GB-COH-RC000655-AUTOMATE-502851 Keele University The emergent and re-emergent of global pandemics present significant challenges in low-and-middle-income countries (LMICs) where health systems have limited capacity for timely identification and monitoring of the potential impact of pandemics. This project aims to strengthen health systems in LMICs via digitalisation to improve preparedness and responsiveness to pandemics. It has three interrelated workstreams: an assessment of current capacity to use routinely collected data for healthcare decisions, including an illustrative analysis to showcase use of data to inform policy/practice; co-development and implementation of digital health and data analytics/visualization tools and processes to facilitate data access and use for timely decisions; and piloting and evaluating feasibility/process of digitalization of healthcare data. The project is jointly led by two partners in Kenya and the UK: the Tropical Institute of Community Health and Development in Africa (TICH) in Kenya and Keele University - UK, in collaboration with Kenyan Ministry of Health and the University of Sunderland - UK. It is a three-year project, starting November 2024, being implemented in two counties of western Kenya: Kisumu and Siaya. Findings will inform the development of appropriate data digitalization and visualization/analytics tools to enhance evidence-based decision making for improved performance of the health systems with feedback loops at all levels. Potential impact extends beyond the study setting in Kenya to other LMICs. Department of Health and Social Care Tropical Institute of Community Health and Development University of Sunderland Keele University School of Medicine Monica Magadi Professor of Epidemiology and Global Health +44 (0) 1782 732925 m.m.magadi@keele.ac.uk https://www.keele.ac.uk/medicine/staff/monicamagadi/ 104432.40 275077.20 326128.50 303991.30 GB-COH-RC000655-IntegratedPsychosocialCarePlanForComorbidDepressionInBreastCancerPatientsInLowResourcesSettings-490649 Keele University Background and Research Question: Worldwide breast cancer the leading cause of death in females and affects 2.1 women annually. Annual mortality rates are double within south Asian women compared to high-income countries. Co-morbid depression and anxiety is reported in more than one third of breast-cancer survivors and predict higher recurrence and poorer survival among these women. Pakistan has one of the highest rates of breast cancer within South Asia. There is a significant delay in first contact with health professionals due poor health literacy, stigma, taboos in seeking care for breast health and denial among women and families. Global Breast Cancer Initiative calls for an integrated psychosocial and physical care plan within health systems especially within low resource settings. There is equipoise as to which integrated psychological interventions are most effective and scalable for breast cancer survivors in low-income settings to address co-morbid mental health conditions among this population. Aim & Objectives: We develop and evaluate the effectiveness and implementation of culturally adapted integrated psychosocial care for depressed breast-cancer survivors across low-resource settings. Methods and timeline: Research plan consist of seven overlapping workstreams (WS). Using a three-phase Sequential, Multiple Assignment, Randomized Trial (SMART) cluster randomised trial in Pakistan based across health facilities, we evaluate both the clinical and cost-effectiveness of an integrated psychosocial care plan delivering a suite of scalable interventions non-specialist delivered interventions. These being a low intensity guided self-help, a cognitive behaviour-based Moving on ABC Plus, and moving on ABC Plus with adjuvant antidepressants. Primary outcome will be depression remission at 48 weeks, measured by Hamilton Depression Rating Scale. Outcomes assessed at baseline, weeks 6,18,30, and 48 post enrolment (0-60 months) Embedded alongside will be the development of an implementation plan for future scale-up of the evidence-based approach (0-60 months). Prevention and early identification of breast cancer will be achieved using community and social media campaigns ( 0-60 months). In order to inform policy and practice, working with policy makers and other stakeholders for policy implementation (0-60 months). To build research and clinical capacity in Pakistan and other South Asian countries: Six PhD and10 MPhil students along with training for large number of early career researchers will be trained in implementation research and , psychosocial care planning for depression and breast cancer (4-60 months) Develop a breast cancer registry, based on WHO guidance, for Sind province (0-60 months). Anticipated Impact and Dissemination The clinical, policy, and scholarly outputs will support the expansion and upscaling of breast cancer care and training programmes across Pakistan and partner countries. The collaborative workshops with key stakeholders in each partner country (WS5) will lead to the development of low-cost interventions (available as patient and carer manuals, in booklet and digital format) and a train-the-trainer programme for healthcare professionals, strengthening research and clinical expertise. A significant reduction in depression associated with breast cancer is aimed along with wide dissemination of findings via key international conferences, and publishing in high impact peer-reviewed journals. Department of Health and Social Care Ishrat Husain Pakistan Institute Of Living and Learning (PILL) Keele University School of Medicine Professor Saeed Farooq Professor of Psychiatry and Public Mental Health s.farooq@keele.ac.uk https://www.keele.ac.uk/medicine/staff/saeedfarooq/ 17871 17871 17870 17870 17870 GB-COH-RC000655-TRANSLATE-535800 Keele University NIHR funded global health professorship: Translating evidence for early intervention in psychosis (TRANSLATE) in Low and Lower-Middle Income Countries (LMIC): Implementation and Evaluation. It is an implementation research programme to scale up evidence-based management of First Episode of Psychosis (FEP) in LMICs. The research plan will aim to (i) establish an Early Intervention in Psychosis (EIP) service for young people with FEP in LMIC settings (Pakistan and Sri Lanka), (ii) evaluate the effectiveness of the service in terms of implementation outcomes, in a cohort of individuals presenting with FEP, and (iii) develop a clinical tool to predict the risk of Treatment Resistant Schizophrenia (TRS) using one-year follow-up data from the FEP cohort Kyber Medical University Institute for Research and Development in Health and Social Care Department of Health and Social Care Keele University Professor Saeed Farooq Project lead, and Professor & Honorary Consultant Psychiatrist s.farooq@keele.ac.uk School of Medicine David Weatherall building. University Road Keele University Staffordshire ST5 5BG 44074 304577 490794 476401 446963 229590 GB-COH-RC000655-CONTROL-project Keele University NIHR Research and Innovation for Global Health Transformation Call 3: CONTROL (COgNitive Therapy for depRessiOn in tubercuLosis treatment) programme of research to improve outcomes for depression and TB in Pakistan and Afghanistan refugees living in Pakistan. A UK and low- and middle-income country (LMIC) research partnership to develop and test a psychosocial intervention for treating depression in TB and improving adherence with antituberclosis treatment (ATT) in Pakistan and Afghanistan refugees living in Pakistan. Khyber Medical University Healthnet Transcultural Psychosocial Organistaion, HealthNet TPO University of Sheffield Department of Health and Social Care Keele University School of Medicine Professor Saeed Farooq Project co-lead, and Professor & Honorary Consultant Psychiatrist s.farooq@keele.ac.uk School of Medicine David Weatherall building. University Road Keele University Staffordshire ST5 5BG Khyber Medical University Office of Research, Innovation, and Commercialization Dr Zohaib Khan Project co-lead, and Director of the Office of Research, Innovation, and Commercialization dr.zohaibkhan@kmu.edu.pk 518159 1217120 1189128 1214024 706276 This is the official webpage for CONTROL programme, which includes information on the aims of the work, team members, news and updates and outputs such as newsletters and community engagement reports. GB-COH-RC000655-ECLIPSE_180244 Keele University A UK and low- and middle-income country (LMIC) research partnership, Empowering people with Cutaneous Leishmaniasis: Intervention Programme to improve patient journey and reduce Stigma via community Education (ECLIPSE) is a five-year healthcare programme which aims to improve the cutaneous leishmaniasis (CL) patient journey and reduce stigma in the most marginalised and underserved communities in Brazil, Ethiopia and Sri Lanka. Keele University Federal University of Bahia Mekelle University Rajarata University Kent and Medway Medical School Department of Health and Social Care Keele University Professor Helen Price Professor of Parasitology +441782734219 h.price@keele.ac.uk https://www.keele.ac.uk/lifesci/ourpeople/helenprice/ Kent and Medway Medical School Professor Lisa Dikomitis Professor of Medical Anthropology and Social Sciences lisa.dikomitis@kmms.ac.uk https://kmms.ac.uk/person/professor-lisa-dikomitis/ 853390 853391 853391 1112701 855066 This is the official website for the ECLIPSE programme, which includes information on the aims of the work, team members, news and updates and outputs such as newsletters and videos.