, including Ebola virus, Sudan virus, Marburg virus, Rift Valley fever, yellow fever, and Crimean-Congo hemorrhagic fever. Other viruses spread by insects, like Zika, Semliki Forest virus, chikungunya, O'Nyong Nyong, and West Nile virus, are also common in this area. Many of these viruses were discovered in East Africa (at the Uganda Virus Research Institute) for the first time. Even with these issues, Uganda has shown it can handle serious health problems, perhaps best illustrated by how it dealt with HIV (human immunodeficiency virus) after its emergence in the 1980s. Today, there are challenges with other viral diseases. The risk of spread of such infections is higher in the context of our heating planet and the climate emergency. Diagnosing viruses is limited at the moment because the tests we have are not always available, accurate, or specific, leading to wrong diagnoses and the unchecked spread of viruses. New more advanced DNA sequencing methods offer a modern solution to this problem. In sub-Saharan Africa, people often come to the doctor with fever, usually thought to be malaria. However, in the majority of cases, such fevers are actually caused by viruses, something that's often missed because of outdated testing methods. These viruses may be very dangerous, for example in the case of Ebola virus which has previously been detected many times in Uganda. This issue not only makes it hard to treat people properly and creates a public health risk but also hurts the local economy. There's a real need for better, more unbiased ways to diagnose these diseases. This research project is about using new DNA sequencing methods to better detect and manage viral infections in Uganda. These methods, which look for virus DNA (or RNA) or how the body reacts to viruses, could change how we understand and respond to virus outbreaks, making the world safer. The goal of this research is to use these new tests in important global locations, starting with Uganda, to have "eyes-on" viruses emerging in the human population. The research will check if these Next-Generation Sequencing (NGS) tests (Metagenomic-NGS, Target-Enrichment NGS and PhipSeq NGS) are better than current tests, if they can be used to detect more cases of disease, if they can be used to find out what risks certain healthcare workers and farmers in Uganda face, and if they can find viruses in sewage in transport hubs, schools and hospitals. The project has several goals: to see how effective the new DNA tests are compared to current tests, to use these tests to find infections in important health sites, to use such testing to find risk factors in people carrying out certain high-risk jobs, and to start using these tests to check sewage in Uganda. This thorough approach aims to find viruses in the community, improving our ability to deal with virus outbreaks and keep the world healthy. Diagnosing viruses is limited at the moment because the tests we have are not always available, accurate, or specific, leading to wrong diagnoses and the unchecked spread of viruses. New more advanced DNA sequencing methods offer a modern solution to this problem. This project has 4 objectives: 1. To check if Next Generation Sequencing (NGS) tests are more sensitive and specific than current tests. Specifically, we will compare Metagenomic-NGS (M-NGS) and Target-Enrichment NGS (TE-NGS) to standard tests. 2. To use M-NGS and TE-NGS to find infections in clinics to see if they improve virus detection for community tracking. 3. To use NGS blood tests to find risk factors in certain jobs. Specifically, we'll see if Phage immunoprecipitation sequencing (PhipSeq) can identify risks in these groups. 4. To use M-NGS and TE-NGS to monitor wastewater in Uganda to see if they can systematically identify viruses in the community. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Glasgow UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Uganda Medical research Research and Innovation 110133 391929 394468 396274 395593 284404 1972801 GB-GOV-10-RP_07_304295 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 110133 GB-GOV-10-RP_07_304295 2025/26 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Glasgow 97444 GB-GOV-10-RP_07_304295 2025/26 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Glasgow 98514 GB-GOV-10-RP_07_304295 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 98792 GB-GOV-10-RP_07_304295 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 97179 GB-GOV-10-RP_07_304295 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 98259 GB-GOV-10-RP_07_304295 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow GB-GOV-10-RP_07_304306 UK - Department of Health and Social Care (DHSC) The NIHR Global Health Research Professorship (GHRP) scheme is open to all professions and all Higher Education Institutions (HEI), based in UK and low- and middle-income countries (LMICs), to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. With advances in healthcare, more of us are living longer. It is also essential that we live well. Disorders of the mind and brain become much more common as we get older. Increased rates of memory difficulties, strokes and seizures are all seen after the age of 50 years. We know that stroke is the most common cause for seizures in older people and that people who are initially from Africa have a higher risk of stroke. But this information is from studies done in America or Europe, and therefore we must study mindbrain health within Africa itself. In this project, I will investigate how memory problems, stroke and seizures may be connected in African populations. I will base my work in Zimbabwe, where there has been a sharp rise in the number of older people. In Zimbabwe, the rates of HIV have been very high and HIV-associated complications are now being seen in later life. The infrastructure to cope with this immense need in older people is, however, extremely limited. I will work closely with my colleagues in Zimbabwe, whom I have known for over seven years. Together, we have delivered a lot of research into epilepsy. In this project, I will take advantage of seizures being a gateway into many neurological disorders to improve our broader understanding of mind-brain health. In Africa, seizures and epilepsy (which is when seizures can happen more than once) are deeply stigmatised, especially among older people. This research will work to understand why. This project has 6 key objectives: 1. Accelerate knowledge about brain disorders at all levels, from community through to Ministers of Health. We will start by holding community-led workshops and focus groups. We will take oral histories from a large number of older people with lived experience of epilepsy, stroke and dementia. These three conditions inter-connect very closely together, especially in older populations. We will speak with affected individuals, their principal carers and family members. 2. Destigmatise brain health disorders: we will explore the stigma that can surround brain disorders, including impacts on relationships, employment, personal well-being and mental health. 3. Better diagnose brain health disorders: we will work with older Zimbabweans to create solutions to these difficulties and engage interested individuals to shape the rest of the project. 4. Refine technologies to enable longitudinal deep phenotyping of people with later onset epilepsy and stroke. We will recruit and monitor a large group of Zimbabweans who have had a stroke to work out what makes a seizure more likely in this population. We will track people with epilepsy that starts after the age of 50 years to identify what happens to their memory and find out if they may be at increased risk of stroke. We will improve the technologies that we have developed to help people with epilepsy in Africa. We will test markers that may stratify people according to their risk of brain health difficulties. 5. Develop tailored guidelines around scalable interventions that align with the World Health Organisation Intersectoral Global Action Plan (WHO IGAP). Once we have better understood the risk factors contributing to brain disorders in older Zimbabweans, we will test whether specific treatments can reduce these risks and improve health outcomes. We will work with the WHO and local Ministers of Health to improve healthcare systems. 6. Create a Zimbabwean Centre of brain health. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Oxford UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Zimbabwe Research for prevention and control of NCDs Research and Innovation 32361 385965 424966 443366 395595 327848 2010101 GB-GOV-10-RP_07_304306 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Oxford 96415 GB-GOV-10-RP_07_304306 2025/26 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Oxford 127732 GB-GOV-10-RP_07_304306 2025/26 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Oxford 96415 GB-GOV-10-RP_07_304306 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 97764 GB-GOV-10-RP_07_304306 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford 105462 GB-GOV-10-RP_07_304306 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Oxford GB-GOV-10-RP_07_304311 UK - Department of Health and Social Care (DHSC) The NIHR Global Health Research Professorship (GHRP) scheme is open to all professions and all Higher Education Institutions (HEI), based in UK and low- and-middle-income-countries (LMICs), to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Health Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the OECD DAC list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. Tuberculosis (TB) is now the leading infectious killer globally, with unacceptably slow progress being made towards elimination targets. Southern Africa has been the centre of the global TB pandemic for the last 30 years, driven by generalised HIV (human immunodeficiency virus) epidemics. In 2022, more than one third of people with TB were not diagnosed or treated, resulting in sustained ongoing transmission, and a high risk of severe illness and death. A major barrier to efforts to control TB is the suboptimal diagnostic tests available. The most-commonly used test is sputum examination by microscopy, culture, or molecular testing. But many people with TB are not able to produce sputum because of severe illness or weakness. Also, the importance of subclinical TB (where sputum tests are positive, but the patient has no symptoms) has recently been recognised. People with subclinical TB have lung changes on chest X-ray, meaning it is possible to detect disease earlier; however, doctors able to interpret chest X-rays for TB are very limited in most high TB-burden countries. Recently we have shown in a randomised trial in Malawi that highly-accurate computer-aided detection of TB by portable and affordable digital chest X-ray using artificial intelligence software (DCXR-CAD) can increase the number of people diagnosed with TB and speed up diagnosis from a median of 11 days to 1 day. DCXR-CAD uses deep-learning algorithms trained on hundreds-of-thousands of X-rays to identify abnormality patterns consistent with TB. A positive DCXR-CAD needs to be confirmed with a sputum test before treatment is started, with sputum testing being by far the largest cost component of this approach. However, we have recently shown that setting a single DCXR-CAD abnormality threshold for all patients is likely to be highly inefficient, resulting in considerable over-referral for sputum testing. This is because individual patient characteristics – including older age, severity of symptoms, HIV status, and history of previous TB – are strongly associated with the presence of TB. I hypothesise that by setting “adaptive thresholds” accounting for these characteristics, we could dramatically reduce the number of confirmatory sputum tests that are required to diagnose TB, without impacting detection or accuracy. If correct, this would have massive implications for cost-saving for public health programmes in the Global South now rolling-out DCXR-CAD. Through knowledge exchange with a high TB/HIV prevalence country in southern Africa (Malawi), we will firstly undertake an individual participant meta-analysis and epidemiological modelling of existing datasets identified through systematic review to identify optimal adaptive thresholds based on patient characteristics, and their potential impact and cost-benefit on TB diagnosis. Subsequently, we will undertake a trial, randomising adults to receive sputum TB testing based on either the fixed DCXRCAD threshold, or the adaptive threshold, with the main outcome being the number of sputum tests required to confirm one TB case. We will embed community needs and voices throughout the project, and work with national, regional, and global policymakers and DCXR-CAD software developers to direct policy and guidelines to include adaptive chest X-ray screening for TB. The key objectives in this project are to: 1. Use past research and data to figure out the costs and health benefits of a new adaptive Digital Chest X-ray with Computer-Aided Detection (DCXR-CAD) algorithms and follow-up sputum tests. This will help us find the best ways to screen for Tuberculosis (TB) in high burden countries. 2. Test how well this new artificial intellegence-powered X-ray and follow-up testing works in real life in Malawi, looking at how accurate, fast, and affordable it is. We'll do this with adults who have TB symptoms at local primary care clinics in a randomised controlled trial. 3. Work with affected communities, national, regional, and global policymakers and software developers to direct policy and guidelines to include adaptive artificial intellegence chest X-ray screening for TB (Policy and knowledge translation). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Glasgow UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Malawi Medical research Research and Innovation 152786 362045 366194 371395 375840 218054 1846314 GB-GOV-10-RP_07_304311 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 152786 GB-GOV-10-RP_07_304311 2025/26 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Glasgow 90049 GB-GOV-10-RP_07_304311 2025/26 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Glasgow 91038 GB-GOV-10-RP_07_304311 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 91473 GB-GOV-10-RP_07_304311 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 89485 GB-GOV-10-RP_07_304311 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow 90479 GB-GOV-10-RP_07_304311 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Glasgow GB-GOV-10-RP_08 UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)’s eighth Global Research Professorship call. The Global Research Professorships programme funds research leaders, with a track-record of applied health research in low- and middle-income countries (LMICs), to promote effective translation of research and to strengthen research leadership at the highest academic levels. Funding of up to £2m over up to 5 years is awarded to Professors based in either an LMIC or the UK, working in close partnership with a research institution in an LMIC. By the end of the award, NIHR Global Research Professors will be expected to: 1) Have demonstrated research leadership at a national and/or international level. 2) Have been developed and protected by their institutions, including being relieved of administrative tasks. 3) Enhance existing and establish new research collaborations in low- and middle-income countries (LMICs). 4) Have supported training and capacity strengthening/mentorship within LMIC and UK (if applicable) institutions that enhances research capacity for future global health and care research. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-RP_08_306394 UK - Department of Health and Social Care (DHSC) The NIHR Global Health Research Professorship (GHRP) scheme is open to all professions and all Higher Education Institutions (HEI), based in UK and low- and middle-income countries (LMICs), to nominate health researchers and methodologists with an outstanding research record of clinical and applied health research and its effective translation for improved health. Global Research Professors are required to have existing strong collaborations or links with collaborators or partners in institutions in countries on the Organisation for Economic Co-operation and Development Development Assistance Committee (OECD) Development Assistance Committee (DAC) list and the award should plan to strengthen these/support training and capacity development/mentorship in these partners. I am a medical scientist with over 15 years of experience working in LMICs to understand and prevent diarrhoeal diseases. Diarrhoea remains a leading cause of death globally, particularly in children and older adults. In LMICs, rotavirus and Shigella are major causes of diarrhoea in children, but the causes in older adults are less understood. Limited diagnostic services in LMICs have led to the overuse of antibiotics, contributing to antibiotic resistance. Vaccination is the single most important public health approach to reduce the burden of diarrhoeal diseases and the use of antibiotics. However, there are no licensed vaccines against Shigella, and those against rotavirus underperform in LMICs. In addition, we currently do not have an easy way to tell in experiments whether a potential vaccine against these diseases is likely to work. There is therefore a pressing need to better understand the biology of these diseases and to develop more effective vaccines against diarrhoea-causing bacteria and viruses. My overall aim is to develop new vaccines that effectively manage and prevent sickness and death from diarrhoea. To do this we need to understand the causes of diarrhoea in all age groups and to better understand how the immune system responds to rotavirus and Shigella infection, as well as to potential vaccines. I will undertake a broad programme of research between 2025 and 2030, based at Malawi Liverpool Wellcome Programme in Malawi, consisting of three workstreams to respond to these needs over the next five years. The overall aim is to develop new vaccines that effectively manage and prevent sickness and death from diarrhoea. To do this we need to understand the causes of diarrhoea in all age groups and to better understand how the immune system responds to rotavirus and Shigella infection, as well as to potential vaccines. I will undertake a broad programme of research, based at Malawi Liverpool Wellcome Programme in Malawi, consisting of three workstreams to respond to these needs over the next five years. The aims of the three workstreams are: Workstream 1. Disease burden: to extend our diarrhoea surveillance to understand why some children are hospitalised despite vaccination, the causes of diarrhoea in adults and how well antibiotics works. Workstream 2. Host response: to study how the immune system in adults responds to infection with rotavirus and Shigella to gain information for designing better vaccines and other preventive strategies; and to study blood samples donated by volunteers to understand how cells and antibodies interact to protect the body. Workstream 3. Prevention: to investigate and continue to monitor the efficacy of the rotavirus vaccine that was introduced in Malawi. Use the knowledge gained from adult studies to know when children are protected from rotavirus and Shigella infection. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Liverpool UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Malawi Medical research Research and Innovation 186416 395053 457103 432636 355529 171164 1997901 GB-GOV-10-RP_08_306394 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Liverpool 94232 GB-GOV-10-RP_08_306394 2025/26 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) University of Liverpool 92184 GB-GOV-10-RP_08_306394 2025/26 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) University of Liverpool 93208 GB-GOV-10-RP_08_306394 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Liverpool GB-GOV-10-GAF_01 UK - Department of Health and Social Care (DHSC) The National Institute for Health and Care Research (NIHR)’s first Global Advanced Fellowships call. The NIHR Global Advanced Fellowships scheme funds and supports postdoctoral researchers with the potential to become future leaders in applied global health research in low- and middle-income countries and the UK. This scheme awards funding of up to £750,000 over 2 to 5 years to support a research project, salary costs, personal training and development, and wider institutional capacity strengthening. The strategic aims of the NIHR Global Advanced Fellowship scheme are to: 1. Develop a pathway to research leadership for postdoctoral global health researchers. 2. Support postdoctoral researchers to conduct a research project in a strategic area of applied global health and receive a bespoke training and development programme relevant to their needs. 3. Strengthen institutional capacity for research in low and middle income countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Centre for the AIDS Programme of Research in South Africa (CAPRISA) Liverpool School of Tropical Medicine London School of Hygiene and Tropical Medicine The Aurum Institute University of Cape Town UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-GAF_01_305365 UK - Department of Health and Social Care (DHSC) The NIHR Global Advanced Fellowship (GAF) scheme is a mid-career postdoctoral award that funds researchers undertaking research that aims to specifically and primarily benefit people in low- and middle-income countries (LMICs). The programme is open to researchers based in a Higher Education Institution (HEI) or Research Institute in a LMIC, or based in a HEI in the UK. The GAF funds research projects, training and development, and institutional capacity strengthening in LMICS. Laws have a special power in our societies - they tell us what we can and cannot do. In many ways, laws are the scaffolding that creates the structures within which society functions and people live. In the modern world, law is a central determinant of and influence on public health responses. Not only can law determine access to medical interventions like vaccines, it is often the mechanism used to implement traditional public health interventions such as quarantines, limits on social gatherings and social distancing requirements. In this way, laws can limit the type of actions a government can implement as well as determine how an intervention is adopted, acting as an intermediary between the scientific evidence about what should be done and how the government can implement this. Law also has a particular status in society, in many instances guiding how people know whether a behaviour is right or wrong – and also creating punishment or reward for acting in particular ways. The COVID-19 pandemic is an example of this where many governments used laws to create lockdowns and introduce regulations with the goal of controlling the spread of the virus in a diversity of ways that changed and evolved over the response. As law can empower or enable a public health response, it can also be immensely disruptive. Legal challenges frequently tried to use the law to derail public health responses. Notwithstanding the centrality of law in shaping public health responses, its role is often under-studied or relegated to legal scholarship which limits our ability to understand how to use law to improve public health responses more generally. In addition, many evaluations of public health responses do not adequately grapple with how the law informed responses or how laws (and in turn responses) change over time. It is these gaps that this study aims to fill. This study aims to use scientific research methods, including qualitative research and a community-based survey, to create data about how law influenced the COVID-19 response, drawing on the knowledge and experiences of key decision-makers and the public, and engaging these communities in the research process. This will include interviewing policymakers and public health experts about how they used the law in their decision-making and responded to legal disruptions. In addition, a survey will be used to reach different communities, including urban and rural, to understand how the COVID-19 laws influenced their behaviour (if at all) and what kinds of measures they found acceptable and appropriate. We will also build longitudinal legal datasets of COVID-19 responses in South Africa, the United Kingdom, Namibia and New Zealand which will be made publicly available for researchers to use in evaluations of COVID-19 responses. We will convene concluding workshops for public health experts and decision-makers to communicate the results of the study and solicit their views on the recommendations. This will be compiled into a policy report with suggestions for reform to be submitted to key law-making bodies. In addition to conference presentations and publication outputs, we will also host community meetings feedback the results to community members. This project has 4 key objectives: 1. To create a timeline and legal map which identifies, describes and analyses how laws facilitated and obstructed the COVID-19 pandemic response (specifically non-pharmaceutical interventions and biological countermeasures) in South Africa and develop comparative datasets for Namibia, New Zealand and the United Kingdom. 2. To analyse the role of legal determinants in shaping the COVID-19 response in South Africa. 3. To evaluate public perception and acceptability of the legal response to COVID-19 in South Africa. 4. To develop a model for legal responses to a public health emergency and make recommendations for law reform in South Africa. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Centre for the AIDS Programme of Research in South Africa (CAPRISA) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU South Africa Medical research Research and Innovation 40901 105793 133644 147161 77144 504643 GB-GOV-10-GAF_01_305365 COMMITMENT UK - Department of Health and Social Care (DHSC) Centre for the AIDS Programme of Research in South Africa (CAPRISA) 16523 GB-GOV-10-GAF_01_305365 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Centre for the AIDS Programme of Research in South Africa (CAPRISA) 24378 GB-GOV-10-GAF_01_305365 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Centre for the AIDS Programme of Research in South Africa (CAPRISA) 24649 GB-GOV-10-GAF_01_305365 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Centre for the AIDS Programme of Research in South Africa (CAPRISA) GB-GOV-10-GAF_01_305492 UK - Department of Health and Social Care (DHSC) The NIHR Global Advanced Fellowship (GAF) scheme is a mid-career postdoctoral award that funds researchers undertaking research that aims to specifically and primarily benefit people in low- and middle-income countries (LMICs). The programme is open to researchers based in a Higher Education Institution (HEI) or Research Institute in a LMIC, or based in a HEI in the UK. The GAF funds research projects, training and development, and institutional capacity strengthening in LMICs. In 2022, there were 39 million people living with Human Immunodeficiency Virus (HIV) globally, 25.6 million of whom were in Africa. Up to 29.8 million of people living with HIV were receiving antiretroviral therapy (ART), essential for individual health and prevention of onward HIV transmission. Despite this some people living with HIV continue to struggle to remain on ART due to mobility. Populations whose occupations require them to move from place to place such as fishing communities, seasonal workers and female sex workers face many challenges that lead to ART interruption. Increased ART interruption increases the overall community viral load among fishing communities in Africa, leading to new HIV cases and more people suffering ill-health. The implication of not addressing the needs of this vulnerable group is that they hold potential to reverse the gains related to UNAIDS targets. Working with key stakeholders: affected mobile fishing communities, healthcare workers and policy makers, I will identify strategies to improve the health of mobile men and women living with HIV. I will explore the reasons leading to poor engagement and retention on HIV treatment. I will work with stakeholders to ensure that people engaged in fishing activities have the capability, opportunity, and motivation to adhere to and continue their ART. This work will inform national and international approaches to ensuring that people living with HIV who are often mobile are well supported to remain on HIV medication. This project will take place in Mangochi, a district on the southern tip of Lake Malawi between 2025 and 2029 and will contribute evidence from user and provider perspectives to address gaps in current strategies for supporting ART adherence among fishing communities. The main participants will be men and women involved directly or indirectly in fishing activities (fishing or fish trading). The project will contain five key work packages. First, using formative qualitative methods to understand the underlying gendered reasons for treatment interruption among fishing communities we will conduct in-depth interviews with mobile fishing communities and policy makers and focus group discussions with health care workers. Second, we will assess user preferences using a discrete choice experiment. Third, through a series of iterative workshops we will co-design a potential strategy for supporting ART adherence with the stakeholders. Fourth, we will pilot the final user-chosen strategy among fishing communities to assess its potential effectiveness to control HIV. Finally, we will assess feasibility, acceptability and costs of the chosen strsategy. We will establish a Community Engagement and Involvement Group to ensure community needs are addressed and monitor responsiveness of the co-developed strategies to support continued engagement in care. This project responds directly to community priorities and puts them at the centre of framing potential strategies that meet the needs they themselves define. This project has four key objectives: 1. Understand how mobile fishing communities navigate the complexity of Human Immunodeficiency Virus care and how this understanding may lead to better models of care that are responsive to their unique and gendered needs. 2. Identify a preferred intervention through a discrete choice experiment. 3. Co-produce a gender responsive intervention with stakeholders (mobile fishing communities, health care workers and policy makers). 4. Pilot final intervention to assess acceptability, efficacy, gender responsiveness, feasibility, affordability and sustainability. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Malawi STD control including HIV/AIDS Research and Innovation 130068.5 250358 247410.5 127121 65569 GB-GOV-10-GAF_01_305492 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 754958 GB-GOV-10-GAF_01_305492 COMMITMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 64143 GB-GOV-10-GAF_01_305492 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine 64856 GB-GOV-10-GAF_01_305492 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Liverpool School of Tropical Medicine GB-GOV-10-GAF_01_305511 UK - Department of Health and Social Care (DHSC) The NIHR Global Advanced Fellowship (GAF) scheme is a mid-career postdoctoral award that funds researchers undertaking research that aims to specifically and primarily benefit people in low- and middle-income countries (LMICs). The programme is open to researchers based in a Higher Education Institution (HEI) or Research Institute in a LMIC, or based in a HEI in the UK. The GAF funds research projects, training and development, and institutional capacity strengthening in LMICs. Africa is the only region in the world where the youth population is expected to rise. When compared to adults, youth in Africa have higher unmet sexual and reproductive health (SRH) needs, including high new Human Immunodeficiency Virus (HIV) infections and sexually transmitted infections (STI) prevalence. My previous study in Zimbabwe found that one in five youth aged between 18-24 years have at least one of three curable STIs. According to UNICEF, one-third of new HIV infections in Zimbabwe are among youth. There is a clear unmet need for SRH services for youth in Zimbabwe. Unfortunately, most services primarily focus on HIV and not the broader SRH of youth. Where SRH services are offered, there is low uptake by youth as they face many barriers, including a lack of youth-friendly health providers. My study aims to design with youth a scalable digital self-care intervention that offers SRH services appropriate and tailored for youth in Zimbabwe. To do this, during 2025 to 2030, I will (1) co-design a digital self-care intervention for SRH services with youth attending tertiary education institutions in Zimbabwe, (2) determine the feasibility, acceptability, and uptake of the intervention and develop optimal user pathways for delivery of SRH services for youth attending tertiary education institutions in Zimbabwe and (3) conduct a process evaluation of the intervention in order to develop a toolkit that will be used to help policymakers and programmers scale up and maintain this intervention. The self-care intervention will offer HIV self-testing, STI screening, condoms, menstrual health products, and contraception. These SRH products will be delivered through a simple and free platform that can be used with the most basic mobile phone. I will work with youth to design this intervention through workshops and a design competition. A youth advisory committee will support the project throughout. During the intervention youth will be able to order services on their mobile phone using short messages without incurring connection or service charges. Their order will then be processed by the study team and delivered to a “grab and go” smart locker, which the youth will be able to access using a code sent to their phone once their order is ready. Youth will be given information on how to receive further support from a nurse in the tertiary educational institution’s clinic should they need it, for example, youth who screen positive for HIV or STIs. Findings from this study will respond directly to calls from the WHO and the Ministry of Health and Child Care in Zimbabwe regarding approaches to improve service delivery for youth. These approaches are important because improving the SRH of youth now has many benefits, including better SRH for them in the future and better health for their future offspring. Findings of this study will be shared with academics, youth, and policymakers via different channels, including journals, meetings, radio, and podcasts. This NIHR GAF will rapidly expand my skills as a global SRH research leader. It will also enable me to build upon my already established track record in epidemiology. I will be able to transfer my experiences from the delivery of HIV and SRH services for youth into the co-development of innovative digital self-care interventions. My proposed intervention will transform the delivery of SRH services for youth in Zimbabwe, resulting in a toolbox of interventions for youth SRH service delivery. This project aims to co-design, implement, and evaluate a digital self-care sexual and reproductive health intervention for youth attending tertiary education institutions in Zimbabwe. The study has three specific objectives: 1. Co-design a digital self-care intervention for integrated sexual and reproductive health services with youth attending tertiary education institutions in Zimbabwe. 2. Determine the feasibility, acceptability, and uptake of the digital self-care intervention and develop optimal user pathways for delivery of integrated sexual and reproductive health services for youth attending tertiary education institutions in Zimbabwe 3. Conduct a process evaluation of the digital self-care intervention and develop a toolkit to inform operationalisation, scale-up and sustainability of the intervention. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Zimbabwe STD control including HIV/AIDS Research and Innovation 55976 169410 164056 140262 83955 613659 GB-GOV-10-GAF_01_305511 COMMITMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 41407 GB-GOV-10-GAF_01_305511 2025/26 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 14262 GB-GOV-10-GAF_01_305511 2025/26 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine 41867 GB-GOV-10-GAF_01_305511 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) London School of Hygiene and Tropical Medicine GB-GOV-10-GAF_01_305519 UK - Department of Health and Social Care (DHSC) The NIHR Global Advanced Fellowship (GAF) scheme is a mid-career postdoctoral award that funds researchers undertaking research that aims to specifically and primarily benefit people in low- and middle-income countries (LMICs). The programme is open to researchers based in a Higher Education Institution (HEI) or Research Institute in a LMIC, or based in a HEI in the UK. The GAF funds research projects, training and development, and institutional capacity strengthening in LMICs. Despite improvements in Human Immunodeficiency Virus (HIV) diagnosis and treatment, more than 600,000 people living with HIV (PLWH) die globally each year, mostly due to advanced HIV disease. In this condition, their immune systems are weak and vulnerable to life-threatening illnesses. Many of those who die are hospitalised before their death. While some die during hospitalisation, many more die after being discharged. In South Africa, around 50,000 PLWH die annually, and about 45% of these deaths happen among people who have returned home from the hospital, mostly about 6 months after being hospitalised. This high post-hospitalisation mortality for PLWH is largely preventable, but research has found that after discharge from hospital, PLWH don't get the care they need. Not much research is being done to address this problem in sub-Saharan Africa, where most of the HIV burden lies. Also, the solutions that have been tried by other researchers to address this issue have not been successful. We believe this is partly because the solutions have been developed without involving the care recipients discharged from hospitals, carers, and healthcare providers. Yet, these people are better placed to know what is likely needed to address some of these challenges. We have also seen from the published research that little work is being done to understand how solutions to reducing these post-hospitalisation deaths can involve the carers providing key support to care recipients discharged from the hospital. The planned research is very important for PLWH, carers, and healthcare providers, as each group has a significant role in influencing the well-being of care recipients after they leave the hospital. By involving these groups as active participants in identifying and developing solutions, we believe we can reduce the number of deaths after hospital discharge. Therefore, we aim to work with these groups to develop and test interventions to lower the risk of post-hospitalisation mortality, focusing on the first six months after hospital discharge. We plan to conduct a study in two phases between 2025 and 2029. In the first phase, we want to understand why PLWH have poor outcomes after leaving the hospital. We will recruit 328 care recipients living with HIV across four different hospitals in South Africa. The hospitals will be of different sizes, including a mix of those in rural and urban areas. We will follow these care recipients for 6 months after they leave the hospital and gather information at different times about how they are accessing healthcare services and their well-being. We will also enrol those caring for these care recipients to understand their needs and challenges as they provide support. With this information, we will work together with the patients, caregivers, and healthcare providers to develop potential solutions. We will then create sample interventions called prototypes to address the challenges we identify at each of the four study sites. In the second phase, we will test these prototypes to see if they can be used in real-world programs and if they are helpful to patients, caregivers, and healthcare providers. The findings may drive advocacy efforts in the short term and inform improvements in service delivery in South Africa and similar settings in the long term. This project has three key objectives: Objective 1: To identify the individual and contextual factors influencing care engagement and mortality in the first six months after hospital discharge among people living with Human Immunodeficiency Virus (HIV). There is a paucity of evidence on this topic to support a scoping review to inform intervention development. We will collect primary data through a mixed-methods, multi-centre prospective study of care recipients and carers in South Africa to provide nuanced evidence to inform the development of effective interventions. Objective 2: To co-develop interventions with care recipients, carers, and healthcare stakeholders aimed at enhancing care engagement and reducing mortality in the first six months after hospital discharge among people living with HIV. Co-developing the intervention with those who use, deliver services, and make decisions about public sector services is crucial for ensuring that solutions are tailored to real-world needs and challenges, thereby increasing the chances of achieving the desired outcomes. We will use a participatory human centered design approach to identify, refine, and prioritise components for co-developed intervention prototypes across four study sites in South Africa. This objective aligns with my training and development plan as an area where I intend to enhance my technical skills. Objective 3: To assess the preliminary feasibility and acceptability of co-developed prototype interventions. We will conduct a single-arm feasibility and acceptability study to determine if the interventions can be successfully implemented in real-world settings and are well-received by care recipients, carers, and healthcare providers. The study's results will be used to refine and enhance the intervention theory, components, and delivery for a future definitive implementation-effectiveness trial. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The Aurum Institute UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU South Africa STD control including HIV/AIDS Research and Innovation 107465.5 228249.5 220228 193215 749158 GB-GOV-10-GAF_01_305519 COMMITMENT UK - Department of Health and Social Care (DHSC) The Aurum Institute 107171 GB-GOV-10-GAF_01_305519 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Aurum Institute 60227 GB-GOV-10-GAF_01_305519 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Aurum Institute GB-GOV-10-GAF_01_305556 UK - Department of Health and Social Care (DHSC) The NIHR Global Advanced Fellowship (GAF) scheme is a mid-career postdoctoral award that funds researchers undertaking research that aims to specifically and primarily benefit people in low- and middle-income countries (LMICs). The programme is open to researchers based in a Higher Education Institution (HEI) or Research Institute in a LMIC, or based in a HEI in the UK. The GAF funds research projects, training and development, and institutional capacity strengthening in LMICs. Stroke is the second leading cause of death in Sub Saharan Africa (SSA) and the burden of stroke does not fall equally across different socioeconomic and ethnic groups. The current evidence in SSA is limited by being hospital based, therefore it only includes patients who have the means to access care at hospitals. This means that stroke may go unrecognised and uncounted amongst underserved and poorer populations, producing biased estimates of the impact of stroke. Measurement is key to improvement and accountability, however current stroke research does not always measure what is most important to patients, including patient experience of care. Between 2026 and 2029 in Sierra Leone and South Africa we will conduct community based surveillance for stroke to identify patients with stroke in the community, using innovative community health worker led models. By training community health workers and primary health care staff on stroke recognition and awareness, we will add stroke surveillance to already funded disease surveillance systems in both settings. This innovative low cost stroke surveillance system will provide valuable learning for other countries in SSA to measure the burden of stroke in their communities. We will map how patients access care for acute stroke and how they previously sought care for risk factors for stroke to improve targeting of stroke prevention services. We will compare this community sample to hospital based data to assess inequalities in access to stroke care. We will measure the impact of stroke for patients in terms of mortality, health-related quality of life and disability. Stroke services are in development in SSA, access to stroke prevention services and stroke unit based care is limited and unevenly distributed. Care pathways for acute stroke care and post hospital care are not well defined, most patients do not seek care early enough or in the most appropriate place. Organized stroke care has shown to be effective in randomised controlled trials, in reducing death and dependence after stroke. However, most stroke patients in Sierra Leone and South Africa are not admitted to a specialist stroke unit. There are differing levels and components of organized stroke care, which require different staffing mixes and ratios. Due to workforce and economic constraints, the highest level of organized stroke care currently or in the medium term cannot be delivered to all who need it. Therefore, there is a need to evaluate the effective of different levels of organized stroke care in this setting to help plan the development and scale up of stroke services. We will assess the relative effectiveness of different levels of organized stroke care in South Africa and Sierra Leone. We aim to engage and involve patients and caregivers in the research, through working with a stroke survivor organisation in each country. Patients will be engaged in selecting and adapting patient experience questionnaires to assess experience of stroke care. We will hold Policy Labs with patients, healthcare workers and policy makers, where findings will be presented to inform patients and policy makers on decision making. We expect findings from the project will be used to guide decision making on the development of more equitable stroke services in both countries. This project has three key objectives: 1. Create population-based stroke registers within two existing and funded surveillance systems in South Africa and Sierra Leone to investigate inequalities in stroke occurrence, care and outcomes (Workpackage 1). 2. Use causal inference methods to understand the effects of different levels of OSC in this setting (Workpackage 2). 3. Use these findings to identify priority areas for quality improvement, and work with local policymakers to drive improvements and equity (Workpackage 3). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) University of Cape Town UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 40157 174749 208216 171572 70115 664809 GB-GOV-10-GAF_01_305556 COMMITMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 40157 GB-GOV-10-GAF_01_305556 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town 40603 GB-GOV-10-GAF_01_305365 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) University of Cape Town GB-GOV-10-Adol_Health UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). This programme is administered by the UK Medical Research Council (MRC), which reports activities under the UK Department for Business, Energy and Industrial Strategy (BEIS). NIHR disburses funds to MRC, which makes onwards disbursements to awardees. This initiative funds research grants to improve adolescent health in low- and middle-income countries (LMICs). The aim of this programme is to generate new knowledge to contribute to improving the effectiveness and accessibility of health interventions that will results in improved adolescent health in low- and middle-income countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council Medical Research Council Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-Adol_Health_call2 UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). This programme is administered by the UK Medical Research Council (MRC), which reports activities under the UK Department for Business, Energy and Industrial Strategy (BEIS). NIHR disburses funds to MRC, which makes onwards disbursements to awardees. This activity is a component of the Applied Research for Adolescent Health in Low and Middle Income Countries programme (GB-GOV-10-Adol_Health). This initiative funds research grants to improve adolescent health in low- and middle-income countries (LMICs). 1 ) Fund high-quality research to address major health issues that emerge at the adolescent phase of life; 2) Provide the research evidence needed to effect real and practical changes to improve adolescent health in Low- and Middle-Income Countries (LMICs); 3) Encourage genuine interdisciplinary collaborations across social science, biomedical science and other disciplines including health economics and political science; 4) Support capacity building in research; 5) Encourage equitable partnerships with, and scientific leadership from, LMIC investigators. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 1316134.52 1859236.0100000002 1812240.3099999998 582663.39 429725.7700000007 6000000 GB-GOV-10-Adol_Health_call2 COMMITMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 701483.7000000001 GB-GOV-10-Adol_Health_call2 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 404878.12 GB-GOV-10-Adol_Health_call2 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 291276.67 GB-GOV-10-Adol_Health 2019/20 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 288811.96 GB-GOV-10-Adol_Health 2019/20 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 286803.47000000003 GB-GOV-10-Adol_Health_call2 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 491295.53 GB-GOV-10-Adol_Health_call2 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 505911.60000000003 GB-GOV-10-Adol_Health_call2 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 476201.61 GB-GOV-10-Adol_Health_call2 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 466688.75 GB-GOV-10-Adol_Health_call2 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 378316.43 GB-GOV-10-Adol_Health_call2 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 110475.51 GB-GOV-10-Adol_Health_call2 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 105551.72 GB-GOV-10-Adol_Health_call2 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 97345.79 GB-GOV-10-Adol_Health_call2 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 45944.9 GB-GOV-10-Adol_Health_call2 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 46317.05 GB-GOV-10-Adol_Health_call2 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 46317.05 GB-GOV-10-Adol_Health_call2 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 300832.25 GB-GOV-10-Adol_Health_call2 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 4211.98 GB-GOV-10-Adol_Health_call2 2023/24 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 92729.54 GB-GOV-10-Adol_Health_call2 2023/24 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council GB-GOV-10-Adol_Health_call3 UK - Department of Health and Social Care (DHSC) This programme is administered by the UK Medical Research Council (MRC), which reports activities under the UK Department for Business, Energy and Industrial Strategy (BEIS). NIHR disburses funds to MRC, which makes onwards disbursements to awardees. This initiative funds research grants to improve adolescent health in low- and middle-income countries (LMICs). Overall this call will support high-quality, applied research answering questions of effectiveness and access that will result in improved adolescent health in LMICs. Sub-objectives include: 1 ) Fund high-quality research to address major health issues that emerge at the adolescent phase of life; 2) Provide the research evidence needed to effect real and practical changes to improve adolescent health in Low- and Middle-Income Countries (LMICs); 3) Encourage genuine interdisciplinary collaborations across social science, biomedical science and other disciplines including health economics and political science; 4) Support capacity building in research UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 457920.04 976297.94 569562.0199999998 2003780 GB-GOV-10-Adol_Health_call3 COMMITMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 121248.04000000001 GB-GOV-10-Adol_Health_call3 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 118970.74 GB-GOV-10-Adol_Health_call3 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 149388.06 GB-GOV-10-Adol_Health_call3 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 190500.69 GB-GOV-10-Adol_Health_call3 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 191464.36 GB-GOV-10-Adol_Health_call3 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 191464.36 GB-GOV-10-Adol_Health_call3 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 191710.73 GB-GOV-10-Adol_Health_call3 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 144883.86 GB-GOV-10-Adol_Health_call3 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 145473.34 GB-GOV-10-Adol_Health_call3 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 117822.05 GB-GOV-10-Adol_Health_call3 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 87096.53 GB-GOV-10-Adol_Health_call3 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 92807.94 GB-GOV-10-Adol_Health_call3 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 68208.42 GB-GOV-10-Adol_Health_call3 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 6070 GB-GOV-10-Adol_Health_call3 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 18446.55 GB-GOV-10-Adol_Health_call3 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 1457.77 GB-GOV-10-Adol_Health_call3 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council GB-GOV-10-Adol_Health_call4 UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). This programme is administered by the UK Medical Research Council (MRC), which reports activities under the UK Department for Business, Energy and Industrial Strategy (BEIS). NIHR disburses funds to MRC, which makes onwards disbursements to awardees. This initiative funds research grants to improve adolescent health in low- and middle-income countries (LMICs). This call seeks to provide the research evidence needed to effect real and practical changes to improve adolescent health in low- and middle-income countries (LMICs). Awards should be genuine interdisciplinary collaborations across social science, biomedical science and other disciplines including health economics and political science. The following thematic area are of particular focus: -research in conflict-affected and fragile states; -road traffic and other injuries; -prevention of interpersonal violence; -self-harm (including suicide); -lower respiratory tract infections such as pneumonia; -prevention and treatment of substance use (alcohol, tobacco and other drugs); -future Non-Communicable Disease (NCD) risk factors (raised blood pressure, raised blood glucose, obesity and smoking); -nutrition, diet and physical activity; -disabilities - mental, intellectual, and physical; -the transition out of adolescence into adulthood, including the transition to adult services; -research addressing social (and commercial) determinants of health. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 475537.34 2146950.92 1326345.81 51165.92999999999 47537.68 GB-GOV-10-Adol_Health_call4 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 4000000 GB-GOV-10-Adol_Health_call4 COMMITMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 143759.65 GB-GOV-10-Adol_Health_call4 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 322959.76 GB-GOV-10-Adol_Health_call4 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 283738.97 GB-GOV-10-Adol_Health_call4 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 259879.05 GB-GOV-10-Adol_Health_call4 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 157716.52 GB-GOV-10-Adol_Health_call4 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 299479.25 GB-GOV-10-Adol_Health_call4 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 307233.05 GB-GOV-10-Adol_Health_call4 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 261820.1 GB-GOV-10-Adol_Health_call4 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 263804.01 GB-GOV-10-Adol_Health_call4 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 225692.37 GB-GOV-10-Adol_Health_call4 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 170305.5 GB-GOV-10-Adol_Health_call4 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 107987.73 GB-GOV-10-Adol_Health_call4 2023/24 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 106027.3 GB-GOV-10-Adol_Health_call4 2023/24 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 26863.09 GB-GOV-10-Adol_Health_call4 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 73185.7 GB-GOV-10-Adol_Health_call4 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 10718 GB-GOV-10-Adol_Health_call4 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 14525.74 GB-GOV-10-Adol_Health_call4 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 34548.57 GB-GOV-10-Adol_Health_call4 2025/26 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 32254.56 GB-GOV-10-Adol_Health_call4 2025/26 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council GB-GOV-10-AHPSR UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR works in partnership with the Alliance for Health Policy and Systems Research (AHPSR), a hosted partnership of the World Health Organization (WHO), to fund the generation and use of health policy and systems research as a means to strengthen the health systems of Low and Middle-Income Countries (LMICs). Stimulate the generation and synthesis of policy-relevant health systems knowledge, encompassing evidence, tools and methods; Promote the dissemination and use of health policy and systems knowledge to improve the performance of health systems; and Facilitate the development of capacity for the generation, dissemination and use of HPSR knowledge among researchers, policy-makers and other stakeholders. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) World Health Organization World Health Organization World Health Organization World Health Organization World Health Organization World Health Organization World Health Organization UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-AHPSR-ClimateCrises UK - Department of Health and Social Care (DHSC) A collaboration between the World Health Organization (WHO) Alliance for Health Policy and Systems Research (AHPSR) and the National Institute for Health and Care Research (NIHR) to support a call for proposals for low- and middle-income country (LMIC) case studies examining how health systems are responding to the climate crisis at the national or sub-national levels. Informed by qualitative data from key country stakeholders, research teams will develop analytical case studies in collaboration with national policy-makers as they attempt to adapt to, mitigate and build broader resilience to the ongoing climate crisis. This collaboration will support a total of twelve country case studies and associated costs for the Alliance secretariat. These country case studies will: - Identify and document examples where health system policymakers and managers are actively responding to climate change, trying to mitigate climate change, as well as adapting health systems and improving health policies and broader resilience in collaboration with national health policymakers; - Share lessons from countries across WHO regions; - Synthesize evidence contributing to the development of improved guidance on how countries can overcome existing barriers, respond to the climate crisis and move towards climate-resilient and low carbon sustainable health systems. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) World Health Organization UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 509120 55440 55440 620000 GB-GOV-10-AHPSR-ClimateCrises 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 620000 GB_GOV_10- AHPSR-ClimateCrises COMMITMENT UK - Department of Health and Social Care (DHSC) World Health Organization GB-GOV-10-AHPSR-Emergency UK - Department of Health and Social Care (DHSC) A collaboration between the World Health Organization (WHO) Alliance for Health Policy and Systems Research (AHPSR) and the National Institute for Health and Care Research (NIHR) to support a call for Health Policy and Systems research that systematically examines how and why fragile, conflict-affected, and vulnerable (FCV) settings have (or have not) been able to manage previous emergencies. Convene national stakeholders (particularly in the Eastern Mediterranean and African regions) to identify Health Policy and Systems Research (HPSR) priorities around emergency preparedness and inform the development of a framework specific to emergency preparedness in fragile, conflict-affected and vulnerable (FCV) settings; Support the development of HPSR led by researchers and practitioners based in selected FCV settings to respond to the identified priorities and support national emergency preparedness efforts - to this end the research programme will specifically identify and support FCV settings where there are existing/envisaged processes to strengthen the emergency preparedness architecture; Draw cross-national and cross-regional learning to inform regional and global emergency preparedness efforts; and Strengthen capacities of selected FCV setting-based researchers and practitioners in the conduct and dissemination of HPSR. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) World Health Organization UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 582938 134524 179367 582938 GB-GOV-10-AHPSR-Emergency 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 896829 GB-GOV-10-AHPSR-Emergency COMMITMENT UK - Department of Health and Social Care (DHSC) World Health Organization 134524 GB-GOV-10-AHPSR-Emergency 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 179367 GB-GOV-10-AHPSR-Emergency 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization GB-GOV-10-AHPSR-VaccineUptake UK - Department of Health and Social Care (DHSC) A collaboration between the World Health Organization (WHO) Alliance for Health Policy and Systems Research (AHPSR) and the National Institute for Health and Care Research (NIHR) to support a call for Health Policy and Systems research proposals tackling the issue of low vaccine acceptance in low- and middle-income countries (LMIC). Improve the understanding of factors underlying low vaccine acceptance through formative and contextual analysis of supply- and demand-side constraints, including around the social determinants of health;   Support the development of cutting-edge Health Policy and Systems Research (HPSR) that uses a variety of methods and approaches, including but not limited to participatory action research and ethnography to identify potential strategies to address low vaccine acceptance as well as appropriate methodologies (including the use of mixed methods approaches) to examine the implementation of these strategies in particular national/sub-national contexts; and  Engage with governments at national and sub-national levels and with civil society to examine how learning can inform the development of programmes and policies to address challenges around vaccine acceptance.   UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) World Health Organization UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 2082966 342766 1065968 2082966 GB-GOV-10-AHPSR-VaccineUptake 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 3491700 GB-GOV-10-AHPSR-VaccineUptake COMMITMENT UK - Department of Health and Social Care (DHSC) World Health Organization 342766 GB-GOV-10-AHPSR-VaccineUptake 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 1065968 GB-GOV-10-AHPSR-VaccineUptake 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization GB-GOV-10-AHPSR-KNOSA UK - Department of Health and Social Care (DHSC) A collaboration between the World Health Organization (WHO) Alliance for Health Policy and Systems Research (AHPSR) and the National Institute for Health and Care Research (NIHR) to support the expansion of the Partnerships for stronger knowledge systems in Africa (KNOSA) programme. KNOSA will build robust knowledge systems in Africa by strengthening institutional capacities and leadership to better inform policy-making processes. This will involve: - Establishing institutional partnerships between a set of African research and policy institutions; - Building research-to-policy networks across institutions; - Generating new knowledge and practice on institutional approaches for research evidence use and national knowledge systems, such as rapid reviews, evidence synthesis, priority-setting, evidence-informed advocacy, dialogue, and engagement with media and public; - Improving local evidence-informed policy and practice; - Co-designing a suite of system-level interventions across those institutions to strengthen the use of research evidence in national policy-making processes; and - Increasing the scholarship on institutional capacity strengthening in Low- and Middle-Income Countriess by documenting and disseminating learning on capacity mechanisms for strengthening knowledge systems, both for global audiences and local practice. The objectives of KNOSA are to strengthen institutional capacities to increase the effectiveness of policy and research institutions in Africa able to deploy a range of evidence generation and synthesis approaches in their own contexts. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) World Health Organization UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research/scientific institutions Research and Innovation 498344 541453 74791 1302936 GB-GOV-10-AHPSR-KNOSA COMMITMENT (1) UK - Department of Health and Social Care (DHSC) World Health Organization 298532 GB-GOV-10-AHPSR-KNOSA 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 199812 GB-GOV-10-AHPSR-KNOSA 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization -188348 GB-GOV-10-AHPSR-KNOSA COMMITMENT (2) UK - Department of Health and Social Care (DHSC) World Health Organization 541453 GB-GOV-10-AHPSR-KNOSA 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization GB-GOV-10-AHPSR-NCDImpRes UK - Department of Health and Social Care (DHSC) A collaboration between the World Health Organization (WHO) Alliance for Health Policy and Systems Research (AHPSR) and the National Institute for Health and Care Research (NIHR) to support a call for proposals for low- and middle-income country (LMIC) research teams to conduct Non-Communicable Disease (NCD) implementation research to combine a range of essential health services into a coordinated and comprehensive system, with a primary care setting as the central point of access for individuals and communities. This collaboration will support four new LMIC country research teams and the scale up of existing programmes of work in India, Nepal, Ghana and Ethiopia. 1) Support the generation of locally relevant evidence and institutionalization of strengthened national capacities in Low- and Middle-Income countries (LMICs). 2) Enhance the impact of these efforts by embedding them within ongoing Non-Communicable Disease (NCD) programmes and strengthen institutional capacity. 3) Contribute to strengthening a global community committed to employing NCD implementation research to improve health outcomes and achieve Sustainable Development Goal target 3.4. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) World Health Organization UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 819076 620773 185370 1625219 GB-GOV-10-AHPSR-NCDImpRes COMMITMENT UK - Department of Health and Social Care (DHSC) World Health Organization 644483 GB-GOV-10-AHPSR-NCDImpRes 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 174593 GB-GOV-10-AHPSR-NCDImpRes 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 620773 GB-GOV-10-AHPSR-NCDImpRes 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization GB-GOV-10-AHPSR-PolicyMakerNW UK - Department of Health and Social Care (DHSC) A collaboration between the World Health Organization (WHO) Alliance for Health Policy and Systems Research (AHPSR) and the National Institute for Health and Care Research (NIHR) to support establishment of a WHO Alliance policy-maker network. This programme of work will: - Convene senior policy-makers from Low- and Middle Income Countries (LMICs) for six convenings over a three year period (twice per year). These two-day convenings will take place either in Geneva or in countries where the Alliance is supporting activities; - Consult with the network to develop WHO Alliance research priorities; and - Include the network in ongoing WHO Alliance project policy processes, as a way to socialize emerging research findings. 1) Convene and facilitate a network of Low- and Middle-Income Country (LMIC) policy-makers to enhance cross-country dialogue, learning and exchange. 2) Expose policy-makers to innovative approaches in the use of research to improve health and health equity through policy and implementation. 3) Solicit policy-maker input into the prioritization and execution of health policy and systems research supported by the WHO Alliance. 4) Document lessons learned about working with national leaders to strengthen country capacities for health policy and systems research. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) World Health Organization UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research/scientific institutions Research and Innovation 165182 0 0 495546 GB-GOV-10-AHPSR-PolicyMakerNW COMMITMENT (1) UK - Department of Health and Social Care (DHSC) World Health Organization 63633 GB-GOV-10-AHPSR-PolicyMakerNW 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 101549 GB-GOV-10-AHPSR-PolicyMakerNW 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization -330364 GB-GOV-10-AHPSR-PolicyMakerNW COMMITMENT (2) UK - Department of Health and Social Care (DHSC) World Health Organization GB-GOV-10-AHPSR-Webinars UK - Department of Health and Social Care (DHSC) A collaboration between the World Health Organization (WHO) Alliance for Health Policy and Systems Research (AHPSR) and the National Institute for Health and Care Research (NIHR) to support the Alliance and Low- and Middle-Income Country (LMIC) researchers and academics to collaboratively develop a set of papers involving a wide range of stakeholders who have been key to growth of the global Health Policy and Systems Research field to date, as well as emerging LMIC health policy and systems researchers, practitioners and thinkers who will play a major role in charting its future evolution. The Alliance will also support a series of webinars demonstrating the value add of HPSR for global health and new growth areas in the field. 1) Explore topical areas that Health Policy and Systems Research (HPSR) has traditionally not focused on and where it has the greatest potential to contribute to improved health and well-being, and identify both broad thematic areas as well as priority research questions related to these areas where HPSR is uniquely positioned to add value to what is already known. 2) Identify the potential range of new methods that HPSR can adopt in a rapidly changing world that will enable it to meet ever evolving challenges to human and planetary health and well-being. 3) Explore how best to conduct HPSR to enable the necessary power shift from global to national actors and from researchers to policy-makers, practitioners and communities. 4) Delivere a series of three webinars to reflect on current issues of importance in HPSR. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) World Health Organization UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research/scientific institutions Research and Innovation 53024 0 76299 GB-GOV-10-AHPSR-WebPub COMMITMENT (1) UK - Department of Health and Social Care (DHSC) World Health Organization 53024 GB-GOV-10-AHPSR-WebPub 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization -23275 GB-GOV-10-AHPSR-WebPub COMMITMENT (2) UK - Department of Health and Social Care (DHSC) World Health Organization GB-GOV-10-EDCTP2 UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR provided funding to the European and Developing Countries Clinical Trials Partnership (EDCTP) which aims to support collaborative research that accelerates the clinical development of new or improved interventions to prevent or treat poverty related diseases as well as emerging and re-emerging infectious diseases affecting sub-Saharan Africa. The NIHR has supported research calls as part of the 2016, 2017 and 2018 workplans, in addition to programme management activities associated with enhancing the wider programme. 1) Increase the number of new or improved medical interventions for poverty-related diseases (PRDs), including neglected ones; 2) Strengthen cooperation with sub-Saharan African countries, in particular on building their capacity for conducting clinical trials in compliance with fundamental ethical principles and relevant national, EU and international legislation; 3) Better coordinate, align and, where appropriate, integrate relevant national programmes to increase the cost-effectiveness of European public investments; 4) Extend international cooperation with other public and private partners to ensure that the impact of all research is maximised and that synergies can be taken into consideration and to achieve leveraging of resources and investments; 5) Increase impact due to effective cooperation with relevant EU initiatives, including its development assistance. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) European and Developing Countries Clinical Trials Partnership (EDCTP) European and Developing Countries Clinical Trials Partnership (EDCTP) European and Developing Countries Clinical Trials Partnership (EDCTP) European and Developing Countries Clinical Trials Partnership (EDCTP) European and Developing Countries Clinical Trials Partnership (EDCTP) European and Developing Countries Clinical Trials Partnership (EDCTP) European and Developing Countries Clinical Trials Partnership (EDCTP) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-EDCTP2_2016WP UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR provided funding to the European and Developing Countries Clinical Trials Partnership (EDCTP) which aims to support collaborative research that accelerates the clinical development of new or improved interventions to prevent or treat poverty related as well as emerging and re-emerging infectious diseases affecting sub-Saharan Africa. NIHR has supported research as part of the 2016 Workplan focussed on, ‘Research and clinical management of patients in PRD epidemics in sub-Saharan Africa Clinical trials’ and ‘Operational research studies to optimise the use of products for poverty-related diseases in mothers, newborns, children and/or adolescents’. This activity is a component of European and Developing Countries Clinical Trials Partnership (EDCTP) phase II programme (GB-GOV-10-EDCTP2). 1) Support the establishment of a multidisciplinary consortium able to provide accelerated evidence for the optimal clinical management of patients and for guiding the public health response to any severe infectious outbreak caused by pathogens with pandemic potential or that may cause significant damage to health and socio-economics in Africa (including antimicrobial-resistant pathogens); 2) To optimise the use, delivery and access to poverty-related disease medicinal products in sub-Saharan Africa for mothers, newborns, children and/or adolescents. Supported projects should contribute to a better understanding of the role of PRDs in maternal, neonatal, child, and adolescent mortality and morbidity, as well as the barriers for the optimal effectiveness of health products, such as existing drugs or vaccines against these diseases in sub-Saharan Africa. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 16765600 1310175 16765600 GB-GOV-10-EDCTP2_2016WP COMMITMENT (1) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 8824000 GB-GOV-10-EDCTP2_2016WP 2017/18 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 7941600 GB-GOV-10-EDCTP2_2016WP 2017/18 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 1310175 GB-GOV-10-EDCTP2_2016WP COMMITMENT (2) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 1310175 GB-GOV-10-EDCTP2_2016WP 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) GB-GOV-10-EDCTP2_2017WP UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR provided funding to the European and Developing Countries Clinical Trials Partnership (EDCTP) which aims to support collaborative research that accelerates the clinical development of new or improved interventions to prevent or treat poverty-related diseases as well as emerging and re-emerging infectious diseases affecting sub-Saharan Africa. NIHR has supported research as part of the 2017 Workplan focussed on: ‘Strategic Actions Supporting Large-Scale Clinical Trials’ and ‘Clinical Trials to reduce health inequities in pregnant women, newborns and children’. This activity is a component of European and Developing Countries Clinical Trials Partnership (EDCTP) phase II programme (GB-GOV-10-EDCTP2). 1) support strategic actions (clinical research activities) that are part of a large-scale clinical trial with the potential to achieve rapid advances in the clinical development of new or improved medical interventions (drugs, diagnostics, vaccines, microbicides) for poverty related diseases; 2) accelerate the adaption and/or optimisation of treatment and prevention products (excluding vaccines) for povertyrelated diseases in sub-Saharan Africa for use in pregnant women, newborns and/or children. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 27000000 1345731 27000000 GB-GOV-10-EDCTP2_2017WP COMMITMENT (1) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 26500000 GB-GOV-10-EDCTP2_2017WP 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 500000 GB-GOV-10-EDCTP2_2017WP 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 1345731 GB-GOV-10-EDCTP2_2017WP COMMITMENT (2) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 1345731 GB-GOV-10-EDCTP2_2017WP 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) GB-GOV-10-EDCTP2_2018WP UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR provided funding to the European and Developing Countries Clinical Trials Partnership (EDCTP) which aims to support collaborative research that accelerates the clinical development of new or improved interventions to prevent or treat poverty related as well as emerging and re-emerging infectious diseases affecting sub-Saharan Africa. NIHR has supported research as part of the 2018 Workplan focussed on: ‘Advances in product development for effective prevention, treatment and management of co-infections and co-morbidities’; ‘Diagnostic tools for poverty-related diseases Challenge’; and "Vaccines for diarrhoeal diseases or lower respiratory tract infections". This activity is a component of European and Developing Countries Clinical Trials Partnership (EDCTP) phase II programme (GB-GOV-10-EDCTP2). 1) Support actions that lead to improvements in the prevention, treatment and/or clinical management of co-infections and co-morbidities in sub-Saharan Africa; 2) provide funding to projects focusing on validation of clinical performance and/or implementation of new or improved diagnostic tools and technologies for the detection of any of the PRDs including co-infections 3) improve the performance of diagnosis, prediction, monitoring, intervention or assessment of therapeutic response, with a significant impact on clinical decision and health outcomes 4) contribute towards the reduction of the burden of diarrhoeal diseases or lower respiratory tract infections in sub-Saharan Africa and lead to the advancement of vaccine candidates along the product development pipeline. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 10000000 21742000 1746900 10000000 GB-GOV-10-EDCTP2_2018WP COMMITMENT (1) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 10000000 GB-GOV-10-EDCTP2_2018WP 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 21742000 GB-GOV-10-EDCTP2_2018WP 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 21742000 GB-GOV-10-EDCTP2_2018WP COMMITMENT (2) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 1746900 GB-GOV-10-EDCTP2_2018WP COMMITMENT (3) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 1746900 GB-GOV-10-EDCTP2_2018WP 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) GB-GOV-10-EDCTP2_2020WP UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR provided funding to the European and Developing Countries Clinical Trials Partnership (EDCTP) which aims to support collaborative research that accelerates the clinical development of new or improved interventions to prevent or treat poverty related as well as emerging and re-emerging infectious diseases affecting sub-Saharan Africa. NIHR has supported research as part of the 2020 Workplan focussed on: ‘Mobilisation of funding for COVID-19 research in sub-Saharan Africa’; ‘Addressing gender and diversity gaps in clinical research capacity at the EDCTP Regional Networks of Excellence; and "Capacity development for disease outbreak and epidemic response in sub-Saharan Africa, in collaboration with Africa Centres for Disease Control and Prevention (Africa CDC)". This activity is a component of European and Developing Countries Clinical Trials Partnership (EDCTP) phase II programme (GB-GOV-10-EDCTP2). The activities of the EDCTP2 programme will contribute towards achieving the following five specific objectives: Increase the number of new or improved medical interventions for poverty-related diseases (PRDs), including neglected ones; Strengthen cooperation with sub-Saharan African countries, in particular on building their capacity for conducting clinical trials in compliance with fundamental ethical principles and relevant national, EU and international legislation; Better coordinate, align and, where appropriate, integrate relevant national programmes to increase the cost-effectiveness of European public investments; Extend international cooperation with other public and private partners to ensure that the impact of all research is maximised and that synergies can be taken into consideration and to achieve leveraging of resources and investments; Increase impact due to effective cooperation with relevant EU initiatives, including its development assistance. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 4800000 1746900 3350000 GB-GOV-10-EDCTP2_2020WP 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 4800000 GB-GOV-10-EDCTP2_2020WP COMMITMENT (1) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 450000 GB-GOV-10-EDCTP2_2020WP 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 1000000 GB-GOV-10-EDCTP2_2020WP 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 1746900 GB-GOV-10-EDCTP2_2020WP 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 1746900 GB-GOV-10-EDCTP2_2020WP COMMITMENT (2) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) GB-GOV-10-EDCTP2_2024WP UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR provided funding to the European and Developing Countries Clinical Trials Partnership (EDCTP) which aims to support collaborative research that accelerates the clinical development of new or improved interventions to prevent or treat poverty related as well as emerging and re-emerging infectious diseases affecting sub-Saharan Africa. NIHR has supported research capacity strengthening and training in sub-Saharan Africa, related to strengthening clinical trials capacity as part of the 2024 Workplan focussed on: • Support for an updated EDCTP Masters scholarship scheme for candidates from sub-Saharan Africa to undertake Masters degrees with an option for an associated project or policy activity • Support for candidates from sub-Saharan Africa to attend training specific to improving clinical trial capability in sub-Saharan Africa 1. Support for an updated EDCTP Masters scholarship scheme for candidates from sub-Saharan Africa to attend relevant Master programmes in subject areas relevant to clinical research, epidemiology, clinical trials and global health, with an associated option for a further research or policy project 2. Scholarships for: (i) candidates from sub-Saharan Africa to attend the 2-week training programme, Advanced Course of Vaccinology (ADVAC) for scientists and decision-makers involved in vaccine development, new vaccination strategies or in associated policy areas (ii) Strengthening the EDCTP Regional Networks of Excellence through bioprocessing training UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 1759385 104814 GB-GOV-10-EDCTP2_2024WS 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 1759385 GB-GOV-10-EDCTP2_2024WS COMMITMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 1654571 GB-GOV-10-EDCTP2_2024WP 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) GB-GOV-10-EDCTP2_PM UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The European & Developing Countries Clinical Trials Partnership (EDCTP) funds clinical research to accelerate the development of new or improved drugs, vaccines, microbicides and diagnostics against HIV/AIDS, tuberculosis and malaria as well as other poverty-related infectious diseases in sub-Saharan Africa, with a focus on phase II and III clinical trials. The NIHR provided a funding contribution to EDCTP 2 programme management activities. This activity is a component of European and Developing Countries Clinical Trials Partnership (EDCTP) phase II programme (GB-GOV-10-EDCTP2). Support the European & Developing Countries Clinical Trials Partnership to effectively deliver EDCTP2 programmes. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 1409500 790909 1409500 GB-GOV-10-EDCTP2_PM COMMITMENT (1) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 500000 GB-GOV-10-EDCTP2_PM 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 258000 GB-GOV-10-EDCTP2_PM 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 167500 GB-GOV-10-EDCTP2_PM 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 160000 GB-GOV-10-EDCTP2_PM 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 324000 GB-GOV-10-EDCTP2_PM 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 185171 GB-GOV-10-EDCTP2_PM 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 790909 GB-GOV-10-EDCTP2_PM COMMITMENT (2) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 605738 GB-GOV-10-EDCTP2_PM 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) GB-GOV-10-EDCTP2_Scheme7 UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR provided funding to European and Developing Countries Clinical Trials Partnership (EDCTP) which aims to support collaborative research that accelerates the clinical development of new or improved interventions to prevent or treat poverty related as well as emerging and re-emerging infectious diseases affecting sub-Saharan Africa. NIHR has supported the research as part of the the Global Research Collaboration for Infectious Diseases Preparedness (GloPID-R) Secretariat on Pandemic Preparedness: Analytical Capacity and Funding Tracking programme (Pandemic PACT). This activity is a component of European and Developing Countries Clinical Trials Partnership (EDCTP) phase II programme (GB-GOV-10-EDCTP2). Support to develop the creation of Pandemic Analytical Capacity and Funding Tracking Programme (Pandemic PACT) database which build on the COVID CIRCLE research tracker established during the COVID-19 pandemic. Pandemic PACT will develop a research funding tracking and analysis capability for a range of emerging infections, in particular focussed on those primariliy affection low and middle-income country poulations, with the outputs linked to major funders, decision makers and WHO. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 2176000 600000 GB-GOV-10-EDCTP2_Scheme7 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 1576000 GB-GOV-10-EDCTP2_Scheme7 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 2176000 GB-GOV-10-EDCTP2_Scheme7 COMMITMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) GB-GOV-10-EDCTP2_Scheme8 UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR provided funding to European and Developing Countries Clinical Trials Partnership (EDCTP) which aims to support collaborative research that accelerates the clinical development of new or improved interventions to prevent or treat poverty related as well as emerging and re-emerging infectious diseases affecting sub-Saharan Africa. NIHR has supported through EDCTP2 proposed actions for WHO to support implementation of the World Health Assembly Clinical Trials Resolution. This activity is a component of European and Developing Countries Clinical Trials Partnership (EDCTP) phase II programme (GB-GOV-10-EDCTP2). Support to WHO to develop global normative implementation guidance to focus clinical trials on key design features that will increase the quality of evidence for decision-making and increase trial capacity, particularly focussed on low and middle-income country settings, as part of implementaion of the World Health Assembly Resolution on Clinical Trials (WAH 75.8). UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 840000 840000 GB-GOV-10-EDCTP2_Scheme8 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 840000 GB-GOV-10-EDCTP2_Scheme8 COMMITMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) GB-GOV-10-EDCTP3 UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR provides funding to the Global Health European and Developing Countries Clinical Trials Partnership 3 (Global Health EDCTP3) Joint Undertaking which works to deliver new solutions to reduce the burden of poverty-related infectious diseases in sub-Saharan Africa and to strengthen research capacities to prepare and respond to re-emerging infectious diseases. Global Health EDCTP3 builds on EDCTP Phase 2, which NIHR has been contributing to since 2016 (GB-GOV-10-EDCTP2). As EDCTP transitions to Global Health EDCTP3, calls under the new work packages will support further clinical research and training in sub-Saharan Africa. The EU Strategic Research and Innovation Agenda (SRIA) for the Global Health EDCTP3 programme has two programmatic aims and five specific objectives for the 2021 to 2031 work programme. The programme aims to: (1) reduce the individual, social, and economic burdens of infectious diseases in sub-Saharan Africa through the development and uptake of new or improved interventions and (2) increase health security in sub-Saharan Africa and globally, particularly in the context of environmental change and the climate crisis, by reducing the risk of outbreaks and pandemics, and enhancing national and regional capacity to address antimicrobial resistance. Five specific objectives: 1) Advance biomedical interventions towards improved overall health, 2) Research capacity development, 3) Enhance coordination, 4) Strengthen capacity for epidemic preparedness and 5) build partnerships and strategic alliances. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) European and Developing Countries Clinical Trials Partnership (EDCTP) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-EDCTP3_GlobalHealth UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The European and Developing Countries Clinical Trials Partnership (EDCTP) funds clinical research to accelerate the development of new or improved drugs, vaccines, microbicides and diagnostics against HIV/AIDS, tuberculosis and malaria as well as other poverty-related infectious diseases in sub-Saharan Africa, with a focus on phase II and III clinical trials. This activity is a component of European and Developing Countries Clinical Trials Partnership (EDCTP) phase III (Global Health EDCTP3) programme (A7397_AA7398). DHSC will support EDCTP3 activities in the fiscal year 2024-2025, which supports relevant Global Health EDCTP3 call topics and capacity strengthening under agreed work programmes. Possible call topic areas include neglected tropical diseases, vector control, digital health and research training fellowships. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 9090909 17890909 9090909 1000000 1000000 2000000 27272727 GB-GOV-10-EDCTP3_GlobalHealth COMMITMENT (1) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 8608442 GB-GOV-10-EDCTP3_GlobalHealth 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 4520000 GB-GOV-10-EDCTP3_GlobalHealth 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 454545 GB-GOV-10-EDCTP3_GlobalHealth 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 9178693 GB-GOV-10-EDCTP3_GlobalHealth 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 12800000 GB-GOV-10-EDCTP3_GlobalHealth COMMITMENT (2) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 10000000 GB-GOV-10-EDCTP3_GlobalHealth 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) GB-GOV-10-EDCTP3_PM UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The Global Health European and Developing Countries Clinical Trials Partnership 3 (Global Health EDCTP3) Joint Undertaking works to deliver new solutions to reduce the burden of poverty-related infectious diseases in sub-Saharan Africa and to strengthen research capacities to prepare and respond to re-emerging infectious diseases. EDCTP Members who have committed to participating in Global Health EDCTP3 are required to make an annual contribution to the EDCTP Association administrative costs. NIHR as a member provides a funding contribution to the EDCTP Association annual administrative costs and EDCTP 3 programme management activities. This activity is a component of European and Developing Countries Clinical Trials Partnership (EDCTP) phase III (Global Health EDCTP3) programme (A7397_AA7398). Support the European & Developing Countries Clinical Trials Partnership to effectively deliver EDCTP programmes to benefit people in sub-Saharan Africa. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 88385.78 909091 909091 909091 88385.78 GB-GOV-10-EDCTP3_PM 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 88385.78 GB-GOV-10-EDCTP3_PM COMMITMENT (1) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 2727273 GB-GOV-10-EDCTP3_PM COMMITMENT (2) UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 860843 GB-GOV-10-EDCTP3_PM 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 45455 GB-GOV-10-EDCTP3_PM 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) 880000 GB-GOV-10-EDCTP3_PM 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) European and Developing Countries Clinical Trials Partnership (EDCTP) GB-GOV-10-GACD UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The Global Alliance for Chronic Diseases (GACD) coordinates and supports research activities that address the prevention and treatment of chronic non-communicable diseases, on a global scale. The GACD is the first collaboration of major research funding agencies to specifically address chronic non-communicable diseases. 1) Coordination - To build increasing levels of research collaboration across the member agencies; 2) Awareness - To create a platform for general awareness raising and to conduct outreach beyond the original founding members; 3) Capacity-building - To develop and maintain global knowledge-sharing platforms in the conduct and management of chronic non-communicable diseases research in low- and middle-income countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council Medical Research Council Medical Research Council Global Alliance for Chronic Diseases (GACD) Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-GACD_Cities UK - Department of Health and Social Care (DHSC) The National Institute for Health and Care Research (NIHR), in partnership with the UK Medical Research Council (MRC) and the Global Alliance for Chronic Diseases (GACD), funds implementation research to generate new knowledge on interventions and their implementation for the prevention or management of chronic non-communicable diseases (NCDs). The GACD funding call for implementation research targeting chronic non-communicable disease risk factors associated with city environments will focus on implementation research proposals with the potential to equip policymakers and practitioners with evidence-based strategies for reducing the risk factors for non-communicable diseases in cities in disadvantaged populations globally. To fund implementation research focused on addressing Non-Communicable Disease (NCD) risk factors associated with city environments and related health inequities, in populations in Low- and Middle-Income countries; provide city leaders globally with evidence-based policy and practice recommendations that promote population health in equitable and environmentally sustainable ways and address the challenges of rapid urbanisation, growing social inequalities, and climate change; to improve capacity for cross-sectoral implementation research; and to contribute to the UN Sustainable Development Goal 3.4 to reduce premature mortality from NCDs by one third by 2030. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 776214.6 1100113.7500000002 1118901.33 681319.23 73451.09 3750000 GB-GOV-10-GACD_Cities COMMITMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 136493.14 GB-GOV-10-GACD_Cities 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 639721.46 GB-GOV-10-GACD_Cities 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 270185.72 GB-GOV-10-GACD_Cities 2025/26 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 276155.34 GB-GOV-10-GACD_Cities 2025/26 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 276886.34 GB-GOV-10-GACD_Cities 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 276886.34 GB-GOV-10-GACD_Cities 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 276886.34 GB-GOV-10-GACD_Cities 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council GB-GOV-10-GACD_Common_Risk_Factors UK - Department of Health and Social Care (DHSC) The National Institute for Health and Care Research (NIHR), in partnership with the UK Medical Research Council (MRC) and the Global Alliance for Chronic Diseases (GACD), funds implementation research to generate new knowledge on interventions and their implementation for the prevention or management of chronic non-communicable diseases (NCDs). The GACD call for reducing global health non-communicable disease risk for young people (the GACD Common Risk Factors Call) funds implementation research proposals that take a life course approach to reducing the risks for NCDs in low- and middle-income countries (LMICs), funding projects that focus on young people (i.e. those aged 10-24), which includes adolescents (ages 10-19) and youth (15-24). This activity is a component of the Global Alliance for Chronic Diseases programme, GB-GOV-10-GACD. The aim of this call is to fund implementation research focused on addressing common Non-Communicable Disease risk factors through interventions that reduce health risk and/or enhance positive health and lifestyle behaviours in young people. The projects funded under this call will collectively: Contribute to the UN Sustainable Development Goal 3.4 to reduce premature mortality from NCDs by one third by 2030; Reduce health inequities linked to socioeconomic status, sex/gender, race/ethnicity, age, and other social and structural factors at both the local and global levels; Improve quality of life across the life course and extend healthy life expectancy; Advance local, regional, or national preventative health policies addressing common risk factors for NCDs; Improve understanding of demographic and life stage variations in managing common NCD risk factors and for sustaining positive change; Establish the contextual effectiveness of reducing exposure to, or impact of, common NCD risk factors at different life stages, including at systems level; Provide evidence and recommendations to national programmes and policies; Inform health service providers, policy, and/or other decision makers on the effective adaptation and/or scaling up of interventions at local, regional, and national levels; Improve local capacity for implementation research, data harmonisation, and stakeholder engagement for management and prevention of common NCD risk factors. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 547948 822788 835232 603653 190379 33541.6 GB-GOV-10-GACD_Common_Risk_Factors 2023/24 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 256193.85 GB-GOV-10-GACD_Common_Risk_Factors 2023/24 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 202272.8 GB-GOV-10-GACD_Common_Risk_Factors 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 3000000 GB-GOV-10-GACD_Common_Risk_Factors COMMITMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 202272.8 GB-GOV-10-GACD_Common_Risk_Factors 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 204550.04 GB-GOV-10-GACD_Common_Risk_Factors 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 207289 GB-GOV-10-GACD_Common_Risk_Factors 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 207289.17 GB-GOV-10-GACD_Common_Risk_Factors 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 207289.17 GB-GOV-10-GACD_Common_Risk_Factors 2025/26 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 209622.9 GB-GOV-10-GACD_Common_Risk_Factors 2025/26 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 209775.94 GB-GOV-10-GACD_Common_Risk_Factors 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 209775.94 GB-GOV-10-GACD_Common_Risk_Factors 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 128525.56 GB-GOV-10-GACD_Common_Risk_Factors 2026/27 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council GB-GOV-10-GACD_Hyp_Dbt UK - Department of Health and Social Care (DHSC) The National Institute for Health and Care Research (NIHR), in partnership with the UK Medical Research Council (MRC) and the Global Alliance for Chronic Diseases (GACD), funds implementation research to generate new knowledge on interventions and their implementation for the prevention or management of chronic non-communicable diseases (NCDs). The Global Alliance for Chronic Diseases Scale-up call for research in the scaling up of evidence-based interventions at the population level for the prevention and/or management of hypertension and/or diabetes (the "Scale-up call") will support research associated with the scale-up of interventions for the prevention and/or detection and management of hypertension and/or diabetes in low- and middle-income countries (LMICs). This activity is a component of the Global Alliance for Chronic Diseases programme, GB-GOV-10-GACD. To support research associated with the scale-up of interventions for the prevention and/or detection and management of hypertension and/or diabetes in low- and middle-income countries (LMICs); To develop a network of researchers that can enhance the cumulative learning across individual projects and work towards understanding how socio-economic, cultural, geopolitical and policy contexts have influenced results and how findings might be adapted and applied in different settings. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 351873.94 868513.56 875546.54 636198.4199999999 343352.52 78958.02000000021 3154443 GB-GOV-10-GACD_Hyp_Dbt COMMITMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 78851.44 GB-GOV-10-GACD_Hyp_Dbt 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 273022.38 GB-GOV-10-GACD_Hyp_Dbt 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 216415.85 GB-GOV-10-GACD_Hyp_Dbt 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 216415.86000000002 GB-GOV-10-GACD_Hyp_Dbt 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 217513.07 GB-GOV-10-GACD_Hyp_Dbt 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 218168.82 GB-GOV-10-GACD_Hyp_Dbt 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 218168.82 GB-GOV-10-GACD_Hyp_Dbt 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 218168.82 GB-GOV-10-GACD_Hyp_Dbt 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 219274.92 GB-GOV-10-GACD_Hyp_Dbt 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 219935.99 GB-GOV-10-GACD_Hyp_Dbt 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 219935.99 GB-GOV-10-GACD_Hyp_Dbt 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 113096.67 GB-GOV-10-GACD_Hyp_Dbt 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 109910.36 GB-GOV-10-GACD_Hyp_Dbt 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 110548.95 GB-GOV-10-GACD_Hyp_Dbt 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 110548.95 GB-GOV-10-GACD_Hyp_Dbt 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 124547.49 GB-GOV-10-GACD_Hyp_Dbt 2023/24 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 57814.06 GB-GOV-10-GACD_Hyp_Dbt 2023/24 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 57814.06 GB-GOV-10-GACD_Hyp_Dbt 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 88850.42 GB-GOV-10-GACD_Hyp_Dbt 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 65441.08 GB-GOV-10-GACD_Hyp_Dbt 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council GB-GOV-10-GACD_Membership UK - Department of Health and Social Care (DHSC) The Global Alliance for Chronic Diseases (GACD) funds implementation research to generate new knowledge on interventions and their implementation for the prevention or management of chronic non-communicable diseases (NCDs). As an Associate Member of the alliance, the Department of Health and Social Care (DHSC) pays an annual fee to support the activities of the GACD. This activity is a component of the Global Alliance for Chronic Diseases programme, GB-GOV-10-GACD. 1. To tackle the burden of chronic non-communicable diseases (NCDs), by systematically building the evidence base for sound policymaking. 2. Ensure a common understanding of health priorities as well as bigger impact of the collective actions of the Global Alliance for Chronic Diseases (GACD). 3. Joint development and management of funding opportunities and research programmes 4. Coordination of research priorities to avoid the potential duplication of efforts and enable a better focus on research areas where the need for evidence to inform policy, programmes and practice is most urgent. 5. Foster research partnerships to enable knowledge sharing and capacity building UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Global Alliance for Chronic Diseases (GACD) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Sectors not specified Research and Innovation 70000 70000 60000 67200 77200 85000 85000 70000 GB-GOV-10-GACD_Membership 2020/21 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) Global Alliance for Chronic Diseases (GACD) 140000 GB-GOV-10-GACD_Membership COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Global Alliance for Chronic Diseases (GACD) 70000 GB-GOV-10-GACD_Membership 2021/22 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) Global Alliance for Chronic Diseases (GACD) 60000 GB-GOV-10-GACD_Membership 2022/23 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) Global Alliance for Chronic Diseases (GACD) 204400 GB-GOV-10-GACD_Membership COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Global Alliance for Chronic Diseases (GACD) 60000 GB-GOV-10-GACD_Membership 2023/24 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) Global Alliance for Chronic Diseases (GACD) 60000 GB-GOV-10-GACD_Membership 2024/25 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) Global Alliance for Chronic Diseases (GACD) 85000 GB-GOV-10-GACD_Membership COMMITMENT (3) UK - Department of Health and Social Care (DHSC) Global Alliance for Chronic Diseases (GACD) 85000 GB-GOV-10-GACD_Membership 2025/26 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) Global Alliance for Chronic Diseases (GACD) 85000 GB-GOV-10-GACD_Membership COMMITMENT (4) UK - Department of Health and Social Care (DHSC) Global Alliance for Chronic Diseases (GACD) 85000 GB-GOV-10-GACD_Membership 2026/27 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) Global Alliance for Chronic Diseases (GACD) GB-GOV-10-GACD_Mental_Health UK - Department of Health and Social Care (DHSC) The National Institute for Health and Care Research (NIHR), in partnership with the UK Medical Research Council (MRC) and the Global Alliance for Chronic Diseases (GACD), funds implementation research to generate new knowledge on interventions and their implementation for the prevention or management of chronic non-communicable diseases (NCDs). The GACD funding call on Prevention and Management of Mental Health Conditions focuses on implementation research on child, adolescent and adult age onset mental disorders in low- and middle-income countries, including, but not limited to, dementia, depression, schizophrenia, bipolar disorders, alcohol- and drug-use disorders in low- and middle-income countries. This activity is a component of the Global Alliance for Chronic Diseases programme, GB-GOV-10-GACD. Advance prevention strategies and implementation of mental health interventions, alleviating global burden of mental disorders; Establish the contextual effectiveness of mental health intervention(s), including at health systems level; Improve tailored prevention and treatment; develop affordable management and treatment modalities for mental disorders and expand access to care; Inform health service providers, policy and decision makers on effective scaling up of mental health interventions at local, national and regional levels, including affordability aspects for users and health providers; Reduce health inequalities and inequities, including due consideration of gender and age issues where relevant, in the prevention, treatment and care of mental disorders at both local and global levels; Maximise the use of existing relevant programmes and platforms (e.g. research, data, and delivery platforms); Contribute to the United Nations' Sustainable Development Goals 3, 5, 10 and 17, the Global Action Against Dementia and the First World Health Organization (WHO) Ministerial Conference on Dementia, the WHO Mental Health Action Plan 2013-2020. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 197252.11 324430.88 478317.00999999995 1000000 GB-GOV-10-GACD_Mental_Health COMMITMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 116191.96 GB-GOV-10-GACD_Mental_Health 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 81060.15000000001 GB-GOV-10-GACD_Mental_Health 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 81060.15 GB-GOV-10-GACD_Mental_Health 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 81344.71 GB-GOV-10-GACD 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 81013.01 GB-GOV-10-GACD_Mental_Health 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 81013.01 GB-GOV-10-GACD_Mental_Health 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 81013.01 GB-GOV-10-GACD_Mental_Health 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 80070.5 GB-GOV-10-GACD_Mental_Health 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 79752.9 GB-GOV-10-GACD_Mental_Health 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 79752.9 GB-GOV-10-GACD_Mental_Health 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 45279.04 GB-GOV-10-GACD_Mental_Health 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 8157.34 GB-GOV-10-GACD_Mental_Health 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council GB-GOV-10-JGHT UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). This programme is administered by the UK Medical Research Council (MRC), which reports activities under the UK Department for Business, Energy and Industrial Strategy (BEIS). NIHR disburses funds to MRC, which makes onwards disbursements to awardees. The aim of this programme is to generate new knowledge to contribute to improving health in low and middle income countries (LMICs). Priority will be given to proposals most likely to yield implementable results and designed to address the major causes of mortality or morbidity in LMICs. To fund rigorous research to produce implementable evidence addressing questions of major importance to mortality and morbidity in low- and middle-income countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-JGHT_1-6 UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). This programme is administered by the UK Medical Research Council (MRC), which reports activities under the UK Department for Business, Energy and Industrial Strategy (BEIS). NIHR disburses funds to MRC, which makes onwards disbursements to awardees. This activity (Joint Global Health Trials Initiative: funding for research calls 1-6) funds proposals designed to yield implementable results and designed to address the major causes of mortality or morbidity in LMICs. This is a component of Joint Global Health Trials Initiative (GB-GOV-10-JGHT), reported by DHSC. The objectives of this activity are detailed under Joint Global Health Trials Initiative (GB-GOV-10-JGHT), reported by DHSC. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 2811679.4 9095714 7681256 2983464 1427886.6000000015 24000000 GB-GOV-10-JGHT_1-6 COMMITMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 418489.01 GB-GOV-10-JGHT_1-6 2017/18 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 701750.77 GB-GOV-10-JGHT_1-6 2017/18 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 769831.59 GB-GOV-10-JGHT_1-6 2017/18 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 1702706.57 GB-GOV-10-JGHT_1-6 2017/18 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 4150113.43 GB-GOV-10-JGHT_1-6 2017/18 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 1352822.48 GB-GOV-10-JGHT_1-6 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 1200392.34 GB-GOV-10-JGHT_1-6 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 1339173.62 GB-GOV-10-JGHT_1-6 2018/19 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 3648763.2600000002 GB-GOV-10-JGHT_1-6 2018/19 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 911302.8300000001 GB-GOV-10-JGHT_1-6 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 820111.14 GB-GOV-10-JGHT_1-6 2019/20 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 873514.34 GB-GOV-10-JGHT_1-6 2019/20 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 708470.04 GB-GOV-10-JGHT_1-6 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 2811679.4 GB-GOV-10-JGHT_1-6 2016/17 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 813663.32 GB-GOV-10-JGHT_1-6 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 336881.36 GB-GOV-10-JGHT_1-6 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 379037.69 GB-GOV-10-JGHT_1-6 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 265864.67 GB-GOV-10-JGHT_1-6 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 305438.17 GB-GOV-10-JGHT_1-6 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 258991.79 GB-GOV-10-JGHT_1-6 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 47345.32 GB-GOV-10-JGHT_1-6 2021/22 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 108782.08 GB-GOV-10-JGHT_1-6 2021/22 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 342882.83 GB-GOV-10-JGHT_1-6 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 141923.19 GB-GOV-10-JGHT_1-6 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 92547.37 GB-GOV-10-JGHT_1-6 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 190247.37 GB-GOV-10-JGHT_1-6 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 48849.99 GB-GOV-10-JGHT_1-6 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council -75101.83 GB-GOV-10-JGHT_1-6 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council GB-GOV-10-JGHT_7-11 UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). This programme is administered by the UK Medical Research Council (MRC), which reports activities under the UK Department for Business, Energy and Industrial Strategy (BEIS). NIHR disburses funds to MRC, which makes onwards disbursements to awardees. This activity (Joint Global Health Trials Initiative: funding for research calls 7-11) funds proposals designed to yield implementable results and designed to address the major causes of mortality or morbidity in LMICs. This is a component of Joint Global Health Trials Initiative (GB-GOV-10-JGHT), reported by DHSC. The objectives of this activity are detailed under Joint Global Health Trials Initiative (GB-GOV-10-JGHT), reported by DHSC. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 160961.47 2000000 3500000 20789038.53 25000000 GB-GOV-10-JGHT_7-11 COMMITMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 98804.9 GB-GOV-10-JGHT_7-11 2017/18 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 14179.23 GB-GOV-10-JGHT_7-11 2017/18 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 47977.34 GB-GOV-10-JGHT_7-11 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 5347.77 GB-GOV-10-JGHT_7-11 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 123684.25 GB-GOV-10-JGHT_7-11 2018/19 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 4563.27 GB-GOV-10-JGHT_7-11 2018/19 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 488510.97000000003 GB-GOV-10-JGHT_7-11 2018/19 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 3923.33 GB-GOV-10-JGHT_7-11 2018/19 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 528793.72 GB-GOV-10-JGHT_7-11 2018/19 Q3 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) Medical Research Council 4997.75 GB-GOV-10-JGHT_7-11 2018/19 Q3 DISBURSEMENT (4) UK - Department of Health and Social Care (DHSC) Medical Research Council 435071.85000000003 GB-GOV-10-JGHT_7-11 2018/19 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 4997.75 GB-GOV-10-JGHT_7-11 2018/19 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 685572.23 GB-GOV-10-JGHT_7-11 2019/20 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 5375.76 GB-GOV-10-JGHT_7-11 2019/20 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 663123.12 GB-GOV-10-JGHT_7-11 2019/20 Q2 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) Medical Research Council 5375.76 GB-GOV-10-JGHT_7-11 2019/20 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 5375.76 GB-GOV-10-JGHT_7-11 2019/20 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 749706.14 GB-GOV-10-JGHT_7-11 2019/20 Q3 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) Medical Research Council 3184.2000000000003 GB-GOV-10-JGHT_7-11 2019/20 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 23881.5 GB-GOV-10-JGHT_7-11 2019/20 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 4776.3 GB-GOV-10-JGHT_7-11 2019/20 Q4 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) Medical Research Council 15921 GB-GOV-10-JGHT_7-11 2019/20 Q4 DISBURSEMENT (4) UK - Department of Health and Social Care (DHSC) Medical Research Council 6184.62 GB-GOV-10-JGHT_7-11 2019/20 Q4 DISBURSEMENT (5) UK - Department of Health and Social Care (DHSC) Medical Research Council 785634.84 GB-GOV-10-JGHT_7-11 2019/20 Q4 DISBURSEMENT (6) UK - Department of Health and Social Care (DHSC) Medical Research Council 6181.04 GB-GOV-10-JGHT_7-11 2020/21 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 927510.8 GB-GOV-10-JGHT_7-11 2020/21 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 6731.75 GB-GOV-10-JGHT_7-11 2020/21 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 911599.6900000001 GB-GOV-10-JGHT_7-11 2020/21 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 1076205.73 GB-GOV-10-JGHT_7-11 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 6309.19 GB-GOV-10-JGHT_7-11 2020/21 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 779520.79 GB-GOV-10-JGHT_7-11 2020/21 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 6369.86 GB-GOV-10-JGHT_7-11 2020/21 Q4 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) Medical Research Council 6557.9 GB-GOV-10-JGHT_7-11 2021/22 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 1173516.29 GB-GOV-10-JGHT_7-11 2021/22 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 6847.3 GB-GOV-10-JGHT_7-11 2021/22 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 1143020.71 GB-GOV-10-JGHT_7-11 2021/22 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 6944.84 GB-GOV-10-JGHT_7-11 2021/22 Q3 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) Medical Research Council 1229811.53 GB-GOV-10-JGHT_7-11 2021/22 Q3 DISBURSEMENT (4) UK - Department of Health and Social Care (DHSC) Medical Research Council 1450000 GB-GOV-10-JGHT_7-11 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 6648.97 GB-GOV-10-JGHT_7-11 2021/22 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 961114.64 GB-GOV-10-JGHT_7-11 2021/22 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 6573.62 GB-GOV-10-JGHT_7-11 2022/23 Q1 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 848794.53 GB-GOV-10-JGHT_7-11 2022/23 Q1 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 676577.09 GB-GOV-10-JGHT_7-11 2022/23 Q2 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 6535.27 GB-GOV-10-JGHT_7-11 2022/23 Q2 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 488053.95 GB-GOV-10-JGHT_7-11 2022/23 Q3 DISBURSMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 7343.31 GB-GOV-10-JGHT_7-11 2022/23 Q3 DISBURSMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 717201.29 GB-GOV-10-JGHT_7-11 2022/23 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 7119.35 GB-GOV-10-JGHT_7-11 2022/23 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 6965.71 GB-GOV-10-JGHT_7-11 2023/24 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 724600.88 GB-GOV-10-JGHT_7-11 2023/24 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 404205.16 GB-GOV-10-JGHT_7-11 2023/24 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 6868.58 GB-GOV-10-JGHT_7-11 2023/24 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 395039.59 GB-GOV-10-JGHT_7-11 2023/24 Q3 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) Medical Research Council 9359.43 GB-GOV-10-JGHT_7-11 2023/24 Q3 DISBURSEMENT (4) UK - Department of Health and Social Care (DHSC) Medical Research Council 481198.13 GB-GOV-10-JGHT_7-11 2023/24 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 9413.81 GB-GOV-10-JGHT_7-11 2023/24 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 342598.03 GB-GOV-10-JGHT_7-11 2024/25 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 7700.25 GB-GOV-10-JGHT_7-11 2024/25 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 7861.11 GB-GOV-10-JGHT_7-11 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 443326.34 GB-GOV-10-JGHT_7-11 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 191407 GB-GOV-10-JGHT_7-11 2024/25 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 8589.67 GB-GOV-10-JGHT_7-11 2024/25 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 148354.24 GB-GOV-10-JGHT_7-11 2024/25 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 8675.56 GB-GOV-10-JGHT_7-11 2024/25 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 10514.78 GB-GOV-10-JGHT_7-11 2025/26 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 140444.34 GB-GOV-10-JGHT_7-11 2025/26 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 72808.25 GB-GOV-10-JGHT_7-11 2025/26 Q2 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) Medical Research Council 10619.93 GB-GOV-10-JGHT_7-11 2025/26 Q2 DISBURSEMENT (4) UK - Department of Health and Social Care (DHSC) Medical Research Council 85786.15 GB-GOV-10-JGHT_7-11 2025/26 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 10726.13 GB-GOV-10-JGHT_7-11 2025/26 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 105977.34 GB-GOV-10-JGHT_7-11 2025/26 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 2467.95 GB-GOV-10-JGHT_7-11 2025/26 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 35536.48 GB-GOV-10-JGHT_7-11 2026/27 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 8079.7 GB-GOV-10-JGHT_7-11 2026/27 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council GB-GOV-10-RSTMH UK - Department of Health and Social Care (DHSC) National Institute for Health and Care Research (NIHR)’s funding to the Royal Society of Tropical Medicine and Hygiene (RSTMH) Early Career Grants Scheme supports early career researchers in low and middle income countries (LMICs) to develop their research skills and expertise. This partnership contributes to the NIHR Global Health Research priority to strengthen research capacity in LMICs. 1) Enable early career researchers and global health professionals of LMIC nationality to undertake applied health research or fieldwork that directly and primarily benefits people in LMICs 2) Develop and improve the research and management skills of early career LMIC researchers through leading a small independent research project 3) Help early career LMIC researchers to widen their networks within their institutions, countries and potentially globally, and within their field of work 4) Establish a peer cohort of awardees to increase collaboration and networking opportunities 5) Support early career LMIC researchers to progress their careers UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene Royal Society of Tropical Medicine & Hygiene Royal Society of Tropical Medicine & Hygiene Royal Society of Tropical Medicine & Hygiene Royal Society of Tropical Medicine & Hygiene UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation GB-GOV-10-RSTMH_SG_2019 UK - Department of Health and Social Care (DHSC) A partnership with the Royal Society of Tropical Medicine and Hygiene (RSTMH) to support small grant awards for early career researchers based in low- and middle-income countries (LMICs). Awards will specifically support research and capacity development for LMIC researchers which will benefit patients and the public in LMICs Enable early career researchers and global health professionals in low- and middle-income countries to undertake clinical and applied health research or fieldwork, and access training in grant writing and mentoring; 'pump-prime' funding to early career researchers in strategic research areas; increase the quality and number of applications to other NIHR Global Health Research funded schemes UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 166599 166599 GB-GOV-10-RSTMH_SG COMMITMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene 161230.26 GB-GOV-10-RSTMH_SG 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene GB-GOV-10-RSTMH_SG_2020 UK - Department of Health and Social Care (DHSC) A partnership with the Royal Society of Tropical Medicine and Hygiene (RSTMH) to support small grant awards for early career researchers based in low- and middle-income countries (LMICs). Awards will specifically support research and capacity development for LMIC researchers which will benefit patients and the public in LMICs Enable early career researchers and global health professionals in low- and middle-income countries to undertake clinical and applied health research or fieldwork, and access training in grant writing and mentoring; 'pump-prime' funding to early career researchers in strategic research areas; increase the quality and number of applications to other NIHR Global Health Research funded schemes UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 590041 587744.9500000001 GB-GOV-10-RSTMH_SG 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene 590041 GB-GOV-10-RSTMH_SG_2020 COMMITMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene GB-GOV-10-RSTMH_SG_2021 UK - Department of Health and Social Care (DHSC) A partnership with the Royal Society of Tropical Medicine and Hygiene (RSTMH) to support small grant awards for early career researchers based in low- and middle-income countries (LMICs). Awards will specifically support research and capacity development for LMIC researchers which will benefit patients and the public in LMICs The 2021 small grants scheme will: 1) enable early career researchers and global health professionals in LMICs to undertake clinical and applied health research or fieldwork 2) develop research and management skills of early career LMIC researchers through leading a small independent research project 3) establish a peer cohort of awardees to increase collaboration and networking opportunities 4) enhance future funding opportunities of LMIC early career researchers 5) strengthen a beneficial scheme to ensure that a higher proportion of fundable applications receive funding than previous years UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 813250 813250 GB-GOV-10-RSTMH_SG_2021 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene 813250 GB-GOV-10-RSTMH_SG_2021 COMMITMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene GB-GOV-10-RSTMH_ECG_2022 UK - Department of Health and Social Care (DHSC) A partnership with the Royal Society of Tropical Medicine and Hygiene (RSTMH) to support small grant awards for early career researchers based in low- and middle-income countries (LMICs). Awards will specifically support research and capacity development for LMIC researchers which will benefit patients and the public in LMICs The 2022 small grants scheme will: 1) enable early career researchers and global health professionals in LMICs to undertake clinical and applied health research or fieldwork 2) develop research and management skills of early career LMIC researchers through leading a small independent research project 3) establish a peer cohort of awardees to increase collaboration and networking opportunities 4) enhance future funding opportunities of LMIC early career researchers 5) strengthen a beneficial scheme to ensure that a higher proportion of fundable applications receive funding than previous years UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 926000 926000 GB-GOV-10-RSTMH_ECG_2022 COMMITMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene 900000 GB-GOV-10-RSTMH_ECG_2022 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene 26000 GB-GOV-10-RSTMH_ECG_2022 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene GB-GOV-10-RSTMH_ECG_2023-25 UK - Department of Health and Social Care (DHSC) A partnership with the Royal Society of Tropical Medicine and Hygiene (RSTMH) to support small grant awards for early career researchers based in low- and middle-income countries (LMICs). Awards will specifically support research and capacity development for LMIC researchers which will benefit patients and the public in LMICs The 2023-2025 rounds of the RSTMH Early Career Grants programme will: 1) enable early career researchers and global health professionals of LMIC nationality to undertake applied health research or fieldwork that directly and primarily benefits people in LMICs 2) develop and improve the research and management skills of early career LMIC researchers through leading a small independent research project 3) help early career LMIC researchers to widen their networks within their institutions, countries and potentially globally, and within their field of work 4) establish a peer cohort of awardees to increase collaboration and networking opportunities 5) support early career LMIC researchers to progress their careers 6) strengthen a beneficial scheme to ensure that a higher proportion of fundable applications receive funding than previous years UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 1227819 1375913 1536160 1200000 GB-GOV-10-RSTMH_ECG_2023-25 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene 4139892 GB-GOV-10-RSTMH_ECG_2023-25 COMMITMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene 21801 GB-GOV-10-RSTMH_ECG_2023-25 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene 1350000 GB-GOV-10-RSTMH_ECG_2023-25 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene 25913 GB-GOV-10-RSTMH_ECG_2023-25 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene 1499536 GB-GOV-10-RSTMH_ECG_2023-25 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene 25000 GB-GOV-10-RSTMH_ECG_2023-25 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene GB-GOV-10-HPSR_SYM UK - Department of Health and Social Care (DHSC) To inform the development of a dedicated NIHR-led Health Policy and Systems Research (HPSR) programme and the co-creation of strategic partnerships addressing global HPSR, NIHR undertakes outreach and consultation activities to establish areas where there is an unmet need or skill shortage, and areas which are under-funded or under-researched. The 5th, 6th, 7th, and 8th Global HSR Symposia presented unique opportunities for NIHR to engage in an international event and consult stakeholders through the organisation of dedicated satellite sessions. 1) Raise the profile of NIHR in the global health research funding landscape. 2) Bring together researchers and thought-leaders to inform the development of the GHR team’s future activities in global Health Policy and Systems Research. 3) Provide support to the participation of low- and middle-income country (LMIC)-based speakers in the Symposium. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) BCD Meetings and Events Health Systems Global Association Wessex Institute of Technology UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Sectors not specified Research and Innovation 16630 5096.79 24377.24 26507.58 15832 GB-GOV-10-HPSR_SYM COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Health Systems Global Association 798 GB-GOV-10-HPSR_SYM COMMITMENT (2) UK - Department of Health and Social Care (DHSC) BCD Meetings and Events 5832 GB-GOV-10-HPSR_SYM 2018/19 Q1 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) Health Systems Global Association 10000 GB-GOV-10-HPSR_SYM 2018/19 Q1 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) Health Systems Global Association 798 GB-GOV-10-HPSR_SYM 2018/19 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) BCD Meetings and Events 4774.87 GB-GOV-10-HPSR_SYM 2020/21 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) BCD Meetings and Events 321.92 GB-GOV-10-HPSR_SYM 2020/21 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) BCD Meetings and Events 4584.65 GB-GOV-10-HPSR_SYM 2022/23 Q2 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) BCD Meetings and Events 19792.59 GB-GOV-10-HPSR_SYM 2022/23 Q2 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) BCD Meetings and Events 4774.87 GB-GOV-10-HPSR_SYM COMMITMENT (3) UK - Department of Health and Social Care (DHSC) BCD Meetings and Events 321.92 GB-GOV-10-HPSR_SYM COMMITMENT (4) UK - Department of Health and Social Care (DHSC) BCD Meetings and Events 4584.65 GB-GOV-10-HPSR_SYM COMMITMENT (5) UK - Department of Health and Social Care (DHSC) BCD Meetings and Events 19792.59 GB-GOV-10-HPSR_SYM COMMITMENT (6) UK - Department of Health and Social Care (DHSC) BCD Meetings and Events 26507.58 GB-GOV-10-HPSR_SYM COMMITMENT (7) UK - Department of Health and Social Care (DHSC) BCD Meetings and Events 26507.58 GB-GOV-10-HPSR_SYM 2024/25 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) BCD Meetings and Events GB-GOV-10-NIHR_CC UK - Department of Health and Social Care (DHSC) Support provided for resourcing at NIHR Coordinating Centres to enable them to carry out global health research activities. To support NIHR Coordinating Centres to effectively deliver NIHR Global Health Research programmes. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust NIHR Central Commissioning Facility hosted by LGC Group NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 472432 804506.8 3121169.8 3338495.57 4905114.17 GB-GOV-10-NIHR_CC COMMITMENT (1) UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 472432 GB-GOV-10-NIHR_CC 2017/18 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 157221 GB-GOV-10-NIHR_CC 2018/19 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 157221 GB-GOV-10-NIHR_CC 2018/19 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 157221 GB-GOV-10-NIHR_CC 2018/19 Q3 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 364288 GB-GOV-10-NIHR_CC 2018/19 Q3 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group -31444.2 GB-GOV-10-NIHR_CC 2018/19 Q4 INCOMING FUNDS UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 97202 GB-GOV-10-NIHR_CC 2019/20 Q1 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group 161247 GB-GOV-10-NIHR_CC 2019/20 Q1 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 97202 GB-GOV-10-NIHR_CC 2019/20 Q1 EXPENDITURE (3) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group 97202 GB-GOV-10-NIHR_CC 2019/20 Q1 EXPENDITURE (4) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group 97202 GB-GOV-10-NIHR_CC 2019/20 Q2 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group 97202 GB-GOV-10-NIHR_CC 2019/20 Q2 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group 97202 GB-GOV-10-NIHR_CC 2019/20 Q2 EXPENDITURE (3) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group 643679 GB-GOV-10-NIHR_CC 2019/20 Q3 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 97202 GB-GOV-10-NIHR_CC 2019/20 Q3 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group 67750 GB-GOV-10-NIHR_CC 2019/20 Q3 EXPENDITURE (3) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 97202 GB-GOV-10-NIHR_CC 2019/20 Q3 EXPENDITURE (4) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group 97206 GB-GOV-10-NIHR_CC 2019/20 Q3 EXPENDITURE (5) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group 33785 GB-GOV-10-NIHR_CC 2019/20 Q3 EXPENDITURE (6) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 0.8 GB-GOV-10-NIHR_CC 2019/20 Q3 EXPENDITURE (7) UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 175047 GB-GOV-10-NIHR_CC 2019/20 Q3 EXPENDITURE (8) UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 1164839 GB-GOV-10-NIHR_CC 2019/20 Q3 EXPENDITURE (9) UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 2546479 GB-GOV-10-NIHR_CC COMMITMENT (3) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group 285011 GB-GOV-10-NIHR_CC COMMITMENT (4) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 94121 GB-GOV-10-NIHR_CC 2020/21 Q1 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 94121 GB-GOV-10-NIHR_CC 2020/21 Q1 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 94121 GB-GOV-10-NIHR_CC 2020/21 Q1 EXPENDITURE (3) UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 61158 GB-GOV-10-NIHR_CC 2020/21 Q1 EXPENDITURE (4) UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 670584.11 GB-GOV-10-NIHR_CC 2020/21 Q2 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 94121 GB-GOV-10-NIHR_CC 2020/21 Q2 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group 349831 GB-GOV-10-NIHR_CC 2020/21 Q2 EXPENDITURE (3) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group 61159 GB-GOV-10-NIHR_CC 2020/21 Q2 EXPENDITURE (4) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 145264 GB-GOV-10-NIHR_CC 2020/21 Q2 EXPENDITURE (5) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group 145264 GB-GOV-10-NIHR_CC 2020/21 Q3 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group 61159 GB-GOV-10-NIHR_CC 2020/21 Q3 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 1177066.46 GB-GOV-10-NIHR_CC 2020/21 Q3 EXPENDITURE (4) UK - Department of Health and Social Care (DHSC) NIHR Evaluation, Trials and Studies Coordinating Centre hosted by Wessex Institute of Technology 145264 GB-GOV-10-NIHR_CC 2020/21 Q3 EXPENDITURE (5) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group 145262 GB-GOV-10-NIHR_CC 2020/21 Q3 EXPENDITURE (6) UK - Department of Health and Social Care (DHSC) NIHR Central Commissioning Facility hosted by LGC Group GB-GOV-10-AGHRB_MNH_call1 UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). This programme is administered by the UK Medical Research Council (MRC), which reports activities under the UK Department for Business, Energy and Industrial Strategy (BEIS). NIHR disburses funds to MRC, which makes onwards disbursements to awardees. The purpose of the call is to address the burden of maternal and neonatal mortality and morbidity in low and middle income countries (LMICs), by funding high-quality proposals across the spectrum of basic to applied research The first call focuses on the period of pregnancy and birth where the highest risks are faced and where the triple burden of maternal death, neonatal death and stillbirth is heaviest. Awards support multidisciplinary approaches, build and strengthen research partnerships, and promote capacity building in global maternal and neonatal health research. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 606860.8 1267056.9529999997 745469.5016 1003412.2454000001 13860.800000000001 GB-GOV-10-MNH_call1 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 3622799.5 GB-GOV-10-MNH_call1 COMMITMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 58812.34 GB-GOV-10-AGHRB_MNH_call1 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 392371.05 GB-GOV-10-AGHRB_MNH_call1 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 488469.46 GB-GOV-10-AGHRB_MNH_call1 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 190861.73 GB-GOV-10-AGHRB_MNH_call1 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 64924.96 GB-GOV-10-AGHRB_MNH_call1 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 39216 GB-GOV-10-AGHRB_MNH_call1 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 380233.12 GB-GOV-10-AGHRB_MNH_call1 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 275770.46 GB-GOV-10-AGHRB_MNH_call1 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 245412.98 GB-GOV-10-AGHRB_MNH_call1 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 342176.77 GB-GOV-10-AGHRB_MNH_call1 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 168587.11 GB-GOV-10-AGHRB_MNH_call1 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 149952.24 GB-GOV-10-AGHRB_MNH_call1 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 18921.07 GB-GOV-10-AGHRB_MNH_call1 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 9460.54 GB-GOV-10-AGHRB_MNH_call1 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 52012.24 GB-GOV-10-AGHRB_MNH_call1 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 9461 GB-GOV-10-AGHRB_MNH_call1 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 80188.49 GB-GOV-10-AGHRB_MNH_call1 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 19077.51 GB-GOV-10-AGHRB_MNH_call1 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 50183.18 GB-GOV-10-AGHRB_MNH_call1 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council GB-GOV-10-AMR_B UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). This programme is administered by the UK Economic and Social Research Council (ESRC), which reports activities under the UK Department for Business, Energy and Industrial Strategy (BEIS). NIHR disburses funds to ESRC, which makes onwards disbursements to awardees. This research call addresses theme four of the cross-Research Council initiative on antimicrobial resistance (AMR): 'Behaviour within and beyond the healthcare setting', and focusses on understanding how the behaviour of public, professionals and organisations impacts on AMR. The Official Development Assistance (ODA)-funded component of this scheme is concerned with focussing high quality research on addressing an issue of global importance and will primarily and directly benefit people in low- and middle-income countries. The call aims to expand understanding of how behaviour impacts on antimicrobial resistance (AMR): 1) how it can enhance or control the spread of AMR; 2) how it is affected by social, psychological and organisational context, cultures and history; and 3) how it can be influenced to create different future scenarios. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 769806.14 957431.07 934974.34 837788.45 3500000 GB-GOV-10-AMR_B COMMITMENT UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 221088.3 GB-GOV-10-AMR_B 2017/18 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 221088.29 GB-GOV-10-AMR_B 2017/18 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 106541.27 GB-GOV-10-AMR_B 2017/18 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 211088.29 GB-GOV-10-AMR_B 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 10000 GB-GOV-10-AMR_B 2018/19 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 221951.27 GB-GOV-10-AMR_B 2018/19 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 241826.6 GB-GOV-10-AMR_B 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 241826.6 GB-GOV-10-AMR_B 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 241826.6 GB-GOV-10-AMR_B 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 242696.58 GB-GOV-10-AMR_B 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 233409.11 GB-GOV-10-AMR_B 2019/20 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 233409.09 GB-GOV-10-AMR_B 2019/20 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 225459.56 GB-GOV-10-AMR_B 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 226336.58000000002 GB-GOV-10-AMR_B 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 221266.02000000002 GB-GOV-10-AMR_B 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 220404.42 GB-GOV-10-AMR_B 2020/21 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 861.48 GB-GOV-10-AMR_B 2020/21 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 89269.37 GB-GOV-10-AMR_B 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council 89865.19 GB-GOV-10-AMR_B 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) The Economic and Social Research Council GB-GOV-10-AMR_GC UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). This programme is administered by the UK Medical Research Council (MRC), which reports activities under the UK Department for Business, Energy and Industrial Strategy (BEIS). NIHR disburses funds to MRC, which makes onwards disbursements to awardees. This research call supports investments in interdisciplinary and focussed research at international levels to identify the burden and primary drivers of antimicrobial resistance (AMR) and specifically antibacterial resistance in low- and middle-income countries. 1) Draw together UK groups with researchers and policy makers in partner low and middle income countries. 2) Support the use of a range of research approaches, from clinical and microbiological to geography, modelling and social sciences, in order to identify, prioritise and understand the specific problem of antibacterial resistance (ABR) across different communities and environments. 3) Help build capacity in this area of research in partner countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 157195.38 2040424 2043491.35 2158889.2699999996 6400000 GB-GOV-10-AMR_GC COMMITMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 65259.35 GB-GOV-10-AMR_GC 2017/18 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 91936.03 GB-GOV-10-AMR_GC 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 570636.89 GB-GOV-10-AMR_GC 2018/19 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 650222.21 GB-GOV-10-AMR_GC 2018/19 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 508713.91000000003 GB-GOV-10-AMR_GC 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 503757.39 GB-GOV-10-AMR_GC 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 510872.82 GB-GOV-10-AMR_GC 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 510872.82 GB-GOV-10-AMR_GC 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 510872.82 GB-GOV-10-AMR_GC 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 510872.82 GB-GOV-10-AMR_GC 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 507426.06 GB-GOV-10-AMR_GC 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 507426.06 GB-GOV-10-AMR_GC 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 370736.53 GB-GOV-10-AMR_GC 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 114415.85 GB-GOV-10-AMR_GC 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 233636.55 GB-GOV-10-AMR_GC 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 122427.43 GB-GOV-10-AMR_GC 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council GB-GOV-10-AMR_SORT_IT UK - Department of Health and Social Care (DHSC) The aim of this programme is to build sustainable operational research capacity to generate and utilize evidence on the emergence, spread and health impact of antimicrobial resistance (AMR), in order to limit this public health problem. The project uses the Structured Operational Research and Training Initiative (SORT IT) and targets a number of low- and middle-income countries, with special focus on Fleming Fund supported countries. 1. To build adequate and sustainable local Operational Research (OR) capacity on antimicrobial resistance (AMR) 2. To support OR for: a) Improved surveillance and monitoring of the AMR situation in countries. b) Identifying drivers of antimicrobial drug resistance in human populations. c) Improving antimicrobial stewardship and procedural interventions 3. To build adequate and sustainable structures and processes for evidence-informed decision-making at national level. 4. To foster mechanisms for knowledge sharing to maximize the potential for broader research impact. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) World Health Organization UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 1169962 3492167 2084489 582718 7329336 GB-GOV-10-AMR_SORT_IT COMMITMENT UK - Department of Health and Social Care (DHSC) World Health Organization 1169962 GB-GOV-10-AMR_SORT_IT 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 801174 GB-GOV-10-AMR_SORT_IT 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 1674693 GB-GOV-10-AMR_SORT_IT 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 372084 GB-GOV-10-AMR_SORT_IT 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 1200000 GB-GOV-10-AMR_SORT_IT 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 650000 GB-GOV-10-AMR_SORT_IT 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 1461428 GB-GOV-10-AMR_SORT_IT 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization -75327.3 GB-GOV-10-AMR_SORT_IT 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization GB-GOV-10-BelmontForum UK - Department of Health and Social Care (DHSC) This funding call supports international research teams working across different disciplines to understand how changes in the climate affect people and the environment. It brings together scientists from natural, medical, and social sciences, as well as communities - especially those in low‑ and middle‑income countries - to create useful, real‑world research. The aim is to better understand how climate change and environmental conditions influence people’s exposure to risks, their behaviour, and their health. The call also encourages teams to develop or link together climate, environmental, and health data, and to work with local partners to build skills and strengthen local leadership. Projects should produce practical information, tools, and evidence that can help governments and organisations make decisions, plan for the long term, and build stronger systems. A key focus is on approaches that look at the whole system, ensuring that groups who are often overlooked - because of income, culture, gender, or minority status - are included and able to shape solutions for climate‑resilient health systems. Overall, the call aims to build a global network of people and organisations working together on climate, environment, and health. The objectives of the call are to: - Build diverse, transdisciplinary research collaborations that bring together climate, environmental, medical, and social sciences with stakeholders, especially in low- and middle-income countries (LMICs) and underrepresented communities. - Strengthen understanding of linkages among climate, environment, and health. - Improve scalability and predictability of climate‑related health risks through robust databases and early‑warning systems. - Develop usable, decision-support data, tools, and innovative solutions. - Enhance understanding of vulnerability, resilience, and health risk for disproportionately affected groups, including those in LMICs. - Build sustainable, long‑term models for collaboration, knowledge-sharing, and workforce development. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Natural Environment Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 757149.8899999999 926012.1900000001 847474.72 469363.20000000036 408771.85 GB-GOV-10-BelmontForum 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Natural Environment Research Council 3000000 GB-GOV-10-BelmontForum COMMITMENT UK - Department of Health and Social Care (DHSC) Natural Environment Research Council GB-GOV-10-BRG_HIV UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR is providing support to a grant awarded under the Wellcome Trust's Biomedical Resources programme looking at the harmonisation and sharing of linked HIV cohort data from communities and clinics in Africa. 1) The new data resource will bridge population-based HIV surveillance in the network for Analysing Longitudinal Population-based HIV data in Africa (ALPHA) and clinical monitoring in the network for International Epidemiologic Databases to Evaluate AIDS (IeDEA), ensuring that data on people who participate in both ALPHA and IeDEA cohorts is exchangable and shared across the two networks. HIV clinics serving ALPHA sites but not currently part of IeDEA will be supported to attain data management standards required for IeDEA membership, using the international standard HIV Cohort Data Exchange Protocol (HICDEP) to ensure global data comparability. 2) The resource will provide robust, population-based data for all stages of the HIV care continuum from infection to viral suppression, enabling empirical monitoring of all three UNAIDS 90-90-90 goals, which neither network can do independently. It will automate and document the creation of standardised analytical datasets, extending the Centre-in-a-box methodology pioneered by the INDEPTH network. Data integration software will build and document transformations for compiling each site’s data into harmonised formats required for pooled datasets. Key summary statistical updates will be disseminated regularly through ALPHA web pages. Pooled datasets will be archived in the INDEPTH "iShare" public repository using the Data Documentation Initiative standard. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The Wellcome Trust UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 156669 183228.5 250000 300000 550790.5 1331688 GB-GOV-10-BRG_HIV COMMITMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 85501.75 GB-GOV-10-BRG_HIV 2017/18 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 97726.75 GB-GOV-10-BRG_HIV 2017/18 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 171905 GB-GOV-10-BRG_HIV 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 156669 GB-GOV-10-BRG_HIV 2016/17 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 176387 GB-GOV-10-BRG_HIV 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 59026.5 GB-GOV-10-BRG_HIV 2020/21 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 965.5 GB-GOV-10-BRG_HIV 2020/21 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 56801.25 GB-GOV-10-BRG_HIV 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 94415.29 GB-GOV-10-BRG_HIV 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 64150.27 GB-GOV-10-BRG_HIV 2021/22 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 33897.29 GB-GOV-10-BRG_HIV 2021/22 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 135291.3 GB-GOV-10-BRG_HIV 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 109000 GB-GOV-10-BRG_HIV COMMITMENT (2) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 88172.47 GB-GOV-10-BRG_HIV 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 125558.69 GB-GOV-10-BRG_HIV 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust GB-GOV-10-DPO UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). This programme is administered by the UK Engineering and Physical Sciences Research Council (EPSRC), which reports activities under the UK Department for Business, Energy and Industrial Strategy (BEIS). NIHR disburses funds to EPSRC, which makes onwards disbursements to awardees. This research call is a high quality programme of research centred on innovative healthcare technologies, to tackle the challenges faced by low- and middle-income countries. Proposals must address one of the two priority areas: (1) low cost, rapid, point of care imagine and diagnostic technologies; (2) affordable prosthetics and orthotics. The overall aim of this call is to develop frugal innovation approaches for healthcare technologies in specific priority areas, which have the potential to revolutionise care pathways in low and middle income countries (LMICs). Such technologies must be developed in partnership with teams from LMICs, and have the delivery of impactful, cost-effective, culturally acceptable, and sustainable welfare and economic benefits within LMICs as their primary objective. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 639217.72 2594951.51 2634864.04 2130966.730000001 8000000 GB-GOV-10-DPO COMMITMENT UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council 639217.72 GB-GOV-10-DPO 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council 647487.39 GB-GOV-10-DPO 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council 646740.66 GB-GOV-10-DPO 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council 646740.66 GB-GOV-10-DPO 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council 653982.88 GB-GOV-10-DPO 2018/19 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council 653982.86 GB-GOV-10-DPO 2019/20 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council 655348.94 GB-GOV-10-DPO 2019/20 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council 655348.9400000001 GB-GOV-10-DPO 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council 670157.88 GB-GOV-10-DPO 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council 679466.55 GB-GOV-10-DPO 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council 674430.47 GB-GOV-10-DPO 2020/21 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council 656.76 GB-GOV-10-DPO 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council 58425.46 GB-GOV-10-DPO 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council 16331.33 GB-GOV-10-DPO 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council -60575.04 GB-GOV-10-DPO 2022/23 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Engineering and Physical Sciences Research Council GB-GOV-10-ECTIMH UK - Department of Health and Social Care (DHSC) NIHR provided sponsorship to the Royal Society of Tropical Medicine and Hygiene to support two panel members from low and middle income countries to attend the 11th European Congress on Tropical Medicine and International Health To support a joint panel session on multimorbidity, including providing travel sponsorships for low and middle income country attendees to participate in the conference UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Sectors not specified Research and Innovation 10000 10000 GB-GOV-10-ECTIMH 2019/20 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene 10000 GB-GOV-10-ECTIMH COMMITMENT UK - Department of Health and Social Care (DHSC) Royal Society of Tropical Medicine & Hygiene GB-GOV-10-Enhancements_ResultsFramework UK - Department of Health and Social Care (DHSC) Technical assistance for a Monitoring and Evaluation expert to develop a results framework for the Global Health Research Units and Groups Programme To develop a Monitoring and Evaluation framework for the Global Health Research Units and Groups programme. There are 53 Units and Groups being funded and there is a need to track performance and delivery against a common set of indicators to allow an assessment of how this meets overarching GHR Programme objectives as set out in the Theory of Change, and to measure what impact this programme has had. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Oxford Policy Management Ltd UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Sectors not specified Research and Innovation 14000 14000 GB-GOV-10-Enhancements_ResultsFramework COMMITMENT UK - Department of Health and Social Care (DHSC) Oxford Policy Management Ltd 10850 GB-GOV-10-Enhancements_ResultsFramework 2018/19 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Oxford Policy Management Ltd 2170 GB-GOV-10-Enhancements_ResultsFramework 2018/19 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Oxford Policy Management Ltd GB-GOV-10-EQUALS UK - Department of Health and Social Care (DHSC) In response to the recommendation made by an independent evaluation of the NIHR Global Health Research (GHR) portfolio (published in August 2024) to refresh the Global Health Research (GHR) evaluation strategy. This work started in November 2024 and the Foreign Commonwealth Development Office (FCDO) Evaluation Quality Assurance and Learning Services (EQUALS) lead consultant is supporting the delivery of some aspects of this work. This work stream has 5 key objectives: 1. Synthesise programme Theories of Change (ToC): Identify common themes across programs to inform a portfolio ToC. 2. Develop the portfolio ToC: Create an integrated framework aligning with strategic priorities. 3. Streamline the results framework: Align the results framework with the portfolio ToC while accommodating program-specific indicators. 4. Refresh the evaluation strategy: Update the strategy to ensure relevance, efficiency, and evidence-driven decision-making. 5. Optimise resources and evidence: Deliver robust, tailored evidence to support timely decisions. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Foreign, Commonwealth & Development Office UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Sectors not specified Research and Innovation 23000 23000 GB-GOV-10-EQUALS COMMITMENT UK - Department of Health and Social Care (DHSC) Foreign, Commonwealth & Development Office 15453 GB-GOV-10-EQUALS 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Foreign, Commonwealth & Development Office 1363.5 GB-GOV-10-EQUALS 2024/25 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Foreign, Commonwealth & Development Office 4090.5 GB-GOV-10-EQUALS 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Foreign, Commonwealth & Development Office 2727 GB-GOV-10-EQUALS 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Foreign, Commonwealth & Development Office GB-GOV-10-GCC UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). This Programme is administered by Grand Challenges Canada (GCC) and funded in partnership with the National Institute for Health and Care Research (NIHR). Through the programme, the NIHR has funded a portfolio of innovative projects in ODA-eligible countries to develop new approaches which meet the mental health needs of the most vulnerable young people aged 10-24 years. The programme aims to seed and transition to scale funding for high impact innovations that improve treatments and/or expand access to care for people living with or are at risk of mental disorders. 75% of all mental disorders start before the age of 24 – the seed call will focus on the mental health needs of young people in low-and middle-income countries. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Grand Challenges Canada UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Research for prevention and control of NCDs Research and Innovation 459176 2707679 2670284 162861 6000000 GB-GOV-10-GCC COMMITMENT UK - Department of Health and Social Care (DHSC) Grand Challenges Canada 459176 GB-GOV-10-GCC 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Grand Challenges Canada 485112 GB-GOV-10-GCC 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Grand Challenges Canada 1554592 GB-GOV-10-GCC 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Grand Challenges Canada 1443541 GB-GOV-10-GCC 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Grand Challenges Canada 1894718 GB-GOV-10-GCC 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Grand Challenges Canada 162861 GB-GOV-10-GCC 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Grand Challenges Canada GB-GOV-10-GCC_GMHI UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). This initiative is administered by Grand Challenges Canada (GCC) and funded in partnership with the National Institute for Health and Care Research (NIHR), Fondation Botnar, the Science for Africa Foundation and United for Global Mental Health. The initiative funds research and innovation in 13 priority ODA-eligible countries to influence change in programming, research and policies relating to young people’s mental wellbeing. 1. Increase low- and middle-income country (LMIC)-driven research and research capacity to better understand the mental health ecosystem as well as impacts of COVID-19; 2. Implement relational wellbeing approaches within mainstream services for young people ages 10 – 24; 3. Increase mental health service coverage through the use of data and digital technology; 4. Generate transformative change in mental health approaches at the community level guided by young people; and 5. Catalyze adoption of key insights by stakeholders and partners. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Grand Challenges Canada UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 2500000 1600000 6275842 2500000 GB-GOV-10-GCC_GMHI 2022/23 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Grand Challenges Canada 8000000 GB-GOV-10-GCC_GMHI COMMITMENT (1) UK - Department of Health and Social Care (DHSC) Grand Challenges Canada 500000 GB-GOV-10-GCC_GMHI 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Grand Challenges Canada 1780000 GB-GOV-10-GCC_GMHI COMMITMENT (2) UK - Department of Health and Social Care (DHSC) Grand Challenges Canada 500000 GB-GOV-10-GCC_GMHI 2023/24 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Grand Challenges Canada 600000 GB-GOV-10-GCC_GMHI 2023/24 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Grand Challenges Canada 2850000 GB-GOV-10-GCC_GMHI 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Grand Challenges Canada 595842 GB-GOV-10-GCC_GMHI COMMITMENT (3) UK - Department of Health and Social Care (DHSC) Grand Challenges Canada 2830000 GB-GOV-10-GCC_GMHI 2024/25 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Grand Challenges Canada 595842 GB-GOV-10-GCC_GMHI 2024/25 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Grand Challenges Canada GB-GOV-10-GECO UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The Global Effort on COVID-19 (GECO) Health Research is a cross UK government funding call aiming to support applied health research that will address COVID-19 knowledge gaps in ODA-eligible countries. The focus is on understanding the pandemic and mitigating its health impacts in low and middle-income country (LMIC) contexts. The call prioritises epidemiology, clinical management, infection control and health system responses, in alignment with the World Health Organization (WHO) COVID-19 Global Research Roadmap. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 2314316.49 5128681.32 2557002.1900000004 936587.68 GB-GOV-10-GECO 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 10000000 GB-GOV-10-GECO COMMITMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 1112002.11 GB-GOV-10-GECO 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 1757412.08 GB-GOV-10-GECO 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 1779489.13 GB-GOV-10-GECO 2021/22 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 1132523.3 GB-GOV-10-GECO 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 313263.27 GB-GOV-10-GECO 2021/22 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 258857.62 GB-GOV-10-GECO 2022/23 Q1 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 182791.69 GB-GOV-10-GECO 2022/23 Q2 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 357329.7 GB-GOV-10-GECO 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 25494 GB-GOV-10-GECO 2023/24 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Medical Research Council 19744.62 GB-GOV-10-GECO 2023/24 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Medical Research Council 127682.29 GB-GOV-10-GECO 2023/24 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 308.82 GB-GOV-10-GECO 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 70112 GB-GOV-10-GECO 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council GB-GOV-10-GFGP UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR provided this funding through the UK Medical Research Council (MRC), which reports activities under the UK Department for Business, Energy and Industrial Strategy (BEIS). The Good Financial Grant Practice (GFGP) is a programme established to strengthen Africa’s research and development infrastructure by developing an innovative standard for the best practices in the management of funds awarded to grantees. The NIHR's funding supported the phase II development of the GFGP standard and associated assessment tools, creating a new and integrated system for the financial governance of grant funds , including international aid, awarded to grantees which will standardise, simplify and strengthen the governance of grant funding. 1) The development of a web-based assessment system to enable pre-award and compliance assessments of grantees to the Good Financial Grant Practice (GFGP) standard. 2) The recruitment of a secretariat at the African Academy of Sciences (AAS) to manage and support the system. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medical Research Council UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 500000 500000 GB-GOV-10-GFGP COMMITMENT UK - Department of Health and Social Care (DHSC) Medical Research Council 500000 GB-GOV-10-GFGP 2017/18 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medical Research Council GB-GOV-10-GHR-ProgrammeCosts UK - Department of Health and Social Care (DHSC) This is an Official Development Assistance (ODA) funded UKaid project from the Department of Health and Social Care (DHSC)’s Global Health Research Portfolio which supports high-quality applied health research and training to address global health security challenges and global clinical trial capability in low- and middle-income countries (LMICs). Programme costs captures the small, infrequent, and irregular business costs incurred in running of the programme, such as bank charges on the foreign currency payments. 0 UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Health policy and administrative management Research and Innovation 35 GB-GOV-10-GHR-ProgrammeCosts 2017/18 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 35 GB-GOV-10-GHR-ProgrammeCosts 2017/18 Q4 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 44.82 GB-GOV-10-GHR-ProgrammeCosts 2025/26 Q3 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified -152.09000000000015 GB-GOV-10-GHR-ProgrammeCosts 2025/26 Q3 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified GB-GOV-10-GPSC UK - Department of Health and Social Care (DHSC) The main objective of the Global Patient Safety Collaborative (GPSC) is to secure and scale up global action on patient safety as well as to work in close collaboration with selected low- and middle-income countries (LMICs) in their quest to reduce the risk of avoidable harm and improve the safety of their national health care systems. 1) Strengthen leadership to promote patient safety across all sectors and settings; 2) Develop a competent workforce through education and training in patient safety; and 3) Support research capacities and evidence-based policies, strategies and standards. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) World Health Organization UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 500195 750150 249730 1500075 GB-GOV-10-GPSC COMMITMENT UK - Department of Health and Social Care (DHSC) World Health Organization 500195 GB-GOV-10-GPSC 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 750150 GB-GOV-10-GPSC 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 249730 GB-GOV-10-GPSC 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization GB-GOV-10-GRSF UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The World Bank’s Global Road Safety Facility aims to address the growing public health crisis of road traffic deaths and injuries in low- and middle-income countries (LMICs) through supporting the scale-up of scientific, technological and managerial capacities to effectively manage road safety. 1) Fund applied research grants under the UN’s five pillars for road safety: Road Safety Management, Safer Roads and Mobility, Safer Vehicles, Safer Road Users, Post-Crash Response. 2) Improve global road safety data collection 3) Increase knowledge and evidence base to support policy interventions UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Transport policy and administrative management Research and Innovation 1700000 1800000 1800000 2200000 5300000 GB-GOV-10-GRSF COMMITMENT (1) UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development 1700000 GB-GOV-10-GRSF 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development 900000 GB-GOV-10-GRSF 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development 900000 GB-GOV-10-GRSF 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development 900000 GB-GOV-10-GRSF 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development 900000 GB-GOV-10-GRSF 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development 2200000 GB-GOV-10-GRSF COMMITMENT (2) UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development 2200000 GB-GOV-10-GRSF 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development GB-GOV-10-GRSF_2 UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). DHSC is funding activities carried out by the World Bank’s Global Road Safety Facility (GRSF) between 2024-2027 to support efforts in low and middle-income countries to halve their road traffic fatalities and serious injuries. The successful delivery of road safety initiatives in low and middle-income countries will result in substantial gains in population health and improved community wellbeing. Within this partnership, DHSC has a particular focus on the creation and dissemination of knowledge relating to the health impacts of road safety. The project has 2 objectives: 1. To catalyze road safety investments by the World Bank and other multilateral development banks in low and middle-income countries. 2. To ensure the high quality of these investments through the creation and transfer of road safety knowledge, expertise, and innovation. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Transport policy and administrative management Research and Innovation 3000000 2000000 0 6000000 GB-GOV-10-GRSF_2 COMMITMENT (1) UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development 1500000 GB-GOV-10-GRSF_2 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development 1500000 GB-GOV-10-GRSF_2 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development 1000000 GB-GOV-10-GRSF_2 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development -1000000 GB-GOV-10-GRSF_2 COMMITMENT (2) UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development 1000000 GB-GOV-10-GRSF_2 2025/26 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) International Bank for Reconstruction and Development GB-GOV-10-HealthEco UK - Department of Health and Social Care (DHSC) To inform the development of a dedicated NIHR-led health economics programme and activities, NIHR is undertaking outreach and consultation activities to establish areas where there is an unmet need or skill shortage and areas which are under-funded or under-researched. The 15th International Health Economics Association (IHEA) World Congress on Health Economics presented a unique opportunity for NIHR to engage in an international event and consult stakeholders on key methodologies, impactful policy research and capacity strenghtening through the organisation of a dedicated satellite session. 1. Raise the profile of NIHR in the global health research funding landscape 2. Bring together researchers and thought-leaders to inform the development of the NIHR Global Health Research programme’s future activities in health economics 3. Provide support to the participation of low-and-middle-income country (LMIC) based speakers in the Symposium UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) International Health Economics Association UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Sectors not specified Research and Innovation 20091.42 20091.42 GB-GOV-10-HealthEco 2023/24 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) International Health Economics Association 4018.28 GB-GOV-10-HealthEco 2023/24 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) International Health Economics Association 20091.42 GB-GOV-10-HealthEco COMMITMENT UK - Department of Health and Social Care (DHSC) International Health Economics Association 19371.95 GB-GOV-10-HealthEco 2024/25 Q4 EXPENDITURE UK - Department of Health and Social Care (DHSC) International Health Economics Association GB-GOV-10-ISAG_Exp UK - Department of Health and Social Care (DHSC) The Independent Scientific Advisory Group (ISAG) provides rigorous independent strategic and scientific advice on the development of the National Institute for Health and Care Research’s (NIHR) Global Health Research (GHR) Portfolio. The ISAG aims to ensure that the GHR Portfolio’s programmes, partnerships, and strategy remain coherent, but is not a decision making body. This group meets approximately twice per year and is comprised of approximately 10-15 members and 3-5 observers. The National Institute of Health and Social Care’s (NIHR) Global Health Research (GHR) Independent Scientific Advisory Group has four main objectives: 1. To provide a scientific sounding board function for the development of new GHR programmes and partnerships. 2. To provide a strategic steer on priorities and focus for the GHR Portfolio. 3. To provide advice on topic refinement and prioritisation for thematic NIHR GHR programmes. 4. To provide advice on promoting coordination and coherence within the GHR Portfolio and in relation to the wider global health research funding landscape. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Health policy and administrative management Research and Innovation 14000 14000 GB-GOV-10-ISAG_Exp COMMITMENT UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 2956.1400000000003 GB-GOV-10-ISAG_Exp 2024/25 Q4 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified 11724.6 GB-GOV-10-ISAG_Exp 2025/26 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) Academic, Training and Research institutions unspecified GB-GOV-10-NIHR GHR_RCS_ActivityPlan UK - Department of Health and Social Care (DHSC) The NIHR Academy Global Health Research Capacity Strengthening Activity Plan outlines activities the NIHR Academy will provide to support research capacity strengthening in the Global Health Research (GHR) Programmes (Units, Groups, Centres, Health Policy & Systems Research programmes and the Research and Innovation for Global Health Transformation programme).The aim is for the NIHR Academy to add value, support and build on the NIHR Official Development Assistance (ODA) investment in global health research programmes through specific demand-led events and community development together with awards and career development activities that help strengthen research capacity. 1. To add value and build on the investment made by the GHR Programmes to research capacity strengthening specifically in the area of academic careers 2. To help those being trained and the individuals supporting them to feel part of NIHR and be part of a larger environment that extends beyond their funded programme/localty 3. To offer an opportunity for individuals to practise the skills they will need to succeed as an independent researcher UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 16600 208603 406472 684840 395400 17102.5 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2020/21 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 10000 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2020/21 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 11215.72 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2021/22 Q2 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 3933.87 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2021/22 Q2 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 55661.99 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2021/22 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 25825.35 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2022/23 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 14601 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2022/23 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 631675 GB-GOV-10-NIHR GHR_RCS_ActivityPlan COMMITMENT (1) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 752500 GB-GOV-10-NIHR GHR_RCS_ActivityPlan COMMITMENT (2) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 139247.62 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2023/24 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 312740 GB-GOV-10-NIHR GHR_RCS_ActivityPlan COMMITMENT (3) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 8944.75 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2024/25 Q1 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 74281.27 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2024/25 Q1 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 15000 GB-GOV-10-NIHR GHR_RCS_ActivityPlan COMMITMENT (4) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 41051.32 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2024/25 Q2 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 46704.07 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2024/25 Q2 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 86083.06 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2024/25 Q2 EXPENDITURE (3) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 2000 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2024/25 Q2 EXPENDITURE (4) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 11817.4 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2024/25 Q3 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 25807.98 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2024/25 Q3 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 22286.16 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2024/25 Q4 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 22321.31 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2024/25 Q4 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 18377.71 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2024/25 Q4 EXPENDITURE (3) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 55678.18 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2025/26 Q1 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 17506.1 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2025/26 Q1 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 39895.2 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2025/26 Q2 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 28018.01 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2025/26 Q2 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 20237.81 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2025/26 Q2 EXPENDITURE (3) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 28168.19 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2025/26 Q2 EXPENDITURE (4) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 76417.04 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2025/26 Q2 EXPENDITURE (5) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 71723.1 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2025/26 Q2 EXPENDITURE (6) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 49930.45 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2025/26 Q3 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 49560.5 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2025/26 Q3 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 5619.31 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2025/26 Q4 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 109774.22 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2025/26 Q4 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 6577.17 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2025/26 Q4 EXPENDITURE (3) UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust 9056.64 GB-GOV-10-NIHR GHR_RCS_ActivityPlan 2026/27 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) NIHR Academy hosted by Leeds Teaching Hospitals NHS Trust GB-GOV-10-PDP_CEPI UK - Department of Health and Social Care (DHSC) The Coalition for Epidemic Preparedness Innovations (CEPI) was formally launched at the World Economic Forum in Davos in January 2017. It is the only international alliance with a primary focus on developing vaccines for diseases with epidemic potential. CEPI’s initial focus has been on developing vaccines against Lassa Fever, Nipah virus and Middle Eastern Respiratory Syndrome (MERS) virus. The aim is to fund and to support the research and development of vaccines for diseases with epidemic potential. Preparedness: - Advance access to safe and effective vaccines against emerging infectious diseases Response: - Accelerate the research, development and use of vaccines during outbreaks Sustainability: - Create durable and equitable solutions for outbreak response capacity UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Coalition for Epidemic Preparedness Innovations UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 20000000 20000000 GB-GOV-10-PDP_CEPI COMMITMENT UK - Department of Health and Social Care (DHSC) Coalition for Epidemic Preparedness Innovations 10000000 GB-GOV-10-PDP_CEPI 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Coalition for Epidemic Preparedness Innovations 10000000 GB-GOV-10-PDP_CEPI 2019/20 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Coalition for Epidemic Preparedness Innovations GB-GOV-10-PDP_FIND UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR provided support to the Foundation for Innovative New Diagnostics (FIND) for the development of critical diagnostic assays for prioritised Target Product Profiles (TPPs) using innovative technology platforms and business models. Develop critical diagnostic assays for prioritised Target Product Profiles (TPPs) using innovative technology platforms and business models. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) FIND UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 1174200 1174200 GB-GOV-10-PDP_FIND COMMITMENT UK - Department of Health and Social Care (DHSC) FIND 1173637 GB-GOV-10-PDP_FIND 2018/19 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) FIND GB-GOV-10-PDP_GARDP_NS UK - Department of Health and Social Care (DHSC) A partnership to fund the development of new treatments for severe bacterial infections in neonates under GARDP’s Neonatal Sepsis Programme The overall purpose of GARDP’s neonatal sepsis programme is to develop up to three new or improved treatments for newborns with severe bacterial infections by 2023. The activities funded under this programme will make an important contribution towards achieving these objectives by prioritising three work packages with the following focus: 1. Improve clinical management of neonatal sepsis This work package includes three key activities: completion of the global observational study; commencing clinical programme to develop a treatment to be used in place of the current WHO recommended empiric treatment, ampicillin and gentamicin for neonatal sepsis, and conducting clinical and laboratory capability strengthening in support of the clinical programme. 2. Developing new and improved treatments for multi drug-resistant infections in neonates This work package will aim to develop an effective and safe treatment for confirmed or highly suspected MDR-GN pathogens, including K. pneumoniae, or Acinetobacter spp., that is affordable and adapted for use in neonates. 3. Accelerating regulatory approval and access in high burden LMICs Through this work package, GARDP will work with WHO, pharmaceutical companies and regulatory authorities to ensure the newly developed treatments are globally accessible and that they are not ‘lost’ to resistance within a few years after their introduction. To achieve this, GARDP, in partnership with the relevant partner(s), will develop regulatory, public health and market access (including supply and distribution) strategies for any treatments developed. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Global Antibiotic Research and Development Partnership UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 2164656 1835344 4000000 GB-GOV-10-PDP_GARDP_NS COMMITMENT UK - Department of Health and Social Care (DHSC) Global Antibiotic Research and Development Partnership 2164656 GB-GOV-10-PDP_GARDP_NS 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Global Antibiotic Research and Development Partnership 783474 GB-GOV-10-PDP_GARDP_NS 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Global Antibiotic Research and Development Partnership 1051870 GB-GOV-10-PDP_GARDP_NS 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Global Antibiotic Research and Development Partnership GB-GOV-10-PDP_MMV UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR provided support to the Medicines for Malaria Venture (MMV) to carry out activities relating to the development of new drugs to treat malaria. 1) Increase investment in chemoprevention; 2) Develop new fast acting molecules to support treatment of uncomplicated and potentially severe malaria; 3) Develop compounds active against laboratory generated resistant strains and field isolates. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Medicines for Malaria Venture (MMV) UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Malaria control Research and Innovation 6100000 6100000 GB-GOV-10-PDP_MMV COMMITMENT UK - Department of Health and Social Care (DHSC) Medicines for Malaria Venture (MMV) 2500000 GB-GOV-10-PDP_MMV 2017/18 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medicines for Malaria Venture (MMV) 3600000 GB-GOV-10-PDP_MMV 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Medicines for Malaria Venture (MMV) GB-GOV-10-PDP_TBA UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The NIHR provided support to the Global Alliance for TB Drug Development to carry out activities relating to the development of new drugs to treat tuberculosis. 1) Develop and sustain a robust and dynamic research and development (R&D) pipeline for tuberculosis (TB); 2) Strengthen existing research capacity and community engagement; 3) Raise awareness and commitment to TB R&D. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Global Alliance for TB Drug Development UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Tuberculosis control Research and Innovation 4500000 4500000 GB-GOV-10-PDP_TBA COMMITMENT UK - Department of Health and Social Care (DHSC) Global Alliance for TB Drug Development 1600000 GB-GOV-10-PDP_TBA 2017/18 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Global Alliance for TB Drug Development 2900000 GB-GOV-10-PDP_TBA 2017/18 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Global Alliance for TB Drug Development GB-GOV-10-R2HC_Phase_3 UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The aim of the Research for Health in Humanitarian Crises (R2HC) programme is to develop more effective responses to humanitarian challenges by providing significant funding for high-quality research on the effectiveness of health interventions in humanitarian crises. 1) To strengthen the evidence base around the health challenges associated with humanitarian crises, leading to demonstrated improvements in the effectiveness/efficiency of humanitarian health interventions and programming. 2) Fund research grants that investigate recognised disaster/humanitarian health challenges with collaborative research teams. 3) Produce peer-reviewed publications and products that contribute to informing the evidence base and improving public health humanitarian response. 4) Advance the global public health knowledge-base through practical operational guidance and by improving practice on ethical and methodological approaches to conducting health research programmes in operational humanitarian contexts. 5) Expand and enhance collaborative partnerships between biomedical/public health researchers and the humanitarian sector. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Save the Children UK UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 1311240 1253939 1434821 4000000 GB-GOV-10-R2HC_Phase_3 COMMITMENT UK - Department of Health and Social Care (DHSC) Save the Children UK 135059 GB-GOV-10-R2HC_Phase_3 2018/19 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Save the Children UK 1184606 GB-GOV-10-R2HC_Phase_3 2018/19 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Save the Children UK 78461 GB-GOV-10-R2HC_Phase_3 2019/20 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Save the Children UK 123426 GB-GOV-10-R2HC_Phase_3 2019/20 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Save the Children UK 704614 GB-GOV-10-R2HC_Phase_3 2019/20 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Save the Children UK 160493 GB-GOV-10-R2HC_Phase_3 2020/21 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Save the Children UK 547901 GB-GOV-10-R2HC_Phase_3 2020/21 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Save the Children UK 747773 GB-GOV-10-R2HC_Phase_3 2020/21 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Save the Children UK 23522 GB-GOV-10-R2HC_Phase_3 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Save the Children UK 59465 GB-GOV-10-R2HC_Phase_3 2020/21 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Save the Children UK 47627 GB-GOV-10-R2HC_Phase_3 2021/22 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Save the Children UK GB-GOV-10-R2HC_Phase_4 UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). The aim of the Research for Health in Humanitarian Crises (R2HC) programme is to develop more effective responses to humanitarian challenges by providing significant funding for high-quality research on the effectiveness of health interventions in humanitarian crises. The expected impact of the programme is that mortality, morbidity and suffering are reduced in humanitarian crises through demonstrated improvements in humanitarian and public health interventions. The expected outcome is that evidence from R2HC funded research positively influences the public health policies and practices of key humanitarian actors. The programme has four output areas: - Priority research gaps and needs are identified in response to demand from humanitarian health practitioners and policy makers - Collaborative research partnerships are funded to generate research addressing priority health evidence gaps and supported to achieve uptake of findings - Knowledge and learning from the R2HC portfolio of work is synthesised and shared in response to demand from practitioners and policy makers - Key humanitarian stakeholders have access to and are informed of key evidence through strategic engagement and communications UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) Elrha UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 858700 4158000 4405700 3245600 2332000 15000000 GB-GOV-10-R2HC_Phase_4 COMMITMENT UK - Department of Health and Social Care (DHSC) Elrha 379210 GB-GOV-10-R2HC_Phase_4 2020/21 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Elrha 184613 GB-GOV-10-R2HC_Phase_4 2020/21 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Elrha 275120 GB-GOV-10-R2HC_Phase_4 2020/21 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Elrha 19767 GB-GOV-10-R2HC_Phase_4 2021/22 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Elrha 66645 GB-GOV-10-R2HC_Phase_4 2021/22 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Elrha 9350 GB-GOV-10-R2HC_Phase_4 2021/22 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Elrha 165237 GB-GOV-10-R2HC_Phase_4 2021/22 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Elrha 146051 GB-GOV-10-R2HC_Phase_4 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Elrha 9998 GB-GOV-10-R2HC_Phase_4 2021/22 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Elrha 48994 GB-GOV-10-R2HC_Phase_4 2021/22 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Elrha 68190 GB-GOV-10-R2HC_Phase_4 2022/23 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Elrha 81077 GB-GOV-10-R2HC_Phase_4 2022/23 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Elrha 52360 GB-GOV-10-R2HC_Phase_4 2022/23 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Elrha 494728 GB-GOV-10-R2HC_Phase_4 2023/24 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Elrha 60124 GB-GOV-10-R2HC_Phase_4 2023/24 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Elrha 55835 GB-GOV-10-R2HC_Phase_4 2023/24 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Elrha 344577 GB-GOV-10-R2HC_Phase_4 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Elrha 54638 GB-GOV-10-R2HC_Phase_4 2023/24 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Elrha 111114 GB-GOV-10-R2HC_Phase_4 2023/24 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Elrha 100629 GB-GOV-10-R2HC_Phase_4 2024/25 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Elrha 36631 GB-GOV-10-R2HC_Phase_4 2024/25 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Elrha 68106 GB-GOV-10-R2HC_Phase_4 2024/25 Q2 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Elrha 70358 GB-GOV-10-R2HC_Phase_4 2024/25 Q2 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Elrha 139276 GB-GOV-10-R2HC_Phase_4 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Elrha 107364 GB-GOV-10-R2HC_Phase_4 2024/25 Q4 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) Elrha 68219 GB-GOV-10-R2HC_Phase_4 2024/25 Q4 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) Elrha 162805 GB-GOV-10-R2HC_Phase_4 2025/26 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) Elrha GB-GOV-10-UKRI_UKCDR UK - Department of Health and Social Care (DHSC) The Department of Health and Social Care (DHSC) provides a funding contribution to the UK Collaborative on Development Research (UKCDR), which is a neutral and impartial entity governed by the Strategic Coherence of Official Development Assistance (ODA)-funded Research (SCOR) Board. UKCDR provide high-level coherence for UK ODA research. The UK Collaborative on Development Research (UKCDR) have a principal commitment to data mapping, analysis and foresight, with remaining activities built upon this strong foundation of knowledge and evidence. UKCDR have four integrated and overlapping aims: 1. Mapping, analysis and foresight. 2. Convening for collaboration and joint action. 3. Sharing information, learning and best practice. 4. A collective voice to shape policy. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK Research and Innovation UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Sectors not specified Research and Innovation 52745 67585 26372.58 GB-GOV-10-UKRI_UKCDR 2025/26 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) UK Research and Innovation 52745 GB-GOV-10-UKRI_UKCDR COMMITMENT (1) UK - Department of Health and Social Care (DHSC) UK Research and Innovation 67585 GB-GOV-10-UKRI_UKCDR COMMITMENT (2) UK - Department of Health and Social Care (DHSC) UK Research and Innovation 13186.29 GB-GOV-10-UKRI_UKCDR 2025/26 Q4 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) UK Research and Innovation 13186.13 GB-GOV-10-UKRI_UKCDR 2025/26 Q4 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) UK Research and Innovation 16896.25 GB-GOV-10-UKRI_UKCDR 2026/27 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) UK Research and Innovation GB-GOV-10-Wellcome_NIHR_2019 UK - Department of Health and Social Care (DHSC) This partnership between the UK’s National Institute for Health and Care Research (NIHR) and Wellcome funds global health researchers who focus on health priorities in low- and middle-income countries.  The aim of the partnership between DHSC Global Health Research and Wellcome is to support high quality applied global health research in areas of mutual interest, with the following components: 1. Develop and deliver a portfolio of Fellowships for applicants from low and middle-income countries (LMICs) using the established Wellcome Trust International Fellowship scheme, expanding this to encourage applications in targeted areas where skills shortages have been identified, which align with the priority areas of DHSC global health research and Wellcome and where there is an identified need to build research capability (skills gap). The first areas under discussion are global mental health, non-communicable diseases, snake bite and multimorbidity. 2. Support Major Awards in eligible global health research areas (through Collaborative Awards, Investigator Awards and Senior Research Fellowship schemes) in collaboration with the Wellcome Science Division where NIHR co-funds a small number of joint NIHR-Wellcome awards (50:50) in strategically relevant areas. 3. Support a policy-uptake initiative with Wellcome Global Health Policy to facilitate global health research uptake into policy and practice. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The Wellcome Trust UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Medical research Research and Innovation 700000 4100000 5900000 5900000 4800000 4300000 2200000 1440000 29340000 GB-GOV-10-Wellcome_NIHR_2019 COMMITMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 268149 GB-GOV-10-Wellcome_NIHR_2019 2019/20 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 824491 GB-GOV-10-Wellcome_NIHR_2019 2019/20 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 101279 GB-GOV-10-Wellcome_NIHR_2019 2019/20 Q3 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 824491 GB-GOV-10-Wellcome_NIHR_2019 2019/20 Q3 DISBURSEMENT (4) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 688305 GB-GOV-10-Wellcome_NIHR_2019 2020/21 Q3 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 77893 GB-GOV-10-Wellcome_NIHR_2019 2020/21 Q3 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 1124915 GB-GOV-10-Wellcome_NIHR_2019 2020/21 Q3 DISBURSEMENT (3) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 1941782 GB-GOV-10-Wellcome_NIHR_2019 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 163762 GB-GOV-10-Wellcome_NIHR_2019 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 1748626 GB-GOV-10-Wellcome_NIHR_2019 2021/22 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 3201451.48 GB-GOV-10-Wellcome_NIHR_2019 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 67379.5 GB-GOV-10-Wellcome_NIHR_2019 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 824594.88 GB-GOV-10-Wellcome_NIHR_2019 2022/23 Q3 DISBURSMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 1253075.05 GB-GOV-10-Wellcome_NIHR_2019 2023/24 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 1609668.99 GB-GOV-10-Wellcome_NIHR_2019 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 155277.43 GB-GOV-10-Wellcome_NIHR_2019 2024/25 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 5130128.62 GB-GOV-10-Wellcome_NIHR_2019 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 1541885.6 GB-GOV-10-Wellcome_NIHR_2019 2025/26 Q3 DISBURSEMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust GB-GOV-10-Wellcome_UKCDR UK - Department of Health and Social Care (DHSC) The Department of Health and Social Care (DHSC) provides a funding contribution to the UK Collaborative on Development Research (UKCDR), a neutral and impartial entity governed by the Strategic Coherence of ODA-funded Research (SCOR) Board. UKCDR provide high-level coherence for UK Official Development Assistance (ODA) research. UKCDR have a principal commitment to data mapping, analysis and foresight, with remaining activities built upon this strong foundation of knowledge and evidence. UKCDR have four integrated and overlapping aims: -Mapping, analysis and foresight -Convening for collaboration and joint action -Sharing information, learning and best practice -A collective voice to shape policy UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The Wellcome Trust UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Sectors not specified Research and Innovation 41000 101000 167667 134333 101000 131000 133110 52745 40182.32 GB-GOV-10-Wellcome_UKCDR 2019/20 Q4 EXPENDITURE UK - Department of Health and Social Care (DHSC) The Wellcome Trust 59863.22 GB-GOV-10-Wellcome_UKCDR 2020/21 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) The Wellcome Trust 344000 GB-GOV-10-Wellcome_UKCDR COMMITMENT UK - Department of Health and Social Care (DHSC) The Wellcome Trust 20867.94 GB-GOV-10-Wellcome_UKCDR 2020/21 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) The Wellcome Trust 45860.74 GB-GOV-10-Wellcome_UKCDR 2020/21 Q4 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 45313.08 GB-GOV-10-Wellcome_UKCDR 2020/21 Q4 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 33809 GB-GOV-10-Wellcome_UKCDR 2021/22 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) The Wellcome Trust 20480.74 GB-GOV-10-Wellcome_UKCDR 2021/22 Q3 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 37657.37 GB-GOV-10-Wellcome_UKCDR 2021/22 Q3 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 100000 GB-GOV-10-Wellcome_UKCDR COMMITMENT (2) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 20183.05 GB-GOV-10-Wellcome_UKCDR 2021/22 Q4 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 21554.9 GB-GOV-10-Wellcome_UKCDR 2021/22 Q4 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 16989.8 GB-GOV-10-Wellcome_UKCDR 2021/22 Q4 EXPENDITURE (3) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 202000 GB-GOV-10-Wellcome_UKCDR COMMITMENT (3) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 30000 GB-GOV-10-Wellcome_UKCDR COMMITMENT (4) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 29604.84 GB-GOV-10-Wellcome_UKCDR 2022/23 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) The Wellcome Trust 56577.12 GB-GOV-10-Wellcome_UKCDR 2022/23 Q4 EXPENDITURE UK - Department of Health and Social Care (DHSC) The Wellcome Trust 27263.36 GB-GOV-10-Wellcome_UKCDR 2023/24 Q2 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 19453.72 GB-GOV-10-Wellcome_UKCDR 2023/24 Q2 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 19308.32 GB-GOV-10-Wellcome_UKCDR 2023/24 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) The Wellcome Trust 28525.33 GB-GOV-10-Wellcome_UKCDR 2023/24 Q4 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 29292.62 GB-GOV-10-Wellcome_UKCDR 2023/24 Q4 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 29406.28 GB-GOV-10-Wellcome_UKCDR 2024/25 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) The Wellcome Trust 185855 GB-GOV-10-Wellcome_UKCDR COMMITMENT (5) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 24284.15 GB-GOV-10-Wellcome_UKCDR 2024/25 Q2 EXPENDITURE (1) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 30000 GB-GOV-10-Wellcome_UKCDR 2024/25 Q2 EXPENDITURE (2) UK - Department of Health and Social Care (DHSC) The Wellcome Trust 24093.28 GB-GOV-10-Wellcome_UKCDR 2024/25 Q3 EXPENDITURE UK - Department of Health and Social Care (DHSC) The Wellcome Trust 27154.11 GB-GOV-10-Wellcome_UKCDR 2024/25 Q4 EXPENDITURE UK - Department of Health and Social Care (DHSC) The Wellcome Trust 19444.73 GB-GOV-10-Wellcome_UKCDR 2025/26 Q1 EXPENDITURE UK - Department of Health and Social Care (DHSC) The Wellcome Trust GB-GOV-10-WHO_WHA_CT_Res UK - Department of Health and Social Care (DHSC) The UK Department of Health and Social Care (DHSC) funds outstanding global health research through the National Institute for Health and Care Research (NIHR). DHSC is supporting the World Health Organization (WHO) between 2024-2026 to implement the World Health Assembly Clinical Trials Resolution with a focus on low and middle-income country (LMIC) settings. Intended impact is to deliver good practice guidelines to implement the WHA Resolution and improve capability and quality of clinical trials in particular in LMIC settings, including increasing participation by under-represented groups and improving ethical considerations. The project has 3 objectives: 1. Implementing the World Health Assembly Clinical Trials Resolution (WHA 75.8) through establishing good practice guildelines with a focus on low and middle-income country (LMIC) settings. 2. Development of equitable research ethics and ethics oversight capacity. 3. Strengthening global public health research and funder policy development in partnership with the Pandemic PACT initiative delivered by the GloPID-R Research Team in collaboration with WHO. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) World Health Organization UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Health policy and administrative management Research and Innovation 3686735 4367378.5 521987.5 8576101 GB-GOV-10-WHO_WHA_CT_Res COMMITMENT UK - Department of Health and Social Care (DHSC) World Health Organization 1144945 GB-GOV-10-WHO_WHA_CT_Res 2024/25 Q1 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 2541790 GB-GOV-10-WHO_WHA_CT_Res 2024/25 Q2 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization 1043975 GB-GOV-10-WHO_WHA_CT_Res 2025/26 Q1 DISBURSEMENT (1) UK - Department of Health and Social Care (DHSC) World Health Organization 2801416 GB-GOV-10-WHO_WHA_CT_Res 2025/26 Q1 DISBURSEMENT (2) UK - Department of Health and Social Care (DHSC) World Health Organization 521987.5 GB-GOV-10-WHO_WHA_CT_Res 2025/26 Q4 DISBURSEMENT UK - Department of Health and Social Care (DHSC) World Health Organization GB-GOV-10-WorldSafetyConf UK - Department of Health and Social Care (DHSC) NIHR funded scholarships to support the attendance of researchers from ODA-eligible countries to attend and participate in the 15th World Conference on Injury Prevention and Safety Promotion (Safety 2024). The conference, which NIHR representatives attended, presented an opportunity for researchers to network and present their research proposals and findings to a global audience of funders, policymakers and civil society representatives. The scholarships were available only to participants presenting at the conference (oral/poster/workshop). This activity has 2 objectives: 1. To enable researchers from ODA-eligible countries to attend Safety 2024, to maximise networking and knowledge exchange opportunities for those individuals. 2. To increase attendance from researchers in ODA-eligible countries, to bring diverse views and ideas to the conference. UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) UK - Department of Health and Social Care (DHSC) The George Institute for Global Health UK - Department of Health and Social Care (DHSC) Science, Research and Evidence Global Health Research Programme GlobalHealthResearch@dhsc.gov.uk https://www.nihr.ac.uk/funding-and-support/global-health-research/ 7th Floor South Wing, 39 Victoria Street, London, SW1H 0EU Sectors not specified Research and Innovation 10824.78 10824.78 GB-GOV-10-WorldSafetyConf COMMITMENT UK - Department of Health and Social Care (DHSC) The George Institute for Global Health 10824.78 GB-GOV-10-WorldSafetyConf 2024/25 Q2 EXPENDITURE UK - Department of Health and Social Care (DHSC) The George Institute for Global Health